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Search Results for " sarcoplasmic "

Targets Recommended: Calcium Channel

27

抑制剂 & 化合物

2

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16873	SERCA2a activator 1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。
T1198	Tetracaine hydrochloride 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。
T84368	Caldaret HCl MCC-135 HCl,Caldaret HCl（192509-24-3 Free base）	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Caldaret HCl 是一种细胞内 Ca2+ 调节剂，可调节肌浆网和细胞膜处的钙稳态，可用于研究急性心肌梗死和心力衰竭。
T8863	VK-II-36	Others	Others
	VK-II-36 是 carvedilol 的类似物，能够在不阻断 β 受体的情况下抑制肌浆网钙释放。它能够抑制早期和延迟后去极化诱发的触发活动，可用于局灶性室性心律失常的研究。
T24239	K201 K-201,JTV 519,JTV-519,K 201	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂，通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T37807	JTV-519 fumarate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	JTV-519 fumarate (K201 fumarate) 是一种 SERCA 阻断剂和兰尼碱受体的部分激动剂，具有抗心律失常和心脏保护作用，可改善肌浆网钙渗漏，可用于研究焦虑症。
T8452	Dantrolene	Others	Others
	Dantrolene 是一种肌肉松弛剂，是人红细胞谷胱甘肽还原酶的非竞争性抑制剂，其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。
T1435	Praziquantel 吡喹酮,Pyquiton,Droncit,Biltricide	Calcium Channel; Antibiotic; Parasite	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Praziquantel (Droncit) 是一种外消旋混合物，由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。
T4054	Dantrolene sodium hemiheptahydrate Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。
T5148	Atosiban acetate RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T68320	L594881 HCl	Others	Others
	L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.
T26383	3',4'-Dichlorobenzamil HCl	Others	Others
	3',4'-Dichlorobenzamil HCl is an inhibitor of Na+ transport, Na+/Ca2+ exchanger, sarcoplasmic reticulum Ca2+ release channels.
T80555	Myoregulin TFA MLN peptide TFA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Myoregulin (MLN peptide) TFA，作为调节蛋白家族成员，通过干预细胞内钙处理机制来调控肌肉功能。该化合物直接作用于肌浆网 Ca2+-ATPase (SERCA)，抑制其将Ca2+传输至肌浆网。
T26830	BK 129 BK-129,BK129	Others	Others
	BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.
T15599	Istaroxime hydrochloride PST2744 hydrochloride	Others	Others
	Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
T11732	JTV-519 hemifumarate K201 hemifumarate	MELK	PI3K/Akt/mTOR signaling
	JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
T80554	Myoregulin MLN peptide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Myoregulin（MLN peptide）为调节蛋白家族成员，作用于肌肉性能调控，通过影响细胞内钙处理机制实现其功能。它直接与SERCA相互作用，抑制Ca2+进入肌浆网。
T68366	Azumolene sodium dihydrate	Others	Others
	Azumolene sodium dihydrate is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.
T11731	JTV-519 free base K201 free base	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partial agonist of ryanodine receptors in striated muscle.
T80063	Imperatoxin A	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Imperatoxin A，源自非洲蝎Pandinus imperator毒液的一种肽毒素，作为Ca2+-释放通道/兰尼碱受体（RyRs）的激活剂，促进Ca2+从肌浆网流入细胞。
T80556	wt hMLN	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	wt hMLN为抑制SR Ca2+泵（SERCA）的微量蛋白，对骨骼肌钙稳态具有关键作用。
T75372	BODIPY FL Thapsigargin
	BODIPY FL Thapsigargin 作为一种高效绿色荧光染料，主要抑制细胞内肌浆/内质网中的serca型Ca2+泵。其应用焦点在于探究Thapsigargin在活细胞中的结合位置。储存需避光处理。
T72004	Azumolene sodium anhydrous	Others	Others
	Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.
T11731L	JTV-519 Formate JTV-519 Formate (145903-06-6 Free base)	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	JTV-519 Formate 是一种 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂，同时也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 Formate 显示出抗心律失常作用，是一种心脏保护剂。
T69975	Istaroxime oxalate	Others	Others
	Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarco...
T80247	Caloxin 3A1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Caloxin 3A1是生物活性肽，属于caloxins系列，特指抑制外质膜(Plasma membrane, PM) Ca2+泵的化合物。具体作用通过抑制质膜钙泵(PMCA)并保持对肌浆网Ca2+泵无影响；同时，该肽不干预ATP合成酰基磷酸中间产物的形成。
T4996	Atosiban 阿托西班,RWJ22164,RW22164	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。

化合物

SERCA2a activator 1

Cat.No: T16873

Target: Calcium Channel

Tetracaine hydrochloride

Cat.No: T1198

Synonym: 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl

Target: Calcium Channel, Sodium Channel

Cat.No: T84368

Synonym: MCC-135 HCl,Caldaret HCl（192509-24-3 Free base）

Target: Calcium Channel

Cat.No: T8863

Target: Others

Cat.No: T24239

Synonym: K-201,JTV 519,JTV-519,K 201

Target: Calcium Channel

JTV-519 fumarate

Cat.No: T37807

Target: Calcium Channel

Cat.No: T8452

Target: Others

Cat.No: T1435

Synonym: 吡喹酮,Pyquiton,Droncit,Biltricide

Target: Calcium Channel, Antibiotic, Parasite

Dantrolene sodium hemiheptahydrate

Cat.No: T4054

Synonym: Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene

Target: Calcium Channel, Autophagy

Atosiban acetate

Cat.No: T5148

Synonym: RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班

Target: Oxytocin Receptor, Vasopressin Receptor

Cat.No: T68320

Target: Others

3',4'-Dichlorobenzamil HCl

Cat.No: T26383

Target: Others

Cat.No: T80555

Synonym: MLN peptide TFA

Target: Calcium Channel

Cat.No: T26830

Synonym: BK-129,BK129

Target: Others

Istaroxime hydrochloride

Cat.No: T15599

Synonym: PST2744 hydrochloride

Target: Others

JTV-519 hemifumarate

Cat.No: T11732

Synonym: K201 hemifumarate

Target: MELK

Cat.No: T80554

Synonym: MLN peptide

Target: Calcium Channel

Azumolene sodium dihydrate

Cat.No: T68366

Target: Others

JTV-519 free base

Cat.No: T11731

Synonym: K201 free base

Target: FLT

Cat.No: T80063

Target: Calcium Channel

Cat.No: T80556

Target: Calcium Channel

BODIPY FL Thapsigargin

Cat.No: T75372

Azumolene sodium anhydrous

Cat.No: T72004

Target: Others

JTV-519 Formate

Cat.No: T11731L

Synonym: JTV-519 Formate (145903-06-6 Free base)

Target: Others, Calcium Channel

Istaroxime oxalate

Cat.No: T69975

Target: Others

Cat.No: T80247

Target: Calcium Channel

Cat.No: T4996

Synonym: 阿托西班,RWJ22164,RW22164

Target: Oxytocin Receptor, Vasopressin Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TQ0302	Thapsigargin 毒胡萝卜素	Apoptosis; SARS-CoV; Calcium Channel	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Thapsigargin 属于天然产物，是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂，也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。
T14293	Annonacin	Others	Others
	Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu

天然产物

Cat.No: TQ0302

Synonym: 毒胡萝卜素

Target: Apoptosis, SARS-CoV, Calcium Channel

Cat.No: T14293

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03090	SCP alpha chain Protein, Penaeus sp., Recombinant (His & Myc & SUMO) Sarcoplasmic calcium-binding protein, alpha-B and -...	Penaeus	E. coli
	Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution. SCP alpha chain Protein, Penaeus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 42.0 kDa and the accession number is P02636.
TMPH-03766	ATP2A2 Protein, Human, Recombinant (C-His) SR Ca(2+)-ATPase 2,Calcium pump 2,SERCA2,ATP2A2,Sarcopla...	Human	E. coli
	ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615.
TMPY-03438	Calsequestrin 1 Protein, Human, Recombinant CASQ,PDIB1,VMCQA,calsequestrin 1 (fast-twitch, skeletal musc...	Human	E. coli
	Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-boun...
TMPY-03458	Sorcin/SRI Protein, Human, Recombinant sorcin,SCN,CP22,V19,CP-22	Human	Baculovirus Insect Cells
	Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Sorcin is overexpressed in the multi-drug resistant chinese hamster ovary cell line CHRC5 and a variety of multidrug-resistant tumor cell lines, but overexpression is not a sufficient or necessary condition for the acquisition of the multidrug-resistant phenotype. Sorc...
TMPY-03257	Calumenin Protein, Human, Recombinant (His) calumenin	Human	HEK293 Cells
	Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the presence of EDTA. Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit gamma-carboxylase GGCX. Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcop...
TMPY-03267	Sorcin/SRI Protein, Human, Recombinant (His & GST) CP-22,CP22,sorcin,V19,SCN	Human	Baculovirus Insect Cells
	Sorcin was originally identified in multidrug-resistant cells. It is a calcium-binding protein. Sorcin modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Sorcin is overexpressed in the multi-drug resistant chinese hamster ovary cell line CHRC5 and a variety of multidrug-resistant tumor cell lines, but overexpression is not a sufficient or necessary condition for the acquisition of the multidrug-resistant phenotype. Sorc...

重组蛋白

SCP alpha chain Protein, Penaeus sp., Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03090

Species: Penaeus

Expression System: E. coli

ATP2A2 Protein, Human, Recombinant (C-His)

Cat.No: TMPH-03766

Species: Human

Expression System: E. coli

Calsequestrin 1 Protein, Human, Recombinant

Cat.No: TMPY-03438

Species: Human

Expression System: E. coli

Sorcin/SRI Protein, Human, Recombinant

Cat.No: TMPY-03458

Species: Human

Expression System: Baculovirus Insect Cells

Calumenin Protein, Human, Recombinant (His)

Cat.No: TMPY-03257

Species: Human

Expression System: HEK293 Cells

Sorcin/SRI Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03267

Species: Human

Expression System: Baculovirus Insect Cells

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