72
10
36
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38629 |
Folate-PEG3-alkyne
Folate-PEG3-alkyne |
Others | Others |
Folate-PEG3-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T38492 |
Folate-PEG2-amine
Folate-PEG2-amine |
Others | Others |
Folate-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T40818 |
Folate-PEG3-amine
Folate-PEG3-amine |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Folate-PEG3-amine is a three-unit polyethylene glycol (PEG) linker, which is cleavable. This linker is specifically employed in the synthesis of antibody-drug conjugates (ADCs). | |||
T34942 |
Triglutamate folate
Pteglu3 |
Others | Others |
Triglutamate folate is a bioactive chemical. | |||
T17984 |
Folate-PEG3-azide
|
Others | Others |
Folate-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T25496 |
Hexaglutamate folate
Pteglu6 |
Others | Others |
Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube | |||
T17861 |
DSPE-PEG46-Folate
|
Others | Others |
DSPE-PEG46-Folate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T82378 |
Folate-MS432
|
PROTACs | PROTAC |
Folate-MS432作为PROTAC,通过叶酸受体依赖途径特异性降解癌细胞中的MEKs。 | |||
T25358 |
EC-17 free acid
EC17,EC 17,EC-17,FTIC-Folate,Folate-FTIC |
Others | Others |
EC17 is a FITC conjugated folic acid, also known as Folate-FITC. It also acts as an FRα-targeting agent that fluoresces at 500nm. EC17 is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic acti | |||
T74308 |
DSPE-PEG-Folate
|
Others | Others |
DSPE-PEG-Folate (Mw 3350) 是一种含有叶酸的 PEG 衍生物。DSPE-PEG-Folate 具有靶向作用并能与癌细胞中的叶酸受体结合。DSPE-PEG-Folate 形成胶束/脂质双层,可用于靶向给药系统的研究。 | |||
T31508 |
Diopterin
Folate monoglutamate,Pteroyl diglutamic acid |
Others | Others |
Diopterin is a folic acid analog. | |||
T77274 |
DSPE-PEG-Folate (MW 5000)
|
Others | Others |
DSPE-PEG-Folate (MW 5000) 是一种含叶酸的 PEG 衍生物,能与癌细胞的叶酸受体结合并具有靶向作用。该化合物可形成胶束/脂质双层,适用于靶向给药系统的研究。 | |||
T77270 |
Cholesterol-PEG-Folate (MW 2000)
|
Others | Others |
Cholesterol-PEG-Folate (MW 2000) 是一种辅料,可用于制备叶酸偶联 PEG 脂质体。 | |||
T3279 |
Silver sulfadiazine
Silvadene,磺胺嘧啶银,Dermazin,Flamazine |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素,具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用,可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构,阻止细菌 DNA 复制。 | |||
T7593 |
Levomefolate calcium
左旋甲状腺素钙,L-5-甲基四氢叶酸钙 |
Antifolate | Cell Cycle/Checkpoint |
Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式,是膳食补充剂中生物利用度更高的替代品。 | |||
T7598 |
Calcium N5-methyltetrahydrofolate
5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐,用于治疗心血管疾病、乳腺癌和结肠直肠癌。 | |||
T26636 |
Antifolate C2
AGF 154,AGF154,AGF-154 |
Others | Others |
Antifolate C2 (AGF 154) 具有抗肿瘤活性,在人肿瘤细胞的生长抑制实验中测得IC为0.14nM。Antifolate C2 可用于研究癌症和自身免疫疾病。 | |||
T68232 |
Epofolate
|
Others | Others |
Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s... | |||
T26635 |
Antifolate C1
AGF 94,AGF94,AGF-94 |
Others | Others |
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate carrier (RFC). | |||
T7593L |
Levomefolate sodium
L 5 MTHF sodium,L-5-MTHF sodium,L5MTHF sodium, |
Others | Others |
Levomefolate calcium is a primary biologically active form of folate used at the cellular level for dna reproduction, the cysteine cycle and the regulation of homocysteine | |||
T29460 |
5-Methyldihydrofolate
|
Others | Others |
5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine. | |||
T32705 |
Levomefolate magnesium
L-Methylfolate magnesium |
Others | Others |
Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th | |||
T32706 |
Levomefolate calcium pentahydrate
|
Others | Others |
Levomefolate calcium pentahydrate is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12. Levomefolate is included in formulations of certain oral contraceptives to ens | |||
T20340 |
10-Formyldihydrofolate
|
Others | Others |
10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase. | |||
T29461 |
5-Methyltetrahydrofolate triglutamate
5-Me-Thf(glu)3 |
Others | Others |
5-Methyltetrahydrofolate triglutamate is a form of folic acid. | |||
T2627 |
Nolatrexed dihydrochloride
盐酸诺拉曲塞,Thymitaq,AG 337 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂,能够在癌细胞 S 期诱导细胞周期停滞,具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用,对人胸苷酸合酶的Ki 值为 11 nM。 | |||
T76766 |
Mirvetuximab
M9346A |
Antifolate | Cell Cycle/Checkpoint |
Mirvetuximab (M9346A) 是一种新型叶酸受体α (FRα) 靶向 anti-FOLR1 (folate receptor 1) 的单克隆抗体。Mirvetuximab soravtansine 常与铂类化合物或与其他化合物偶联成为抗体-药物偶联物用来治疗卵巢癌和其他 FRα 阳性的癌症。 | |||
T6120 |
Pralatrexate
Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙 |
Apoptosis; DHFR; Antifolate; TAM Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T0959 |
Ethopabate
Ethyl pabate,乙氧酰胺苯甲酯 |
Others; Antibiotic; Parasite | Microbiology/Virology; Others |
Ethopabate (Ethyl pabate) 是一种用于家禽的抗原虫药。 | |||
T15827 |
LY 345899
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
LY 345899 是叶酸的类似物,也是亚甲基四氢叶酸脱氢酶 (MTHFD1;DC301) 和MTHFD2抑制剂,其IC50值分别为 96 nM 和 663 nM,对MTHFD1的Ki=为 18 nM。 | |||
T1485 |
Methotrexate
NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。 | |||
T76720 |
Farletuzumab
MORAb-003 |
Antifolate | Cell Cycle/Checkpoint |
Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种对 FRα 具有高亲和力的人源化单克隆抗体。Farletuzumab 抑制过表达 FRα 的细胞的生长。Farletuzumab 可用于研究癌症。 | |||
T0189L |
Pemetrexed disodium
培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed |
Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂,用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶,二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM,7.2 nM 和 65 nM。 | |||
T0020 |
Sodium 4-aminosalicylate dihydrate
对氨基水杨酸钠二水合物,Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt |
Free radical scavengers; NF-κB; Antibacterial; Antibiotic | Microbiology/Virology; NF-κB; oxidation-reduction |
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) 是一种抗耐药性结核化合物。 | |||
T2160 |
Suramin Sodium Salt
苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060 |
Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。 | |||
T24572 |
OSI-7904L free acid
OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904 |
Others | Others |
OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties. | |||
T29284 |
10-Formylpteroylpentaglutamate
|
Others | Others |
10-Formylpteroylpentaglutamate is a folate conjugate. | |||
T25981 |
Pralatrexate, (S)-
|
Others | Others |
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T24963 |
10-Methyl-10-deazaaminopterin
|
Others | Others |
10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity. | |||
T70583 |
Pemetrexed Diethyl Ester
|
Others | Others |
Pemetrexed Diethyl Ester is a protected intermediate in the synthesis of Pemetrexed, a multi-targeted anti-folate that inhibits thymidylate synthase as well as other folate dependent enzymes. | |||
T25980 |
Pralatrexate, (R)-
|
Others | Others |
Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T39757 |
EC2629
EC2629 |
Others | Others |
EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent. | |||
T34184 |
Pteroyltyrosine
|
Others | Others |
Pteroyltyrosine is an analog of tyrosyl folate used in folate radioassay. | |||
T12635L |
Plevitrexed
BGC9331,ZD 9331 |
Others | Others |
Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical. | |||
T24981 |
5,6,7,8-Tetrahydro-8-deazahomofolic acid
5,6,7,8-Tdfa |
Others | Others |
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor. | |||
T24966 |
11-Oxahomoaminopterin
NSC-325304,NSC 325304,NSC325304 |
Others | Others |
11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR. | |||
T38490 |
ONX 0801 trisodium
Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium |
Others | Others |
ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor. | |||
T24991 |
8-Deazahomofolic acid
|
Others | Others |
8-Deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor. | |||
T25332 |
Dihydrohomofolic acid
|
Others | Others |
Dihydrohomofolic acid is a substrate for dihydrofolate reductase that produces tetrahydro-homo folate which in turn suppresses thymidylate synthetase and then DNA synthesis. | |||
T29434 |
4-Desacetylvinblastine hydrazide
DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide |
Others | Others |
Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21367 |
Tetrahydrofolic acid
5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate |
Endogenous Metabolite | Metabolism |
Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) 是一种维生素 B9 衍生物,是生物体常见的一碳供体,参与生物体生长代谢。 | |||
T31836 |
Folate sodium
Folic acid, monosodium salt,Folvite sodium |
||
Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia. | |||
T0062 |
Folic acid
Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folic acid (Vitamin B9) 是维生素B9,是合成DNA/RNA,新细胞产生和维持的必要成分。 | |||
T1153 |
Trimethoprim
NIH 204,BW 56-72,甲氧苄啶,NSC-106568 |
DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Trimethoprim (NSC-106568) 是抑菌抗生素,也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性,可用于尿路感染,肺孢子菌肺炎和志贺氏菌病的研究。 | |||
T13516 |
5-Methyltetrahydrofolic acid
甲基叶酸盐,5-Methyl THF |
Endogenous Metabolite | Metabolism |
5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物,具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸,是血浆和脑脊液中叶酸的主要形式。 | |||
T7094 |
Levomefolic Acid
L-5-甲基四氢叶酸,5-MTHF,5-甲基四氢叶酸 |
Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB |
Levomefolic Acid (5-MTHF) 是一种具有口服活性、可穿过血脑屏障的天然活性叶酸,是广泛使用的叶酸食品补充剂。 | |||
T1721 |
2'-Deoxyuridine
Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷 |
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
2'-Deoxyuridine (2-deoxyuridine) 可以促使染色体断裂,从而抑制 thymidylate 的合成活性,它也是合成 Edoxudine 的前体。 | |||
T4909 |
N-Acetyl-DL-methionine
N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-DL-methionine 是内源性代谢产物的一种。 | |||
T4877 |
L-Homocystine
|
Endogenous Metabolite | Metabolism |
L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子,也是研究心血管疾病发生机制的内质网应激反应的诱导剂。 | |||
T32704 |
Levoleucovorin
levo-Folinic,LFP-754,Levofolinic acid,Levofolene,LFP 754 |
||
Levoleucovorin, as a folate analog, consists of the pharmacologically active isomer of leucovorin. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00147 |
FOLR1 Protein, Human, Recombinant (hFc)
Folate receptor 1,Folate receptor,Fola... |
Human | HEK293 Cells |
FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328. | |||
TMPY-01815 |
FOLR1 Protein, Human, Recombinant (His)
FBP,Folate Binding Protein,folate receptor... |
Human | HEK293 Cells |
FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1. | |||
TMPY-06022 |
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)
folate receptor 1 (adult) |
Cynomolgus,Rhesus | HEK293 Cells |
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1. | |||
TMPY-01803 |
FOLR1 Protein, Mouse, Recombinant (His)
folate receptor 1 (adult),Folbp1,FBP1,Folbp-1 |
Mouse | HEK293 Cells |
FOLR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P35846. | |||
TMPY-01280 |
FOLR2 Protein, Human, Recombinant (His)
FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2 (fetal),... |
Human | HEK293 Cells |
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc... | |||
TMPY-00381 |
PSMA Protein, Human, Recombinant (His)
FGCP,GCP2,PSMA,GCPII,NAALAdase,folate hydrolase (pr... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.86 kDa and the accession number is Q04609-1. | |||
TMPY-00622 |
FOLR1 Protein, Canine, Recombinant (His)
folate receptor 1 (adult) |
Canine | HEK293 Cells |
FOLR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is A0A8C0Z2T7. | |||
TMPY-02417 |
FOLR1 Protein, Canine, Recombinant (hFc)
folate receptor 1 (adult) |
Canine | HEK293 Cells |
FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7. | |||
TMPY-06929 |
FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated
Folate Binding Protein,folate receptor 1 (... |
Human | HEK293 Cells |
FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 27.83 kDa and the accession number is NP_057937.1. | |||
TMPJ-00148 |
FOLR1 Protein, Rhesus macaque, Recombinant (His)
FR-alpha,Adult folate-binding protein,Ovarian tumor... |
Rhesus | HEK293 Cells |
FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60. | |||
TMPY-06928 |
FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
FOLR,Folate Binding Protein,folate recepto... |
Human | HEK293 Cells |
FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.11 kDa and the accession number is NP_057937.1. | |||
TMPY-00543 |
FOLR1 Protein, Rat, Recombinant (His)
folate receptor 1 (adult) |
Rat | HEK293 Cells |
FOLR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is G3V8M6. | |||
TMPY-04128 |
FOLR1 Protein, Rat, Recombinant (hFc)
folate receptor 1 (adult) |
Rat | HEK293 Cells |
FOLR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is G3V8M6. | |||
TMPH-02016 |
SLC19A1 Protein, Human, Recombinant (His & Myc)
Reduced folate carrier protein,Intestinal folat... |
Human | E. coli |
SLC19A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPK-00878 |
FOLR3 Protein, Human, Recombinant (His)
FR-γ,Folate receptor 3,FR-gamma,FR-G |
Human | HEK293 Cells |
Folic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine (Hcy), a risk factor of Alzheimer's disease, thrombosis, neuropsychiatric illness and fractures. | |||
TMPK-00150 |
FOLR1 Protein, Human, Recombinant (His & Avi)
Folate receptor 1,Folbp1,Folate receptor a... |
Human | HEK293 Cells |
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t... | |||
TMPY-01390 |
PSMA Protein, Mouse, Recombinant (His)
mopsm,folate hydrolase (prostate-specific membrane ... |
Mouse | HEK293 Cells |
PSMA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.8 kDa and the accession number is O35409. | |||
TMPH-03190 |
CPG2 Protein, Pseudomonas sp., Recombinant (GST)
Folate hydrolase G2,Pteroylmonoglutamic acid hydrol... |
Pseudomonas | E. coli |
Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity. CPG2 Protein, Pseudomonas sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.7 kDa and the accession number is P06621. | |||
TMPK-00585 |
FOLR4/Juno Protein, Human, Recombinant (His)
Folate receptor 4,FR-δ,Folbp3,FR-delta,Izumo1r,Juno... |
Human | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro... | |||
TMPK-01171 |
FOLR4/Juno Protein, Mouse, Recombinant (His)
Juno,FOLR4, LOC390243,Folate receptor 4,FR δ,FR-del... |
Mouse | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro... | |||
TMPY-06960 |
PSMA Protein, Human, Recombinant (His & Avi), Biotinylated
GCPII,FGCP,folate hydrolase (prostate-specific memb... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 82.72 kDa and the accession number is NP_004467.1. | |||
TMPK-00521 |
PSMA Protein, Cynomolgus, Recombinant (His)
PSMA,FOLHNAALADase I,FGCP,GCPII,PSMAFGCP,NAALADase I,PSM,NAA... |
Cynomolgus | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ... | |||
TMPY-05269 |
PSMA Protein, Human, Recombinant (His), Biotinylated
PSM,GCP2,folate hydrolase (prostate-specific membra... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.7 kDa and the accession number is Q04609-1. | |||
TMPK-00371 |
PSMA Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
NAALADase I,FOLH1,GCPIImGCP,FGCP,GCP2,PSM,mGCP,NAALAdase,FOL... |
Mouse | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein (Primary Amine Labeling), Mouse, Recombinant (His), Bi... | |||
TMPK-00370 |
PSMA Protein, Human, Recombinant (hFc)
NAALAdase,FOLH1,FOLHNAALADase I,FGCP,mGCP,PSMAFGCP,NAALADase... |
Human | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein, Human, Recombinant (hFc) is expressed in HEK293 mamma... | |||
TMPK-00522 |
PSMA Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
PSMAFGCP,PSM,NAALAdase,NAALADase I,FOLHNAALADase I,GCPIImGCP... |
Cynomolgus | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His... | |||
TMPH-00608 |
Dihydrofolate reductase Protein, E. coli, Recombinant (His)
Dihydrofolate reductase,folA,tmrA |
E. coli | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
TMPH-03581 |
Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
dfrC,folA1,Dihydrofolate reductase,folA,DHFR |
Staphylococcus epidermidis | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1. | |||
TMPH-01224 |
Dihydrofolate reductase Protein, Human, Recombinant (His)
DHFR,Dihydrofolate reductase |
Human | E. coli |
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. | |||
TMPH-03535 |
Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
DHFR,Dihydrofolate reductase,folA |
Staphylococcus aureus | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.6 kDa and the accession number is P99079. | |||
TMPJ-00989 |
MTHFS Protein, Human, Recombinant (His)
5-formyltetrahydrofolate cyclo-ligase,10-methenyl-t... |
Human | E. coli |
5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increas... | |||
TMPH-03585 |
Dihydropteroate synthase Protein, S. haemolyticus, Recombinant (His)
folP,Dihydropteroate synthase,DHPS,Dihydropteroate pyrophosp... |
Staphylococcus haemolyticus | E. coli |
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Dihydropteroate synthase Protein, S. haemolyticus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is Q59919. | |||
TMPY-05055 |
GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)
GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase (conjugase, fo... |
Human | HEK293 Cells |
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. | |||
TMPJ-01299 |
RTBDN Protein, Human, Recombinant (His)
Retbindin,RTBDN |
Human | HEK293 Cells |
Human Retbindin is a 229 amino acid secreted protein that belongs to the folate receptor family. The gene that encodes retbindin exists as two alternatively spliced isoforms. Retbindin is first expressed in retina. It may play a role in binding retinoids and other carotenoids as it shares homology with;riboflavin binding proteins. RTBDN gene was first identified in a study of human eye tissues. | |||
TMPJ-00932 |
PBLD Protein, Human, Recombinant (His)
MAWBP,MAWD-Binding Protein,PBLD,MAWDBP,Unknown Protein 32 Fr... |
Human | E. coli |
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension. | |||
TMPJ-01118 |
GNMT Protein, Human, Recombinant (His)
GNMT,Glycine N-Methyltransferase |
Human | E. coli |
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0335 |
Methotrexate-d3
|
ADC Cytotoxin | Antibody-drug Conjugate/ADC Related |
Methotrexate-d3 是 Methotrexate 的氘代化合物。Methotrexate 的 CAS 号为 59-05-2。Methotrexate 是一种叶酸类似物代谢抑制剂,具有免疫抑制剂和抗肿瘤特性,用于类风湿关节炎和研究多种癌症。 | |||
TMIJ-0375 |
Levomefolic Acid-13C-d3
|
||
Levomefolic Acid-13C-d3 是 Levomefolic Acid 的 13C 和氘代化合物。Levomefolic Acid 的 CAS 号为 31690-09-2。Levomefolic acid是一种具有口服活性、可穿过血脑屏障的天然活性叶酸,是广泛使用的叶酸食品补充剂。 |