a-2-binding peptide

A2-Binding peptide has involved in the assembly of MHC Class I molecules.

PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate)(171436-38-7 free base) 是 Protease-Activated Receptor-2 (PAR-2) 的激动剂。

Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集，还抑制血小板与玻连蛋白的粘附

Autocamtide-2-related inhibitory peptide, myristoylated acetate 是CaM 激酶II 抑制剂;是 Autocamtide-2相关抑制肽的增强细胞渗透性衍生物。

OVA G4 peptide acetate(148274-82-2 free base) (SIIGFEKL acetate) 是激动剂卵清蛋白 (OVA) 肽 (257-264) SIINFEKL 的变体。 OVA 肽是卵清蛋白的 I 类 (Kb) 限制性肽表位，由 I 类 MHC（主要组织相容性复合物）分子 H-2Kb（小鼠 MHC I 类基因）呈递。

Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base) 来自大黄蜂 Vespa orientalis 的肥大细胞脱粒肽，其生物学效应类似于来自蜂毒的肥大细胞脱粒肽。

Autocamtide-2-related inhibitory peptide 是一种高度特异性和有效的 CaMKII 抑制剂，IC50 为 40 nM。

ErbB-2-binding peptide (HER2-binding peptide)为具结合肿瘤功能的肽类，其在癌症研究中显示出应用潜力。

Casein Kinase2 Substrate Peptide 是一种常见的 CK2底物肽。Casein Kinase2 Substrate Peptide 的 C 端与 5-[(2-氨基乙基)氨基]萘-1-磺酸 (EDANS) 结合。Casein Kinase2 Substrate Peptide 可用于蛋白激酶 CK2活性的测定。

Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.

Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂，其IC50值为 40 nM。

Autocamtide-2-related inhibitory peptide, myristoylated TFA 是 Autocamtide-2-related inhibitory peptide 烷基化修饰后的形式。 Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂，其 IC50值为 40 nM。

This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat.

Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom.

Hyaluronan-binding peptide, biotin labeled 是通过 C 端 GGGSK 残基生物素化的透明质酸结合肽，能够干预 HA 与 CD44 受体的作用，并阻碍 T 细胞增殖。 HA 在细胞外基质和细胞表面广泛表达，参与多种生物过程，包括受精、胚胎发育、伤口修复、血管新生、炎症反应和肿瘤转移。

C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.

Phospho-Glycogen Synthase Peptide-2, a substrate for glycogen synthase kinase-3 (GSK-3), serves as a peptide substrate effective in the affinity purification of protein-serine kinases.

C-Peptide 2, rat acetate 是一种可抑制葡萄糖诱导的胰岛素分泌胰岛素原组分，由31个氨基酸残基构成的多肽和醋酸盐组成。

Xenopsin-Related Peptide 2 (XP-2)，作为Xenopsin在鸟类中的对应物，具有诱导分离大鼠肥大细胞释放组胺的能力，其效力与合成Bradykinin相媲美。

Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM.

Bombinin-like peptide 2, 源自亚洲蟾蜍Bombina orientalis的皮肤分泌物，为一种具有抗菌功能的肽。

Phospho-Glycogen Synthase Peptide-2 (底物)为糖原合酶激酶-3 (GSK-3) 的特异性肽底物，适用于蛋白丝氨酸激酶的亲和纯化。

Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.

Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411).

Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, serves as a cofactor in platelet activation and is converted.

OVA G4 peptide TFA is an TFA salt form of OVA G4 peptide. G4 peptide (SIIGFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).

Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1].

WRW4 TFA (878557-55-2 free base) 是一种特异性的甲酰肽受体样 1 (FPRL1) 拮抗剂，抑制 WKYMVm 与 FPRL1 的结合，IC50 为 0.23 μM。 WRW4 通过 FPRL1 激动剂 MMK-1、淀粉样蛋白 beta42 (Abeta42) 肽和 F 肽特异性抑制细胞内钙的增加。

Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段，可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点（Lys16-Leu17 键）。它还包含负责与小胶质细胞结合的 HHQK 结构域（残基 13-16）。

PKA inhibitor fragment (6-22) amide Acetate 是一种通过结合底物位点选择性抑制PKA 活性的合成肽(IC50 < 2 nM)。

TfR-T12 TFA为能穿透血脑屏障的转铁蛋白受体(TfR)结合肽，展现出纳摩尔级的结合活性。

Hepatitis B Virus Receptor Binding Fragment（hepatitis B peptide 4980）为一合成肽类似物，特异性结合Hep G2细胞。基于病毒中和粘附阻断理念，此Fragment可望激发保护性抗体生成，展现作为免疫原的巨大潜力。

BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1 PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 with dissociation constants (Kd) of 19 nM and 19.88 nM in MicroScale Thermophoresis (MST) and Surface Plasmon Resonance (SPR) assays, respectively. This compound enhances T cell functionality by promoting Interleukin-2 (IL-2) production within Peripheral Blood Mononuclear Cells (PBMCs).

mSIRK (G-Protein βγ Binding Peptide) 是一种细胞渗透性 ERK1 和 ERK2 双重激活剂，是一种由15个氨基酸组成的多肽，可促进α亚基解离。

TAT-CIRP为小肽，指Tat融合的冷诱导RNA结合蛋白。作为骨髓分化蛋白2（MD2）的抑制剂，该化合物对小鼠缺血性及出血性中风显示出显著的神经保护效果。

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions[1][2]. TLQP-21 TFA is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of the corresponding contraction promoted by acetylcholine[1][2]. [1]. Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130. [2]. Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753.

Phytochelatin 2, a short plant peptide, serves as an essential metal-binding compound. Phytochelatins are a diverse group of plant compounds that play a crucial role in chelating metals, safeguarding against metal toxicity, and maintaining metal homeostasis.

Cyclotraxin B TFA 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。

Bivalirudin TFA 是20个氨基多肽，可逆地抑制凝血酶。

Bad BH3 (mouse) 是源自 Bad 蛋白的 BH3 结构域（亦称死亡结构域）的氨基酸残基 140 至 165 的一种生物活性肽，它是 bcl-2 结合肽。

Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)（c(GRGDSP)）为RGD 抑制肽。该化合物作为合成的α5β1整联蛋白配体，能够竞争性阻断 invasin（Inv）与Caco-2细胞表面α5β1整联蛋白的相互结合。

PNC-28为源自p53蛋白mdm-2结合结构域（残基17-26）的p53肽，含有使其能穿透细胞膜的膜交叉穿透蛋白序列。该化合物可应用于胰腺癌研究领域。

IKKγ NBD 抑制肽 TFA 是一种高度特异性的NF-κB 抑制剂。IKKγ NBD 抑制肽 TFA 通过阻断 IKKγ NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用，而阻断 TNF-α 诱导的NF-κB 激活。IKKγ NBD 抑制肽 TFA 可显著降低炎症、改善脑缺血所致的神经功能缺损。

bFGF (119-126) 为具备生物活性的肽段，对应人类、牛(119-126)、小鼠、大鼠(118-125)以及肝素结合生长因子2(118-125)的相应残基。该肽能够抑制bFGF受体的二聚化及其激活作用。

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4 1.Bohm, S.K., Kong, W., Bromme, D., et al.Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2Biochem. J.314(Pt 3)1009-1016(1996) 2.Kanke, T., Ishiwata, H., Kabeya, M., et al.Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2Br. J. Pharmacol.145(2)255-263(2005) 3.Miike, S., McWilliam, A.S., and Kita, H.Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2J. Immunol.167(11)6615-6622(2001) 4.Nishikawa, H., Kawai, K., Tanaka, M., et al.Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: Involvement of PAR-2 and non-PAR-2 mechanismsJ. Pharmacol. Exp. Ther.312(2)324-331(2005)

GRGDSPK TFA (EMD 56574 TFA) 是一种含有精氨酸-甘氨酸-天冬氨酸 (RGD) 序列的多肽。作为竞争性且可逆的抑制剂，它能够抑制整联蛋白与纤连蛋白的结合，用于探究整联蛋白在骨形成及吸收过程中的功能。

Methionylserine (H-MET-SER-OH) 是一种含有蛋氨酸和丝氨酸的二肽。Methionylserine 可与肠道二/三肽转运蛋白 1 (hPEPT1) 结合并易位，Km 值为 0.2 mM。Methionylserine 抑制ACE 酶的活性。Methionylserine 可用于高血压的研究。

Protein Kinase C (19-35) Peptide 是PKC 假底物抑制剂 区域。Protein Kinase C (19-35) Peptide 阻断PKC 激酶结构域的底物结合位点，使PKC 的细胞质形式失活。