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Search Results for " follicle "
Targets Recommended: Others

39

抑制剂 & 化合物

2

天然产物

38

重组蛋白

1

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T78515 Follicle-stimulating hormone

Others Others
卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白,其参与调控动物的生殖能力与繁殖效率。
T9625 Sandalore

Apoptosis Apoptosis
Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。
T8135 Minoxidil sulfate

Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Potassium Channel Membrane transporter/Ion channel
Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物,是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂,在动物实验模型中,促进头发生长。
TP1342L GnRH-I acetate

GnRH-I acetate(33515-09-2 free base)

Others Others
GnRH-I acetate 在血液中释放具有生物活性的促卵泡激素 (FSH) 和促黄体激素 (LH)。
TP2373L Biotinoyl tripeptide-1 Acetate

Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)

Others Others
Biotinoyl tripeptide-1 Acetate 可通过促进头皮微循环产生毛囊,减少毛囊萎缩和衰老。
T5520L Cetrorelix diacetate

NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

GNRH Receptor GPCR/G Protein
Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
TP1700L LGnRH-III, lamprey acetate(147859-97-0 free base)

GNRH Receptor GPCR/G Protein
LGnRH-III, lamprey acetate(147859-97-0 free base) 是 GnRH 家族进化上保守的成员,可刺激促性腺激素的分泌,同时刺激促黄体激素和促卵泡激素的分泌。
T2597 Norgestrel

甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850

Estrogen/progestogen Receptor; Reactive Oxygen Species Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
Norgestrel (WY-3707) 是一种孕酮的合成类似物,是一种口服避孕药中常见的化合物,也是一种神经保护性强抗氧化剂,能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。
T21309 Nafarelin acetate(76932-56-4 free base)

RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel

GNRH Receptor GPCR/G Protein
Nafarelin acetate(76932-56-4 free base) (RS-94991-298) 是一种 GnRH 激动剂,可作为 GnRH 的类似物。 Nafarelin acetate(76932-56-4 free base) 导致促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的垂体分泌减少。它可用于治疗雌激素依赖性病症。
TP2107L Histrelin acetate

Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林

GNRH Receptor GPCR/G Protein
Histrelin acetate 是促性腺激素释放激素 (GnRH) 的九肽类似物,具有增加的效力。当存在于血流中时,它作用于称为促性腺激素的垂体特定细胞。 Histrelin 刺激这些细胞释放促黄体激素和促卵泡激素。因此,它被认为是促性腺激素释放激素激动剂或 GnRH 激动剂。
T21410 Triptorelin acetate(57773-63-4 free base)

醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003

GNRH Receptor GPCR/G Protein
Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症,如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。
T3630 Relugolix

RVT-601,瑞卢戈利,TAK-385

GNRH Receptor GPCR/G Protein
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T5015L2 Gonadorelin HCl

Factrel,AY-24,031,AY24,031,AY 24,031,LH-RH hydrochloride,Gonadorelin hydrochloride

Others Others
Gonadorelin HCl, as a decapeptide, can stimulate the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE, and FOLLICLE STIMULATING HORMONE.
TP2373 Biotinoyl tripeptide-1

Biotin GHK,BiotinGHK,Biotin-GHK

Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.
T21375 Clomifene

Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate

Others Others
Clomifene is a selective estrogen receptor modulator (SERM), it has both estrogenic and anti-estrogenic activities. This agent causes the release of the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to ov
TP2010 Kisspeptin 10 (dog)

Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo.
T83489 [Lys8] LH-RH

"[Lys8] LH-RH"为LH-RH的类似物, 能够有效促进LH与FSH的释放。
TP1700 LGnRH-III, lamprey

GnRH III, an evolutionarily conserved member of the GnRH family, can stimulate the secretion of gonadotropins, it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
T75991 Ganirelix

Ganirelix为一种竞争性且选择性的促性腺激素释放激素(GnRH)拮抗剂,其主要作用机制为抑制内源性GnRH,从而抑制黄体生成素(LH)及促卵泡激素的释放。
T81270 Ripafollitropin alfa (bovine)

Ripafollitropin alfa (bovine)为一种结合了重组促卵泡激素(FSH)与绒毛膜促性腺激素(HCG)的融合蛋白。
T64270 Lutropin

Others Others
Lutropin 是一种异二聚体糖蛋白,是一种由垂体前叶促性腺细胞产生的激素,对卵泡的发育具有刺激作用。Lutropin 能够用于研究不孕症。
T76620 (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是黄体生成素释放激素 (LHRH) 的类似物。LHRH 通过刺激垂体黄体生成素 (LH) 和促卵泡激素 (FSH) 的释放,在控制生殖中发挥核心作用。
T76615 (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH是一种LHRH(黄体生成素释放激素)的类似物,主要通过激活垂体分泌黄体生成素(LH)和促卵泡激素(FSH)来在生殖调控中发挥核心作用。
T73680 Urofollitropin

Urofollitropin是从更年期人类尿液中提取的蛋白质,具有促进卵泡发育和成熟的作用,但其含有的尿蛋白量极少。
T82162 Human follicular gonadotropin releasing peptide

hF-GRP

Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽,其作用可在体外实现。
T82307 Glp-His-Pro-Gly-NH2

pGlu-His-Pro-Gly-NH2

pGlu-His-Pro-Gly-NH2(Glp-His-Pro-Gly-NH2)为含四氨基酸肽类化合物,可激发促性腺激素、黄体生成素(LH)与促卵泡激素(FSH)释放。
T72835 FSHR agonist 1

Others Others
FSHR agonist 1是一种对卵泡刺激素(FSH)受体(FSHR)具有高亲和力并能引起变构的激动剂,具有pEC50值为7.72。它通过与TMD广泛相互作用直接激活FSHR。
T70309 Dicetrorelix pamoate

Others Others
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T76616 (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是一种黄体生成素释放激素 (LHRH) 的类似物,主要通过促进垂体分泌黄体生成素 (LH) 和促卵泡激素 (FSH) 来在生殖调控中发挥关键作用。
T76222 hFSH-β-(33-53) (TFA)

hFSH-β-(33-53) TFA 是一种含有硫醇的肽,对应于第二个 FSH 受体结合域,是 FSHR(卵泡刺激素受体) 拮抗剂。hFSH-β-(33-53) TFA 抑制 FSH 与受体的结合,是 Sertoli 细胞中雌二醇合成的部分激动剂。
T84706 DCOIT

Kathon 930

Others Others
DCOIT是一种典型的异噻唑啉酮,能激活促性腺激素释放激素受体(GnRHR)在大脑中引发卵泡刺激素和黄体生成素的合成。此外,DCOIT干扰了G蛋白偶联受体、MAPK和Ca2+信号传递途径。
T85273 Gonadorelin acetate

Others Others
Gonadorelin, a gonadotropin-releasing hormone receptor (GNRHR; Ki= 13 nM in CHO cells expressing the human receptor) agonist and tropic hormone, effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from rat anterior pituitary cultures at 0.1 μg doses. Additionally, it triggers LH release from bovine anterior pituitary cultures at a 1 μM concentration. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (ED50= 610.3 ng/kg). ...
T71149 Triptorelin pamoate

Others Others
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T68292 GTX-758

Others Others
GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in ...
T68525 Nafarelin acetate hydrate

Others Others
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T36912 17α,20β-Dihydroxy-4-pregnen-3-one

17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one

Others Others
17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 μg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production...
T69492 Ozarelix

Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T76566 Fsh receptor-binding inhibitor fragment(bi-10)

FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合,并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。
T76047 TAK-683 TFA

TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM),拥有较好的代谢稳定性,是九肽metastin的类似物,对KISS1R有激动效应,其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平,进而减少血浆FSH、LH、睾酮的浓度,显示出对激素依赖性前列腺癌研究的可能性。

化合物

Follicle-stimulating hormone
Cat.No: T78515
Synonym:
Target: Others
Sandalore
Cat.No: T9625
Synonym:
Target: Apoptosis
Minoxidil sulfate
Cat.No: T8135
Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐
Target: Potassium Channel
GnRH-I acetate
Cat.No: TP1342L
Synonym: GnRH-I acetate(33515-09-2 free base)
Target: Others
Biotinoyl tripeptide-1 Acetate
Cat.No: TP2373L
Synonym: Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)
Target: Others
Cetrorelix diacetate
Cat.No: T5520L
Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate
Target: GNRH Receptor
LGnRH-III, lamprey acetate(147859-97-0 free base)
Cat.No: TP1700L
Synonym:
Target: GNRH Receptor
Norgestrel
Cat.No: T2597
Synonym: 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850
Target: Estrogen/progestogen Receptor, Reactive Oxygen Species
Nafarelin acetate(76932-56-4 free base)
Cat.No: T21309
Synonym: RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel
Target: GNRH Receptor
Histrelin acetate
Cat.No: TP2107L
Synonym: Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林
Target: GNRH Receptor
Triptorelin acetate(57773-63-4 free base)
Cat.No: T21410
Synonym: 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003
Target: GNRH Receptor
Relugolix
Cat.No: T3630
Synonym: RVT-601,瑞卢戈利,TAK-385
Target: GNRH Receptor
Gonadorelin HCl
Cat.No: T5015L2
Synonym: Factrel,AY-24,031,AY24,031,AY 24,031,LH-RH hydrochloride,Gonadorelin hydrochloride
Target: Others
Biotinoyl tripeptide-1
Cat.No: TP2373
Synonym: Biotin GHK,BiotinGHK,Biotin-GHK
Target:
Clomifene
Cat.No: T21375
Synonym: Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate
Target: Others
Kisspeptin 10 (dog)
Cat.No: TP2010
Synonym:
Target:
[Lys8] LH-RH
Cat.No: T83489
Synonym:
Target:
LGnRH-III, lamprey
Cat.No: TP1700
Synonym:
Target:
Ganirelix
Cat.No: T75991
Synonym:
Target:
Ripafollitropin alfa (bovine)
Cat.No: T81270
Synonym:
Target:
Lutropin
Cat.No: T64270
Synonym:
Target: Others
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
Cat.No: T76620
Synonym:
Target:
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
Cat.No: T76615
Synonym:
Target:
Urofollitropin
Cat.No: T73680
Synonym:
Target:
Human follicular gonadotropin releasing peptide
Cat.No: T82162
Synonym: hF-GRP
Target:
Glp-His-Pro-Gly-NH2
Cat.No: T82307
Synonym: pGlu-His-Pro-Gly-NH2
Target:
FSHR agonist 1
Cat.No: T72835
Synonym:
Target: Others
Dicetrorelix pamoate
Cat.No: T70309
Synonym:
Target: Others
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
Cat.No: T76616
Synonym:
Target:
hFSH-β-(33-53) (TFA)
Cat.No: T76222
Synonym:
Target:
DCOIT
Cat.No: T84706
Synonym: Kathon 930
Target: Others
Gonadorelin acetate
Cat.No: T85273
Synonym:
Target: Others
Triptorelin pamoate
Cat.No: T71149
Synonym:
Target: Others
GTX-758
Cat.No: T68292
Synonym:
Target: Others
Nafarelin acetate hydrate
Cat.No: T68525
Synonym:
Target: Others
17α,20β-Dihydroxy-4-pregnen-3-one
Cat.No: T36912
Synonym: 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one
Target: Others
Ozarelix
Cat.No: T69492
Synonym:
Target:
Fsh receptor-binding inhibitor fragment(bi-10)
Cat.No: T76566
Synonym:
Target:
TAK-683 TFA
Cat.No: T76047
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5S0896 Loureirin A

龙血素 A,龙血素A

Akt; PI3K Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。
T40442 Propylparaben sodium

Propyl4-hydroxybenzoatesodium,羟苯丙酯钠,Propylparahydroxybenzoatesodium

Others Others
Propylparaben sodium (propyl parahydroxybenzoate) is a naturally occurring antimicrobial preservative found in plants and bacteria. Widely utilized in cosmetics, pharmaceuticals, and foods, this compound impairs antral follicle growth and steroidogenic function by modifying the cell-cycle, apoptosis, and steroidogenesis pathways. Additionally, propylparaben sodium reduces sperm count and motility in rats.

天然产物

Loureirin A
Cat.No: T5S0896
Synonym: 龙血素 A,龙血素A
Target: Akt, PI3K
Propylparaben sodium
Cat.No: T40442
Synonym: Propyl4-hydroxybenzoatesodium,羟苯丙酯钠,Propylparahydroxybenzoatesodium
Target: Others
Cat. No. Product Name Species Expression System
TMPY-00091 FSH Beta Protein, Human, Recombinant (His)

HH24,FSH β,follicle stimulating hormone, β polypept...

Human HEK293 Cells
FSH Beta Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.9 kDa and the accession number is A0A0F7RQE8.
TMPY-04890 FSH Beta Protein, Human, Recombinant (hFc)

follicle stimulating hormone, beta polypeptide,...

Human HEK293 Cells
FSH Beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is A0A0F7RQE8.
TMPH-01347 FSHR Protein, Human, Recombinant (E. coli, His)

Follicle-stimulating hormone receptor,Follitropin r...

Human E. coli
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
TMPH-01348 FSHR Protein, Human, Recombinant (His)

Follitropin receptor,FSHR,Follicle-stimulating horm...

Human HEK293 Cells
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945.
TMPH-00488 Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His)

Follicle-stimulating hormone alpha chain,Glycoprote...

Canine P. pastoris (Yeast)
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) is expressed in Yeast.
TMPH-00489 Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc)

Follitropin alpha chain,CGA,Luteinizing hormone alpha chain,...

Canine E. coli
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-01471 Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain

Human/Mouse/Rat HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm...
TMPH-02831 PLET1 Protein, Mouse, Recombinant (His & SUMO)

Plet1,Placenta-expressed transcript 1 protein,Antigen mAgK11...

Mouse E. coli
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
TMPH-02830 PLET1 Protein, Mouse, Recombinant (His)

Plet1,Placenta-expressed transcript 1 protein,Antigen mAgK11...

Mouse Baculovirus Insect Cells
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
TMPH-03354 Progonadoliberin-1/GNRH1 Protein, Rat, Recombinant (His)

Progonadoliberin-1,Gnrh1,Progonadoliberin I

Rat E. coli
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Progonadoliberin-1/GNRH1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 12.2 kDa and the accession number is P07490.
TMPH-02670 Gasdermin-A3 Protein, Mouse, Recombinant (His)

Gsdma3,Gasdermin-3,Gasdermin-A3

Mouse E. coli
Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal moiety (Gasdermin-A3, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage in vitro of genetically engineered Gsdma3, and binds to membrane inner leaflet lipids. Hom...
TMPH-01865 PLET1 Protein, Human, Recombinant (His)

PLET1,Placenta-expressed transcript 1 protein

Human E. coli
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. PLET1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.4 kDa and the accession number is Q6UQ28.
TMPH-01866 PLET1 Protein, Human, Recombinant (His & Myc)

Placenta-expressed transcript 1 protein,PLET1

Human Baculovirus Insect Cells
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. PLET1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 22.3 kDa and the accession number is Q6UQ28.
TMPJ-00017 GNRH2 Protein, Human, Recombinant (His)

GnRH-Associated Peptide 2,LH-RH II,Gonadoliberin-2,GnRH II,L...

Human HEK293 Cells
Progonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-fold). GNRH2 can be cleaved into two chains, gonadoliberin-2 and GnRH-associated peptide 2. gonadoliberin-2 regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. The proproteins produce three transcript variants, bu...
TMPH-03262 Cathepsin K Protein, Rat, Recombinant (His)

CTSO,CTSO2,Cathepsin O2,Cathepsin X,Cathepsin O,CTSK,Catheps...

Rat E. coli
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
TMPK-01020 FSHB Protein, Mouse, Recombinant (hFc)

FSH-beta,FSH-B,FSHB,FSH-β,Follitropin

Mouse HEK293 Cells
Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Mouse, Recombinant (hFc) is expressed in HE...
TMPH-01059 Cathepsin B Protein, Human, Recombinant (GST)

Cathepsin B1,APPS,Cathepsin B,CPSB,APP secretase,CTSB

Human E. coli
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis. Cathepsin B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 54.6 kDa and the accession number is P07858.
TMPH-02565 Cathepsin K Protein, Mouse, Recombinant (His)

Cathepsin O,Cathepsin K,CTSK,Cathepsin O2,CTSO2,Cathepsin X,...

Mouse E. coli
Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.4 kDa and the accession number is P...
TMPH-02654 FGF-5 Protein, Mouse, Recombinant (His)

Fgf5,Heparin-binding growth factor 5,Fibroblast growth facto...

Mouse E. coli
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is P15656.
TMPH-01335 FGF-5 Protein, Human, Recombinant (GST & His & Myc)

Smag-82,FGF5,Fibroblast growth factor 5,Heparin-binding grow...

Human E. coli
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 62.4 kDa and the ...
TMPH-01061 Cathepsin K Protein, Human, Recombinant (His)

CTSO2,Cathepsin X,Cathepsin O2,CTSK,Cathepsin O,Cathepsin K,...

Human E. coli
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Cathepsin K Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The pre...
TMPK-01193 GPRC5D Protein-VLP, Mouse, Recombinant

MGC129713,orphan G-protein coupled receptor,GPRC5D,MGC129714

Mouse HEK293 Cells
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Mouse, R...
TMPH-02244 Trichohyalin Protein, Human, Recombinant (His & Myc)

TCHH,Trichohyalin

Human E. coli
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing dur...
TMPK-01285 FSHB Protein, Cynomolgus, Recombinant (His)

Follitropin,FSH-B,FSH-beta,FSH-β,FSHB

Cynomolgus HEK293 Cells
Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Cynomolgus, Recombinant (His) is expressed ...
TMPK-00528 GPRC5D Protein-VLP, Cynomolgus, Recombinant

MGC129713,GPRC5D,MGC129714,orphan G-protein coupled receptor

Cynomolgus HEK293 Cells
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolg...
TMPJ-00482 SEMG1 Protein, Human, Recombinant (His)

SGI,SEMG,Semenogelin-1,Seminal Basic Protein,Alpha-Inhibin-3...

Human HEK293 Cells
Semenogelin-1 (SEMG1) is the predominant protein in semen; it is a secretory protein involved in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes SEMG1 into smaller peptides, each possibly having a separate function. In the proteolysis process, Alpha-inhibin-92 and alpha-inhibin-31 are produced; they inhibit the secretion of pituitary follicle-stimulating hormone. At the same time, it breaks...
TMPH-02857 Wnt10a Protein, Mouse, Recombinant (His & Myc)

Wnt10a,Protein Wnt-10a

Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Requir...
TMPJ-00227 Follistatin 288 Protein, Human, Recombinant (His)

FSActivin-binding protein,Follistatin,follistatin isoform FS...

Human HEK293 Cells
Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Follistatin shows the highest affinity for activins due to its extended configuration. Genetic deletion of follistatin in mice, or expression of only the Follistatin form, is perinatally lethal due to defects of lung, skin ...
TMPH-02078 Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO)

Cancer/testis antigen 103,Semenogelin I,Semenogelin-1,SEMG1

Human E. coli
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.; Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. Sem...
TMPY-00163 SPINK2 Protein, Human, Recombinant (hFc)

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin in...

Human HEK293 Cells
Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas ...
TMPY-04307 GNRH2 Protein, Human, Recombinant (hFc)

LH-RHII,gonadotropin releasing hormone 2,GnRH-II,GNRH2

Human HEK293 Cells
GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian...
TMPY-02376 BNIP3L Protein, Human, Recombinant

BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI...

Human E. coli
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to...
TMPY-01190 INHBB Protein, Human, Recombinant (His)

inhibin beta B,INHBB,Inhibin β B Protein,MGC157939,inhibin β...

Human HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB). Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in...
TMPY-02495 p19 INK4d Protein, Human, Recombinant (GST)

p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i...

Human E. coli
Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...
TMPY-04561 SGK3 Protein, Human, Recombinant (His & GST)

serum/glucocorticoid regulated kinase family, member 3,SGK2,...

Human Baculovirus Insect Cells
Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein that belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486...
TMPY-01846 Activin A Protein, Mouse, Recombinant (His)

inhibin, β A,inhibin, beta A

Mouse HEK293 Cells
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in...
TMPY-03046 APCDD1 Protein, Human, Recombinant (hFc)

HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS...

Human HEK293 Cells
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells...
TMPH-02690 PLA2G10 Protein, Mouse, Recombinant (His & Myc)

Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...

Mouse E. coli
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li...

重组蛋白

FSH Beta Protein, Human, Recombinant (His)
Cat.No: TMPY-00091
Species: Human
Expression System: HEK293 Cells
FSH Beta Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04890
Species: Human
Expression System: HEK293 Cells
FSHR Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01347
Species: Human
Expression System: E. coli
FSHR Protein, Human, Recombinant (His)
Cat.No: TMPH-01348
Species: Human
Expression System: HEK293 Cells
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His)
Cat.No: TMPH-00488
Species: Canine
Expression System: P. pastoris (Yeast)
Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc)
Cat.No: TMPH-00489
Species: Canine
Expression System: E. coli
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Cat.No: TMPJ-01471
Species: Human/Mouse/Rat
Expression System: HEK293 Cells
PLET1 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02831
Species: Mouse
Expression System: E. coli
PLET1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02830
Species: Mouse
Expression System: Baculovirus Insect Cells
Progonadoliberin-1/GNRH1 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03354
Species: Rat
Expression System: E. coli
Gasdermin-A3 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02670
Species: Mouse
Expression System: E. coli
PLET1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01865
Species: Human
Expression System: E. coli
PLET1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01866
Species: Human
Expression System: Baculovirus Insect Cells
GNRH2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00017
Species: Human
Expression System: HEK293 Cells
Cathepsin K Protein, Rat, Recombinant (His)
Cat.No: TMPH-03262
Species: Rat
Expression System: E. coli
FSHB Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-01020
Species: Mouse
Expression System: HEK293 Cells
Cathepsin B Protein, Human, Recombinant (GST)
Cat.No: TMPH-01059
Species: Human
Expression System: E. coli
Cathepsin K Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02565
Species: Mouse
Expression System: E. coli
FGF-5 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02654
Species: Mouse
Expression System: E. coli
FGF-5 Protein, Human, Recombinant (GST & His & Myc)
Cat.No: TMPH-01335
Species: Human
Expression System: E. coli
Cathepsin K Protein, Human, Recombinant (His)
Cat.No: TMPH-01061
Species: Human
Expression System: E. coli
GPRC5D Protein-VLP, Mouse, Recombinant
Cat.No: TMPK-01193
Species: Mouse
Expression System: HEK293 Cells
Trichohyalin Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02244
Species: Human
Expression System: E. coli
FSHB Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01285
Species: Cynomolgus
Expression System: HEK293 Cells
GPRC5D Protein-VLP, Cynomolgus, Recombinant
Cat.No: TMPK-00528
Species: Cynomolgus
Expression System: HEK293 Cells
SEMG1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00482
Species: Human
Expression System: HEK293 Cells
Wnt10a Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02857
Species: Mouse
Expression System: E. coli
Follistatin 288 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00227
Species: Human
Expression System: HEK293 Cells
Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02078
Species: Human
Expression System: E. coli
SPINK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00163
Species: Human
Expression System: HEK293 Cells
GNRH2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04307
Species: Human
Expression System: HEK293 Cells
BNIP3L Protein, Human, Recombinant
Cat.No: TMPY-02376
Species: Human
Expression System: E. coli
INHBB Protein, Human, Recombinant (His)
Cat.No: TMPY-01190
Species: Human
Expression System: HEK293 Cells
p19 INK4d Protein, Human, Recombinant (GST)
Cat.No: TMPY-02495
Species: Human
Expression System: E. coli
SGK3 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04561
Species: Human
Expression System: Baculovirus Insect Cells
Activin A Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01846
Species: Mouse
Expression System: HEK293 Cells
APCDD1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-03046
Species: Human
Expression System: HEK293 Cells
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02690
Species: Mouse
Expression System: E. coli
Cat. No. Product Name Target Signaling Pathways
TMIJ-0268 Relugolix-d6

Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Relugolix-d6
Cat.No: TMIJ-0268
Synonym:
Target:
TargetMol Loading
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