26
13
1
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Cat. No. | Product Name | ||
---|---|---|---|
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11696 |
Ivachtin
Caspase-3 Inhibitor VII |
Caspase | Apoptosis; Proteases/Proteasome |
Ivachtin (Caspase-3 Inhibitor VII) 是一种非肽,非竞争性和可逆的caspase-3抑制剂,IC50为 23 nM。它是其余胱天蛋白酶的适度抑制剂。 | |||
T12617L |
(R)-CR8
(R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8 |
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
(R)-CR8 ((R)-Isomer) 是 Roscovitine 类似物,是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。 | |||
T36819 |
Ac-FLTD-CMK
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-FLTD-CMK 是由消皮素 D (GSDMDD) 衍生的抑制剂,具有对炎症性 caspases 特异性的抑制作用。Ac-FLTD-CMK 对 Ac-FLTD-CMK 对 caspases-1、caspases-4和 caspases-11有抑制作用 ,IC50分别为 为 46.7 nM、 1.49 μM 和 329 nM。 Ac-FLTD-CMK 对 caspases-1、caspases-4、 caspases-11均表现出有效性,但对凋亡相关的 caspase-3 无效。 | |||
T6738 |
Z-FA-FMK
|
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒蛋白酶3CL,Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶,也可以抑制效应半胱天冬酶。 | |||
T22812 |
GRI977143
GRI 977143 |
LPA Receptor | GPCR/G Protein |
GRI977143 是 LPA2 的选择性非脂质激动剂 (EC50 = 3.3 μM)。 GRI977143 抑制半胱天冬酶 3、7、8 和 9 的激活,并减少 DNA 片段化。 | |||
T9118 |
KEA1-97
|
Apoptosis; Others; Caspase | Apoptosis; Others; Proteases/Proteasome |
KEA1-97 是一种选择性硫氧还蛋白-半胱天冬酶 3相互作用干扰剂,IC50为10 μM。它在不影响硫氧还蛋白活性的情况下, 破坏硫氧还蛋白与 caspase 3 的相互作用,激活半胱天冬酶,诱导细胞凋亡。 | |||
T8866 |
GW779439X
|
Apoptosis; Antibacterial; CDK; Aurora Kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Microbiology/Virology |
GW779439X 属于吡唑并吡啶类,是一种金黄色葡萄球菌 PASTA 激酶 Stk1抑制剂。它是一种AURKA 抑制剂,可通过 caspases 3/7 诱导细胞凋亡。 | |||
T6007 |
Birinapant
TL32711,比瑞那帕 |
Apoptosis; IAP; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Birinapant (TL32711) 是一种二价 Smac 模拟物,是 XIAP 和 cIAP1的强效拮抗剂,Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP,并消除 TNF 诱导的 NF-κB 活化。 | |||
T7020 |
Z-VAD-FMK
Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂。Z-VAD-FMK 可以与活化的 caspase 结合,从而抑制细胞凋亡。Z-VAD-FMK即使在高达 440μM 的浓度下也不会抑制 UCHL1 的活性。 | |||
T36493 |
CMLD-2
|
Apoptosis; HuR | Apoptosis; Chromatin/Epigenetic |
CMLD-2是一种 HuR-ARE 相互作用的抑制剂(Ki:350 nM),能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素(ARE)的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2(30μM;24-48小时)减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2(35μM;72小时)降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。 | |||
T0859 |
Fenbufen
芬布芬,CL-82204,Lederfen |
ATPase; Caspase; COX | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome |
Fenbufen (Lederfen) 是一种非甾体抗炎药,主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折,具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性,其 IC50分别为 3.9 μM 和 8.1 μM。 | |||
T36189 |
CAY10406
|
Others | Others |
CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently a... | |||
T26242 |
SW IV-52
SW-IV-52,SW IV52,SW IV 52,SWIV52 |
Others | Others |
SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic. | |||
T10548 |
Biotin-VAD-FMK
|
Caspase | Apoptosis; Proteases/Proteasome |
Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates. | |||
T68869 |
TP-110
|
Others | Others |
TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases. | |||
T36331 |
Z-AEVD-FMK
Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2] | |||
T80537 |
Ac-AAVALLPAVLLALLAP-LEHD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-AAVALLPAVLLALLAP-LEHD-CHO 是半胱天冬酶4、5和9的抑制剂,能够对Neocarzinostatin处理的MCF-7细胞展现保护效果。 | |||
T36658 |
Boc-Glu-OBzl
|
||
Boc-Glu-OBzl is an amino acid building block.1,2It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activityin vitro. 1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Dragovich, P.S., Webber, S.E., Babine, R.E., et al.Structure-based design, synthesis, and biological evaluation of i... | |||
T70430 |
XK469
|
Others | Others |
XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. | |||
T68262 |
AEG40826
|
Others | Others |
AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhib... | |||
T69632 |
VRT-043198
|
Others | Others |
VRT-043198 是 VX-765 (Belnacasan) 的活性代谢物,是有效的、选择性的、能透过血脑屏障的caspase-1的抑制剂。VRT-043198 对caspase-1和 caspase-4 的 Ki 值分别为 0.8 nM 和 0.6 nM。 | |||
T41240 |
Verrucarin A
|
Others | Others |
Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂,来源于Myrothecium verrucaria,可抑制白血病细胞系生长,并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。 | |||
T29060 |
UNBS-1450
UNBS 1450,UBS1450,UBS-1450,UBS 1450 |
Others | Others |
UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce | |||
T73683 |
AC-VEID-CHO TFA
|
||
AC-VEID-CHO (TFA) 是一种源自多肽的半胱天冬酶抑制剂,针对Caspase-6、Caspase-3和Caspase-7展示出优异的抑制效果,其IC50值分别为16.2 nM、13.6 nM和162.1 nM。该化合物常用于研究阿尔茨海默病、亨廷顿病等神经退行性疾病。 | |||
T61673 |
Anticancer agent 56
|
Others | Others |
Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat... | |||
T79482 |
Anticancer agent 137
|
PI3K | PI3K/Akt/mTOR signaling |
Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂,展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡(apoptosis),并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13818 |
Phytohemagglutinin
PHA-M,植物血球凝集素,PHA,植物血凝素 |
Apoptosis | Apoptosis |
Phytohemagglutinin (PHA-M) 是一种普通豆菜豆的主要种子凝集素,聚集在子叶的薄壁细胞中。它是一种 T 细胞激活剂,能够刺激人单核白细胞,可诱导 ChAT mRNA 表达,增强 ACh 合成。 | |||
T6185 |
Gambogic Acid
藤黄酸,Beta-Guttiferrin,藤黄酸 A,Guttatic Acid,Guttic Acid |
BCL; Autophagy | Apoptosis; Autophagy |
Gambogic Acid (Guttic Acid) 是来自藤黄树的一种藤黄树脂,抑制 Bcl-XL、Bcl-2、Bcl-W、Bcl-B、Bfl-1和 Mcl-1,IC50分别为 1.47 μM、1.21 μM、2.02 μM、0.66 μM、1.06 μM 和 0.79 μM。 | |||
T3894 |
Polyphyllin II
重楼皂苷 II,Chonglou Saponin II |
Apoptosis; Others | Apoptosis; Others |
Polyphyllin II (Chonglou Saponin II) 是重楼中重要的一种皂苷,具有止血、祛痰、抑菌、抗细胞毒和抗孕杀精作用。它通过 caspases 激活和细胞周期停滞诱导细胞凋亡。 | |||
T3867 |
Alpinetin
山姜素,(-)-alpinetin |
BCL; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物,能够活化PPAR-γ,具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
T5574 |
Guggulsterone
Guggulsterone E&Z,香胶甾酮 |
Apoptosis; FXR; Akt; Caspase; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Guggulsterone (Guggulsterone E&Z) E&Z 是来自Commiphora wightii 树中树胶脂的植物甾醇。 它通过下调抗细胞凋亡基因产物 ,调节细胞周期蛋白,激活caspases,JNK,抑制Akt,抑制多种肿瘤细胞的生长并诱导细胞凋亡。它是法尼醇 X 受体拮抗剂,可降低 CDCA 诱导的 FXR 活化。 | |||
T2966 |
Beta-Sitosterol
Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis; Lipase; Endogenous Metabolite | Apoptosis; Metabolism |
Beta-Sitosterol (SKF 14463) 属于天然产物,是一种植物甾醇,广泛存在于植物界。Beta-Sitosterol 的摄人量与许多慢性病的发生率有关系,比如具有明显降低血清胆固醇的功效。 | |||
T14003 |
15-Acetoxyscirpenol
|
Caspase | Apoptosis; Proteases/Proteasome |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1]. | |||
T71784 |
Asukamycin
|
Others | Others |
Asukamycin is polyketide isolated from the S. nodosus subspecies asukaensis that demonstrates a broad range of antibiotic functions. It has been shown to inhibit growth of various tumor cell lines by activating caspases 8 and 3. | |||
TN3682 |
Clerosterol glucoside
|
Others | Others |
Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis. | |||
TN1139 |
Dehydrocavidine
Dehydrocorydaline,岩黄连碱 |
BCL; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Dehydrocavidine (Dehydrocorydaline) 具有抗肿瘤活性,它通过诱导调节 Bax/Bcl-2 介导的细胞凋亡、激活半胱天冬酶以及切割 PARP 来抑制 MCF-7 细胞增殖。 | |||
TN5201 | Uncarinic acid E | BCL; MEK; Caspase; PI3K; Antifection; p53 | Apoptosis; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p-( |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-02831 |
Caspase-7 Protein, Human, Recombinant (His)
ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-related cyst... |
Human | E. coli |
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r... | |||
TMPH-00021 |
Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His)
omp38,Outer membrane protein Omp38 |
Acinetobacter baumannii | P. pastoris (Yeast) |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor). | |||
TMPJ-01256 |
Caspase-10 Protein, Human, Recombinant (His)
CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co... |
Human | E. coli |
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca... | |||
TMPY-00924 |
SMAC Protein, Human, Recombinant (His)
DFNA64,diablo, IAP-binding mitochondrial protein,SMAC |
Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, bot... | |||
TMPY-04118 |
Livin/BIRC7 Protein, Human, Recombinant (His)
MLIAP,baculoviral IAP repeat containing 7,RNF50,KIAP,ML-IAP,... |
Human | E. coli |
BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecu... | |||
TMPK-00636 |
BID Protein, Mouse, Recombinant (His)
BID,p22 BID |
Mouse | E. coli |
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. Bid is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Bid is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. | |||
TMPK-00276 |
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRSF10B,TRIC... |
Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. | |||
TMPY-01824 |
Caspase-14 Protein, Human, Recombinant (His)
caspase 14, apoptosis-related cysteine peptidase,ARCI12 |
Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp... | |||
TMPH-00022 |
Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO)
omp38,Outer membrane protein Omp38 |
Acinetobacter baumannii | E. coli |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor). Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.5 kDa and the accession number is A3M8K2. | |||
TMPJ-00770 |
Granzyme B/GZMB Protein, Mouse, Recombinant (His)
Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,Granzyme ... |
Mouse | HEK293 Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. | |||
TMPJ-00215 |
Fas/CD95 Protein, Mouse, Recombinant (hFc)
CD95,Apoptosis-mediating surface antigen FAS,TNFRSF6,Fas,Tum... |
Mouse | HEK293 Cells |
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which... | |||
TMPK-00277 |
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fas-li... |
Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. | |||
TMPY-04768 |
PRPS2 Protein, Human, Recombinant (His)
PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase 2 |
Human | E. coli |
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine... | |||
TMPJ-01066 |
CYCS Protein, Human, Recombinant (His)
CYC,Cytochrome C,CYCS |
Human | E. coli |
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic... | |||
TMPY-01176 |
cIAP1 Protein, Human, Recombinant (Avi)
Hiap-2,API1,HIAP2,RNF48,baculoviral IAP repeat containing 2,... |
Human | E. coli |
The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase... | |||
TMPH-02671 |
Gasdermin-D Protein, Mouse, Recombinant (His & Myc)
Gasdermin-D,Gasdermin domain-containing protein 1,Gsdmd |
Mouse | E. coli |
Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canon... |