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Search Results for " aminotransferase "

Targets Recommended: Endogenous Metabolite

34

抑制剂 & 化合物

8

天然产物

13

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T78364	Alanine aminotransferase	Endogenous Metabolite	Metabolism
	Alanine aminotransferase是一种酶，能促进L-丙氨酸与2-氧代谷氨酸之间可逆的转化为丙酮酸和L-谷氨酸。
T76178	Aspartate aminotransferase
	Aspartate aminotransferase (AST) 是一种转氨酶，常用于生化研究。Aspartate aminotransferase 催化天冬氨酸和 α-酮戊二酸转化为草酰乙酸和谷氨酸。Aspartate aminotransferase 可存在于在脑脊液、渗出液和渗出物。
T8648	6-AZATHYMINE	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	6-Azathymine 是胸腺嘧啶的 6-氮类似物，是 D-3-氨基异丁酸酯-丙酮酸氨基转移酶抑制剂，具有抗菌和抗病毒活性，可抑制DNA 的生物合成。
T8765	iGOT1-01	Others	Others
	iGOT1-01 是一种天冬氨酸转氨酶 1 (谷氨酸草酰乙酸转氨酶 1；GOT1) 抑制剂，在 GOT1/GLOX/HRP 测定中IC50为 11.3 μM，在 MDH 偶联 GOT1 酶法测定中IC50为 85 μM。它显示出抗癌活性。
T8766	GOT1 inhibitor-1 GOT1 inhibitor 2c	Others	Others
	GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM)，是一种戊酸衍生物。它可用于以及胰腺导管腺癌 (PDAC) 。
T26399	7-Methyl-6-mercaptopurine 7-Methyl-6-thiopurine,6-Mercapto-7-methylpurine	Others	Others
	7-Methyl-6-mercaptopurine (7-Methyl-6-thiopurine) 是 PRPP 氨基转移酶的抑制剂，抑制 IMP 代谢并阻止嘌呤、DNA 和 RNA 合成。
T7045	Clonidine Nexiclon,Catapres,Kapvay,可乐定	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Clonidine (Kapvay) 是 alpha2 肾上腺素能激动剂。
T67865	BJJF078	Glutaminase	Proteases/Proteasome
	BJJF078 是一种氨基哌啶衍生物，是一种有效的重组人和小鼠谷氨酰胺转氨酶 (TG2) 活性的抑制剂，对人和小鼠谷氨酰胺转氨酶的IC50 值分别为 41 和 54 nM。BJJF078 对 TG1 酶有抑制作用，其IC50 为 0.16 μM。 BJJF078 可用于研究多发性硬化症 (MS) 。
T67842	ERG240 EGR240	Others	Others
	ERG240 是支链氨基酸转氨酶 1 (BCAT1) 抑制剂。ERG240 有潜力用于癌症、类风湿性关节炎和骨病相关研究。
T1356	4-Hydroxy-3-methoxybenzylamine hydrochloride 香兰素胺盐酸盐,N-Vanillylamine hydrochloride	Others	Others
	4-Hydroxy-3-methoxybenzylamine hydrochloride (N-Vanillylamine hydrochloride) 是一种生物碱，是capsaicin 生物合成的中间体。
T2395	Vortioxetine 沃替西汀,Lu AA 21004	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Vortioxetine (Lu AA 21004) 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂，Ki 值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药，用于治疗重度抑郁症。
T35868	BCAT-IN-2	Others	Others
	BCAT-IN-2 是一种具有口服活性和选择性的线粒体支链氨基转移酶（BCATm）抑制剂，抑制 BCATm 和 BCATc，可用于肥胖症和血脂异常。
T0805	Quinapril hydrochloride CI-906,PD-109452-2,盐酸喹那普利,Quinapril HCl	RAAS	Endocrinology/Hormones
	Quinapril hydrochloride (PD-109452-2) 是一种血管紧张素转化酶(ACE) 抑制剂的原药。
T0180	Benazepril hydrochloride 盐酸贝那普利,CGS 14824A HCl,Benazepril HCl,CGS14824A	RAAS	Endocrinology/Hormones
	Benazepril hydrochloride (CGS 14824A HCl) 是一种血管紧张素转化酶（ACE）抑制剂，能够作用于高血压。
T0137	Mirtazapine 米氮平,6-Azamianserin,Org3770	Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mirtazapine (6-Azamianserin) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。它也是一种5-HT2、5-HT3、组胺 H1 受体和 α2-肾上腺素受体拮抗剂，pKi 值分别为 8.05、8.1、9.3 和 6.95。
T1189	Milnacipran hydrochloride 盐酸米那普仑,Milnacipran HCl,Savella,Dalcipran	Serotonin Transporter; Norepinephrine	Neuroscience
	Milnacipran hydrochloride (Savella) 是一种5-羟色胺-去甲肾上腺素重吸收抑制剂（SNRI），可用于纤维肌痛的研究。
T0192	Levetiracetam 左乙拉西坦,UCB L059,SIB-S1	DNA Methyltransferase; Others; Calcium Channel	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others
	Levetiracetam (SIB-S1) 是一种化学增敏剂，增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平，最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药，可结合突触小泡蛋白 SV2A。
T0078L	Lapatinib ditosylate monohydrate Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,二甲苯磺酸拉帕替尼单水合物,Tyverb	EGFR; Ferroptosis; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Lapatinib ditosylate (Lapatinib tosilate) monohydrate 是一种有效的 EGFR 和 ErbB2 抑制剂，对 EGFR 和 ErbB2的 IC50值分别为 10.8 和 9.2 nM。它用于治疗晚期乳腺癌和其他实体瘤。
T4297	Flibanserin BIMT-17BS,氟立班丝氨,Girosa,BIMT-17	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂，Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合，Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药，用于治疗性欲减退症。
T1951	Asenapine Maleate Org 5222 maleate,Org 5222,马来酸阿塞那平,阿塞那平马来酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	Asenapine Maleate (Org 5222 maleate) 是5-HT 和D2的拮抗剂，Ki 值分别为 0.03-4.0 nM, 1.3 nM。它也是抗精神病药物，用于治疗与双相 1 型障碍相关的精神分裂症和躁狂或混合发作。
T0083	Eplerenone Epoxymexrenone,CGP 30083,依普利酮,SC-66110	Glucocorticoid Receptor	Endocrinology/Hormones
	Eplerenone (CGP 30083) 是一种竞争性的、选择性的、具有口服活性的醛固酮 (aldosterone) 拮抗剂，IC50=138 nM。它对孕酮，雄激素，雌激素和糖皮质激素受体的亲和力低，可用于研究高血压和心肌梗死后的心力衰竭。
T25288	DapL-IN-1 DapLIN1,DapL-inhibitor-1,DapL inhibitor 1	Others	Others
	DapL-IN-1 is a L,L-diaminopimelate aminotransferase (DapL) inhibitor.
T26785	BFF122 BFF 122,BF5,BFF-122	Others	Others
	BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II).
T27075	CPP-115	Others	Others
	CPP-115 is a GABA-aminotransferase inhibitor and a high-affinity vigabatrin analogue.
T68451	AG-28262 besylate	Others	Others
	AG-28262 besylate is a VEGFR-2 Inhibitorwhich may affect alanine aminotransferase gene expression and enzymatic activity in the liver.
T19364	Hydroxypyruvic acid lithium hydrate β-Hydroxypyruvic acid lithium hydrate,3-Hydroxypyruvic acid lithium hydrate	Others	Others
	Hydroxypyruvic acid lithium hydrate is an intermediate in the metabolism of serine, glycine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.
T78197	5-Fluoromethylornithine dihydrochloride 5-FMOrn dihydrochloride	Others	Others
	5-Fluoromethylornithine (5-FMOrn) dihydrochloride 是一种特异性且不可逆的 L-Ornithine:2-oxoacid aminotransferase (OAT) 抑制剂，常用于探索回旋状脉络膜视网膜萎缩。
T29033	U-7524 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA	Others	Others
	U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attac
TP1496	p5 Ligand for Dnak and DnaJ
	p5 Ligand for Dnak and DnaJ is a non-apeptide and correspond to the main binding sites of the 23 residues of the mitochondrial aspartate aminotransferase presequence.P5 ligand is a high affinity ligand for Dnak and DnaJ.
T35636	SHS4121705	Others	Others
	SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as effic...
T22509	3-Methyl-GABA	Others	Others
	3-Methyl-GABA 是一种有效的GABA 氨基转移酶激活剂。3-Methyl-GABA 能与 GABAA 受体 (GABAaR) 结合。3-Methyl-GABA 能够激活 L-谷氨酸脱羧酶 (GAD)，表现出抗惊厥作用。
T35800	MD001	Others	Others
	MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It...
T35816	ZLY032	Others	Others
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...
T83735	Pap12-6 TFA
	Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌（MIC50s = 4-8 µM）以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126（MRSA-3126）、B. subtilis和S. epidermidis（MIC50s = 4-8 µM）具有活性，但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6（10 µM）预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮（NO2-）、Tnf-α和Il-6的分泌水平。在体内，Pap12-6（10 mg/kg）可以提高感染E. coli的小鼠的存活率，并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位（CFUs）的数量。Pap12-6（1 mg/kg）在E. co...

化合物

Alanine aminotransferase

Cat.No: T78364

Target: Endogenous Metabolite

Aspartate aminotransferase

Cat.No: T76178

Cat.No: T8648

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis, Antibacterial

Cat.No: T8765

Target: Others

GOT1 inhibitor-1

Cat.No: T8766

Synonym: GOT1 inhibitor 2c

Target: Others

7-Methyl-6-mercaptopurine

Cat.No: T26399

Synonym: 7-Methyl-6-thiopurine,6-Mercapto-7-methylpurine

Target: Others

Cat.No: T7045

Synonym: Nexiclon,Catapres,Kapvay,可乐定

Target: Adrenergic Receptor

Cat.No: T67865

Target: Glutaminase

Cat.No: T67842

Synonym: EGR240

Target: Others

4-Hydroxy-3-methoxybenzylamine hydrochloride

Cat.No: T1356

Synonym: 香兰素胺盐酸盐,N-Vanillylamine hydrochloride

Target: Others

Cat.No: T2395

Synonym: 沃替西汀,Lu AA 21004

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T35868

Target: Others

Quinapril hydrochloride

Cat.No: T0805

Synonym: CI-906,PD-109452-2,盐酸喹那普利,Quinapril HCl

Target: RAAS

Benazepril hydrochloride

Cat.No: T0180

Synonym: 盐酸贝那普利,CGS 14824A HCl,Benazepril HCl,CGS14824A

Target: RAAS

Cat.No: T0137

Synonym: 米氮平,6-Azamianserin,Org3770

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Milnacipran hydrochloride

Cat.No: T1189

Synonym: 盐酸米那普仑,Milnacipran HCl,Savella,Dalcipran

Target: Serotonin Transporter, Norepinephrine

Cat.No: T0192

Synonym: 左乙拉西坦,UCB L059,SIB-S1

Target: DNA Methyltransferase, Others, Calcium Channel

Lapatinib ditosylate monohydrate

Cat.No: T0078L

Synonym: Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,二甲苯磺酸拉帕替尼单水合物,Tyverb

Target: EGFR, Ferroptosis, Autophagy

Cat.No: T4297

Synonym: BIMT-17BS,氟立班丝氨,Girosa,BIMT-17

Target: Dopamine Receptor, 5-HT Receptor

Asenapine Maleate

Cat.No: T1951

Synonym: Org 5222 maleate,Org 5222,马来酸阿塞那平,阿塞那平马来酸盐

Target: 5-HT Receptor

Cat.No: T0083

Synonym: Epoxymexrenone,CGP 30083,依普利酮,SC-66110

Target: Glucocorticoid Receptor

Cat.No: T25288

Synonym: DapLIN1,DapL-inhibitor-1,DapL inhibitor 1

Target: Others

Cat.No: T26785

Synonym: BFF 122,BF5,BFF-122

Target: Others

Cat.No: T27075

Target: Others

AG-28262 besylate

Cat.No: T68451

Target: Others

Hydroxypyruvic acid lithium hydrate

Cat.No: T19364

Synonym: β-Hydroxypyruvic acid lithium hydrate,3-Hydroxypyruvic acid lithium hydrate

Target: Others

5-Fluoromethylornithine dihydrochloride

Cat.No: T78197

Synonym: 5-FMOrn dihydrochloride

Target: Others

Cat.No: T29033

Synonym: 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA

Target: Others

p5 Ligand for Dnak and DnaJ

Cat.No: TP1496

Cat.No: T35636

Target: Others

Cat.No: T22509

Target: Others

Cat.No: T35800

Target: Others

Cat.No: T35816

Target: Others

Cat.No: T83735

Cat. No.	Product Name	Target	Signaling Pathways
T0710	L-Cycloserine Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone	HIV Protease; GABA Receptor	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	L-Cycloserine ((-)-Cycloserine) 不可逆地抑制大肠杆菌以及各种动物大脑中的 GABA 吡哆醛 5'-磷酸依赖性转氨酶，导致体内抑制性神经递质 γ-氨基丁酸水平升高。
T0224	Meropenem 美罗培南,SM 7338	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL，0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T5089	5-Aminovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	5-Aminovaleric acid 被认为是 GABA 的亚甲基同系物，是GABA 的弱激动剂。它是赖氨酸降解产物。它既能够内源性产生，也能够通过赖氨酸的细菌分解代谢产生。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T19365	Hydroxypyruvic acid 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid	Others	Others
	Hydroxypyruvic acid is an intermediate in the metabolism of glycine, serine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.
T83673	4-Hydroxyphenylpropionylglycine Phloretylglycine,4-hydroxy PPG,Phloretic Acid Glycine Conjugate	Others	Others
	4-Hydroxyphenylpropionylglycine是一种由条件必需氨基酸酪氨酸代谢形成的代谢产物。通过芳香族氨基酸转氨酶、酪氨酸转氨酶以及肠道微生物作用后，结合甘氨酸共轭生成。此外，4-Hydroxyphenylpropionylglycine也是酚类化合物phloretin的代谢产物。
T11802	L-Canaline	Others	Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.

天然产物

Cat.No: T0710

Synonym: Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone

Target: HIV Protease, GABA Receptor

Cat.No: T0224

Synonym: 美罗培南,SM 7338

Target: Others, Antibacterial, Antibiotic

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

5-Aminovaleric acid

Cat.No: T5089

Target: Others, Endogenous Metabolite

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Hydroxypyruvic acid

Cat.No: T19365

Synonym: 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid

Target: Others

4-Hydroxyphenylpropionylglycine

Cat.No: T83673

Synonym: Phloretylglycine,4-hydroxy PPG,Phloretic Acid Glycine Conjugate

Target: Others

Cat.No: T11802

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00573	DAPA aminotransferase Protein, E. coli, Recombinant (His & Myc) DAPA AT,bioA,7,8-diaminononanoate synthase,DAPA aminotra...	E. coli	E. coli
	Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Complements a bioU deletion in Synechocystis PCC 6803.
TMPH-00857	ABAT Protein, Human, Recombinant (His & Myc & SUMO) L-AIBAT,GABA aminotransferase,GABA transaminase,GAB...	Human	E. coli
	Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 73.3 kDa and the accession number is P80404.
TMPH-03434	BIO3 Protein, S. cerevisiae, Recombinant (His & Myc) Diaminopelargonic acid synthase,BIO3,7,8-diamino-pelargonic ...	Saccharomyces cerevisiae	E. coli
	Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor. BIO3 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.7 kDa and the accession number is P50277.
TMPH-01596	AADAT Protein, Human, Recombinant (His & SUMO) 2-aminoadipate transaminase,Glycine transaminase AADAT,Alpha...	Human	E. coli
	Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
TMPY-01099	GPT Protein, Rat, Recombinant (His) Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminot...	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc...
TMPY-01100	GPT2 Protein, Rat, Recombinant (His) glutamic pyruvate transaminase (alanine aminotransferase...	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ...
TMPY-03445	Aspartate Aminotransferase Protein, Human, Recombinant (His) ASTQTL1,glutamic-oxaloacetic transaminase 1, soluble,cCAT,cA...	Human	E. coli
	GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme that exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. GOT1 is an important regulator of levels of glut...
TMPH-01597	KYAT1 Protein, Human, Recombinant (His & SUMO) Kynurenine aminotransferase 1,KYAT1,Glutamine--phen...	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl...
TMPH-02554	BCAT2 Protein, Mouse, Recombinant (His & Myc) Bcat2,BCAT(m),Eca40,Branched-chain-amino-acid aminotrans...	Mouse	E. coli
	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. BCAT2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.2 kDa and the accession number is O35855.
TMPH-01598	CCBL2 Protein, Human, Recombinant (His & SUMO) KAT3,Kynurenine--oxoglutarate transaminase 3,CCBL2,Kynurenin...	Human	E. coli
	CCBL2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.4 kDa and the accession number is Q6YP21.
TMPH-00188	BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) Adenosylmethionine-8-amino-7-oxononanoate aminotransfera...	Bacteroides fragilis	E. coli
	Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p...
TMPH-00911	GPT Protein, Human, Recombinant (His) Glutamic--alanine transaminase 1,Glutamate pyruvate transami...	Human	E. coli
	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. GPT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.5 kDa and the accession number is P24298.
TMPY-03754	SCLY Protein, Human, Recombinant (His) selenocysteine lyase,hSCL,SCL	Human	Baculovirus Insect Cells
	SCLY, also known as selenocysteine lyase, belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. It is a novel enzyme that exclusively decomposes L-selenocysteine into L-alanine and H2Se in various mammalian tissues. SCLY contains pyridoxal 5'-phosphate and weighs approximately 85,000. SCLY participates in selenoamino acid metabolism. It employs one cofactor, pyridoxal phosphate. Its maximum reactivity is at about pH 9.0. It was shown that 1 mol of selenocysteine is conver...

重组蛋白

DAPA aminotransferase Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00573

Species: E. coli

Expression System: E. coli

ABAT Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00857

Species: Human

Expression System: E. coli

BIO3 Protein, S. cerevisiae, Recombinant (His & Myc)

Cat.No: TMPH-03434

Species: Saccharomyces cerevisiae

Expression System: E. coli

AADAT Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01596

Species: Human

Expression System: E. coli

GPT Protein, Rat, Recombinant (His)

Cat.No: TMPY-01099

Species: Rat

Expression System: Baculovirus Insect Cells

GPT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01100

Species: Rat

Expression System: Baculovirus Insect Cells

Aspartate Aminotransferase Protein, Human, Recombinant (His)

Cat.No: TMPY-03445

Species: Human

Expression System: E. coli

KYAT1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01597

Species: Human

Expression System: E. coli

BCAT2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02554

Species: Mouse

Expression System: E. coli

CCBL2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01598

Species: Human

Expression System: E. coli

BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc)

Cat.No: TMPH-00188

Species: Bacteroides fragilis

Expression System: E. coli

GPT Protein, Human, Recombinant (His)

Cat.No: TMPH-00911

Species: Human

Expression System: E. coli

SCLY Protein, Human, Recombinant (His)

Cat.No: TMPY-03754

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0130	Vortioxetine-d8
	Vortioxetine-d8 是 Vortioxetine 的氘代化合物。Vortioxetine 的 CAS 号为 508233-74-7。Vortioxetine 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂，Ki值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药，用于治疗重度抑郁症。
TMIJ-0253	Benazepril-d5 HCl
	Benazepril-d5 HCl 是 Benazepril HCl 的氘代化合物。Benazepril HCl 的 CAS 号为 86541-74-4。Benazepril hydrochloride 是一种血管紧张素转化酶（ACE）抑制剂，能够作用于高血压。
TMIH-0605	Vortioxetine-d8 2HBr
	Vortioxetine-d8 2HBr 是 Vortioxetine 2HBr 的氘代化合物。Vortioxetine 2HBr 的 CAS 号为 508233-74-7。Vortioxetine 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和 5-羟色胺转运体抑制剂，Ki值分别为 15、33、3.7、19 和 1.6 nM。它作为抗抑郁药，用于治疗重度抑郁症。
TMID-0126	Clonidine-d4 Hydrochloride
	Clonidine-d4 Hydrochloride 是 Clonidine Hydrochloride 的氘代化合物。Clonidine Hydrochloride 的 CAS 号为 4205-91-8。Clonidine hydrochloride 是一种α2-adrenoceptor激动剂，是一种抗高血压药。
TMID-0190	Milnacipran-d10 Hydrochloride
	Milnacipran-d10 Hydrochloride 是 Milnacipran Hydrochloride 的氘代化合物。Milnacipran Hydrochloride 的 CAS 号为 101152-94-7。Milnacipran hydrochloride 是一种5-羟色胺-去甲肾上腺素重吸收抑制剂（SNRI），可用于纤维肌痛的研究。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
TMIJ-0287	Meropenem-d6-1
	Meropenem-d6-1 是 Meropenem-1 的氘代化合物。Meropenem-1 的 CAS 号为 96036-03-2。Meropenem是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL，0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。
T36055	Nitisinone-13C6 Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F...

同位素标记化合物

Vortioxetine-d8

Cat.No: TMIJ-0130

Benazepril-d5 HCl

Cat.No: TMIJ-0253

Vortioxetine-d8 2HBr

Cat.No: TMIH-0605

Clonidine-d4 Hydrochloride

Cat.No: TMID-0126

Milnacipran-d10 Hydrochloride

Cat.No: TMID-0190

Cat.No: T70990

Cat.No: TMIJ-0287

Nitisinone-13C6

Cat.No: T36055

Synonym: Nitisinone-13C6

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