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Search Results for " farnesyltransferase inhibitor "

Targets Recommended: Transferase

28

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2678	LB42708	Transferase	Metabolism
	LB42708 是一种口服有活力的特异性法尼基转移酶抑制剂。它对H-Ras、N-Ras 和K-Ras4B 的法尼基化均有抑制作用，其IC50分别为 0.8 nM、1.2 nM 和 2.0 nM。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T17102	Tipifarnib (S enantiomer) Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer	Transferase	Metabolism
	Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体，它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂，IC50=0.6 nM。
T27773L	L-739750 2HCl L-739750 2HCl(160141-08-2 Free base)	Transferase	Metabolism
	L-739750 2HCl 是一种有效的拟肽法尼基转移酶的抑制剂，是一种新型假肽模拟物，具有潜在的抗癌活性。
T2700	FTI-277 hydrochloride FTI 277 HCl	Apoptosis; Transferase; Ras	Apoptosis; GPCR/G Protein; MAPK; Metabolism
	FTI-277 hydrochloride (FTI 277 HCl) 是一种法尼基转移酶FTase 抑制剂，高效 Ras CAAX 肽模拟物，可抑制H-Ras 和K-Ras 信号转导，还可抑制hepatitis delta virus 感染。
T24273	Kurasoin B Kurasoin-B	Others	Others
	Kurasoin B is an inhibitor of protein farnesyltransferase.
T24351	L 731735 L-731,735,L731735,L-731735,L731,735,L 731,735	Others	Others
	L 731735 is a farnesyltransferase inhibitor.
T15770	(Rac)-CP-609754 LNK754	Influenza Virus	Microbiology/Virology
	LNK754 is a farnesyltransferase inhibitor. It is used for the treatment of cancer and Alzheimer's disease.
T27773	L-739750	Others	Others
	L-739,750 is an inhibitor (FTI) of peptidomimetic farnesyltransferase.
T40331	Ftase inhibitor III	Others	Others
	Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase.
T71375	FTI-2600	Others	Others
	FTI-2600 is a farnesyltransferase inhibitor.
T24350	L 731734 L-731,734,L 731,734,L731734,L731,734,L-731734	Others	Others
	L 731734 is a farnesyltransferase inhibitor.
T11331L	FTI 276	Others	Others
	FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human).
T69710	LB42908	Others	Others
	LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity.
T25939	Pepticinnamin E	Others	Others
	Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor.
T70372	FTI-249	Others	Others
	FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100Â–200 nM).
T70554	Chaetomellic acid A	Others	Others
	Chaetomellic acid A is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).
T70405	L-744832	Others	Others
	L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity.
T68923	FTI-2628	Others	Others
	FTI-2628 is a novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia.
T68227	BMS-214662 HCl	Others	Others
	BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cell...
T15353	FTI-2153	Others	Others
	FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing.
T64101	FTI-2153 TFA	Others	Others
	FTI-2153 TFA 是一种高选择性的、有效的法尼基转移酶 farnesyltransferase (FTase) 抑制剂 (IC50: 1.4 nM)。FTI-2153 TFA 可有效抑制 H-Ras 蛋白的加工修饰 (IC50: 10 nM)，对其抑制活性是对 Rap1A 蛋白加工的 3000 多倍。
T69993	BIM-46068	Others	Others
	BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents.
T69994	BIM-46050	Others	Others
	BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bon...
T62675	FTI-277	Others	Others
	FTI-277 是一种法尼基转移酶 FTase 抑制剂，也是一种高效 Ras CAAX 肽模拟物。FTI-277 对 H-Ras 和 K-Ras 信号转导具有抑制作用，能够抑制 hepatitis delta virus (HDV) 感染。
T70287	BMS-186511	Others	Others
	BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a clos...
T85180	GGTI 2133 TFA	Others	Others
	GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the farnesylation of H-Ras (IC50= >30 µM). Moreover, GGTI 2133 reduces the growth, migration, and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control levels, respectively. ...
T10512	Prenyl-IN-1	Transferase	Metabolism
	Prenyl-IN-1 是一种具有有效性和选择性的 prenylation 抑制剂，对香叶烯基转移酶 (geranylgeranyltransferase) 或法尼基转移酶 (farnesyltransferase) 具有抑制作用。Prenyl-IN-1 在帕金森模型中显示出抗氧化应激作用。

化合物

Cat.No: T2678

Target: Transferase

Cat.No: T38050

Target: Transferase

Tipifarnib (S enantiomer)

Cat.No: T17102

Synonym: Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer

Target: Transferase

Cat.No: T27773L

Synonym: L-739750 2HCl(160141-08-2 Free base)

Target: Transferase

FTI-277 hydrochloride

Cat.No: T2700

Synonym: FTI 277 HCl

Target: Apoptosis, Transferase, Ras

Cat.No: T24273

Synonym: Kurasoin-B

Target: Others

Cat.No: T24351

Synonym: L-731,735,L731735,L-731735,L731,735,L 731,735

Target: Others

(Rac)-CP-609754

Cat.No: T15770

Synonym: LNK754

Target: Influenza Virus

Cat.No: T27773

Target: Others

Ftase inhibitor III

Cat.No: T40331

Target: Others

Cat.No: T71375

Target: Others

Cat.No: T24350

Synonym: L-731,734,L 731,734,L731734,L731,734,L-731734

Target: Others

Cat.No: T11331L

Target: Others

Cat.No: T69710

Target: Others

Pepticinnamin E

Cat.No: T25939

Target: Others

Cat.No: T70372

Target: Others

Chaetomellic acid A

Cat.No: T70554

Target: Others

Cat.No: T70405

Target: Others

Cat.No: T68923

Target: Others

Cat.No: T68227

Target: Others

Cat.No: T15353

Target: Others

Cat.No: T64101

Target: Others

Cat.No: T69993

Target: Others

Cat.No: T69994

Target: Others

Cat.No: T62675

Target: Others

Cat.No: T70287

Target: Others

Cat.No: T85180

Target: Others

Cat.No: T10512

Target: Transferase

Cat. No.	Product Name	Target	Signaling Pathways
T16011	Manumycin A	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A acts as a selective, competitive inhibitor of

天然产物

Cat.No: T16011

Target: Prostaglandin Receptor

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