tricyclic antidepressant

Fezolamine 是一种新型可口服的非三环类化合物，具有抗抑郁活性。它在体外阻断[3H]去甲肾上腺素的突触体摄取方面的选择性是摄取[4H]3-羟色胺或[3H]多巴胺的3至2倍。在使用单胺耗尽动物的经典行为测试中，它阻止了利血平和四苯的抑制作用。

Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。

Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。

Amoxapine (CL-67772) 是一种dibenzoxazepine 家族的四环抗抑郁药，常被归类为仲胺三环类抗抑郁药。

Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。

Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。

Melitracen hydrochloride (Thymeol hydrochloride) 是一种可口服的双相抗抑郁药和抗焦虑药。它可以通过突触前膜抑制去甲肾上腺素和5-羟色胺(5-HT)的吸收，从而诱导突触空间中单胺递质的增加。

Maprotiline hydrochloride (Psymion) 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。

Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白，IC50=32 nM。它可阻止胰酶的易位，阻碍 MV 和外泌体的分泌。

Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。

Nitroxazepine (CIBA 2330Go) 是三环抗抑郁化合物，是一种 5-羟色胺去甲肾上腺素再摄取抑制剂，可用于抗抑郁的研究。

Quinupramine (LM 208) 是一种可口服的典型三环类抗抑郁化合物，对毒蕈碱和5-HT受体有的很强的亲和力。Quinupramine 可透过中枢神经系统，可用于研究神经系统疾病。

Mesoridazine Besylate (Serentil) 是一种哌啶类精神安定药，属于称为吩噻嗪类的药物，用于治疗精神分裂症。它是硫利达嗪的代谢物。

Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals.

Iprindole，一种三环吲哚类抗抑郁化合物，是去甲肾上腺素和5-羟色胺摄取的双重弱抑制剂[1]。

Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。

Desipramine 是一种具有抗抑郁活性的三环类化合物。Desipramine 可抑制中枢神经系统的去甲肾上腺素再摄取受体，减少睡眠相关的腮舌肌活性丧失，可用于改善咽塌陷的研究。

Lofepramine (Leo 640) 是一种有效的三环抗抑郁药，广泛地代谢为 Desipramine。它能够抑制摄取促进去甲肾上腺素能神经传递，以及抑制神经元摄取 5-羟色胺和色氨酸吡咯酶，增强 5-羟色胺能神经传递，进而发挥其抗抑郁作用。它还具有显著的抗焦虑效果。

Butriptyline (Butriptylene)，三环抗抑郁剂，具有口服生物活性。

(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.

Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.

Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.

Trimipramine N-oxide 为三环抗抑郁药trimipramine的活性代谢物，其对人去甲肾上腺素单胺转运体(hNAT)、血清素(hSERT)、多巴胺(hDAT)以及人体有机阳离子转运蛋白(hOCT1与hOCT2)的IC50值分别为11.7、3.59、9.4、9.35及27.4 nM。因此，Trimipramine N-oxide在忧郁和焦虑研究中有应用价值。

Amitriptyline-d6 Hydrochloride 是 Amitriptyline Hydrochloride 的氘代化合物。Amitriptyline Hydrochloride 的 CAS 号为 549-18-8。Amitriptyline hydrochloride 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA和TrkA受体的激动剂，具有强神经营养活性和有抗抑郁作用。

Protriptyline hydrochloride (Protriptyline HCl) 是一种含有一个仲胺的三环结构抗抑郁试剂，可以用于抑郁和 ADHD 的相关研究。它使动物精力充沛起激励作用，并且有时用于嗜睡症的相关研究。

Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.

(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

Desipramine-d3 HCl 是 Desipramine HCl 的氘代化合物。Desipramine HCl 的 CAS 号为 58-28-6。Desipramine hydrochloride 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。 它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。

Melitracen is a tricyclic antidepressant.

Depramine (GP 31406) 是三环抗抑郁剂，具药理活性。该化合物可抑制乙酰胆碱酯酶、Mg2+-ATPase 与 Na+ K+ ATPase 活性。

(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms.

Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is used to relieve depressive symptoms.

Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, significantly inhibiting CYP450 2C19 and

Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

作为三环类抗抑郁药，Doxepin 抑制血清素和去甲肾上腺素的再摄取。Doxepin 具有抗炎作用，可减少抗氧化应激。Doxepin 显示出对特应性皮炎和慢性荨麻疹的治疗效果，并且能改善认知过程和保护中枢神经系统。

Imipramine N-oxide 是 Imipramine 的代谢物。Imipramine 是一种叔胺三环类抗抑郁药。

Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.

Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.

Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.

Amitriptyline 是一种具有镇痛特性的三环类抗抑郁药 (TCA)。它广泛用于治疗抑郁症和神经性疼痛。

Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].

Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.

Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.

Maprotiline-d5 Hydrochloride 是 Maprotiline Hydrochloride 的氘代化合物。Maprotiline Hydrochloride 的 CAS 号为 10347-81-6。Maprotiline hydrochloride 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。