47
16
6
15
1
Cat. No. | Product Name | ||
---|---|---|---|
L1700 | 抗病毒库 | 1040 compounds | |
1040 种具有抗病毒活性的化合物的特有集合,是筛选新型抗病毒药的有效工具;可用于高通量筛选和高内涵筛选; | |||
L1720 | 核苷类化合物库 | 334 compounds | |
334 种核苷类化合物,包括核苷酸、核苷酸类似物及衍生物等,适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发; | |||
L6730 | 抗病毒中药单体化合物库 | 268 compounds | |
268 种具有抗病毒活性的中药单体集合,是药物开发、药理研究的有效工具; | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L1710 | 抗COVID-19化合物库 | 1133 compounds | |
1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合,可用于高通量和高内涵筛选; | |||
L6400 | 海洋天然产物库 | 144 compounds | |
144 种海洋来源的单体化合物,是药物开发、药理研究等领域的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9705 |
TL-895
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
TL-895 是口服有效的,ATP 竞争性的,以及高度选择性和不可逆的BTK 抑制剂,IC50和Ki 分别为 1.5 nM 和 11.9 nM。TL-895在 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症方面有研究的价值。 | |||
T2162 |
Maribavir
BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Maribavir (GW257406X) 是一种可口服的苯并咪唑核苷化合物,具有抗巨细胞病毒的活性。 | |||
T4121 |
Bicyclol
SY801,双环醇 |
HBV; Autophagy | Autophagy; Microbiology/Virology |
Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。 | |||
T61793 |
HIV-IN-6
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-IN-6 是一种 HIV 病毒抑制剂,可抑制HIV 病毒的复制。HIV-IN-6 具有抗HIV 病毒的活性,通过靶向与病毒 Nef 蛋白相互作用的 Src 家族激酶 (SFK) (如 Hck) 而起作用。 | |||
T5396 |
Letermovir
AIC246,MK-8828,莱莫维韦 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Letermovir (AIC246) 是一种新型抗 CMV 抑制剂,靶向病毒末端酶,抑制其活性。 | |||
T1370 |
2-Amino-5-Fluorophenol
|
Others | Others |
2-Amino-5-Fluorophenol(2-AF)用于合成各种药物和化合物,包括抗癌药、抗炎药和其他药物,以及抗微生物、抗真菌和抗病毒的化合物。 | |||
T38343 |
Quercetin pentaacetate
Pentaacetylquercetin |
RSV | Microbiology/Virology |
Quercetin pentaacetate (Pentaacetylquercetin) 具有多种生物活性,包括抗氧化、抗炎和抗癌特性。 Quercetin pentaacetate 与 RSV 相互作用并抑制病毒在细胞表面的粘附。 | |||
T8736 |
Cidofovir dihydrate
HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物 |
Others | Others |
Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂,通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制,从而阻止病毒复制和转录。 | |||
T15777 |
Loxoribine
RWJ 21757,7-Allyl-8-oxoguanosine,洛索立宾 |
Influenza Virus; TLR | Immunology/Inflammation; Microbiology/Virology |
Loxoribine (RWJ 21757) 是一种鸟苷类似物,是一种口服生物可利用的选择性 Toll 样受体 (TLR) 7 激动剂。 具有抗病毒和抗肿瘤活性。它是一种新型的强效免疫刺激剂,具有较广谱的免疫生物学活性。 | |||
T78704 |
PLpro/RBD-IN-1
|
SARS-CoV | Microbiology/Virology |
PLpro/RBD-IN-1 为 SARS-CoV-2 PLpro 与刺突蛋白 RBD的双重抑制剂,具有抗新型冠状病毒的活性,看用于研究病毒感染。 | |||
T67833 |
HIV-1 inhibitor-54
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 inhibitor-54 是一种有效的 HIV-1 抑制剂,在 MT-4 细胞中对 WT HIV-1 (菌株 IIIB) x 显示出抗 HIV 活性(EC50 : 32 nM)。HIV-1 inhibitor-54 可用于研究病毒感染。 | |||
T73375 |
CK2-IN-4
|
Casein Kinase | Metabolism; Stem Cells |
CK2-IN-4 是一种蛋白激酶 (CK2) 抑制剂 ,IC50 值为 8.6 µM。 CK2-IN-4 具有潜在的抗癌啊和抗炎活性,可用于研究病毒感染和肾小球肾炎的疾病。 | |||
T72505L |
CTP Synthetase-IN-1 Ammonium salt
CTPS-IN-1 Ammonium salt,CTP Synthetase-IN-1 Ammonium salt(2338811-71-3 Free base) |
Others | Others |
CTP Synthetase-IN-1 Ammonium salt 是一种具有口服活性和高效性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂,具有潜在的抗菌抗炎抗肿瘤活性,可用于研究 SARS-CoV-2病毒感染。 | |||
TNU0007 |
3'-Deoxy-3'-fluoroadenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3'-Deoxy-3'-fluoroadenosine 是一种嘌呤核苷类似物,具有广泛的抗肿瘤活性和抗病毒活性,对蜱传脑炎病毒(TBEV),寨卡病毒和西尼罗河病毒(WNV)具有抑制作用,EC50分别为1.1μM、 0.1 μM和4.7 1.5 μM。3'-Deoxy-3'-fluoroadenosine可用于研究肿瘤疾病。 | |||
T60540 |
Netivudine
|
Others | Others |
Netivudine 是一种有效的核苷类逆转录酶抑制剂(NRTIs),是一种核苷类似物,具有抗水痘带状疱疹病毒活性,可用于治疗人类免疫缺陷病毒(HIV)感染。Netivudine 通过抑制逆转录酶起作用,通过抑制作用减少体内的病毒载量,减缓疾病的进展。 | |||
T67801 |
GS-6620 PM
|
Others | Others |
GS-6620 PM 是GS-6620的衍生物。GS-6620是一种口服的抗丙型肝炎病毒聚合酶抑制剂,是一种新型强效的C-核苷腺嘌呤类似物单磷酸酯原药。GS-6620对其他病毒的活性有限,对密切相关的牛病毒性腹泻病毒仅保持部分活性(EC50,1.5μM)。 | |||
T28701 |
SC-58272
SC58272 |
Others | Others |
SC-58272 is an inhibitor of N-myristoyltransferase (Nmt), a target for anti-fungal and anti-viral therapy. | |||
T40971 |
Dehydroandrographolide succinate potassium sodium salt
|
Others | Others |
Dehydroandrographolide succinate (potassium sodium salt), derived from the herbal medicine Andrographis paniculata (Burm f) Nees, is a versatile compound highly utilized for the treatment of viral pneumonia and viral upper respiratory tract infections due to its potent immunostimulatory, anti-infective, and anti-inflammatory properties. | |||
TQ0030 |
Tomeglovir
托美洛韦,BAY 38-4766 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV). | |||
T61824 |
NIOCH 14
|
Others | Others |
NIOCH 14 is an antiviral agent and pro-drug with demonstrated potency against orthopoxviruses. It exhibits significant efficacy in reducing infection rates and lung viral load in mice. NIOCH 14 is particularly useful for anti-smallpox research [1] [2], as it displays marked anti-orthopoxvirus activity. | |||
T40949 |
5'-O-TBDMS-N2-ibu-dG
5'-O-TBDMS-N2-ibu-dG |
Others | Others |
5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative that possesses potent anti-bovine viral diarrhea virus activity. It serves as a valuable compound for the synthesis of lead compounds with such activity. | |||
T61856 |
Antiviral agent 10
|
Others | Others |
Antiviral agent 10 是一种可抑制呼吸道合胞病毒 (RSV) 的抗病毒剂。 | |||
T36651 |
Anti-MERS-2E6 mAb
Anti-MERS-2E6 mAb |
||
Anti-MERS-2E6 mAb (MERS-2E6), a human IgG1 neutralizing antibody, is expressed in CHO cells. It effectively competes with the virus Spike protein for binding to the CD26 receptor, consequently inhibiting viral invasion into host cells. | |||
T63412 |
DB772 hydrate
|
Others | Others |
DB772 hydrate 是一种牛病毒性腹泻病毒 (BVDV) 抑制剂,同时表现出抗朊病毒作用。 | |||
T60709 |
Acyclovir monophosphate
|
Others | Others |
Acyclovir monophosphate 是抗单纯疱疹病毒 (HSV)剂,并且具有抗肿瘤活性。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶从而阻断 DNA 合成,同时能终止病毒 DNA 的链延伸。 | |||
T61613 |
SARS-CoV-2-IN-17
|
Others | Others |
SARS-CoV-2-IN-17 (Compound 16) is a highly effective inhibitor of SARS-CoV-2 nucleocapsid protein (NPro). It demonstrates potent anti-viral activity, with an EC50 value of 2.18 μM. Furthermore, SARS-CoV-2-IN-17 binds to NPro with a low Kd value of 7.82 μM, highlighting its potency as a NPro ligand [1]. | |||
T61606 |
Indomethacin sodium
|
Others | Others |
Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3]. | |||
T61080 |
L-I-OddU
|
Others | Others |
L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM. | |||
T83046 |
Anti-Influenza agent 5
|
Influenza Virus | Microbiology/Virology |
Anti-Influenza agent 5 (Compound IIB-2)为查耳酮类衍生物,具有抑制流感病毒核输出的活性。该化合物能有效抑制对Oseltamivir具有耐药性的病毒株,主要通过阻断流感病毒核蛋白输出作用来抑制病毒复制。 | |||
T38946 |
C8 Dihydroceramide
C8 Dihydroceramide |
Others | Others |
C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and anti-proliferation effects. Additionally, it stimulates dendritic cells to enhance T cell responses during viral infections. In vitro studies have also shown that C8 Ceramide induces a slight activation of protein kinase (PKC) [4]. | |||
T69731 |
Remdesivir maleate
|
Others | Others |
Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Remdesivir is a broad spectrum anti-viral drug that has shown to inhibit SARS-CoV-2, in vitro and in vivo. Efficacy of remdesivir against Ebola virus has been demonstrated. Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary les... | |||
T70859 |
ent-Abacavir
|
Others | Others |
ent-Abacavir is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuroni... | |||
T77158 | Diridavumab | ||
Diridavumab为一种针对HA茎的单克隆抗体。它能稳定HA的融合前结构,阻断细胞膜与病毒膜在核内体内因pH变化引起的融合。此抗体主要用于H2流感病毒研究。 | |||
T82215 |
HEP-1
Human ezrin peptide (324-337) |
||
HEP-1 (Human ezrin peptide (324-337)) 是一种具抗HIV活性的口服多肽,能增强乙型肝炎疫苗接种后的抗体滴度,表现出潜在的抗病毒感染研究价值。 | |||
T78756 |
Yhhu6669
|
HBV | Microbiology/Virology |
Yhhu6669为抗HBV药物,能够抑制HBVDNA。该化合物通过诱导无DNA衣壳的形成,从而抑制HBV复制,且能有效降低AAV/HBV感染小鼠中的HBVDNA及HBcAg水平,展现出优良的药代动力学特性。 | |||
T38340 |
10-Norparvulenone
|
Others | Others |
10-Norparvulenone is a fungal metabolite originally isolated fromMicrosphaeropsis.1It decreases viral sialidase activity in, and increases survival of, MDCK cells infected with the mouse-adapted influenza virus A/PR/8/34 when used at a concentration of 1 μg/ml. 1.Fukami, A., Nakamura, T., Kim, Y.P., et al.A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050J. Antibiot. (Tokyo)53(10)1215-1218(2000) | |||
T80657 |
SARS-CoV-2 3CLpro-IN-15
|
Virus Protease | Microbiology/Virology |
SARS-CoV-2 3CLpro-IN-15(compound a)为β-硝基苯乙烯型抑制剂,专门针对SARS-CoV-2的3CL蛋白酶(3CLpro)而设计。该化合物能有效抑制病毒的复制转录过程,是研发抗COVID-19候选先导化合物的关键因素。 | |||
T68957 |
Eprociclovir dihydrate
|
Others | Others |
Eprociclovir dihydrate is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica... | |||
T62888 |
Influenza A virus-IN-7
|
Others | Others |
Influenza A virus-IN-7 (compound 16r) 是一种有效的、口服具有活力的甲型流感病毒抑制剂 (IC50: 3.43 μM, CC50>100 μM)。Influenza A virus-IN-7 具有抗 IAV 作用,细胞毒性低,对病毒 RNA 的转录和复制表现出抑制作用。 | |||
T70027 |
Eprociclovir potassium
|
Others | Others |
Eprociclovir potassium is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica... | |||
T71291 |
EICAR
|
Others | Others |
EICAR is a drug which acts as an inhibitor of the enzyme IMP dehydrogenase. It is a nucleoside derivative which has both anti-cancer and antiviral effects, and was originally developed for the treatment of leukemia, but was unsuccessful in human clinical trials. It has broad spectrum antiviral effects with activity against vaccinia virus, Semliki forest virus, Junin virus, reovirus, influenza, measles virus and respiratory syncytial virus among others, although it is not active against SARS. T... | |||
T69817 |
Eprociclovir Na
|
Others | Others |
Eprociclovir Na is the salt form of Eprociclovir, also known as A-5021, a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applie... | |||
T82937 |
ATV041
|
||
ATV041是一种结合了布洛芬和核苷酸类似物的口服活性化合物。该化合物优化了口服药物动力学(PK)特性和组织分布,显示出对抗小鼠肝炎病毒(MHV)的能力。ATV041能够剂量依赖性地降低病毒载量,减少组织损伤并减轻病毒引发的炎症。 | |||
T83143 |
Alloferon 1
|
||
Alloferon 1 是一种具有抗病毒和抗肿瘤功能的肽。它能激活人外周血淋巴细胞的天然细胞毒性,诱导IFN合成,并在小鼠体内增强其抗病毒和抗肿瘤的防御机制。此外,Alloferon 1 在 λ-角叉菜胶诱导的足水肿模型中展现出抗炎作用。它可从双翅目昆虫丽蝇Calliphora vicina的血液中提取。 | |||
T69081 |
KRH-1636
|
Others | Others |
KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem... | |||
T37295 |
Ganglioside GM1 Asialo Mixture
|
Others | Others |
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na... | |||
T79567 |
Antiviral agent 35
|
Influenza Virus | Microbiology/Virology |
Antiviralagent 35 (compound 4d) 作为一种口服抗流感病毒药物,针对流感病毒复制的早期阶段有效。该化合物能够阻断流感病毒引发的ROS积聚、自噬及细胞凋亡,同时在肺部感染的小鼠模型中,抑制RIG-1通路所介导的炎症响应。Antiviralagent 35展现出低细胞毒性(CC50>800 μM,MDCK细胞)且对H1N1(A/Weiss/43)展现出显著的抗病毒活性,EC50为2.28 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
T2982 |
Xanthone
Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide |
Apoptosis; Others; Influenza Virus; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology; Others |
Xanthone (Xanthenone) 是一种从山竹果中分离得到的天然产物,具有抗炎,抗氧化,抗肿瘤,抗过敏,抗细菌,抗真菌和抗病毒活性。在癌变的不同阶段可控制细胞分裂和生长,凋亡,炎症和转移。 | |||
T5S0018 |
Betulonic acid
路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid |
Parasite; HSV | Microbiology/Virology |
Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物,具有抗肿瘤,抗炎,抗寄生虫和抗病毒的活性。 | |||
TN1788 |
Isookanin
|
Amylase | Metabolism |
Isookanin 在多种疾病领域有研究价值,包括肿瘤,皮疹,蛇和昆虫叮咬,糖尿病,腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。 | |||
T2S1975 |
Ponicidin
冬凌草乙素,Rubescensine B |
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Ponicidin (Rubescensine B) 是来源于冬凌草的一种二萜,具有免疫调节、抗炎、抗病毒和抗癌作用。它可诱导胃癌细胞凋亡,降低 JAK2 和 STAT3 的磷酸化水平。 | |||
T40660 |
Kansuinine B
|
IL Receptor; SARS-CoV | Immunology/Inflammation; Microbiology/Virology |
Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性,可用于 COVID-19 研究。 | |||
T13229 |
Tunicamycin
|
Influenza Virus; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Tunicamycin 是一种抗生素的混合物,通过阻断 GlcNAc 磷酸转移酶 (GPT),抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性,还具有抗细菌、抗真菌和抗病毒活性。 | |||
T75675 |
Nepasaikosaponin K
|
Antiviral | Immunology/Inflammation |
Nepasaikosaponin K 是一种从柴胡根中分离出来小分子化合物,具有抗流感和抗病毒活性,可用于研究病毒感染。 | |||
T0875 |
Acetylcysteine
N-Acetylcysteine,乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,N-Acetyl Cysteine,易咳净 |
Apoptosis; TNF; Ferroptosis; Influenza Virus; Reactive Oxygen Species; ROS; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Acetylcysteine (NAC) 是半胱氨酸的 N-乙酰衍生物,是一种 ROS 抑制剂和粘液溶解剂。Acetylcysteine 可诱导细胞凋亡,可用于减少粘液的厚度,还具有抗流感病毒活性。 | |||
TN1622 |
Ermanin
堪非醇3,4'-二-O-甲醚 |
NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集,具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达,从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。 | |||
T4S0999 |
(2S)-Isoxanthohumol
Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇 |
Virus Protease; HSV | Microbiology/Virology |
(2S)-Isoxanthohumol 是一种由啤酒花原异戊烯基二氢黄酮 Isoxanthohumol 的微生物转化代谢物。 | |||
T6519 |
Gramine
NSC 16892,芦竹碱,Donaxine |
Adiponectin receptor; Reverse Transcriptase; Adrenergic Receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Gramine (Donaxine) 是从芦竹中得到的一种生物碱,是脂联素受体激动剂,对 AdipoR2 和 AdipoR1 的 IC50值分别为 3.2 和 4.2 µM。它也是小鼠和人β2-肾上腺素受体激动剂,具有抗肿瘤、抗炎和抗病毒作用。 | |||
TN5005 |
Shegansu B
|
Influenza Virus | Microbiology/Virology |
Shegansu B exhibits significant in vitro anti-influenza viral activity in MDCK cells. | |||
T8521 |
Gnetin D
|
||
Gnetin D exhibits significant in vitro anti-influenza viral activity in MDCK cells, with IC(50) values from 0.67 to 11.99 ug/mL. | |||
TN2176 |
Sanggenol A
|
Influenza Virus; Antifection | Microbiology/Virology |
Sanggenol A 抑制甲型流感病毒和肺炎球菌神经氨酸酶,因此可作为双重作用的抗感染试剂。 | |||
TN1104 |
Cyanidin 3-sambubioside chloride
Cyanidin-3-O-sambubioside chloride |
RAAS; Antioxidant; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation; oxidation-reduction |
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride) 是一种从植物中提取的花青素,是一种 NO和 H274Y 突变的抑制剂,对流感神经氨酸酶具有抑制作用。Cyanidin 3-sambubioside chloride 具有抗氧化,抗血管生成和抗病毒活性,抑制血管紧张素转换酶 (ACE) 的活性,可用于研究病毒感染和心血管疾病。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06981 |
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ... |
Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... | |||
TMPY-04552 |
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homol... |
Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPJ-01449 |
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant
M Proteinase,3C-like Proteinase,3CL Proteinase |
SARS-CoV-2 | E. coli |
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec... | |||
TMPH-00776 |
Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His & Myc)
Griffithsin |
Griffithsia | Baculovirus Insect Cells |
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine. | |||
TMPH-00777 |
Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His)
Griffithsin |
Griffithsia | E. coli |
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine. | |||
TMPJ-01448 |
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)
M Proteinase,3CL Proteinase |
2019-nCoV | E. coli |
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t... | |||
TMPY-05693 |
SARS-CoV-2 Methyltransferase/ME Protein (His)
|
SARS-CoV-2 | E. coli |
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design ... | |||
TMPY-04480 |
UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)
CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM... |
Human | Baculovirus Insect Cells |
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi... | |||
TMPJ-01426 |
SARS-CoV-2 NSP2 Protein (His)
SARS-CoV 2 nsp2,SARS-CoV 2 p65 homolog |
SARS-CoV-2 | E. coli |
The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. | |||
TMPY-06983 |
IFN gamma Protein, Human, Recombinant (E. coli)
Interferon Gamma,IFN γ,IFN gamma,IFG,IFI,干扰素,Interferon γ |
Human | E. coli |
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activ... | |||
TMPH-01552 |
IRF1 Protein, Human, Recombinant (GST & His)
IRF1,Interferon regulatory factor 1 |
Human | Baculovirus Insect Cells |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm... | |||
TMPJ-00527 |
SP-D Protein, Human, Recombinant (His)
Lung Surfactant Protein D,SFTP4,COLEC7,SFTPD,PSP-D,SP-D,Pulm... |
Human | HEK293 Cells |
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. ... | |||
TMPJ-01056 |
IL-18 Protein, Mouse, Recombinant (His)
Interferon γ-inducing factor,Interleukin-1 gamma,Igif,IL-1 g... |
Mouse | E. coli |
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins... | |||
TMPH-02613 |
ATF-5 Protein, Mouse, Recombinant (His & Myc)
Transcription factor ATFx,Transcription factor-like protein ... |
Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0298 |
Letermovir-d8
|
||
Letermovir-d8 是 Letermovir 的氘代化合物。Letermovir 的 CAS 号为 917389-32-3。Letermovir是一种新型抗 CMV 抑制剂,靶向病毒末端酶,抑制其活性。 |