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Search Results for " ganglia "

Targets Recommended: TRP/TRPV Channel

20

抑制剂 & 化合物

2

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21543	AP 18	TRP/TRPV Channel	Membrane transporter/Ion channel
	AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活，在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。
T0287	Hexamethonium Bromide Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide	Apoptosis; Dopamine Receptor; AChR	Apoptosis; GPCR/G Protein; Neuroscience
	Hexamethonium Bromide (Hexamethonium Dibromide) 是神经节中神经元型烟碱型 AChR 的特异性拮抗剂。在自发性高血压动物模型中，它能降低其交感神经活动和血压。
T20344	Acetylcholine bromide	Others	Others
	Acetylcholine bromide 是乙酰胆碱的溴化物盐。它是一种神经递质，存在于神经肌肉接头、自主神经节、副交感神经效应器接头、交感神经效应器接头的一个子集以及中枢神经系统的许多部位。
T22963	McN-A 343	AChR	Neuroscience
	McN-A 343作为选择性M1 muscarinic激动剂, 以其刺激交感神经节中muscarinic传导的能力而闻名。在溃疡性结肠炎的实验模型中，它已被发现能有效减轻炎症和氧化应激。
T26334	WWamide-1 H-Trp-lys-glu-met-ser-val-trp-NH2	Others	Others
	WWamide-1 is a neuromodulatory peptide isolated from the ganglia of Afrian giant snail, Achatina fulica.
T3289L2	Amifostine sodium WR-2721 sodium,WR2721 sodium,WR 2721 sodium	Others	Others
	Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
T26336	WWamide-3 H-Trp-lys-gln-met-ser-val-trp-NH2	Others	Others
	WWamide-3 is a neuromodulatory peptide isolated from the ganglia of African giant snail, Achatina fulica.
T0068L	Fluphenazine Decanoate Dihydrochloride	Others	Others
	Fluphenazine Decanoate Dihydrochloride is an antipsychotic agent, it could block postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia.
T26335	WWamide-2 H-Trp-arg-glu-met-ser-val-trp-NH2	Others	Others
	WWamide-2 is used as a neuromodulatory peptide isolated from the ganglia of African giant snail, Achatina fulica.
T0068L2	Fluphenazine free base Siqualine,Fluphenazine,Fluorophenazine,Fluorphenazine,Triflumethazine,Fluorfenazine	Others	Others
	Flufenazine is an antipsychotic drug. It is used to treat chronic mental illnesses such as schizophrenia. Flufenazine works by blocking postsynaptic dopamine D2 receptors in the limbic system, cortical system, and basal ganglia. This prevents the effects
T69023	Hexamethonium chloride	Others	Others
	Hexamethonium chloride is a preferential nicotinic receptor blocker at the level of autonomic ganglia. It has been shown to cross the blood-brain barrier only in high doses.
T29809	AL-1 AL 1,AL1	Others	Others
	AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variety of adult tissues of BRAIN; HEART;
T68811	Trimetaphan camsilate	Others	Others
	Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously.
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)	Others	Others
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T71236	Oxybutynin R-isomer HCl	Others	Others
	Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blo...
T37439	C18 Globotriaosylceramide (d18:1/18:0)	Others	Others
	C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma...
T36185	Globotriaosylceramides (hydroxy) (porcine)	Others	Others
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...
T36186	Globotriaosylceramides (porcine)	Others	Others
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...
T83701	TRPV1-Tat TFA Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat
	TRPV1-Tat是一种针对瞬时受体电位范烤苷1 (TRPV1) 的肽类拮抗剂。它由来自TRPV1的A-激酶锚蛋白(AKAP)结合域的736-745个氨基酸以及来自HIV Tat的细胞穿透肽序列组成。TRPV1-Tat (200 µM) 能够在使用初级小鼠背根神经节的整细胞膜片钳技术中抑制由热或棕榈酸酯12-肉豆蔻酸13-醋酸酯(PMA014)引起的电流。当以10或30 µM剂量给药时，它能增加大鼠后爪机械痛阈。
T83732	Tat-CBD3A6K TFA
	Tat-CBD3A6K是一种肽类化合物，为N型电压门控钙通道Cav2.2以及collapsin response mediator protein 2 (CRMP2) 蛋白-蛋白相互作用抑制剂Tat-CBD3的衍生物。Tat-CBD3A6K (10 mg/kg) 能够阻止由d4T (stavudine)引发的大鼠抗逆转录病毒神经病痛模型中爪撤回阈值的下降，并减少同一大鼠分离的背根神经节(DRG)神经元的动作电位数量。通过硬膜途径给予Tat-CBD3A6K (30 µM/animal) 能够减少由萜类生物碱辣椒素引发的大鼠硬脑膜血流增加。

化合物

Cat.No: T21543

Target: TRP/TRPV Channel

Hexamethonium Bromide

Cat.No: T0287

Synonym: Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide

Target: Apoptosis, Dopamine Receptor, AChR

Acetylcholine bromide

Cat.No: T20344

Target: Others

Cat.No: T22963

Target: AChR

Cat.No: T26334

Synonym: H-Trp-lys-glu-met-ser-val-trp-NH2

Target: Others

Amifostine sodium

Cat.No: T3289L2

Synonym: WR-2721 sodium,WR2721 sodium,WR 2721 sodium

Target: Others

Cat.No: T26336

Synonym: H-Trp-lys-gln-met-ser-val-trp-NH2

Target: Others

Fluphenazine Decanoate Dihydrochloride

Cat.No: T0068L

Target: Others

Cat.No: T26335

Synonym: H-Trp-arg-glu-met-ser-val-trp-NH2

Target: Others

Fluphenazine free base

Cat.No: T0068L2

Synonym: Siqualine,Fluphenazine,Fluorophenazine,Fluorphenazine,Triflumethazine,Fluorfenazine

Target: Others

Hexamethonium chloride

Cat.No: T69023

Target: Others

Cat.No: T29809

Synonym: AL 1,AL1

Target: Others

Trimetaphan camsilate

Cat.No: T68811

Target: Others

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Target: Others

Oxybutynin R-isomer HCl

Cat.No: T71236

Target: Others

C18 Globotriaosylceramide (d18:1/18:0)

Cat.No: T37439

Target: Others

Globotriaosylceramides (hydroxy) (porcine)

Cat.No: T36185

Target: Others

Globotriaosylceramides (porcine)

Cat.No: T36186

Target: Others

Cat.No: T83701

Synonym: Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat

Tat-CBD3A6K TFA

Cat.No: T83732

Cat. No.	Product Name	Target	Signaling Pathways
T6751	Acetylcholine iodide Acetylcolina	Others	Others
	Acetylcholine iodide (Acetylcolina) 是一种在中枢和外周神经系统中常见的神经递质。
T5S0994	N-Methylcytisine N-甲基野靛碱,Caulophylline	Others; AChR	Neuroscience; Others
	N-Methylcytisine (Caulophylline) 是苦参中的一种三环喹啉类生物碱，具有降血糖、缓解疼痛和抗炎活性。它是中枢神经系统中乙酰胆碱烟碱受体的选择性配体，对鱿鱼视神经节中的烟碱乙酰胆碱受体具有很高的亲和力，Kd 为 50 nM。

天然产物

Acetylcholine iodide

Cat.No: T6751

Synonym: Acetylcolina

Target: Others

N-Methylcytisine

Cat.No: T5S0994

Synonym: N-甲基野靛碱,Caulophylline

Target: Others, AChR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01675	Meteorin Protein, Human, Recombinant (His) Meteorin,METRN	Human	E. coli
	Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
TMPY-03053	Ezrin Protein, Human, Recombinant (His) HEL-S-105,CVL,VIL2,CVIL,ezrin	Human	E. coli
	VIL2, also known as villin-2, belongs to the ERM protein family. It is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. VIL2 contains 1 FERM domain and may be involved in connections of major cytoskel
TMPK-00592	Latexin Protein, Human, Recombinant (His) ECI,TCI,LXN,MUM	Human	E. coli
	Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
TMPY-02579	NRN1 Protein, Human, Recombinant (His) NRN,dJ380B8.2,MGC44811,neuritin 1	Human	Baculovirus Insect Cells
	Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified rec...
TMPK-00861	A2AR Protein-VLP, Human, Recombinant RDC8,Adenosine A2a R,ADORA2,ADORA 2,ADORA2A,A2aR	Human	HEK293 Cells
	Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3 adenosine receptor subtypes have been cloned recently.Expression of A2a adenosine receptor mRNA in cranial ganglia, carotid body, and intermediate lobe of the pituitary gland similarly suggests novel sites of adenosine action during development and in the adult.
TMPY-03185	METRN Protein, Mouse, Recombinant (hFc) meteorin, glial cell differentiation regulator,Hyrac,1810034...	Mouse	HEK293 Cells
	METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. The encoded protein belongs to the meteorin family. It is broadly expressed in the brain, kidney, and other tissues. Meteorin is a novel secreted protein that is expressed in undifferentiated neural progenitors and the astrocyte lineage, including radial glia. It plays important role in the differentiation of glial cells and also in axonal network formation during neurogenesis. Meteorin selectively promoted astrocyt...
TMPK-01113	IL-31RA Protein, Human, Recombinant (aa 20-519, hFc) PRO21384,GLM-RMGC125346,GLM-R,IL-31R-alpha,IL-31RA,ZcytoR17,...	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPK-01114	IL-31RA Protein, Human, Recombinant (aa 20-519, His) GLM-RMGC125346,CRL3,GLM-R,PRO21384,Gp130-like receptor,CRL3G...	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPK-01096	IL-31RA Protein, Mouse, Recombinant (His) GPL,CRL3Glmr,IL-31RA,GLM-R,ZcytoR17,CRL3,PRO21384,GLM-RMGC12...	Mouse	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPJ-01130	NPTX1 Protein, Human, Recombinant (His) Neuronal pentraxin-1,NPTX1,NP1	Human	HEK293 Cells
	Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ...
TMPJ-00858	Ezrin Protein, Human, Recombinant Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin	Human	E. coli
	Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele...
TMPY-01620	MDGA2 Protein, Mouse, Recombinant (His) 6720489L24Rik,Adp,MAM domain containing glycosylphosphatidyl...	Mouse	HEK293 Cells
	MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His) R-CAD,cadherin 4, type 1, R-cadherin (retinal),RCAD,CAD4	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-de...

重组蛋白

Meteorin Protein, Human, Recombinant (His)

Cat.No: TMPH-01675

Species: Human

Expression System: E. coli

Ezrin Protein, Human, Recombinant (His)

Cat.No: TMPY-03053

Species: Human

Expression System: E. coli

Latexin Protein, Human, Recombinant (His)

Cat.No: TMPK-00592

Species: Human

Expression System: E. coli

NRN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02579

Species: Human

Expression System: Baculovirus Insect Cells

A2AR Protein-VLP, Human, Recombinant

Cat.No: TMPK-00861

Species: Human

Expression System: HEK293 Cells

METRN Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03185

Species: Mouse

Expression System: HEK293 Cells

IL-31RA Protein, Human, Recombinant (aa 20-519, hFc)

Cat.No: TMPK-01113

Species: Human

Expression System: HEK293 Cells

IL-31RA Protein, Human, Recombinant (aa 20-519, His)

Cat.No: TMPK-01114

Species: Human

Expression System: HEK293 Cells

IL-31RA Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01096

Species: Mouse

Expression System: HEK293 Cells

NPTX1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01130

Species: Human

Expression System: HEK293 Cells

Ezrin Protein, Human, Recombinant

Cat.No: TMPJ-00858

Species: Human

Expression System: E. coli

MDGA2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01620

Species: Mouse

Expression System: HEK293 Cells

R-Cadherin/CDH4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01052

Species: Human

Expression System: HEK293 Cells

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