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Search Results for " gastrointestinal diseases "

Targets Recommended: Others

15

抑制剂 & 化合物

4

天然产物

6

化合物库

2

重组蛋白

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Cat. No.	Product Name
L6600	胃肠炎天然产物库		219 compounds
	219 种胃肠炎相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2620	神经退行性疾病化合物库		2154 compounds
	2154 种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；
L4700	免疫/炎症分子化合物库		4720 compounds
	4720 种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；
L3300	组胺&褪黑色素化合物库		153 compounds
	153 种生物活性小分子化合物，用于高通量、高内涵筛选；
L4300	Wnt/Hedgehog/Notch 通路化合物库		237 compounds
	237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。

化合物库

胃肠炎天然产物库

Cat.No: L6600

Compounds: 219

神经退行性疾病化合物库

Cat.No: L2620

Compounds: 2154

免疫/炎症分子化合物库

Cat.No: L4700

Compounds: 4720

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

组胺&褪黑色素化合物库

Cat.No: L3300

Compounds: 153

Wnt/Hedgehog/Notch 通路化合物库

Cat.No: L4300

Compounds: 237

Cat. No.	Product Name	Target	Signaling Pathways
T38612	Linaprazan glurate	Others	Others
	Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。
T2192	Indazole	Sodium Channel	Membrane transporter/Ion channel
	Indazole 又称benzpyrazole 或isoindazone，它的衍生物表现出广泛的生物活性，吲哚唑及其衍生物可用于癌症、神经系统疾病、心血管疾病、胃肠道疾病的研究
T9842	5-HT2B antagonist-1	Others	Others
	5-HT2B antagonist-1 是一种具有口服活性的5-HT2B 受体拮抗剂，IC50值为 33.4 nM。5-HT2B antagonist-1可用于以 5-HT2B 受体信号传导为特征的疾病研究，如肝细胞癌、心血管疾病或胃肠道疾病。
T5051	Isopropamide Iodide	AChR	Neuroscience
	Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病，尤其是胃酸过多和运动过度。
T63809	Ansornitinib	Others	Others
	Ansornitinib 是口服具有活力的双激酶抑制剂，能够抑制血小板衍生生长因子受体 (PDGFR) 和血管内皮生长因子受体 (VEGFR2)。Ansornitinib 是一种抗纤维化剂，能够用于研究肺部，肝脏，肾脏以及胃肠等纤维化疾病。
T67385	Neratinib maleate HKI-272 maleate	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib maleate (HKI-272 maleate) 是一种不可逆且具有口服活性和高选择性的 HER2 和 EGFR 抑制剂，IC50 值分别为 59 nM 和 92 nM。Neratinib maleate具有抗肿瘤活性，可用于治疗消化系统疾病、呼吸系统疾病、泌尿生殖系统疾病和皮肤和肌肉骨骼疾病，可用于研究乳腺癌和前列腺癌。
T10121	Substance P Receptor Antagonist 1	Others	Others
	Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders.
T13570	Benzamide Derivative 1	Others	Others
	Benzamide Derivative 1 苯甲酰胺衍生物，具有胃动力学活性。Benzamide Derivative 1可用于研究胃肠疾病。
T39583	Zastaprazan	Others	Others
	Zastaprazan, a proton pump inhibitor (WO2018008929), is utilized in the research of gastrointestinal inflammatory diseases and conditions related to gastric acid.
T31396	Dexbrompheniramine maleate D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral	Others	Others
	Dexbrompheniramine is an antihistamine with anticholinergic properties. It is used to treat allergic diseases such as hay fever or urticaria. It can compete with histamine for H1 receptor sites on effector cells of the gastrointestinal tract, blood vessel
T69622	Ritivixibat	Others	Others
	Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂，同时也是胆汁酸调节剂，主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。
T73240	PDE5-IN-4	Others	Others
	PDE5-IN-4为磷酸二酯酶5（PDE5）抑制剂，应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。
T71179	LON63114	Others	Others
	LON63114, also known as FFA2-Agonist-1 is a selective orthosteric agonist of human FFA2. FFA2-Agonist-1 is potentially useful in the treatment of gastrointestinal disorders and inflammatory bowel diseases. LON63114 was reported in WO2011076732. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T72812	(R)-Tegoprazan	Others	Others
	(R)-Tegoprazan (example 3) 是一种苯并咪唑衍生物，是一种有效的胃H+/K+-ATP 酶抑制剂，对犬肾 Na+/K+-ATPase 的IC50为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。
T4633	Asimadoline EMD-61753,阿西马朵林	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Asimadoline (EMD-61753) 是一种 κ-阿片(κ-opioid)受体激动剂，对豚鼠和人重组 κ-opioid 的IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛，具有外周抗炎作用，并有用于肠易激综合征的研究潜力。

化合物

Linaprazan glurate

Cat.No: T38612

Target: Others

Cat.No: T2192

Target: Sodium Channel

5-HT2B antagonist-1

Cat.No: T9842

Target: Others

Isopropamide Iodide

Cat.No: T5051

Target: AChR

Cat.No: T63809

Target: Others

Neratinib maleate

Cat.No: T67385

Synonym: HKI-272 maleate

Target: EGFR, HER

Substance P Receptor Antagonist 1

Cat.No: T10121

Target: Others

Benzamide Derivative 1

Cat.No: T13570

Target: Others

Cat.No: T39583

Target: Others

Dexbrompheniramine maleate

Cat.No: T31396

Synonym: D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral

Target: Others

Cat.No: T69622

Target: Others

Cat.No: T73240

Target: Others

Cat.No: T71179

Target: Others

Cat.No: T72812

Target: Others

Cat.No: T4633

Synonym: EMD-61753,阿西马朵林

Target: Opioid Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T0700	Ursodeoxycholic acid 熊去氧胆酸,UDCA,Ursodiol	Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂，通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收，用于溶解胆结石，并具有研究与肥胖相关的脂肪肝疾病的潜力。
T29078	Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸，具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子，通过与胆汁酸激活受体相互作用发挥其作用，包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
TN1834	Kobusin 去甲槟郎碱,自旋七叶素	Others; NOS; NF-κB	Immunology/Inflammation; NF-κB; Others
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-express...
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。

天然产物

Ursodeoxycholic acid

Cat.No: T0700

Synonym: 熊去氧胆酸,UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Ursodeoxycholic acid sodium

Cat.No: T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

Cat.No: TN1834

Synonym: 去甲槟郎碱,自旋七叶素

Target: Others, NOS, NF-κB

Cat.No: T38108

Target: Antioxidant, PDE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04207	Motilin Protein, Human, Recombinant (His) MLN,Motilin	Human	HEK293 Cells
	MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. The encoded protein belongs to the motilin family. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). MLN plays an important role in the regulation of Interdigestive...
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,NT	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...

重组蛋白

Motilin Protein, Human, Recombinant (His)

Cat.No: TMPY-04207

Species: Human

Expression System: HEK293 Cells

Neurotensin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00561

Species: Human

Expression System: HEK293 Cells

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