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Search Results for " thymine "

Targets Recommended: Apoptosis

26

抑制剂 & 化合物

8

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TNU0352	1-beta-D-Arabinofuranosylthymine Thymine 1-β-D-arabinofuranoside,Spongothymidine	Apoptosis	Apoptosis
	1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.
T19086	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine	Others	Others
	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
TNU1548	(R)-DMT-glycidol-thymine	Others	Others
	(R)-DMT-glycidol-thymine is a Nucleoside Derivative - Acyclic nucleoside.
TNU1336	1-(alpha-L-Threofuranosyl)thymine	Others	Others
	1-(alpha-L-Threofuranosyl)thymine is a Nucleoside Derivative - L-nucleoside.
TNU0641	7’-OH-N-trityl morpholino thymine	Others	Others
	Morpholino nucleoside
TNU1447	7'-O-DMT-morpholino thymine	Others	Others
	7'-O-DMT-morpholino thymine is a Nucleoside Derivative - Morpholino nucleoside.
T8648	6-AZATHYMINE	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	6-Azathymine 是胸腺嘧啶的 6-氮类似物，是 D-3-氨基异丁酸酯-丙酮酸氨基转移酶抑制剂，具有抗菌和抗病毒活性，可抑制DNA 的生物合成。
TNU1337	1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine	Others	Others
	Nucleoside Derivatives - L-Nucleosides; Protected nucleosides w/NH2/OH open
TNU0790	1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine	Others	Others
	3’-N-modified nucleoside
TNU0788	1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine	Others	Others
	Azido-nucleoside; 3’-N-modified nucleoside
TNU1420	1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite	Others	Others
	1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a Nucleoside Phosphoramidite.
TNU0789	3-epi-Azido-3-deoxythymidine	Others	Others
	3’-N-modified nucleoside; Azido-nucleoside
TNU1607	DMTr-TNA-5MeU-amidite	Others	Others
	DMTr-TNA-5MeU-amidite is a Nucleoside Phosphoramidite.
T29896	alpha-Glutamylthymine	Others	Others
	alpha-Glutamylthymine is a hypermodified base for DNA.
T38813	6-Azathymine acid	Others	Others
	6-Azathymine acid is a metabolite derived from Pymetrozine, a potent insecticide known for its effectiveness against plant-sucking insects, specifically aphids and whiteflies. Pymetrozine's neuroactivity disrupts the feeding behavior of these pests, making it a valuable tool in protecting various crops, including vegetables, cotton, field crops, and fruits.
TNU0159	FMAU 2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine	Apoptosis	Apoptosis
	FMAU (2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine) is a thymine nucleoside analog with insertional activity on replicating DNA.FMAU can be used to label cells and track DNA synthesis.
T2627	Nolatrexed dihydrochloride 盐酸诺拉曲塞,Thymitaq,AG 337	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂，能够在癌细胞 S 期诱导细胞周期停滞，具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用，对人胸苷酸合酶的Ki 值为 11 nM。
T19151	5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU	Others	Others
	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) 是胸腺嘧啶的类似物，可用于次氯酸对 DNA 和 DNA 前体的破坏作用的研究。
T19827	DAPI Dihydrochloride FxCycle Violet,4',6-二脒基-2-苯基吲哚二盐酸盐,4',6-diamidino-2-phenylindole	Others	Others
	DAPI Dihydrochloride (FxCycle Violet) 是一种可渗透细胞的荧光探针，通过结合在富含 A-T 的 DNA 序列的小树林中，用于染色 DNA 和染色体，优先选择富含腺嘌呤和胸腺嘧啶的 DNA。
T1349	5-Fluorouridine	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	5-Fluorouridine 是一种 5-fluorouracil 的代谢物，具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用，其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。
T25286	DANP	Others	Others
	DANP is a bulge base recognition probe. It is a potent and specific ligand of the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.
T70462	Pibrozelesin	Others	Others
	Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
T40345	AV-153	Others	Others
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
T37031	Quinacrine mustard hydrochloride Quinacrine mustard HCl	Autophagy	Autophagy
	Quinacrine mustard hydrochloride 是一种荧光染料,也是一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard hydrochloride 能选择性地与腺嘌呤-胸腺嘧啶（AT）碱基对结合，而不是与鸟嘌呤-胞嘧啶（GC）碱基对结合，诱导细胞周期停滞在 G2/M 期。Quinacrine mustard (hydrochloride) 已被用于标记移相染色体，以通过自动放射摄影技术进行核型分析。
T85123	3-Aminoisobutyric Acid sodium BAIBA,β-Aminoisobutyric Acid	Others	Others
	3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its ad...
T60649	AV-153 free base	Others	Others
	AV-153 free base 是一种 1,4-二氢吡啶(1,4-DHP) 衍生物。AV-153 free base 是一种抗诱变剂，具有抗癌活性。AV-153 free base 可以与胞嘧啶和胸腺嘧啶相互作用，并影响聚 (ADP) 核糖基化。在体外实验中，AV-153 free base 在 DNA 的单链断裂处插入到 DNA 并减少 DNA 损伤，刺激 DNA 修复。

化合物

1-beta-D-Arabinofuranosylthymine

Cat.No: TNU0352

Synonym: Thymine 1-β-D-arabinofuranoside,Spongothymidine

Target: Apoptosis

1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine

Cat.No: T19086

Target: Others

(R)-DMT-glycidol-thymine

Cat.No: TNU1548

Target: Others

1-(alpha-L-Threofuranosyl)thymine

Cat.No: TNU1336

Target: Others

7’-OH-N-trityl morpholino thymine

Cat.No: TNU0641

Target: Others

7'-O-DMT-morpholino thymine

Cat.No: TNU1447

Target: Others

Cat.No: T8648

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis, Antibacterial

1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine

Cat.No: TNU1337

Target: Others

1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine

Cat.No: TNU0790

Target: Others

1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine

Cat.No: TNU0788

Target: Others

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite

Cat.No: TNU1420

Target: Others

3-epi-Azido-3-deoxythymidine

Cat.No: TNU0789

Target: Others

DMTr-TNA-5MeU-amidite

Cat.No: TNU1607

Target: Others

alpha-Glutamylthymine

Cat.No: T29896

Target: Others

6-Azathymine acid

Cat.No: T38813

Target: Others

Cat.No: TNU0159

Synonym: 2'-Deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine

Target: Apoptosis

Nolatrexed dihydrochloride

Cat.No: T2627

Synonym: 盐酸诺拉曲塞,Thymitaq,AG 337

Target: DNA/RNA Synthesis

5-Chloro-2'-deoxyuridine

Cat.No: T19151

Synonym: 5-Chlorodeoxyuridine,5-氯-2-脱氧尿嘧啶核苷,CldU

Target: Others

DAPI Dihydrochloride

Cat.No: T19827

Synonym: FxCycle Violet,4',6-二脒基-2-苯基吲哚二盐酸盐,4',6-diamidino-2-phenylindole

Target: Others

5-Fluorouridine

Cat.No: T1349

Target: Others, DNA/RNA Synthesis

Cat.No: T25286

Target: Others

Cat.No: T70462

Target: Others

Cat.No: T40345

Target: Others

Quinacrine mustard hydrochloride

Cat.No: T37031

Synonym: Quinacrine mustard HCl

Target: Autophagy

3-Aminoisobutyric Acid sodium

Cat.No: T85123

Synonym: BAIBA,β-Aminoisobutyric Acid

Target: Others

AV-153 free base

Cat.No: T60649

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TWO2759	Thymine 胸腺嘧啶,5-methyluracil	Others; Endogenous Metabolite	Metabolism; Others
	Thymine 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。
TN7153	1-(2-hydroxyethyl)thymine 1-(hydroxyethyl)thymine,2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-	Others	Others
	1-(2-hydroxyethyl)thymine (2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-) 是一种海洋来源的天然产物，存在于Zoanthus sp。
T5282	5-Methyluridine Ribothymidine,5-甲基尿甙,Thymine riboside	Others; Endogenous Metabolite	Metabolism; Others
	5-Methyluridine (Thymine riboside) 是发现于人体液中的内源性甲基化核苷。
T0069	Uracil	Others; Endogenous Metabolite	Metabolism; Others
	Uracil 是普遍存在的天然嘧啶衍生物，是 RNA 核酸中的四个碱基之一。
T0532	5,6-Dihydro-5-methyluracil 5, 6-Dihydrothymine,二氢朐腺嘧啶,Dihydrothymine	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Dihydrothymine 是胸腺嘧啶的中间代谢产物之一，来源于动植物，浓度过高时会产生毒性。
T7357	(S)-b-aminoisobutyric acid	Endogenous Metabolite	Metabolism
	(S)-b-aminoisobutyric acid 是由胸腺嘧啶和缬氨酸分解代谢得到的非蛋白质氨基酸。
T4711	2,4-Dihydroxypyrimidine-5-carboxylic acid 脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) 是内源性代谢产物的一种。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。

天然产物

Cat.No: TWO2759

Synonym: 胸腺嘧啶,5-methyluracil

Target: Others, Endogenous Metabolite

1-(2-hydroxyethyl)thymine

Cat.No: TN7153

Synonym: 1-(hydroxyethyl)thymine,2,4(1H,3H)-Pyrimidinedione, 1-(2-hydroxyethyl)-5-methyl-

Target: Others

5-Methyluridine

Cat.No: T5282

Synonym: Ribothymidine,5-甲基尿甙,Thymine riboside

Target: Others, Endogenous Metabolite

Cat.No: T0069

Target: Others, Endogenous Metabolite

5,6-Dihydro-5-methyluracil

Cat.No: T0532

Synonym: 5, 6-Dihydrothymine,二氢朐腺嘧啶,Dihydrothymine

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

(S)-b-aminoisobutyric acid

Cat.No: T7357

Target: Endogenous Metabolite

2,4-Dihydroxypyrimidine-5-carboxylic acid

Cat.No: T4711

Synonym: 脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid

Target: Others, Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02403	JBP1 Protein, Leishmania infantum, Recombinant (His & V5) J-binding protein 1,Thymine dioxygenase JBP1,Thymid...	Leishmania infantum	E. coli
	JBP1 Protein, Leishmania infantum, Recombinant (His & V5) is expressed in E. coli expression system with N-10xHis-V5 tag. The predicted molecular weight is 53.4 kDa and the accession number is A4HU70.
TMPJ-01374	UPB1 Protein, Human, Recombinant (His) β-Ureidopropionase,Beta-Alanine Synthase,β-Alanine Synthase,...	Human	E. coli
	β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidi...
TMPY-02798	NEIL1 Protein, Human, Recombinant (His) NEI1,nei endonuclease VIII-like 1 (E. coli),FPG1,hFPG1	Human	E. coli
	NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r...

重组蛋白

JBP1 Protein, Leishmania infantum, Recombinant (His & V5)

Cat.No: TMPH-02403

Species: Leishmania infantum

Expression System: E. coli

UPB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01374

Species: Human

Expression System: E. coli

NEIL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02798

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0166	Thymine-d4
	Thymine-d4 是 Thymine 的氘代化合物。Thymine 的 CAS 号为 65-71-4。Thymine 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。

同位素标记化合物

Cat.No: TMID-0166

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