首页工具

登录

搜索结果

Search Results for " amyloid precursor protein "

40

抑制剂 & 化合物

1

天然产物

23

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1655	β-Amyloid Protein Precursor 770 (135-155) β-Amyloid Protein Precursor 770 135-155
	Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)
T6483	EHT 1864 EHT 1864 2HCl	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHT 1864 是 Rac 家族 GTPase 抑制剂，对 Rac1、Rac1b、Rac2 和 Rac3的Kd 为 40、50、60 和 250 nM。
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T80695	β-Amyloid precursor protein (96-110), cyclized (human)
	β-Amyloid precursor protein (96-110), cyclized (human) 为一种淀粉样前体蛋白衍生物，特别适用于阿尔茨海默病相关研究。
T7490	ARN2966	Beta Amyloid	Neuroscience
	ARN2966 是高效的，针对 APP 表达的转录后调节剂，能够抑制 APP 的表达从而使 Aβ的量降低。
T11178L	ELN318463 racemate ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	ELN318463 racemate (ELN 318463 racemate) 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
T14673	BMS 299897	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS 299897 是一种磺胺类 γ 分泌酶抑制剂。它在稳定过表达淀粉样前体蛋白（APP）的 HEK293 细胞中抑制 Aβ 生成的 IC50 值为 7 nM。
T61439	DSS30	Beta Amyloid; BACE; CDK	Cell Cycle/Checkpoint; Neuroscience
	DSS30 是一种 P25/CDK5抑制剂。DSS30通过抑制淀粉样前体蛋白裂解酶1 (BACEl) 磷酸化，减少 β-淀粉样蛋白 (Aβ) 的分泌发挥作用。DSS30 可用于预防和治疗阿尔茨海默病等神经退行性疾病。
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T14338	Atabecestat RSC-385896,JNJ-54861911	BACE	Neuroscience
	Atabecestat (JNJ-54861911) 是一种具有口服活性和脑渗透性的 β-位淀粉样蛋白前体蛋白裂解酶 1 (BACE1) 抑制剂，减缓临床前阿尔茨海默病参与者的认知能力下降。Atabecestat 可用于研究阿尔茨海默氏病。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T80622	Trontinemab RO-7126209,RG6102	Beta Amyloid	Neuroscience
	Trontinemab (RG6102) 是一种选择性靶向Aβ前体蛋白(APP)与转铁蛋白受体p90, CD71 (TFRC)的人源IgG1-κ抗体，抑制淀粉样蛋白产生，可用于研究阿兹海默症等神经系统疾病。
T13253	Umibecestat CNP520	BACE	Neuroscience
	Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂，对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM，可用于阿尔茨海默病的研究。
T27944	LY3202626 LY 3202626,LY-3202626	Others	Others
	LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.
T3161	β-Secretase inhibitor-STA	Beta-Secretase	Neuroscience
	BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。
T14525	Begacestat GSI-953	Beta Amyloid	Neuroscience
	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
T12429	PF-06751979	BACE	Neuroscience
	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TP1303	β-Amyloid (1-40) β-Amyloid 1-40
	Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.
TP1099	M-2420 Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
	M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).
T80563	Sabirnetug
	Sabirnetug为人源化IgG2κ型抗体，专一性靶向Amyloid-β A4前体蛋白。
T70366	PF-06663195	Others	Others
	PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).
T25685	Leucyl-phenylalanine amide Leu-phe-NH2	Others	Others
	Leucyl-phenylalanine amide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to produce amyloid β-peptide (Aβ) which is the major causative agent in Alzheime
T10318	Anatabine dicitrate	NF-κB	NF-κB
	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein.
T76087	Biotin-β-Amyloid (17-40)
	Biotin-β-Amyloid (17-40) 是 N 端标记的生物素化的β-Amyloid (17-40) 肽段。该化合物为 Aβ 蛋白中的 24 个氨基酸残基构成的片段，源自于淀粉样前体蛋白(APP)的翻译及加工过程。
T11178	ELN318463 ELN 318463	Others	Others
	ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T37148	TML-6	Others	Others
	TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, and enhancement of the anti-oxidative Nrf2 gene activity. Considering its diverse pharmacological profile, TML-6 holds promise as a valuable research tool for investigating Alzheimer's disease (AD)[1].
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T81299	Remternetug LY3372993
	Remternetug为一种人源化IgG1-kappa型单克隆抗体，针对APP (Aβ42 N3pGlu)的特定焦谷氨酸形式。该抗体能够特异性识别并结合形成淀粉样斑块的Aβ聚集体。
T71855	Z640	Others	Others
	Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from amyloid‑β (Aβ) oligomer‑induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose‑dependent manner and shift amyloid precursor protein processing towards the non‑amyloid pathway
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...
T83123	Amyloid β-Protein (3-42)
	Amyloid β-Protein (3-42) 为Pyr肽前体, 其焦谷氨酸修饰的形式 Aβ (pEAβ) (3-42) 构成阿尔茨海默病淀粉样斑块的关键。pEAβ (3-42) 能促进 Aβ(1-42) 聚集，并且 Aβ(1-42) 显著延缓pEAβ(3-42) 的初级及次级成核过程。
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。
T10453	BACE1-IN-5	Beta Amyloid; BACE	Neuroscience
	BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂，IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ，IC50为 0.82 nM。并且，BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T61206	AChE/BChE/BACE-1-IN-1	Others	Others
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 values of 0.058 μM, 0.082 μM, and 0.115 μM against hAChE, hBChE, and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 exhibits significant binding affinity with PAS-AChE, excellent ability to cross the blood-brain barrier, potential disassembly of amyloid-beta (Aβ) aggregates, and ne...
T62181	BACE-IN-1	Others	Others
	BACE-IN-1 是一种咪唑[1,2-a ]吡啶衍的生物，对 β 位点淀粉样蛋白前体蛋白切割酶 (BACE) 句有抑制作用。BACE-IN-1 具有研究涉及 BACE 疾病（如阿尔茨海默氏病）的潜力。
T83506	[Asn23]-beta-Amyloid (1-42), iowa mutation
	[Asn23]-beta-Amyloid (1-42), iowa mutation 是具有生物活性的肽，与阿尔茨海默病中的一种严重神经病理状况——大脑淀粉样蛋白血管病 (CAA) 密切相关。这种变异是由于在 APP 694 位点发生了错义突变，其中 Asp 23 被 Asn 取代，导致的。该变异形式的β-淀粉样肽倾向于更快聚集，形成具有毒性的原纤维。
T37369	Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) Peptide	Others	Others
	Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). An Aβ (1-40) (Aβ40) A2V peptide increases the production of Aβ and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type Aβ40. Aβ40 and Aβ42 levels are increased in CHO ...
T35608	16F16	Others	Others
	16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ...
T36639	Donecopride (fumarate hydrate)	Others	Others
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value...
T78739	PD07	Others	Others
	PD07是一种口服AChE抑制剂，对hAChE的IC50为0.29 μM。体外实验表明PD07也能抑制ChE、BACE1（IC50：13.42 μM）和Aβ1-42的聚集。作为抗氧化剂，PD07显示出DPPH抑制活性（IC50：26.46 μM），能改善因Scopolamine诱导而失忆的大鼠的记忆和认知功能。该化合物适用于阿尔茨海默病的研究。

化合物

β-Amyloid Protein Precursor 770 (135-155)

Cat.No: TP1655

Synonym: β-Amyloid Protein Precursor 770 135-155

Cat.No: T6483

Synonym: EHT 1864 2HCl

Target: Rho, Ras

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

β-Amyloid precursor protein (96-110), cyclized (human)

Cat.No: T80695

Cat.No: T7490

Target: Beta Amyloid

ELN318463 racemate

Cat.No: T11178L

Synonym: ELN318463 (racemate),ELN 318463 racemate

Target: Gamma-secretase

Cat.No: T14673

Target: Beta Amyloid, Gamma-secretase

Cat.No: T61439

Target: Beta Amyloid, BACE, CDK

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Cat.No: T14338

Synonym: RSC-385896,JNJ-54861911

Target: BACE

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T80622

Synonym: RO-7126209,RG6102

Target: Beta Amyloid

Cat.No: T13253

Synonym: CNP520

Target: BACE

Cat.No: T27944

Synonym: LY 3202626,LY-3202626

Target: Others

β-Secretase inhibitor-STA

Cat.No: T3161

Target: Beta-Secretase

Cat.No: T14525

Synonym: GSI-953

Target: Beta Amyloid

Cat.No: T12429

Target: BACE

β-Amyloid (1-40)

Cat.No: TP1303

Synonym: β-Amyloid 1-40

Cat.No: TP1099

Synonym: Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl

Cat.No: T80563

Cat.No: T70366

Target: Others

Leucyl-phenylalanine amide

Cat.No: T25685

Synonym: Leu-phe-NH2

Target: Others

Anatabine dicitrate

Cat.No: T10318

Target: NF-κB

Biotin-β-Amyloid (17-40)

Cat.No: T76087

Cat.No: T11178

Synonym: ELN 318463

Target: Others

Cat.No: T37148

Target: Others

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T81299

Synonym: LY3372993

Cat.No: T71855

Target: Others

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

Amyloid β-Protein (3-42)

Cat.No: T83123

Amyloid 17-42

Cat.No: T76393

Cat.No: T10453

Target: Beta Amyloid, BACE

AChE/BChE/BACE-1-IN-1

Cat.No: T61206

Target: Others

Cat.No: T62181

Target: Others

[Asn23]-beta-Amyloid (1-42), iowa mutation

Cat.No: T83506

Amyloid-β (1-8, A2V) Peptide

Cat.No: T37369

Synonym: Amyloid-β (1-8, A2V) Peptide

Target: Others

Cat.No: T35608

Target: Others

Donecopride (fumarate hydrate)

Cat.No: T36639

Target: Others

Cat.No: T78739

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。

天然产物

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Pre...	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPY-04693	APLP1 Protein, Mouse, Recombinant (His) amyloid β (A4) precursor-like protein<...	Mouse	HEK293 Cells
	APLP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.4 kDa and the accession number is Q03157.
TMPY-03628	APLP1 Protein, Human, Recombinant (His) amyloid beta (A4) precursor-like prote...	Human	HEK293 Cells
	APLP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.9 kDa and the accession number is P51693-1.
TMPY-02110	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) AD1,ABPP,CTFγ,APPI,ABETA,β-amyloid 40/β-APP40,Aβ,CV...	Human	E. coli
	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 31.8 kDa and the accession number is P05067-1.
TMPY-03885	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) AD1,AAA,ABETA,CVAP,PN-II,CTFgamma,Aβ,APPI,PN2,CTFγ,β-amy...	Human	E. coli
	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.1 kDa and the accession number is P05067-1.
TMPY-02221	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) CVAP,PN2,amyloid β (A4) precursor prot...	Human	E. coli
	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.4 kDa and the accession number is P05067-1.
TMPY-03884	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) CTFgamma,PN-II,AAA,Aβ,PN2,APPI,AD1,amyloid beta (A4...	Human	E. coli
	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.2 kDa and the accession number is P05067-1.
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor prote...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPY-06318	Alpha-Synuclein Protein,Human,Recombinant (H50Q) Human α-Synuclein Protein (H50Q),synuclein, alpha (...	Human	E. coli
	Alpha-Synuclein Protein,Human,Recombinant (H50Q) is expressed in E. coli expression system. The predicted molecular weight is 14.45 kDa and the accession number is P37840-1.
TMPJ-00722	APBA3 Protein, Human, Recombinant (His) Neuronal Munc18-1-Interacting Protein 3,Neuron-Spec...	Human	E. coli
	Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-α and -β which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amylo...
TMPH-00929	APBA2 Protein, Human, Recombinant (His & Myc) Adapter protein X11beta,MINT2,Neuronal Munc18-1-int...	Human	HEK293 Cells
	Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. APBA2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 87.5 kDa and the accession number is Q99767.
TMPH-00928	APBA2 Protein, Human, Recombinant (E. coli, His & Myc) Neuronal Munc18-1-interacting protein 2 (Mint-2),	Human	E. coli
	APBA2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli.
TMPK-00935	APLP2 Protein, Human, Recombinant (His) APPL2,YWK-II,APPH,CDEI box-binding,CDEBP	Human	HEK293 Cells
	Amyloid β precursor-like protein 2 (APLP2) has been determined to serve an important role in the progression of a number of cancer types. APLP2 expression was significantly associated with disease-specific survival (P<0.001). APLP2 may be used to potentially predict patient prognosis, and to guide clinical diagnosis and treatment in CCRCC.
TMPK-01146	LGMN Protein, Human, Recombinant (His) AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324	Human	HEK293 Cells
	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
TMPK-01065	SEZ6 Protein, Mouse, Recombinant (His) BSRP-C,SEZ-6,BSRPC,SEZ6	Mouse	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPK-00996	SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated BSRPC,BSRP-C,SEZ6,SEZ-6	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi...
TMPK-00997	SEZ6 Protein, Human, Recombinant (hFc) SEZ-6,BSRP-C,SEZ6,BSRPC	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is...
TMPK-00998	SEZ6 Protein, Human, Recombinant (His) BSRPC,BSRP-C,SEZ-6,SEZ6	Human	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is...
TMPK-00541	SEZ6 Protein, Cynomolgus, Recombinant (His) SEZ-6,BSRPC,BSRP-C,SEZ6	Cynomolgus	HEK293 Cells
	Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig...
TMPK-00507	TREM2 Protein, Cynomolgus, Recombinant (His) TREM2,Trem2a,PLOSL2,TREM-2,Trem2c,Trem2b	Cynomolgus	HEK293 Cells
	TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta prote...
TMPJ-01008	THOP1 Protein, Human, Recombinant (His) THOP1,MP78,Thimet Oligopeptidase,Endopeptidase 24.15	Human	E. coli
	Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degrada...
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His) kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...	Human	HEK293 Cells
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh...
TMPY-02001	RTN4 Protein, Human, Recombinant (GST) UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X,NSP,UNG1...	Human	E. coli
	Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ...

重组蛋白

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

APLP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04693

Species: Mouse

Expression System: HEK293 Cells

APLP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03628

Species: Human

Expression System: HEK293 Cells

Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02110

Species: Human

Expression System: E. coli

Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)

Cat.No: TMPY-03885

Species: Human

Expression System: E. coli

Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02221

Species: Human

Expression System: E. coli

Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)

Cat.No: TMPY-03884

Species: Human

Expression System: E. coli

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

Alpha-Synuclein Protein,Human,Recombinant (H50Q)

Cat.No: TMPY-06318

Species: Human

Expression System: E. coli

APBA3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00722

Species: Human

Expression System: E. coli

APBA2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00929

Species: Human

Expression System: HEK293 Cells

APBA2 Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-00928

Species: Human

Expression System: E. coli

APLP2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00935

Species: Human

Expression System: HEK293 Cells

LGMN Protein, Human, Recombinant (His)

Cat.No: TMPK-01146

Species: Human

Expression System: HEK293 Cells

SEZ6 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01065

Species: Mouse

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00996

Species: Human

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00997

Species: Human

Expression System: HEK293 Cells

SEZ6 Protein, Human, Recombinant (His)

Cat.No: TMPK-00998

Species: Human

Expression System: HEK293 Cells

SEZ6 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00541

Species: Cynomolgus

Expression System: HEK293 Cells

TREM2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00507

Species: Cynomolgus

Expression System: HEK293 Cells

THOP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01008

Species: Human

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02759

Species: Human

Expression System: HEK293 Cells

RTN4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02001

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...

同位素标记化合物

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼