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TMPH-01248
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ADAR Protein, Human, Recombinant (His & SUMO)
ADAR1,IFI-4,136 kDa double-stranded RNA-bi...
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Human
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E. coli
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Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri... |
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TMPH-00280
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PRKRA Protein, Bovine, Recombinant (His & Myc)
Protein kinase, interferon-inducible double-str...
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Bovine
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E. coli
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PRKRA Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q2HJ92. |
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TMPH-01249
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ADAR Protein, Human, Recombinant (GST)
DRADA,K88DSRBP,p136,136 kDa double-stranded
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Human
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E. coli
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ADAR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 47.2 kDa and the accession number is P55265. |
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TMPH-00525
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DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc)
dsbA,rpbB,Double-stranded DNA-binding prot...
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Enterobacteria phage T4
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E. coli
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May play a role in transcription of several T4 genes. Binds double-stranded DNA and interacts preferentially with T4 late promoter regions. DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.8 kDa and the accession number is P13320. |
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TMPH-01556
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EIF2AK2 Protein, Human, Recombinant (His)
EIF2AK2,PKR,eIF-2A protein kinase 2,PRKR,p68 kinase,Interfer...
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Human
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P. pastoris (Yeast)
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EIF2AK2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is P19525. |
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TMPJ-01396
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PIN4 Protein, Human, Recombinant (His)
Peptidyl-prolyl cis-trans isomerase Pin4,Parvulin-14,Peptidy...
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Human
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E. coli
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4(PIN4) is a peptidyl-prolyl cis/trans isomerase (PPIase) which interacts with NIMA and is vital for cell cycle regulation. PIN4 has 2 different isoforms: PAR14 and PAR17. Furthermore, PIN4 protein binds to double-stranded DNA under physiological salt conditions. PIN4 is involved as a ribosomal RNA processing factor in ribosome biogenesis. The PAR14 binds to tightly bent AT-rich stretches of double-stranded DNA, but PAR17 binds to double-stran... |
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TMPJ-00668
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HMGB3 Protein, Human, Recombinant (His)
HMG4,High Mobility Group Protein 2a,HMG-2a,High Mobility Gro...
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Human
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HEK293 Cells
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High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferentiallly single-stranded DNA and unwinds double stranded DNA. HMGB3 consists of 200 amino acids and is localized to the cell nucleus. It contains two HMG box DNA-binding domain. HMGB3 binds preferentially single-stranded DNA and unwinds double stranded DNA. |
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TMPH-00039
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Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)
Single-strand DNA-binding protein,63.5 kDa virulence protein...
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Agrobacterium fabrum
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E. coli
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Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence composition. Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 70.3 kDa and the accession number is P08062. |
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TMPH-03440
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RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)
RAD52,DNA repair and recombination protein RAD52
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Saccharomyces cerevisiae
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E. coli
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Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778. |
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TMPK-01250
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M1R Protein, Monkeypox virus, Recombinant (His)
Monkeypox virus,M1R
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Monkeypox virus
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HEK293 Cells
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Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. M1R Protein, Monkeypox virus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 20.41 kDa and the accession number is QJQ40223.1. |
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TMPH-03712
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Clp1 Protein, Xenopus laevis, Recombinant (His)
clp1,Pre-mRNA cleavage complex II protein Clp1,Polyadenylati...
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Xenopus laevis
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E. coli
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Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the... |
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TMPK-01253
|
A35R Protein, Monkeypox virus, Recombinant (His)
A35R
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Monkeypox virus
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HEK293 Cells
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Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. A35R Protein, Monkeypox virus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 14.77 kDa and the accession number is QJQ40286.1. |
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TMPK-01123
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A29 Protein, Monkeypox virus, Recombinant (His)
A29L,IMV surface,14 kDa protein,14kDa fusion
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Monkeypox virus
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E. coli
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Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. A29 Protein, Monkeypox virus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.65 kDa and the accession number is Q90188. |
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TMPH-00531
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SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)
Single-stranded DNA-binding protein,Gene product 2....
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Enterobacteria phage T7
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E. coli
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Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... |
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TMPK-01116
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A30 Protein, Monkeypox virus, Recombinant (His)
Envelope protein A28 homolog,A30,A30L,Protein A30
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Monkeypox virus
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HEK293 Cells
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Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. A30L is an envelope protein required for the fusion of virus and host cell to form syncytia, and is also considered to be an important target in MPXV research. |
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TMPH-03184
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P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)
P2,Protein P2,RNA-directed RNA polymerase
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Pseudomonas phage phi6
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E. coli
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Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them. P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.2 kDa and the accession number is P11124. |
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TMPH-00425
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DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)
ligA,DNA ligase,Polydeoxyribonucleotide synthase [NAD(+)]
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Colwellia psychrerythraea
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E. coli
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DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.1 kDa and the accession number is Q47YI0. |
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TMPH-00120
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Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc)
cla,Ribonuclease clavin
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Aspergillus clavatus
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E. coli
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Clavin has the same substrate specificity as alpha-sarcin. It is specific for purines in both single- and double-stranded RNA. Its toxic action on eukaryotic cells is the result of cleavage of a single phosphodiester bond in the 60S subunit of ribosomes. Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.5 kDa and the accession number is P0CL71. |
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TMPH-00532
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SSB Protein, Enterobacteria phage T7, Recombinant
Gene product 2.5,Single-stranded DNA-binding protei...
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Enterobacteria phage T7
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P. pastoris (Yeast)
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Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ... |
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TMPH-00848
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OASL Protein, Human, Recombinant (His)
59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid re...
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Human
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E. coli
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Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646. |
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TMPJ-01450
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SARS-CoV-2 Helicase Protein (His & MBP)
SARS-CoV 2 nsp13,SARS-CoV 2 Helicase
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SARS-CoV-2
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E. coli
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The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nu... |
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TMPH-03193
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Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)
DNA/RNA-binding protein Alba
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Pyrococcus furiosus
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E. coli
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Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes. Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molec... |
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TMPH-01431
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HELQ Protein, Human, Recombinant (His & Myc)
Mus308-like helicase,POLQ-like helicase,HELQ,Helicase POLQ-l...
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Human
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E. coli
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Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. HELQ Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 4... |
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TMPJ-00918
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HMGB2 Protein, Human, Recombinant (His)
High Mobility Group Protein B2,HMG2,High Mobility Group Prot...
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Human
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HEK293 Cells
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High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ... |
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TMPH-00533
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T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)
T7 RNA polymerase,DNA-directed RNA polymerase
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Escherichia phage T7
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E. coli
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Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible... |
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TMPH-01213
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DNASE1L3 Protein, Human, Recombinant (His)
DNase I homolog protein DHP2,DNAS1L3,DNase I-like 3,Deoxyrib...
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Human
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Baculovirus Insect Cells
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPH-02315
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XRCC5 Protein, Human, Recombinant (His & Myc)
ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa...
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Human
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E. coli
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Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |
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TMPH-01214
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DNASE1L3 Protein, Human, Recombinant
DHP2,Deoxyribonuclease I-like 3,Deoxyribonuclease gamma,DNas...
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Human
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E. coli
|
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPH-01212
|
DNASE1L3 Protein, Human, Recombinant (His & Myc)
LSD,Liver and spleen DNase,Deoxyribonuclease I-like 3,DNAS1L...
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Human
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E. coli
|
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Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPH-02314
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XRCC5 Protein, Human, Recombinant (His & MBP)
Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...
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Human
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Baculovirus Insect Cells
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Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind... |
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TMPH-01694
|
MLKL Protein, Human, Recombinant (E. coli, His)
MLKL,Mixed lineage kinase domain-like protein
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Human
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E. coli
|
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Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB... |
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TMPH-01239
|
XPC Protein, Human, Recombinant (His)
Xeroderma pigmentosum group C-complementing protein,p125,XPC...
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Human
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E. coli
|
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Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i... |
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TMPH-02521
|
PYCARD Protein, Mouse, Recombinant (His & Myc)
Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...
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Mouse
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E. coli
|
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Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ... |
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TMPH-03732
|
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
Polymerase cofactor VP35,Ebola VP35,VP35
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ZEBOV
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E. coli
|
|
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... |
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TMPH-00610
|
gyrA Protein, E. coli, Recombinant (His)
DNA gyrase subunit A,gyrA
|
E. coli
|
E. coli
|
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A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has hig... |
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TMPH-03733
|
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
Polymerase cofactor VP35,VP35,Ebola VP35
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ZEBOV
|
HEK293 Cells
|
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Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... |
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