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Search Results for " polymorphonuclear leukocytes "

Targets Recommended: Lipoxygenase

27

抑制剂 & 化合物

4

天然产物

10

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27026	CJ-13,610 CJ 13610,CJ-13610	Lipoxygenase	Metabolism
	CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T68166	Traxanox	Others	Others
	Traxanox 是一种可口服的利尿剂。Traxanox 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox 对抑制BALB/c小鼠抗体产生的恢复作用。
T36879L	H-Leu-Leu-OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others	Others
	H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
T68166L	Traxanox TFA Traxanox TFA(58712-69-9 Free base)	Others	Others
	Traxanox TFA 是一种可口服的利尿剂。Traxanox TFA 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox TFA 对抑制BALB/c小鼠抗体产生的恢复作用。
T69110	Aseanostatin P5	Others	Others
	Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T24305	L 651142 L651,142,L651142,L-651,142,L 651,142,L-651142	Others	Others
	L 651142 is a weak inhibitor of the platelet-activating factor receptor. It is also binding to polymorphonuclear leukocytes.
T27408	Gea 3162 Gea3162,Gea-3162	Others	Others
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
TP2395	Nph-peptide
	Nph-peptide can be used for photoaffinity labeling of the N-formyl peptide receptor site of intact human polymorphonuclear leukocytes.
T84569	Thromboxane B3 Δ17-TXB2	Others	Others
	Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.
T15825	LY 178002	Retinoid Receptor	Metabolism
	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cycloox
T37460	Lipoxin B4 Lipoxin B4	Others	Others
	Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T21962	HZ52	Others	Others
	HZ52 是一种有效可逆的5-脂氧合酶(5-LO)抑制剂，在完整的人类多形核白细胞中可阻断白三烯的合成，IC50为 0.7 μM。
T38308	Lipoxin B4 methyl ester	Others	Others
	Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T37649	5(S),12(S)-DiHETE	Others	Others
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotrie...
T84529	Δ17-6-keto Prostaglandin F1α ω-3 6-keto PGF2α	Others	Others
	Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α), a cyclooxygenase (COX) metabolite produced from eicosapentaenoic acid (EPA) in a variety of tissues including seminal vesicles, lungs, polymorphonuclear leukocytes, and ocular tissues, alongside other 3-series COX products from EPA such as PGF3α, PGE3, and thromboxane B3, is potentially linked to a lower occurrence of glaucoma in individuals consuming a marine-rich (EPA-rich) diet.
T37382	1,2,3-Trieicosapentaenoyl-rac-glycerol	Others	Others
	1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid , which is an ω-3 fatty acid. An EPA-TG emulsion, administered i.v., lowers leukotriene B4 production by 40% in polymorphonuclear leukocytes from rabbits and reduces platelet aggregation. It suppresses natural killer cell activity both in vitro and in vivo, in human lymphocytes and murine spleens, respectively, with the in vivo effects lasting up to seven days.
T37975	13(S)-HODE-biotin	Others	Others
	13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes. The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.
T84493	CAY10649	Others	Others
	1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neu...
T84638	Butanoyl PAF	Others	Others
	Oxidized low-density lipoprotein (oxLDL) encompasses low molecular weight entities that facilitate monocyte differentiation and activate polymorphonuclear leukocytes. A substance, recently isolated and purified from oxLDL and identified as azelaoyl PC, exemplifies this. Similarly, Butanoyl PAF, a compound closely related to azelaoyl PC, maintains over 10% of the agonist potency of platelet-activating factor (PAF). Notably, Butanoyl PAF's concentration in oxLDL surpasses that of enzymatically gen...
T34917	Traxanox sodium Y 12141,Y12141,Y-12141	Others	Others
	Traxanox sodium 是一种可口服的利尿剂。Traxanox sodium 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox sodium 对抑制BALB/c小鼠抗体产生的恢复作用。
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T36423	Leukotriene B5	Others	Others
	Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platele...
T83669	PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
	PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂（IC50 = 0.3 µM）。它能抑制C5a诱导的人类分离性多形核白细胞（PMNs）中的髓过氧化物酶（MPO）分泌。在大鼠腹膜亚瑟斯反应模型中，PMX-53（10 mg/kg, p.o.）能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸（3-NP）诱导的亨廷顿病大鼠模型中，它能减少体重损失和厌食，抑制纹状体退化。PMX-53（3 mg/kg）还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。
T35836	PMX-205 (trifluoroacetate salt)	Others	Others
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...
T35881	Resolvin E2	Others	Others
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...

化合物

Cat.No: T27026

Synonym: CJ 13610,CJ-13610

Target: Lipoxygenase

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T68166

Target: Others

H-Leu-Leu-OMe . HBr

Cat.No: T36879L

Synonym: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Target: Others

Cat.No: T68166L

Synonym: Traxanox TFA(58712-69-9 Free base)

Target: Others

Aseanostatin P5

Cat.No: T69110

Target: Others

Cat.No: T24305

Synonym: L651,142,L651142,L-651,142,L 651,142,L-651142

Target: Others

Cat.No: T27408

Synonym: Gea3162,Gea-3162

Target: Others

Cat.No: TP2395

Cat.No: T84569

Synonym: Δ17-TXB2

Target: Others

Cat.No: T15825

Target: Retinoid Receptor

Cat.No: T37460

Synonym: Lipoxin B4

Target: Others

Cat.No: T21962

Target: Others

Lipoxin B4 methyl ester

Cat.No: T38308

Target: Others

5(S),12(S)-DiHETE

Cat.No: T37649

Target: Others

Δ17-6-keto Prostaglandin F1α

Cat.No: T84529

Synonym: ω-3 6-keto PGF2α

Target: Others

1,2,3-Trieicosapentaenoyl-rac-glycerol

Cat.No: T37382

Target: Others

13(S)-HODE-biotin

Cat.No: T37975

Target: Others

Cat.No: T84493

Target: Others

Cat.No: T84638

Target: Others

Traxanox sodium

Cat.No: T34917

Synonym: Y 12141,Y12141,Y-12141

Target: Others

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

Cat.No: T36423

Target: Others

Cat.No: T83669

Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

Target: Others

Cat.No: T35881

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S1422	Praeruptorin E 白花前胡素 E,白花前胡素E	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
TN4486	Magnolianin	Others	Others
	Magnolianin can inhibit strongly (IC50 = 0.45 uM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.
T13716	(+)-Guaiacin	Others	Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF).
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

Cat.No: T4S1422

Synonym: 白花前胡素 E,白花前胡素E

Target: Others, Calcium Channel

Cat.No: TN4486

Target: Others

Cat.No: T13716

Target: Others

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03562	Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO) Gamma-hemolysin, H-gamma-I subunit,Leukocidin-F subunit,lukF	Staphylococcus aureus	E. coli
	Leukocidin causes cytotoxic changes in polymorphonuclear leukocytes. Gamma-hemolysin causes hemolysis in red blood cells. Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 54.0 kDa and the accession number is P31715.
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His) Complement C5a anaphylatoxin,C5	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation....
TMPH-03156	Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) Lysine-specific cysteine proteinase Kgp,Lys-gingipain,kgp	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO) is expressed in E. col...
TMPH-03155	Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) Lys-gingipain HG66,kgp	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc) is expressed in E....
TMPH-03154	Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) kgp,Lys-gingipain 381	Porphyromonas gingivalis	E. coli
	Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli e...
TMPJ-00419	CD16b Protein, Human, Recombinant (hFc & His) Fc-γ RIII-beta,FCG3,FcR-10,Fc-gamma RIII-β,FCGR3,FCGR3B,Low ...	Human	HEK293 Cells
	Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of infl...
TMPY-02908	BPI Protein, Human, Recombinant (His) BPIFD1,bactericidal/permeability-increasing protein,rBPI	Human	HEK293 Cells
	Bactericidal/permeability-increasing protein is a member of the BPI/LBP/Plunc superfamily and BPI/LBP family. It is a cationic protein which can be detected in the azurophilic granule and on the surface of polymorphonuclear leukocytes. Bactericidal/permeability-increasing protein also is a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. Bactericidal/permeability-increasing protein contains two domains t...
TMPJ-00011	CXCL2 Protein, Mouse, Recombinant Gro-beta,GRO β,GROB,melanoma growth stimulatory activity bet...	Mouse	E. coli
	C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the hum...
TMPY-05252	Myeloperoxidase/MPO Protein, Human, Recombinant (His) myeloperoxidase	Human	HEK293 Cells
	MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ...
TMPY-02163	PGLYRP1 Protein, Mouse, Recombinant (His) Tnfsf3l,peptidoglycan recognition protein 1,PGRP,Tasg7,Tag7,...	Mouse	HEK293 Cells
	Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 / PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1 / PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-posi...

重组蛋白

Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03562

Species: Staphylococcus aureus

Expression System: E. coli

Complement C5a Protein, Pig, Recombinant (His)

Cat.No: TMPH-03107

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Lys-gingipain Protein, Porphyromonas gingivalis, Recombinant (His & SUMO)

Cat.No: TMPH-03156

Species: Porphyromonas gingivalis

Expression System: E. coli

Lys-gingipain HG66 Protein, Porphyromonas gingivalis, Recombinant (His & Myc)

Cat.No: TMPH-03155

Species: Porphyromonas gingivalis

Expression System: E. coli

Lys-gingipain 381 Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03154

Species: Porphyromonas gingivalis

Expression System: E. coli

CD16b Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00419

Species: Human

Expression System: HEK293 Cells

BPI Protein, Human, Recombinant (His)

Cat.No: TMPY-02908

Species: Human

Expression System: HEK293 Cells

CXCL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00011

Species: Mouse

Expression System: E. coli

Myeloperoxidase/MPO Protein, Human, Recombinant (His)

Cat.No: TMPY-05252

Species: Human

Expression System: HEK293 Cells

PGLYRP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02163

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

Flufenamic Acid-d4

Cat.No: T71303

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