38
12
2
15
Cat. No. | Product Name | ||
---|---|---|---|
L2195 | 抗前列腺癌化合物库 | 2070 compounds | |
2070 种与前列腺癌相关的化合物,可以用于高通量和高内涵筛选 | |||
L2196 | 抗卵巢癌化合物库 | 1867 compounds | |
1867 种与卵巢癌相关的化合物,可以用于抗卵巢癌药物研发和药理研究 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14094 |
Acetamiprid
|
AChR | Neuroscience |
Acetamiprid 是广泛使用的新烟碱类杀虫剂,是一种烟碱型乙酰胆碱受体激动剂,与神经肌肉和生殖系统疾病有关。 | |||
T4382 |
Proguanil hydrochloride
Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil |
Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others |
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
T31532 |
Disperse Red 1
Celliton Scarlet B,Neosetile Scarlet B,Diacelliton Scarlet B,Fenacet Scarlet B,分散红 1,Celliton Red B |
Others | Others |
Disperse Red 1 (Celliton Scarlet B) 是偶氮苯衍生物,是偶氮纺织品染料,普遍用于纺织工业中的聚酯织物染色。 | |||
T38144 |
Elinzanetant
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Elizanetant 是有效的神经激肽受体拮抗剂,在精神分裂症研究中有价值。 | |||
T6858 |
Hydroxyprogesterone caproate
Primolut Depot,Delalutin,Hormofort,己酸孕酮,17α-Hydroxyprogesterone hexanoate,17α-Hydroxyprogesterone caproate |
Autophagy | Autophagy |
Hydroxyprogesterone caproate (Delalutin) 是一种甾体,是一种人工合成的孕激素。 | |||
TP1648L |
[Gln8]-C517 (LH-RH), chicken acetate
[Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base) |
Others | Others |
[Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base) 是一种鸟类下丘脑肽,可刺激垂体前叶释放促性腺激素,从而调节生殖功能。 | |||
T5015 |
Gonadorelin Acetate (33515-09-2 free base)
醋酸戈那瑞林,Luteinizing Hormone Releasing Hormone (LH-RH),Luteinizing Hormone Releasing Hormone (LH-RH), human,Gonadorelin Acetate |
Reductase | Endocrinology/Hormones; Metabolism |
Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) 是下丘脑神经肽,在控制生殖功能中起关键作用。 | |||
T19735 |
Flucycloxuron
氟螨脲,(E)-flucycloxuron,Andalin |
Others | Others |
Flucycloxuron ((E)-flucycloxuron) 是一种甲壳素合成抑制剂,用作杀虫剂。在昆虫模型中,该抑制剂已被证明会影响几种生殖事件,例如产卵前的持续时间。 | |||
TP1112L |
LH-RH, salmon acetate(86073-88-3 free base)
Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate |
Others | Others |
LH-RH, salmon acetate(86073-88-3 free base) (Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate) 是一种在下丘脑中合成的垂体激素,在控制生殖功能中起着至关重要的作用。 | |||
T2527 |
Ulipristal acetate
Ulipristal,醋酸乌利司他,CDB-2914 |
Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Others |
Ulipristal acetate (CDB-2914) 是一种具有抗孕酮活性的选择性孕酮受体调节剂。它可抑制子宫平滑肌瘤病的生长。它通过抑制或延迟排卵和影响子宫内膜组织,可用作紧急避孕药。 | |||
T0976 |
Propoxur
残杀威,Aprocarb,Propoxure,Baygon |
AChR; Antifungal | Microbiology/Virology; Neuroscience |
Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂,用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。 | |||
T29475 |
6-Methylene-4-pregnene-3,20-dione
|
Others | Others |
6-Methylene-4-pregnene-3,20-dione has reproductive effect. | |||
T71781 |
Xylamidine tosylate
|
Others | Others |
Xylamidine tosylate is a Serotonin inhibitor with reproductive effects | |||
T31715 |
Ethynylestradiol mixture with lynestrenol
|
Others | Others |
Ethynylestradiol mixture with lynestrenol is a drug/ therapeutic agent with reproductive effect. | |||
T32076 |
Hippadine
|
Others | Others |
Hippadine is isolated from Crinum bulbs and has reproductive effect. | |||
T40491 |
Luteinizing hormone (human)
|
||
Luteinizing hormone (LH), a heterodimeric glycoprotein hormone synthesized by the pituitary gland, serves vital functions in human reproductive processes. | |||
T70570 |
Erlosiban
|
Others | Others |
Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART). | |||
TP1648 |
[Gln8]-C517 (LH-RH), chicken
|
||
[Gln8] Luteinizing hormone releasing hormone ([Gln8] LH-RH), Avian hypothalamic peptide that stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions. | |||
TP1112 |
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
LH-RH, salmon |
||
Luteinizing Hormone Releasing Hormone (LH-RH) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function. | |||
T78524 |
Polystyrene
|
Others | Others |
聚苯乙烯微塑料(PS-MPs)是一种潜在的有毒危害物质,对斑马鱼心脏造成损害,同时能诱导小鼠雄性生殖毒性。 | |||
T78515 |
Follicle-stimulating hormone
|
Others | Others |
卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白,其参与调控动物的生殖能力与繁殖效率。 | |||
T40550 |
Human β-defensin-1
Human β-defensin-1,HβD-1 |
||
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. It exhibits antimicrobial activity against a wide range of sperm bacteria. | |||
T37230 |
(+)-5-trans Cloprostenol
|
Others | Others |
Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster. | |||
T36469 |
Atrazine Mercapturate
|
Others | Others |
Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples. | |||
T76616 |
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
|
||
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是一种黄体生成素释放激素 (LHRH) 的类似物,主要通过促进垂体分泌黄体生成素 (LH) 和促卵泡激素 (FSH) 来在生殖调控中发挥关键作用。 | |||
T75839 |
Kisspeptin-10, rat TFA
|
||
Kisspeptin-10, rat TFA 作为有效的血管收缩剂及血管生成抑制剂,为GPR54 (亦称KISS1) 亲吻蛋白受体的配体。此外,Kisspeptin-10, rat TFA 能降低Methotrexate引起的生殖毒性并显示出抗氧化潜力。 | |||
T80424 |
Phoenixin-20 TFA
PNX-20 TFA |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Phoenixin-20 (TFA) (PNX-20 (TFA)) 是一种在脊椎动物中发挥激素作用的生物活性肽,能够激活下丘脑-垂体-性腺轴,从而调控哺乳类动物的生殖机能。此外,该肽通过CREB-PGC-1α途径,增强神经元的线粒体生物生成。 | |||
T37231 |
(+)-Cloprostenol methyl ester
|
Others | Others |
(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprosteno... | |||
T76620 |
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
|
||
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是黄体生成素释放激素 (LHRH) 的类似物。LHRH 通过刺激垂体黄体生成素 (LH) 和促卵泡激素 (FSH) 的释放,在控制生殖中发挥核心作用。 | |||
T76615 |
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
|
||
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH是一种LHRH(黄体生成素释放激素)的类似物,主要通过激活垂体分泌黄体生成素(LH)和促卵泡激素(FSH)来在生殖调控中发挥核心作用。 | |||
T72683 |
PRRSV/CD163-IN-1
|
Others | Others |
PRRSV/CD163-IN-1 是一种 PRRSV/CD163抑制剂。PRRSV/CD163-IN-1 可以抑制 PRRSV 糖蛋白(GP2a 或 GP4)与 CD163-SRCR5 结构域之间的相互作用。PRRSV/CD163-IN-1 可用于猪繁殖与呼吸综合征(PRRS)的研究。 | |||
T84406 |
5α-Androst-16-en-3-one
Androstenone |
Others | Others |
5α-Androst-16-en-3-one, a mammalian pheromone present in boar saliva, plays a crucial role in facilitating social and sexual interactions by acting as a volatile chemical cue. It is utilized to prime sows in estrus for mating or artificial insemination, underscoring its significance in reproductive behavior. Additionally, this compound is detected in human sweat and urine, where it is involved in studies concerning receptor-mediated odorant detection and the genetic foundations of anosmias, ther... | |||
T63183 |
RET-IN-9
|
Others | Others |
RET-IN-9 是一种 RET 的有效抑制剂。其中 RET 激酶是一种单通道跨膜受体酪氨酸激酶,在肾脏和肠神经系统的发育以及维持神经、内分泌、造血和男性生殖系统的体内平衡中发挥着重要作用。RET-IN-9 具有潜力进行 RET 相关疾病的研究(包括非小细胞肺癌和甲状腺髓样癌)。 | |||
T84963 |
5α-Androstan-3β-ol
NSC 50887 |
Others | Others |
5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profil... | |||
T83890 |
Flavokawain 1i
Flavokavain 1i |
Others | Others |
Flavokawain 1i是chalcones的派生物,包括flavokawain A、flavokawain B和flavokawain C,具有抗癌和抗病毒活性。在30 µM浓度下,Flavokawain 1i能够抑制gefitinib抵抗性的H1975非小细胞肺癌(NSCLC)细胞的增殖率达到36%,同时降低热休克蛋白90(Hsp90)客体蛋白EGFR、c-Met、HER2、Akt和细胞周期依赖性激酶4(Cdk4)的蛋白水平,并提高Hsp70蛋白水平,这是Hsp90抑制的标志。肌肉内给药的Flavokawain 1i能够降低感染猪生殖与呼吸综合征病毒(PRRSV)猪只的病毒滴度。 | |||
T13460 |
(+)-Cevimeline hydrochloride hemihydrate
(+)-AF102B hydrochloride hemihydrate,(+)-SNI-2011 |
Others | Others |
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011) 是一种有效的 mAChR 激动剂。 | |||
T13421 |
(-)-Cevimeline hydrochloride hemihydrate
(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate |
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是一种新型mAChR 激动剂,是一种治疗干燥综合征口干症的候选治疗药物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8002 |
3-Hydroxycoumarin
|
Lipoxygenase | Metabolism |
3-hydroxycoumarin 是一种 15-LOX-1的有效氧化还原抑制剂,近期被证明能保护海胆生殖细胞免受紫外线 B 的损伤。 | |||
T5623 |
Bisphenol A
|
Others; Endogenous Metabolite | Metabolism; Others |
Bisphenol A 是酚类内源性代谢合成物,广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质,常被归类为内分泌干扰物。它与许多疾病有关,包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。 | |||
T6S1880 |
Benzoylaconine
苯甲酰乌头原碱,Pikraconitin,Isaconitine,Benzoylaconitine |
Others | Others |
Benzoylaconine (Isaconitine) 是一种中药附子生物碱。 | |||
T4960 |
VASICINE
|
Anti-infection; AChR | Microbiology/Virology; Neuroscience |
Vasicine 是一种分离自Justicia adhatoda 中的喹唑啉类生物碱。它具有抗结核作用。 | |||
T7913 |
2-Bromobiphenyl
|
Others | Others |
2-Bromobiphenyl 是一种持久性有机污染物,主要存在于土壤和水中。它是一种已知的人类致癌物,与生殖和发育毒性等多种健康影响有关。 | |||
T1429 |
17α-Hydroxyprogesterone
Hydroxyprogesterone,17-OHP,羟孕酮,17-Hydroxyprogesterone,17α-羟孕酮 |
Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; Others |
17α-Hydroxyprogesterone (17-OHP) 是一种内源性孕激素,其他类固醇激素(包括糖皮质激素,雌激素,和雄激素)生物合成的化学中间体。 | |||
T7931 |
16a,17a-Epoxy-4-Pregnen-3,20-Dione
|
Others | Others |
16a,17a-Epoxy-4-Pregnen-3,20-Dione 是一种合成孕激素,是黄体酮激素的代谢产物,它通过与黄体酮受体结合发挥作用,已被用于研究孕激素对生殖器官的影响,激素对细胞生长和发育的影响,以及激素对免疫系统的影响。 | |||
T25664 |
Lepidiline A
Macaline A |
Others | Others |
Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性,IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分,可改善小鼠内源性性激素的平衡,提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性,提高性激素的生物转化效率,提高生殖能力。Lepidiline A 具有抗癌活性。 | |||
T3746 |
Dimethyl phthalate
邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯 |
Others | Others |
Dimethyl phthalate (Fermine) 是一种邻苯二甲酸酯 (PAEs),是一种已知的内分泌干扰物,也是一种普遍存在的污染物。它常作为增塑剂,赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。 | |||
T14548 |
Beta-Zearalanol
|
Others | Others |
Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1]. | |||
T13797 |
Nivalenol
|
Caspase | Apoptosis; Proteases/Proteasome |
Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡,从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。 | |||
TN4277 |
Isocupressic acid
|
cAMP; P450; PKA | GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors |
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01549 |
Interferon epsilon/IFNE Protein, Human, Recombinant (His)
IFNE,Interferon epsilon,Interferon epsilon-1 |
Human | E. coli |
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections. | |||
TMPH-02337 |
Hydrophobin-1 Protein, Hypocrea jecorina, Recombinant (His & SUMO)
hfb1,Hydrophobin-1,Hydrophobin I |
Hypocrea jecorina | E. coli |
Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures. Hydrophobin-1 Protein, Hypocrea jecorina, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and the accession number is P52754. | |||
TMPY-02845 |
CST9L Protein, Human, Recombinant (hFc)
bA218C14.1,CTES7B,UNQ1835,PRO3543,cystatin 9-like |
Human | HEK293 Cells |
Testatin is a member of the Cystatin family. Cystatins comprise genes that all show expression patterns that are strikingly restricted to reproductive tissue. Cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. There are typically about 115 amino acids in this family. They are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds, may be glycosylated and/or phosphorylated, with similarity to fetuins, kininogens, stefins, ... | |||
TMPH-02897 |
SPINK1 Protein, Mouse, Recombinant (His)
Serine protease inhibitor Kazal-type 3,Serine protease inhib... |
Mouse | P. pastoris (Yeast) |
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. SPINK1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 8.1 kDa and the accession number is P09036. | |||
TMPJ-00762 |
ER alpha Protein, Human, Recombinant (His)
Estrogen Receptor,ER α,estrogen receptor α,ER-Alpha,ER alpha... |
Human | E. coli |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ... | |||
TMPH-02832 |
Serpin A5 Protein, Mouse, Recombinant (His)
Protein C inhibitor,Plasminogen activator inhibitor 3,Serpin... |
Mouse | Baculovirus Insect Cells |
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin comple... | |||
TMPY-04307 |
GNRH2 Protein, Human, Recombinant (hFc)
LH-RHII,gonadotropin releasing hormone 2,GnRH-II,GNRH2 |
Human | HEK293 Cells |
GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian... | |||
TMPY-01783 |
SMOC1 Protein, Human, Recombinant (His)
OAS,SPARC related modular calcium binding 1 |
Human | HEK293 Cells |
SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri... | |||
TMPJ-00771 |
TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-beta-1,TGF-beta 1 protein,latency-as... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... | |||
TMPH-01551 |
IFNLR1 Protein, Human, Recombinant (His & SUMO)
Cytokine receptor class-II member 12,Likely interleukin or c... |
Human | E. coli |
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar... | |||
TMPY-02651 |
p63 Protein, Human, Recombinant (His & GST)
p40,TP53L,RHS,B(p51A),p51,KET,NBP,B(p51B),OFC8,tumor protein... |
Human | Baculovirus Insect Cells |
Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63, and p73 have similar features in their gene structures and functions. An animal model, p63-/- mice has been useful in difining the role p63 plays in the development and maintenance of stratified epithelial tissues. This p63 encoding protein p63 has a dramatic impact on replenishment of cutaneous epith... | |||
TMPY-02495 |
p19 INK4d Protein, Human, Recombinant (GST)
p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i... |
Human | E. coli |
Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind... | |||
TMPJ-00521 |
CHL2 Protein, Mouse, Recombinant (His)
CHRDL2,chordin-like 2,chordin-like protein 2,BNF-1 |
Mouse | HEK293 Cells |
Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites, one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney, partly expressed in the connective ... | |||
TMPY-01826 |
Relaxin 1/RLN1 Protein, Human, Recombinant (His)
RLXH1,H1RLX,relaxin 1,bA12D24.3.1,H1,RLN1,bA12D24.3.2 |
Human | HEK293 Cells |
Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 8 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has impo... | |||
TMPH-00064 |
MRJP1 Protein, Apis mellifera, Recombinant (His)
Royalactin,Major royal jelly protein 1,Apalbumin 1,MRJP1,56-... |
Apis mellifera | P. pastoris (Yeast) |
Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The ... |