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Search Results for " vasculature "

Targets Recommended: Calcium Channel Autophagy

12

抑制剂 & 化合物

4

天然产物

1

化合物库

19

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；

化合物库

血管生成库

Cat.No: L4800

Compounds: 1353

Cat. No.	Product Name	Target	Signaling Pathways
T0119	Nitrendipine BAY-E-5009,Bayotensin,尼群地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Nitrendipine (BAY-E-5009) 是 Nifedipine 的类似物，是一种钙通道阻滞剂，具有显着的血管扩张作用。它是一种有效的抗高血压药且不会降低肾小球滤过率，并且具有轻微的利钠作用。
T3216	Selexipag NS-304,ACT-293987,赛乐西帕,Uptravi	Others; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Others
	Selexipag (ACT-293987) 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。
T16859	SBI-425	Others	Others
	SBI-425 是一种有效且具有口服生物利用度的 TNAP 抑制剂。 SBI-425 有效抑制脉管系统中的 TNAP，改善心血管参数和存活率，而骨骼没有检测到变化。
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T2090	Lexibulin CYT-997	Apoptosis; Reactive Oxygen Species; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂，可诱导细胞凋亡，并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M，在体内外具有高细胞毒性和血管增生阻断作用。
T1577	Midodrine hydrochloride Pro-Amatine,盐酸米多君	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差，因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式，是一种直接作用的前药和拟交感神经药，具有抗低血压特性。
T26905	BRL 55834 BRL55834,BRL-55834	Others	Others
	BRL 55834, a potassium channel activator, has shown to relax airways and vasculature in vivo.
T71032	Melafolone	Others	Others
	Melafolone is a natural dual inhibitor of cox-2 and egfr, improving program death 1 (pd-1) checkpoint blockade therapy through normalizing tumor vasculature and pd-l1 downregulation
T77031	Ifabotuzumab
	Ifabotuzumab (KB004) 是靶向 EphA3的 IgG1κ 抗体 (KD=610 pM)。Ifabotuzumab 能够导致肿瘤细胞凋亡，并激活抗体依赖性细胞介导的细胞毒作用 (ADCC)，破坏肿瘤脉管系统。Ifabotuzumab 能够减少人特发性肺纤维化 (IPF) CCR10+细胞，改善肺纤维化。
T68317	VJ115	Others	Others
	VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy...
T61604	PKC-IN-4	Others	Others
	PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α. Moreover, this compound effectively impedes the permeability of the retinal vasculature, induced by both VEGF and TNFα. [1]
T68273	BNC105P	Others	Others
	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi...

化合物

Cat.No: T0119

Synonym: BAY-E-5009,Bayotensin,尼群地平

Target: Calcium Channel, Autophagy

Cat.No: T3216

Synonym: NS-304,ACT-293987,赛乐西帕,Uptravi

Target: Others, Prostaglandin Receptor

Cat.No: T16859

Target: Others

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Midodrine hydrochloride

Cat.No: T1577

Synonym: Pro-Amatine,盐酸米多君

Target: Adrenergic Receptor

Cat.No: T26905

Synonym: BRL55834,BRL-55834

Target: Others

Cat.No: T71032

Target: Others

Cat.No: T77031

Cat.No: T68317

Target: Others

Cat.No: T61604

Target: Others

Cat.No: T68273

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6272	Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂，是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。
T2803	Monocrotaline 野百合碱,Crotaline	TGF-beta/Smad	Stem Cells
	Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。

天然产物

Fosbretabulin Disodium

Cat.No: T6272

Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Target: Apoptosis, Microtubule Associated

Cat.No: T2803

Synonym: 野百合碱,Crotaline

Target: TGF-beta/Smad

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04644	PDGFB Protein, Human, Recombinant (His) platelet-derived growth factor beta polypeptide,SSV,c-sis,SI...	Human	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPJ-00603	TL1A/TNFSF15 Protein, Mouse, Recombinant TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V...	Mouse	E. coli
	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ...
TMPJ-01011	FGF-9 Protein, Mouse, Recombinant (His) heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...	Mouse	E. coli
	Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His) FXA,FX,coagulation factor X,coagulation factor 10	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema...
TMPH-01025	CALCA Protein, Human, Recombinant (GST) Calcitonin gene-related peptide 1,CGRP-I,CALCA,CALC1,Alpha-t...	Human	E. coli
	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CALCA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.6 kDa and the accession number is P06881.
TMPH-00949	APOLD1 Protein, Human, Recombinant (His) Vascular early response gene protein,APOLD1,VERGE,Apolipopro...	Human	E. coli
	May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9.
TMPY-05076	PDGFB Protein, Canine, Recombinant (His) platelet-derived growth factor beta polypeptide,platelet-der...	Canine	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Canine, Recombinant (His) is expressed in yeast with His tag. The predicte...
TMPH-01341	FILIP1L Protein, Human, Recombinant (His) FILIP1L,Protein down-regulated in ovarian cancer 1,130 kDa G...	Human	E. coli
	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. FILIP1L Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.6 kDa and the accession number is Q4L180.
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...
TMPY-04877	PDGFB Protein, Mouse, Recombinant (His) platelet-derived growth factor β polypeptide,血小板源生长因子,Sis,pl...	Mouse	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted...
TMPK-00645	VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) KRD1,VEGFR2,FLK1,CD309,Ly73,VEGFR,VEGFR-21,KDR	Rhesus	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with ...
TMPY-02395	PDGFB Protein, Cynomolgus, Recombinant (mFc) 血小板源生长因子,platelet-derived growth factor beta polypeptide,pla...	Cynomolgus	HEK293 Cells
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with ...
TMPY-05077	PDGFB Protein, Rhesus, Recombinant (His) platelet-derived growth factor β polypeptide,platelet-derive...	Rhesus	P. pastoris (Yeast)
	Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Rhesus, Recombinant (His) is expressed in yeast with His tag. The predicte...
TMPK-00359	Endoglin/CD105 Protein, Human, Recombinant (His & Avi) CD105,ORW,ORW1,ENG,END,Endoglin,HHT1	Human	HEK293 Cells
	Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response...
TMPK-00454	VEGFR2/KDR Protein, Human, Recombinant (His & Avi) VEGFR-21,Ly73,KRD1,VEGFR2,CD309,FLK1,VEGFR,KDR	Human	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-H...
TMPY-03963	CALCB Protein, Human, Recombinant (mFc) CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...	Human	HEK293 Cells
	CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ...
TMPJ-00362	MMP-2 Protein, Human, Recombinant (His) 72 kDa Gelatinase,TBE-1,Gelatinase A,Matrix Metalloproteinas...	Human	HEK293 Cells
	72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathologic...
TMPY-00090	SPARCL1 Protein, Mouse, Recombinant (His) Sc1,SPARC like 1,mast9,hevin,Ecm2	Mouse	HEK293 Cells
	SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasc...
TMPY-01996	SorCS1 Protein, Human, Recombinant (His) hSorCS,RP11-446H13.1,sortilin-related VPS10 domain containin...	Human	HEK293 Cells
	VPS1 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein that belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps1p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps1p domain, which either represents the only module of the luminal/extracellular moiety or is combined...

重组蛋白

PDGFB Protein, Human, Recombinant (His)

Cat.No: TMPY-04644

Species: Human

Expression System: P. pastoris (Yeast)

TL1A/TNFSF15 Protein, Mouse, Recombinant

Cat.No: TMPJ-00603

Species: Mouse

Expression System: E. coli

FGF-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01011

Species: Mouse

Expression System: E. coli

Coagulation factor X/F10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01101

Species: Human

Expression System: Baculovirus Insect Cells

CALCA Protein, Human, Recombinant (GST)

Cat.No: TMPH-01025

Species: Human

Expression System: E. coli

APOLD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00949

Species: Human

Expression System: E. coli

PDGFB Protein, Canine, Recombinant (His)

Cat.No: TMPY-05076

Species: Canine

Expression System: P. pastoris (Yeast)

FILIP1L Protein, Human, Recombinant (His)

Cat.No: TMPH-01341

Species: Human

Expression System: E. coli

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

PDGFB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04877

Species: Mouse

Expression System: P. pastoris (Yeast)

VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00645

Species: Rhesus

Expression System: HEK293 Cells

PDGFB Protein, Cynomolgus, Recombinant (mFc)

Cat.No: TMPY-02395

Species: Cynomolgus

Expression System: HEK293 Cells

PDGFB Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-05077

Species: Rhesus

Expression System: P. pastoris (Yeast)

Endoglin/CD105 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00359

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00454

Species: Human

Expression System: HEK293 Cells

CALCB Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03963

Species: Human

Expression System: HEK293 Cells

MMP-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00362

Species: Human

Expression System: HEK293 Cells

SPARCL1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00090

Species: Mouse

Expression System: HEK293 Cells

SorCS1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01996

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0520	Selexipag-d7
	Selexipag-d7 是 Selexipag 的氘代化合物。Selexipag 的 CAS 号为 475086-01-2。Selexipag 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。

同位素标记化合物

Cat.No: TMIH-0520

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