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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T82215	HEP-1 Human ezrin peptide (324-337)
	HEP-1 (Human ezrin peptide (324-337)) 是一种具抗HIV活性的口服多肽，能增强乙型肝炎疫苗接种后的抗体滴度，表现出潜在的抗病毒感染研究价值。
T28212	NSC668394 NSC-668394,NSC 668394	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	NSC668394 是一种有效的小分子 ezrin (Thr567) 磷酸化抑制剂。NSC668394 具有潜在的抗肿瘤活性，抑制 ezrin T567 磷酸化，增加 Ca2+依赖性ezrin裂解。NSC668394 可用于研究肿瘤转移。
T12263	NSC305787	Others	Others
	NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity.
T24491	MMV-667492 MMV667492	Others	Others
	MMV-667492 is an effective inhibitor of Ezrin.
T12263L	NSC305787 hydrochloride (Rac)-NSC305787 hydrochloride	Others	Others
	NSC305787 hydrochloride ((Rac)-NSC305787 hydrochloride) 是一种可透过细胞膜且具有选择性和有效性的小分子 Cdc25 dual specificity phosphatase 和 EZR 双重抑制剂，在胰腺癌细胞中显示出抗肿瘤活性，对Cdc25B2， Cdc25A，Cdc25B2 和 Cdc25C 具有抑制作用。NSC 663284 抑制 NSD2 (IC50 of 170 nM) 酶的活性。

化合物

HEP-1

Cat.No: T82215

Synonym: Human ezrin peptide (324-337)

Target:

NSC668394

Cat.No: T28212

Synonym: NSC-668394,NSC 668394

Synonym: MMV667492

Target: Others

NSC305787 hydrochloride

Cat.No: T12263L

Synonym: (Rac)-NSC305787 hydrochloride

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00858	Ezrin Protein, Human, Recombinant Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin	Human	E. coli
	Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele...
TMPY-03053	Ezrin Protein, Human, Recombinant (His) HEL-S-105,CVL,VIL2,CVIL,ezrin	Human	E. coli
	VIL2, also known as villin-2, belongs to the ERM protein family. It is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. VIL2 contains 1 FERM domain and may be involved in connections of major cytoskel
TMPH-01662	Merlin Protein, Human, Recombinant (His) Merlin,Moesin-ezrin-radixin-like protein,Schwannomi...	Human	E. coli
	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress...
TMPH-02781	Merlin Protein, Mouse, Recombinant (His & Trx) Moesin-ezrin-radixin-like protein,Schwannomin,Neuro...	Mouse	E. coli
	Merlin Protein, Mouse, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 55.9 kDa and the accession number is P46662.
TMPK-01305	CD43 Protein, Cynomolgus, Recombinant (His) CD43,A630014B01Rik,LSN,GPL115,Galgp,SPN,Ly-48,Leukosialin,Si...	Cynomolgus	HEK293 Cells
	CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. CD43 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ...
TMPK-00832	CD43 Protein, Human, Recombinant (His) Galgp,SPN,LSN,Sialophorin,CD43,A630014B01Rik,GPL115,Ly-48,Le...	Human	HEK293 Cells
	CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. CD43 Protein, Human, Recombinant (His) is expressed in HEK293 mamma...
TMPY-02847	Moesin Protein, Human, Recombinant (aa 1-346, His) moesin,HEL70	Human	E. coli
	Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM proteins function as cross-linkers between plasma membranes and actin-based cytoskeletons. The sole Drosophila ERM protein, moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking moesin lose epithelial characteristics and adopt invasi...