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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27730 |
KGP94
KGP-94,KGP 94 |
Cysteine Protease | Proteases/Proteasome |
KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。 | |||
T12695 |
RBN-2397
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂,IC50 小于 3 nM。它选择性结合 PARP7 ,Kd 为0.001 μM,可恢复干扰素 I 型信号转导,有用于晚期或转移性实体肿瘤的研究潜力。 | |||
T22450 |
Tyrphostin B44, (+) enantiomer
酪氨酸磷酸化抑制剂AG 835 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂,IC50 为 0.86 μM,活性低于 (-) 对映体。 | |||
T2618 |
LGK974
LGK 974,LGK-974,NVP-LGK974,WNT974 |
Porcupine | Stem Cells |
LGK974 (NVP-LGK974) 是一种有效的、特异性的、具有口服活性的Porcupine(PORCN) 抑制剂(IC50:0.1 nM)。 | |||
T24644 |
Piritrexim
BW 301U |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Piritrexim (BW 301U) 是一种可口服的脂溶性二氢叶酸还原酶抑制剂,具有肺毒性,用于研究尿路上皮癌和转移性乳腺癌。 | |||
T76828 |
Sonepcizumab
LT 1009 |
LPL Receptor | GPCR/G Protein |
Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性,可用于研究转移性肾细胞癌 (mRCC) ,可预防青光眼滤过手术后的眼部瘢痕形成。 | |||
T77149 |
Cobolimab
TSR-022,GSK4069889 |
Others | Others |
Cobolimab (TSR-022) 是一种有效的 TIM-3 单克隆抗体。Cobolimab 诱导 TIM-3 的内化,IC50 值为 0.4464 nM。Cobolimab 具有抗肿瘤活性,可用于研究晚期/转移性黑色素瘤和晚期肝细胞癌。 | |||
T76890 |
Petosemtamab
MCLA 158 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Petosemtamab (MCLA 158) 是一种高效的抗 EGFR (Kd: 0.22 nM) 和抗 LGR5 (Kd: 0.86 nM) 单克隆抗体。Petosemtamab 促使 LGR5+ 癌细胞中的 EGFR 信号传导中断和受体分解。Petosemtamab 可用于头颈部鳞状细胞癌 (HNSCC)、转移性结直肠癌 (CRC) 等实体瘤的研究。 | |||
T37037 |
Vinflunine ditartrate
|
Others | Others |
Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for studying transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and breast carcinoma[1][2]. | |||
T72740 |
n-Octyl caffeate
|
Others | Others |
n-Octyl caffeate 具有抗癌、诱导凋亡活性。 | |||
T76918 | Barecetamab | ||
Barecetamab (ISU-104) 是一种人源话抗 ErbB3单克隆抗体。Barecetamab 可用于复发/转移性 (R/M) 头颈部鳞状细胞癌 (HNSCC) 的研究。 | |||
T78332 |
Eftilagimod alfa
IMP321,LAG-3Ig |
||
Eftilagimod alfa为重组LAG-3Ig融合蛋白,具有MHC II 类分子结合能力。该药物通过介导抗原提呈细胞(APC)的激活进而激活CD8 T细胞,可用于研究转移性黑色素瘤及转移性乳腺癌。 | |||
T76970 | Tagitanlimab | ||
Tagitanlimab (HBM-9167),一种人源化抗PD-L1抗体(IgG1κ型),通过选择性阻断PD-L1与PD-1的相互作用,展现出对研究复发性或转移性鼻咽癌(NPC)的潜力。 | |||
T76997 |
Socazolimab
|
||
Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2813 |
23-deoxojessic acid
|
Others | Others |
23-Deoxojessic acid possesses strong cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, with ED50 values equal to or less than 6 microM. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02384 |
MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)
metastasis suppressor 1,MIMB,MIM,MIMA |
Human | E. coli |
MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor... |