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Search Results for " renal cell carcinoma "

Targets Recommended: Topoisomerase

17

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T26046	Razoxane	Topoisomerase	DNA Damage/DNA Repair
	Razoxane 是拓扑异构酶 II 的有效抑制剂，具有抗血管生成的作用，在肾细胞癌中具有研究价值。
T6683	STF-62247 STF 62247	Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	STF-62247 是一种自噬诱导剂，在 RCC4 和 RCC4/VHL 细胞中的IC50分别为 0.625 μM 和 16 μM。它对 VHL 缺陷型肾细胞癌有选择性的细胞毒性。
T2456	Tivozanib 替沃扎尼,AV-951,KRN951	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂，它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T16777	ROC-325	Apoptosis; Autophagy	Apoptosis; Autophagy
	ROC-325 是一种有效的口服活性自噬抑制剂，具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。
T24818	Sparfosic Acid NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131	Apoptosis	Apoptosis
	Sparfosic Acid (Acide sparfosique) 是一种天门冬氨酸氨甲酰转移酶抑制剂，具有抗肿瘤活性，可用于研究晚期肾细胞癌。
T77810	XPW1	CDK	Cell Cycle/Checkpoint
	XPW1 是一种新的强效和选择性 CDK9 抑制剂，具有抗肿瘤活性，转录抑制ccRCC细胞中的DNA修复程序。XPW1 可用于研究透明细胞肾细胞癌。
T16679	Belzutifan PT2977,MK-6482	HIF	Angiogenesis; Chromatin/Epigenetic
	Belzutifan (MK-6482) 是具有口服活性的 HIF-2α选择性抑制剂，IC50为 9 nM。Belzutifan 具有提高的效力和改善的药代动力学特征。Belzutifan (MK-6482) 可以抑制透明细胞肾细胞癌。
T1916	Apitolisib RG 7422,GNE 390,GDC-0980	Apoptosis; PI3K; mTOR	Apoptosis; PI3K/Akt/mTOR signaling
	Apitolisib (RG 7422) 是一种口服有效的 PI3K 和 mTOR(TORC1/2) 激酶抑制剂，抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ的活性，IC50值为 5 nM/27 nM/7 nM/14 nM，抑制 mTOR，Ki 为 17 nM。它用于乳腺癌、前列腺癌、肾细胞癌和子宫内膜癌等实体癌的试验研究。
T76828	Sonepcizumab LT 1009	LPL Receptor	GPCR/G Protein
	Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性，可用于研究转移性肾细胞癌 (mRCC) ，可预防青光眼滤过手术后的眼部瘢痕形成。
T28408	Phosphostim Sodium IPH1101,Phosphostim,IPH 1101,IPH-1101	Others	Others
	Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection.
T31058	CP-461 free base CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461	Others	Others
	CP-461 (OSI-461) is a pde2a / 5A inhibitor, which may be used in the treatment of renal cell carcinoma, prostate cancer, and Crohn's disease.
T74597	Zifcasiran	Others	Others
	Zifcasiran为缺氧诱导因子(HIF)合成抑制剂，显示抗肿瘤活性，适用于晚期肾细胞癌研究。
T61442	HIF-1/2α-IN-1	Others	Others
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)	Others	Others
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T81704	Naptumomab
	Naptumomab是一种针对肿瘤细胞的超级抗原(TTS)融合蛋白。它能激活免疫系统，使之识别并消灭肿瘤细胞。该化合物主要应用于肾细胞癌等难治性实体肿瘤的研究领域。
T76803	Elsilimomab
	Elsilimomab (B-E8) 是一种抗白介素-6 (IL-6) 的 IgG1单克隆抗体，其 KD 为 22 pM，IC50为 1.4 nM。Elsilimomab 可用于多发性骨髓瘤、肾细胞癌和类风湿性关节炎 (RA) 的研究。
T63008	PERK-IN-5	Others	Others
	PERK-IN-5 是一种高度选择性的、高效的、口服具有活力的蛋白激酶 R 样内质网 (ER) 激酶 (PERK) 抑制剂，能够作用于 PERK (IC50: 2 nM) 与 p-eIF2α (IC50: 9 nM)。在 786-O 肾细胞癌异种移植瘤模型中，PERK-IN-5 可以明显抑制肿瘤生长。

化合物

Cat.No: T26046

Target: Topoisomerase

Cat.No: T6683

Synonym: STF 62247

Target: Estrogen/progestogen Receptor, Autophagy

Cat.No: T2456

Synonym: 替沃扎尼,AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

Cat.No: T16777

Target: Apoptosis, Autophagy

Cat.No: T24818

Synonym: NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131

Target: Apoptosis

Cat.No: T77810

Target: CDK

Cat.No: T16679

Synonym: PT2977,MK-6482

Target: HIF

Cat.No: T1916

Synonym: RG 7422,GNE 390,GDC-0980

Target: Apoptosis, PI3K, mTOR

Cat.No: T76828

Synonym: LT 1009

Target: LPL Receptor

Phosphostim Sodium

Cat.No: T28408

Synonym: IPH1101,Phosphostim,IPH 1101,IPH-1101

Target: Others

CP-461 free base

Cat.No: T31058

Synonym: CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461

Target: Others

Cat.No: T74597

Target: Others

Cat.No: T61442

Target: Others

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Target: Others

Cat.No: T81704

Cat.No: T76803

Cat.No: T63008

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T36439	Gramicidin A	Antibacterial; HIF; Parasite	Angiogenesis; Chromatin/Epigenetic; Microbiology/Virology
	Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体，在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解，并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin A 具有抗菌、抗疟活性以及溶血活性。

天然产物

Cat.No: T36439

Target: Antibacterial, HIF, Parasite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00724	LDHA Protein, Human, Recombinant (His) LDH-M,Renal Carcinoma Antigen NY-REN-59,	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria.
TMPK-00172	B7-H4 Protein, Human, Recombinant (His & Avi) B7H4,B7x,VTCN1,PRO1291,B7S1,B7h.5,FLJ22418,B7-H4	Human	HEK293 Cells
	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status .
TMPJ-00457	OGG1 Protein, Human, Recombinant OGH1,N-Glycosylase/DNA Lyase,DNA-(Apurinic or Apyrimidinic S...	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.

重组蛋白

LDHA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00724

Species: Human

Expression System: E. coli

B7-H4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00172

Species: Human

Expression System: HEK293 Cells

OGG1 Protein, Human, Recombinant

Cat.No: TMPJ-00457

Species: Human

Expression System: E. coli

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