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Search Results for " ribonucleotide reductase "

Targets Recommended: Apoptosis Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy

21

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0297	Clofarabine Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Clofarabine (Clofarex) 是一种核糖核苷酸还原酶抑制剂，IC50值为65 nM。它是核苷类似物，可用于癌症研究。
T14864	Caracemide NSC-253272,卡醋胺	Others; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Caracemide (NSC-253272) 抑制大肠杆菌的核糖核苷酸还原酶。 Caracemide 可用于抗癌研究。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。
T0353	Osalmid Oxaphenamide,4'-Hydroxysalicylanilide,羟苯水杨胺,柳胺酚	HBV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Osalmid (Oxaphenamide) 是一种利胆药物，通过靶向核糖核苷酸还原酶小亚基 M2 来抑制核糖核苷酸还原酶的活性，IC50值为8.23 μM。
T1982	3-AP NSC663249,Triapine,PAN-811,OCX191	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	3-AP (Triapine) 是一种新型的核糖核苷酸还原酶 M2 亚基抑制剂，也是一种放射致敏剂。
T8800	NSAH 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂，无细胞 IC50 为 32 μM，基于细胞的 IC50 约为 250 nM。
T31163	Cytidine 5'-diphosphate disodium CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt	Others	Others
	Cytidine 5'-diphosphate disodium (CDP sodium salt) 产生 CTP 以支持 DNA 和 RNA 生物合成和核糖核苷酸还原酶以产生 dCMP。
T7525	Didox 3,4-二羟基苯甲羟肟酸,NSC-324360	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Didox (NSC-324360) 是一种合成的核糖核苷酸还原酶抑制剂，可降低患有痴呆症的 HIV 患者大脑中氧化损伤标志物的水平。
T6501	Fludarabine Phosphate NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶，从而中断 DNA 合成并抑制肿瘤细胞生长。
T68230	Amidox	Others	Others
	Amidox is a ribonucleotide reductase inhibitor.
T29197	YZ51	Others	Others
	YZ51, a novel potent inhibitor of ribonucleotide reductase (RR), inhibits hepatitis B virus replication by targeting ribonucleotide reductase M2 protein.
T10068	2'-Azido-2'-deoxyuridine N3dUrd	Others	Others
	2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity.
T40862	Fludarabine triphosphate 三磷酸氟达拉滨,F-ara-ATP	Others	Others
	Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate , inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
TNU0133	3’-Azido-3’-deoxycytidine	Others	Others
	Nucleoside Derivatives –Azido-nucleosides, 3’-Modified nucleosides; Drugs and Inhibitors; Ribonucleotide reductase inhibitor
TNU0230	2’-Azido-2’-deoxycytidine	Others	Others
	Nucleoside Derivatives - Azido-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; antiviral agent, DNA synthesis inhibitor; Ribonucleotide reductase inhibitor
T78814	COH1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH1为核糖核苷酸还原酶(RR)抑制剂，主要应用于癌症、线粒体疾病和神经退行性疾病的研究领域。
T76515	Herpes virus inhibitor 1
	Herpes virus inhibitor 1 是一种抑制疱疹病毒的化合物，能破坏疱疹病毒的核糖核苷酸还原酶四级结构，从而抑制病毒复制。
T76517	Herpes virus inhibitor 2
	Herpes virus inhibitor 2 为一种疱疹病毒抑制剂，专门破坏疱疹病毒的核糖核苷酸还原酶四级结构，从而抑制病毒复制。
T15378	Gemcitabine elaidate Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。
T74088	Fludarabine triphosphate trisodium	Others	Others
	Fludarabine triphosphate (F-ara-ATP) trisodium 是Fludarabine 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA 引发酶 (DNA primase) 抑制剂，其IC50为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA 聚合酶，导致细胞凋亡 (apoptosis)。
T60401	Tezacitabine	Others	Others
	Tezacitabine 是一种抑制细胞生长和细胞毒性的抗代谢物。 Tezacitabine 是一种核苷类似物，具有双重作用机制。 Tezacitabine 不可逆地抑制核糖核苷酸还原酶，并可在复制或修复过程中掺入 DNA，导致 DNA 链终止。 Tezacitabine 在细胞周期的 G1 期和 S 期阻断肿瘤细胞并诱导凋亡细胞死亡。 Tezacitabine 具有治疗白血病和实体瘤的潜力[1][2]。

化合物

Cat.No: T0297

Synonym: Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Cat.No: T14864

Synonym: NSC-253272,卡醋胺

Target: Others, DNA/RNA Synthesis, Antibacterial

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat.No: T0353

Synonym: Oxaphenamide,4'-Hydroxysalicylanilide,羟苯水杨胺,柳胺酚

Target: HBV, DNA/RNA Synthesis

Cat.No: T1982

Synonym: NSC663249,Triapine,PAN-811,OCX191

Target: DNA/RNA Synthesis

Cat.No: T8800

Synonym: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Target: DNA/RNA Synthesis

Cytidine 5'-diphosphate disodium

Cat.No: T31163

Synonym: CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt

Target: Others

Cat.No: T7525

Synonym: 3,4-二羟基苯甲羟肟酸,NSC-324360

Target: DNA/RNA Synthesis

Fludarabine Phosphate

Cat.No: T6501

Synonym: NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T68230

Target: Others

Cat.No: T29197

Target: Others

2'-Azido-2'-deoxyuridine

Cat.No: T10068

Synonym: N3dUrd

Target: Others

Fludarabine triphosphate

Cat.No: T40862

Synonym: 三磷酸氟达拉滨,F-ara-ATP

Target: Others

3’-Azido-3’-deoxycytidine

Cat.No: TNU0133

Target: Others

2’-Azido-2’-deoxycytidine

Cat.No: TNU0230

Target: Others

Cat.No: T78814

Target: DNA/RNA Synthesis

Herpes virus inhibitor 1

Cat.No: T76515

Herpes virus inhibitor 2

Cat.No: T76517

Gemcitabine elaidate

Cat.No: T15378

Synonym: Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy

Fludarabine triphosphate trisodium

Cat.No: T74088

Target: Others

Cat.No: T60401

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00937	RRM2 Protein, Human, Recombinant (His) RRM2,RR2,Ribonucleotide Reductase Small Su...	Human	HEK293 Cells
	Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) belongs to the ribonucleoside diphosphate reductase small chain family. The reductase of RRM2 catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. RRM2 supplies the precursors essential for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Phosphorylation on Ser-20 relieves the in...
TMPY-02527	p53R2 Protein, Human, Recombinant (His) P53R2,MTDPS8A,MTDPS8B,ribonucleotide reductase<...	Human	E. coli
	Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phospho...
TMPY-03287	RRM1 Protein, Human, Recombinant (His & GST) ribonucleotide reductase M1,R1,RR1,RIR1	Human	Baculovirus Insect Cells
	RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocort...
TMPY-03605	Glutaredoxin 1/GRX1 Protein, Human, Recombinant (His) GLRX,GRX,GRX1,glutaredoxin	Human	E. coli
	Glutaredoxin-1, also known as GRX1 and GLRX, belongs to theglutaredoxin family. Glutaredoxinsare smallredoxenzymes that useglutathioneas a cofactor. Glutaredoxins are oxidized by substrates, and reduced non-enzymatically by glutathione. Glutaredoxin-1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Glutaredoxin-1 exists in either a reduced or an oxidized form. Glutaredoxins function as electron carriers ...
TMPY-02084	Thioredoxin 2/TRX2 Protein, Human, Recombinant (His) MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX,thioredoxin 2	Human	E. coli
	Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ...

重组蛋白

RRM2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00937

Species: Human

Expression System: HEK293 Cells

p53R2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02527

Species: Human

Expression System: E. coli

RRM1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03287

Species: Human

Expression System: Baculovirus Insect Cells

Glutaredoxin 1/GRX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03605

Species: Human

Expression System: E. coli

Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02084

Species: Human

Expression System: E. coli

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