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Search Results for " adipocyte "

Targets Recommended: Dehydrogenase

17

抑制剂 & 化合物

18

天然产物

20

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2057	BVT 2733	Dehydrogenase	Metabolism
	BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。
T16074	Mifobate SR-202,米福贝特	PPAR	DNA Damage/DNA Repair; Metabolism
	Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。
TP1082L	Neuropeptide AF (human) acetate Neuropeptide AF (93-110), human Acetate,Neuropeptide AF (human) acetate (192387-38-5 Free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Neuropeptide AF (human) acetate (Neuropeptide AF (human) acetate (192387-38-5 Free base)) 属于抗阿片类神经肽，是 Neuropeptide AF (human) 衍生物，可调节脂肪细胞代谢。
T69146	Suksdorfin	PPAR	DNA Damage/DNA Repair; Metabolism
	Suksdorfin 具有降血糖作用，可促进脂肪细胞分化并增强脂联素的产生，可激活过氧化物酶体增殖物激活受体 γ （PPARγ），可促进脂肪细胞对胰岛素依赖性葡萄糖的摄取，可用于肥胖相关研究。
TP1305	LEP(116-130)(mouse)	Others	Others
	LEP(116-130)(mouse) 是合成的瘦素肽片段之一。
T10830	CL 316243	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	CL316243 是一种高效的 β3 肾上腺素受体选择性激动剂，EC50 为 3 nM。它是一种有效的脂肪细胞脂解刺激剂，可增加棕色脂肪组织的产热和代谢率，具有治疗肥胖症、糖尿病和急迫性尿失禁的潜力。
T36720	Deacetylforskolin	Others	Others
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucose transport in rat adipocyte plasma membranes.2Deactylforskolin (30-1,000 μg/kg) reduces blood pressure in spontaneously hypertensive rats.3It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4 1.Gabetta, B., Zini, G., and Danieli, B.Minor...
T40058	IQZ23 IQZ23	Others	Others
	IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.
T68822	Tyrphostin AG17	Others	Others
	Tyrphostin AG17 is a biochemical that promotes adipocyte apoptosis in vivo and is an effective modulator of adipocyte differentiation and WAT hypertrophy in vitro and in vivo. It is thought to possibly be useful as a pharmacological obesity treatment. It is a tyrosine kinase antagonist that has also been found to inhibit tumor cell growth.
T82202	H-Gly-Leu-Phe-OH	Others	Others
	H-Gly-Leu-Phe-OH (GLF)为源于α-乳白蛋白的三肽，具有免疫刺激性，能够抑制抗癌药物依托泊苷所引起的脱发、表皮增厚以及脂肪细胞层的变薄。
T37477	L-858,051 (hydrochloride)	Others	Others
	L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.
T79712	TPH1-IN-1	Others	Others
	TPH1-IN-1（compound 40），一种黄嘌呤衍生物，作为色氨酸羟化酶TPH1的抑制剂，显示出110.1 nM的IC50值。该化合物展现了优异的体外活性以及在肝微粒体中的稳定性，并且能有效抑制T3-L1细胞的脂肪细胞分化。
T37614	LDN-0088050	Others	Others
	LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1] LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1]. [1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biolo...
T76022	Chemerin-9 (149-157) (TFA)
	Chemerin-9 (149-157) TFA 作为趋化因子样受体1 (CMKLR1) 的有效激动剂，展现出抗炎活性，并能促进Akt与ERK磷酸化及活性氧生成，进而改善Aβ1-42诱发的记忆障碍。此外，该化合物还参与调节免疫反应、脂肪细胞分化以及糖代谢。
T63355	BMS-309403 sodium	Others	Others
	BMS-309403 sodium 是一种有效的选择性脂肪细胞脂肪酸结合蛋白aFABP, 也称为FABP4，aP2抑制剂，对 FABP4，FABP3 和 FABP5 的Ki 分别为 <2 nM，250 nM，350 nM。BMS-309403 sodium 与蛋白质内部的脂肪酸结合口袋相互作用，竞争性地抑制内源性脂肪酸的结合。BMS-309403 sodium 可改善载脂蛋白E 缺乏症小鼠和培养的人内皮细胞的内皮功能。
T37787	10-Nitrolinoleic acid	Others	Others
	10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxisome proliferator-activated receptor γ (PPARγ; Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake. Nitrolinoleates can also be metabolized by smooth muscle cells to produce nitrite derivatives which in turn form NO, leading to incr...
T14383	AZD8329	Dehydrogenase	Metabolism
	AZD8329 是一种可选择且高效的人重组11β-HSD1 和离体人脂肪细胞11ß-HSD1 的抑制剂，是大鼠11β-HSD1 (IC50 - 89nM)和狗重组11β-HSD1的抑制剂。AZD8329在体外实验中对11β-HSD1的亲和力高于人重组11β-HSD2和17β- hsd1和17β-HSD3酶。AZD8329具有降低脂肪组织和肝脏样品中11β-HSD1的活性。

化合物

Cat.No: T2057

Target: Dehydrogenase

Cat.No: T16074

Synonym: SR-202,米福贝特

Target: PPAR

Neuropeptide AF (human) acetate

Cat.No: TP1082L

Synonym: Neuropeptide AF (93-110), human Acetate,Neuropeptide AF (human) acetate (192387-38-5 Free base)

Target: Opioid Receptor

Cat.No: T69146

Target: PPAR

LEP(116-130)(mouse)

Cat.No: TP1305

Target: Others

Cat.No: T10830

Target: Adrenergic Receptor

Deacetylforskolin

Cat.No: T36720

Target: Others

Cat.No: T40058

Synonym: IQZ23

Target: Others

Tyrphostin AG17

Cat.No: T68822

Target: Others

H-Gly-Leu-Phe-OH

Cat.No: T82202

Target: Others

L-858,051 (hydrochloride)

Cat.No: T37477

Target: Others

Cat.No: T79712

Target: Others

Cat.No: T37614

Target: Others

Chemerin-9 (149-157) (TFA)

Cat.No: T76022

BMS-309403 sodium

Cat.No: T63355

Target: Others

10-Nitrolinoleic acid

Cat.No: T37787

Target: Others

Cat.No: T14383

Target: Dehydrogenase

Cat. No.	Product Name	Target	Signaling Pathways
T2S0712	Sinigrin 黑芥子苷,Allylglucosinolate,2-Propenylglucosinolate	Others; Antioxidant	Others; oxidation-reduction
	Sinigrin 是十字花科植物中主要的硫代葡萄糖苷，具有抗脂肪生成作用。它在芥子油苷的分离和鉴定程序中用作参考材料。Sinigrin 具有有效的抗氧化、抗肿瘤和抗炎作用。
T8015	4-METHOXYCHALCONE 2-(4-Methoxybenzal)Acetophenone,4-甲氧基查耳酮	Others	Others
	4-METHOXYCHALCONE (2-(4-Methoxybenzal)Acetophenone) 是一种增强脂肪细胞分化的天然化合物。
T5690	7,4'-Di-O-methylapigenin 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE	Amylase	Metabolism
	7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) 可能具有抗真菌c.zeyheri 的作用，是一种潜在的抗真菌药物。它还能抑制药物流出泵(IC50 = 51.64μg /毫升)。
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
TN1206	2,4,6-Trihydroxybenzaldehyde	Others	Others
	2,4,6-Trihydroxybenzaldehyde 是一种天然产物。 2,4,6-三羟基苯甲醛是一种潜在的抗肥胖治疗药物，可抑制 C57BL/6 小鼠的 3T3-L1 细胞中的脂肪细胞分化和高脂饮食诱导的脂肪积累。它也是一种有效的抗糖尿病药物。 2,4,6-三羟基苯甲醛具有潜在的抗癌活性。
T13803	N-Oleoyl glycine	Cannabinoid Receptor; Akt; Endogenous Metabolite; PPAR	Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	N-Oleoyl glycine 是一种脂氨酸。在 3T3-L1 脂肪细胞中，N-Oleoyl glycine 通过激活CB1受体和Akt 信号通路来刺激脂肪形成。
TN3885	Dodoviscin J	transporter	Metabolism
	Dodoviscin J can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
TN3884	Dodoviscin I	transporter	Metabolism
	Dodoviscin I can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
T39098	Pulsatilloside C	Others	Others
	Pulsatilloside C, an isolated compound from Pulsatilla koreana, exhibits notable inhibition of adipocyte differentiation.
TN3883	Dodoviscin H	transporter	Metabolism
	Dodoviscin H can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
TN2535	1-Hydroxy-2-oxopomolic acid	transporter; PPAR; Fatty Acid Synthase	DNA Damage/DNA Repair; Metabolism
	1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
TN3882	Dodoviscin A	cAMP; Tyrosinase; transporter	GPCR/G Protein; Metabolism; Proteases/Proteasome
	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact
TN2228	Soyasaponin Aa 大豆皂苷 AA,大豆皂苷Aa	PPAR	DNA Damage/DNA Repair; Metabolism
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat
TN2641	15-Methoxypinusolidic acid	ERK; IL Receptor; p38 MAPK; Calcium Channel; NOS; NF-κB; COX; JNK; NMDAR; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dep
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.B
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c

天然产物

Cat.No: T2S0712

Synonym: 黑芥子苷,Allylglucosinolate,2-Propenylglucosinolate

Target: Others, Antioxidant

4-METHOXYCHALCONE

Cat.No: T8015

Synonym: 2-(4-Methoxybenzal)Acetophenone,4-甲氧基查耳酮

Target: Others

7,4'-Di-O-methylapigenin

Cat.No: T5690

Synonym: 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE

Target: Amylase

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

2,4,6-Trihydroxybenzaldehyde

Cat.No: TN1206

Target: Others

N-Oleoyl glycine

Cat.No: T13803

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Cat.No: TN3885

Target: transporter

Cat.No: TN3884

Target: transporter

Pulsatilloside C

Cat.No: T39098

Target: Others

Cat.No: TN3883

Target: transporter

1-Hydroxy-2-oxopomolic acid

Cat.No: TN2535

Target: transporter, PPAR, Fatty Acid Synthase

Cat.No: TN3882

Target: cAMP, Tyrosinase, transporter

Cat.No: TN2228

Synonym: 大豆皂苷 AA,大豆皂苷Aa

Target: PPAR

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

15-Methoxypinusolidic acid

Cat.No: TN2641

Target: ERK, IL Receptor, p38 MAPK, Calcium Channel, NOS, NF-κB, COX, JNK, NMDAR, PPAR

Cat.No: TN5655

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01151	MXRA8 Protein, Human, Recombinant (His) Asp3,Limitrin,Adipocyte-specific 3,DICAM,Adipoc...	Human	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.70 kDa and the accession number is Q9BRK3-1.
TMPK-01166	MXRA8 Protein, Mouse, Recombinant (His) Asp3,DICAM,Adipocyte-specific protein 3,Adipocy...	Mouse	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.11 kDa and the accession number is Q9DBV4.
TMPH-00350	Adiponectin Protein, Feline, Recombinant apM-1,30 kDa adipocyte complement-related protein,A...	Feline	E. coli
	Adiponectin Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24.9 kDa and the accession number is A4PB30.
TMPH-00219	Adiponectin Protein, Bovine, Recombinant (His) ACRP30,Adipocyte complement-related 30 kDa protein,...	Bovine	P. pastoris (Yeast)
	Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is Q3Y5Z3.
TMPH-02495	APMAP Protein, Mouse, Recombinant (His & Myc) Adipocyte plasma membrane-associated protein,Protei...	Mouse	E. coli
	Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. APMAP Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.3 kDa and the accession number is Q9D7N9.
TMPY-01482	FABP4 Protein, Mouse, Recombinant (His) ALBP/Ap2,Lbpl,422/aP2,Ap2,fatty acid binding protein 4, ...	Mouse	HEK293 Cells
	FABP4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P04117.
TMPY-02103	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) HEL-S-104,fatty acid binding protein 4, adipocyte,A...	Human	E. coli
	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090.
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His) C3 convertase activator,28 kDa adipocyte protein,Cf...	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the...
TMPH-02494	AEBP1 Protein, Mouse, Recombinant (His & SUMO) Adipocyte enhancer-binding protein 1,Aortic carboxy...	Mouse	E. coli
	AEBP1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.8 kDa and the accession number is Q640N1.
TMPJ-00908	LMW-PTP Protein, Human, Recombinant (His) Low Molecular Weight Cytosolic Acid Phosphatase,Adipocyt...	Human	E. coli
	Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphatase (PTPase) by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. LMW-PTP can be detected in all human tissues, including adipocytes. LMW-PTP is a cytosolic enzyme that regulate cell proliferation and growth of leiomyomas during dephosphorylation of t...
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr...	Human	Baculovirus Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli...
TMPH-01563	IAPP Protein, Human, Recombinant (His) IAPP,Diabetes-associated peptide,Insulinoma amyloid peptide,...	Human	P. pastoris (Yeast)
	Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
TMPH-01562	IAPP Protein, Human, Recombinant (GST) Insulinoma amyloid peptide,IAPP,Islet amyloid polypeptide,Am...	Human	E. coli
	Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.4 kDa and the accession number is P10997.
TMPH-03711	PPAR gamma Protein, Xenopus laevis, Recombinant (His) Nuclear receptor subfamily 1 group C member 3,Peroxisome pro...	Xenopus laevis	E. coli
	Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
TMPY-03227	CISD1 Protein, Human, Recombinant (His) ZCD1,CDGSH iron sulfur domain 1,C10orf70,mitoNEET,MDS029	Human	E. coli
	Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death. At the ce...
TMPY-00992	ERAP2 Protein, Human, Recombinant (His) L-RAP,endoplasmic reticulum aminopeptidase 2,FLJ23633,LRAP.E...	Human	HEK293 Cells
	Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 96-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyz...
TMPJ-01010	PLA2G16 Protein, Human, Recombinant (His) Renal Carcinoma Antigen NY-REN-65,HRAS-Like Suppressor 1,HRS...	Human	E. coli
	Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models.
TMPY-06815	SYAP1 Protein, Human, Recombinant (His) PRO3113,synapse associated protein 1	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the C-terminus. Expressed near neuronal Golgi and synaptic regions of cerebellar Purkinje cells, SYAP1 has been linked to intact sensorimotor control and general vesicular trafficking in neurons. SYAP1-deficient mice display impaired locomotor activity. In cultured adipocytes, SYAP1 ...
TMPY-01427	AACS Protein, Human, Recombinant (His) SUR-5,acetoacetyl-CoA synthetase,ACSF1	Human	Baculovirus Insect Cells
	Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter ...
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc) Transcription factor ATFx,Transcription factor-like protein ...	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip...

重组蛋白

MXRA8 Protein, Human, Recombinant (His)

Cat.No: TMPK-01151

Species: Human

Expression System: HEK293 Cells

MXRA8 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01166

Species: Mouse

Expression System: HEK293 Cells

Adiponectin Protein, Feline, Recombinant

Cat.No: TMPH-00350

Species: Feline

Expression System: E. coli

Adiponectin Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00219

Species: Bovine

Expression System: P. pastoris (Yeast)

APMAP Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02495

Species: Mouse

Expression System: E. coli

FABP4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01482

Species: Mouse

Expression System: HEK293 Cells

FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)

Cat.No: TMPY-02103

Species: Human

Expression System: E. coli

Complement Factor D/CFD Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00149

Species: Mouse

Expression System: HEK293 Cells

AEBP1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02494

Species: Mouse

Expression System: E. coli

LMW-PTP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00908

Species: Human

Expression System: E. coli

PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02575

Species: Human

Expression System: Baculovirus Insect Cells

IAPP Protein, Human, Recombinant (His)

Cat.No: TMPH-01563

Species: Human

Expression System: P. pastoris (Yeast)

IAPP Protein, Human, Recombinant (GST)

Cat.No: TMPH-01562

Species: Human

Expression System: E. coli

PPAR gamma Protein, Xenopus laevis, Recombinant (His)

Cat.No: TMPH-03711

Species: Xenopus laevis

Expression System: E. coli

CISD1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03227

Species: Human

Expression System: E. coli

ERAP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00992

Species: Human

Expression System: HEK293 Cells

PLA2G16 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01010

Species: Human

Expression System: E. coli

SYAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06815

Species: Human

Expression System: Baculovirus Insect Cells

AACS Protein, Human, Recombinant (His)

Cat.No: TMPY-01427

Species: Human

Expression System: Baculovirus Insect Cells

ATF-5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02613

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...

同位素标记化合物

Cat.No: T71328

Cat.No: T71981

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