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Search Results for " urticaria "

Targets Recommended: Others Antibacterial

27

抑制剂 & 化合物

2

天然产物

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1532	Pidotimod	Others; Antibacterial	Microbiology/Virology; Others
	Pidotimod 是一种具有免疫调节特性的合成二肽。它增加巨噬细胞活性和体液免疫功能。它可研究慢性支气管炎、慢性阻塞性肺疾病、支气管扩张、慢性特发性荨麻疹等。
T7893	Bepotastine Bepotastine free base,贝托斯汀	Others; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others
	Bepotastine (Bepotastine free base) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T6242	Rupatadine Fumarate 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber	PAFR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
T6405	Bepotastine Besilate Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T2335	Ebastine Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ebastine (Kestine) 是一种可口服的组胺 H1 受体拮抗剂，用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。
T1553	Chlorpheniramine maleate 马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Chlorpheniramine maleate (NCI-C55265) 是一种组胺 H1 拮抗剂，IC50为12 nM，用于过敏反应、花粉热、鼻炎、荨麻疹和哮喘。
T20444	Hexyl nicotinate AI3 15769,AI3-15769,烟酸己酯,AI315769	Others	Others
	Hexyl nicotinate (AI3 15769) 是一种皮肤血管扩张剂，可用于研究头皮、面部和背部的非免疫性接触性荨麻疹。
T1470	Fexofenadine hydrochloride Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,盐酸非索非那定,Telfast,Fexofenadine HCl,Allegra,MDL 16455A	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) 是一种抗组胺药，用于治疗过敏性鼻炎、血管性水肿和慢性荨麻疹。
T0785	Dexchlorpheniramine Maleate S-(+)-Chlorpheniramine maleate salt,右泛醇,马来酸右氯苯那敏	Dopamine Receptor; 5-HT Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) 是一种具有抗胆碱能特性的抗组胺药，用于治疗花粉热或荨麻疹等过敏性疾病。
T22354	Levocetirizine Dihydrochloride Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
T1097	Loratadine 氯雷他定,SCH 29851,Loratidine	Influenza Virus; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Loratadine (SCH 29851) 是一种组胺 H1受体反向激动剂，IC50>32 μM。它抑制炎症介质的免疫释放，具有抗登革热病毒的活性。
T16730	Remibrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM)，在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。
T21390	Fexofenadine Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine (Carboxyterfenadine) 是一种抗组胺药物，用于治疗过敏症状，如鼻塞、花粉热和荨麻疹。与第一代抗组胺药相比，它通过血脑屏障并引起镇静的能力较差。
T0053	Hydroxyzine Pamoate Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine Pamoate (Bobsule) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。
T2200	Hydroxyzine dihydrochloride Hydroxyzine 2HCl,盐酸羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) 是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T0089	Cetirizine dihydrochloride 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物，是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化，可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。
T1278	Astemizole Laridal,Histaminos,Paralergin,阿司咪唑	Potassium Channel; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Astemizole (Laridal) 是一种长效、非镇静抗组胺药，用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂，IC50值为 4 nM，还阻断 hERG K+通道，IC50值为 0.9 nM，具有抗胆碱能和止痒作用。
T21112	Triprolidine hydrochloride 295 C 51,Pro-Entra,Entra,盐酸曲普利啶,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil	Others	Others
	Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria.
T0785L	Dexchlorpheniramine free base Polaramine,Dexchlorpheniramine Maleate,Mylaramine	Others	Others
	Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.
T21247	Carbinoxamine Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine	Others	Others
	Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an H1-antagonist.
T31396	Dexbrompheniramine maleate D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral	Others	Others
	Dexbrompheniramine is an antihistamine with anticholinergic properties. It is used to treat allergic diseases such as hay fever or urticaria. It can compete with histamine for H1 receptor sites on effector cells of the gastrointestinal tract, blood vessel
T78289	Ligelizumab QGE 031,Anti-IGHE Recombinant Antibody
	Ligelizumab (QGE 031)为一种针对慢性自发性荨麻疹研究的人源化高亲和性抗IgE单克隆抗体。
T76919	Barzolvolimab
	Barzolvolimab (CDX 0159)为人源化抗KIT IgG1单克隆抗体。其特异性地抑制KIT激活，有效降低慢性诱导性荨麻疹中皮肤肥大细胞数量及疾病活动程度。
T75276	Dexbrompheniramine	Others	Others
	Dexbrompheniramine为口服活性H1受体拮抗剂(H1 receptor)，具有抗组胺药属性，能够减轻天然化学组胺的作用。该化合物适用于花粉热与荨麻疹的研究。
T63965	Bepotastine tosylate	Others	Others
	Bepotastine tosylate 是一种选择性、口服具有活力的第二代组胺 H1 受体 (histamine H1 receptor) 拮抗剂，对组胺介导的神经生长因子 (NGF) 表达上调表现出抑制作用。Bepotastine tosylate 能够用于研究过敏性鼻炎，过敏性结膜炎和荨麻疹/瘙痒症。
T73972	Fexofenadine Impurity F	Others	Others
	Fexofenadine Impurity F 是 Fexofenadine 的杂质。 Fexofenadine 是一种H1R 拮抗剂，可用于研究季节性过敏性鼻炎和慢性特发性荨麻疹。
T60521	Doxepin	Others	Others
	作为三环类抗抑郁药，Doxepin 抑制血清素和去甲肾上腺素的再摄取。Doxepin 具有抗炎作用，可减少抗氧化应激。Doxepin 显示出对特应性皮炎和慢性荨麻疹的治疗效果，并且能改善认知过程和保护中枢神经系统。

化合物

Cat.No: T1532

Target: Others, Antibacterial

Cat.No: T7893

Synonym: Bepotastine free base,贝托斯汀

Target: Others, Histamine Receptor

Rupatadine Fumarate

Cat.No: T6242

Synonym: 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber

Target: PAFR, Autophagy, Histamine Receptor

Bepotastine Besilate

Cat.No: T6405

Synonym: Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate

Target: Histamine Receptor

Cat.No: T2335

Synonym: Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305

Target: Histamine Receptor

Chlorpheniramine maleate

Cat.No: T1553

Synonym: 马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate

Target: Histamine Receptor

Hexyl nicotinate

Cat.No: T20444

Synonym: AI3 15769,AI3-15769,烟酸己酯,AI315769

Target: Others

Fexofenadine hydrochloride

Cat.No: T1470

Synonym: Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,盐酸非索非那定,Telfast,Fexofenadine HCl,Allegra,MDL 16455A

Target: Histamine Receptor

Dexchlorpheniramine Maleate

Cat.No: T0785

Synonym: S-(+)-Chlorpheniramine maleate salt,右泛醇,马来酸右氯苯那敏

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine, Histamine Receptor

Levocetirizine Dihydrochloride

Cat.No: T22354

Synonym: Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride

Target: Histamine Receptor

Cat.No: T1097

Synonym: 氯雷他定,SCH 29851,Loratidine

Target: Influenza Virus, Histamine Receptor

Cat.No: T16730

Target: BTK

Cat.No: T21390

Synonym: Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra

Target: Histamine Receptor

Hydroxyzine Pamoate

Cat.No: T0053

Synonym: Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose

Target: Histamine Receptor

Hydroxyzine dihydrochloride

Cat.No: T2200

Synonym: Hydroxyzine 2HCl,盐酸羟嗪

Target: Histamine Receptor

Cetirizine dihydrochloride

Cat.No: T0089

Synonym: 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl

Target: Histamine Receptor

Cat.No: T1278

Synonym: Laridal,Histaminos,Paralergin,阿司咪唑

Target: Potassium Channel, Histamine Receptor

Triprolidine hydrochloride

Cat.No: T21112

Synonym: 295 C 51,Pro-Entra,Entra,盐酸曲普利啶,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil

Target: Others

Dexchlorpheniramine free base

Cat.No: T0785L

Synonym: Polaramine,Dexchlorpheniramine Maleate,Mylaramine

Target: Others

Cat.No: T21247

Synonym: Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine

Target: Others

Dexbrompheniramine maleate

Cat.No: T31396

Synonym: D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral

Target: Others

Cat.No: T78289

Synonym: QGE 031,Anti-IGHE Recombinant Antibody

Cat.No: T76919

Dexbrompheniramine

Cat.No: T75276

Target: Others

Bepotastine tosylate

Cat.No: T63965

Target: Others

Fexofenadine Impurity F

Cat.No: T73972

Target: Others

Cat.No: T60521

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T40712	Diethyl fumarate	Others	Others
	Diethyl fumarate 是农药马拉硫磷的分解产物。 Diethyl fumarate 会在皮肤上引起非免疫性接触性荨麻疹。
T25687	Leukotriene C4 LTC4,Leukotriene C	Endogenous Metabolite	Metabolism
	Leukotriene C4 (LTC4) 是一种类花生酸脂质介质，可调节炎症部位白细胞的募集和功能。Leukotriene C4 是支气管收缩、粘液分泌过多和嗜酸性粒细胞增多的介质，在荨麻疹中具有介导作用。

天然产物

Diethyl fumarate

Cat.No: T40712

Target: Others

Cat.No: T25687

Synonym: LTC4,Leukotriene C

Target: Endogenous Metabolite

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0200	Loratadine-d5
	Loratadine-d5 是 Loratadine 的氘代化合物。Loratadine 的 CAS 号为 79794-75-5。Loratadine是一种组胺 H1受体反向激动剂，IC50>32 μM。它抑制炎症介质的免疫释放，具有抗登革热病毒的活性。
TMIH-0271	Hydroxyzine dihydrochloride-d4 (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride
	Hydroxyzine dihydrochloride-d4 是 Hydroxyzine dihydrochloride 的氘代化合物。Hydroxyzine dihydrochloride 的 CAS 号为 2192-20-3。Hydroxyzine dihydrochloride是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。

同位素标记化合物

Cat.No: TMIJ-0200

Hydroxyzine dihydrochloride-d4

Cat.No: TMIH-0271

Synonym: (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy-1,1,2,2-d4)ethan-1-ol dihydrochloride

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