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Search Results for " recurrent "
Targets Recommended: Others

21

抑制剂 & 化合物

3

天然产物

15

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T26889 Borofalan(10B)

L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸

Others Others
Borofalan(10B) (L-4-Boronophenylalanine) 具有抗肿瘤作用,可用于研究复发性或局部晚期头颈癌。
T7697 BIX-01294

Histone Methyltransferase; Autophagy Autophagy; Chromatin/Epigenetic
BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP,可诱导坏死性凋亡和自噬,具有抗肿瘤活性。
T1163 Betamethasone valerate

Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq

Glucocorticoid Receptor Endocrinology/Hormones
Betamethasone valerate (Luxiq) 的 17 戊酸酯,是一种具有抗炎活性的局部皮质类固醇。它能够抑制放射标记的糖皮质激素地塞米松与人表皮(IC50:5 nM)及小鼠皮肤(IC50:6 nM)的结合。它可用于研究复发性口疮。
T1959 BIX-01294 trihydrochloride

BIX 01294

Histone Methyltransferase; Autophagy Autophagy; Chromatin/Epigenetic
BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂,IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬,具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。
T2073 GSK2636771

GSK 2636771,GSK-2636771

PI3K PI3K/Akt/mTOR signaling
GSK2636771 是选择性的、口服有效的PI3Kβ抑制剂,Ki=0.89 nM,IC50=5.2 nM,比p110α和p110γ的选择性高900倍,比p110δ同种型的选择性高10倍。
T16071 MGB-BP-3

DNA/RNA Synthesis; Antibiotic Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
MGB-BP-3 是一种合成抗生素,具有杀菌活性,抑制细菌 DNA 复制,可用于研究复发性艰难梭菌感染。
T77416 Opicinumab

BIIB033

Others Others
Opicinumab (BIIB033) 是一种新型抗 LINGO-1 的单克隆抗体,可用于预防和延缓急性视神经炎和复发性多发性硬化。
T35390 Magrolimab

Hu5F9-G4,Magrolimab (anti-CD47)

Others Others
Magrolimab (Hu5F9-G4) 是一种人源化抗 CD47 IgG4 单克隆抗体,通过阻断CD47来展现其抗肿瘤活性,主要与CD47的 N 末端焦谷氨酸结合,可用于和其他化合物联合治疗复发性骨髓瘤。
T11449L Golotimod

Gamma-D-glutamyl-L-tryptophan,SCV 07

Antibiotic Microbiology/Virology
Golotimod (SCV 07) 是一种具有抗菌活性的二肽,具有免疫调节活性,能显著提高抗结核治疗的疗效,诱导胸腺和脾脏细胞增殖,调节巨噬细胞功能,抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 (HSV-2)感染和口腔黏膜炎。
T28778 Silperisone HCl

RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336

Others Others
Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道,使肌肉细胞的兴奋度和收缩度降低,降低外周张力,充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物,具有中枢作用的肌肉松弛剂特性。
T16152 Betamethasone 17-benzoate

Kinesin Cytoskeletal Signaling
Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
T17930 EC1167

Others; ADC Linker Antibody-drug Conjugate/ADC Related; Others
EC1169 is a targeted tubulysin conjugate that utilizes EC1167 as its linker. This compound shows promise in the treatment of recurrent metastatic, castration-resistant prostate cancer (MCRPC)[1].
T76918 Barecetamab

Barecetamab (ISU-104) 是一种人源话抗 ErbB3单克隆抗体。Barecetamab 可用于复发/转移性 (R/M) 头颈部鳞状细胞癌 (HNSCC) 的研究。
T76789 Imalumab

Imalumab (BAX69) 是重组的,人 IgG1单克隆抗体,靶向巨噬细胞抑制因子 (MIF)。Imalumab 可用于卵巢癌、复发性恶性腹水和恶性肿瘤的研究。
T77815 EC1167 hydrochloride

Others; ADC Linker Antibody-drug Conjugate/ADC Related; Others
EC1167 hydrochloride为EC1169的linker,后者是针对前列腺特异性膜抗原的小管溶解蛋白偶联物。EC1169 hydrochloride展现了对治疗复发性转移性去势性前列腺癌(MCRPC)的研究潜力。
T76970 Tagitanlimab

Tagitanlimab (HBM-9167),一种人源化抗PD-L1抗体(IgG1κ型),通过选择性阻断PD-L1与PD-1的相互作用,展现出对研究复发性或转移性鼻咽癌(NPC)的潜力。
T77108 Olinvacimab

Olinvacimab (TTAC-0001) 是一种人抗 VEGFR2单克隆抗体。Olinvacimab 抑制 VEGF 与 KDR 结合,Kd 值为 0.23 nM。Olinvacimab 具有抗血管生成活性。Olinvacimab 可用于复发性胶质母细胞瘤和乳腺癌的研究。
T76997 Socazolimab

Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。
T76920 Bectumomab

Bectumomab (IMMU-LL 2) 是一种针对人CD22(抗原) 的人源化IgG2a 单抗。Bectumomab 也是一种抗淋巴瘤抗体片段。Bectumomab 可与锝 99 (Tc99m LL2 Fab) 联合用于成像。此外,Bectumomab 能够检查复发性或新诊断的非霍奇金淋巴瘤 (NHL) 的分期,并在放射免疫研究 (RIT) 前评估靶向性。
T11449L2 Golotimod (TFA) (229305-39-9 free base)

SCV 07 (TFA),Gamma-D-glutamyl-L-tryptophan (TFA),Golotimod (TFA)

STAT JAK/STAT signaling; Stem Cells
Golotimod TFA (SCV 07 TFA) 一种免疫调节肽,具有抗菌作用,能够明显增加抗结核研究的效果,刺激胸腺和脾细胞增殖,改善巨噬细胞功能。Golotimod TFA 能够抑制 STAT3 信号传导,调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod TFA 具有潜力进复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的研究。
T11449 Golotimod hydrochloride (229305-39-9 free base)

Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

STAT JAK/STAT signaling; Stem Cells
Golotimod (SCV 07) hydrochloride 是一种免疫调节肽,具抗菌活性,能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能,展现其生物调节能力。此外,Golotimod hydrochloride 通过抑制STAT3信号传导,有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。

化合物

Borofalan(10B)
Cat.No: T26889
Synonym: L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸
Target: Others
BIX-01294
Cat.No: T7697
Synonym:
Target: Histone Methyltransferase, Autophagy
Betamethasone valerate
Cat.No: T1163
Synonym: Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq
Target: Glucocorticoid Receptor
BIX-01294 trihydrochloride
Cat.No: T1959
Synonym: BIX 01294
Target: Histone Methyltransferase, Autophagy
GSK2636771
Cat.No: T2073
Synonym: GSK 2636771,GSK-2636771
Target: PI3K
MGB-BP-3
Cat.No: T16071
Synonym:
Target: DNA/RNA Synthesis, Antibiotic
Opicinumab
Cat.No: T77416
Synonym: BIIB033
Target: Others
Magrolimab
Cat.No: T35390
Synonym: Hu5F9-G4,Magrolimab (anti-CD47)
Target: Others
Golotimod
Cat.No: T11449L
Synonym: Gamma-D-glutamyl-L-tryptophan,SCV 07
Target: Antibiotic
Silperisone HCl
Cat.No: T28778
Synonym: RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336
Target: Others
Betamethasone 17-benzoate
Cat.No: T16152
Synonym:
Target: Kinesin
EC1167
Cat.No: T17930
Synonym:
Target: Others, ADC Linker
Barecetamab
Cat.No: T76918
Synonym:
Target:
Imalumab
Cat.No: T76789
Synonym:
Target:
EC1167 hydrochloride
Cat.No: T77815
Synonym:
Target: Others, ADC Linker
Tagitanlimab
Cat.No: T76970
Synonym:
Target:
Olinvacimab
Cat.No: T77108
Synonym:
Target:
Socazolimab
Cat.No: T76997
Synonym:
Target:
Bectumomab
Cat.No: T76920
Synonym:
Target:
Golotimod (TFA) (229305-39-9 free base)
Cat.No: T11449L2
Synonym: SCV 07 (TFA),Gamma-D-glutamyl-L-tryptophan (TFA),Golotimod (TFA)
Target: STAT
Golotimod hydrochloride (229305-39-9 free base)
Cat.No: T11449
Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride
Target: STAT
Cat. No. Product Name Target Signaling Pathways
T5231 2-Methylsuccinic acid

Pyrotartaric Acid,Methylbutanedioic acid,甲基丁二酸

Others; Endogenous Metabolite Metabolism; Others
2-Methylsuccinic acid (Pyrotartaric Acid) 是乙基丙二酸脑病的主要生化指标,是人体液中的正常代谢物。
T0884 1-Docosanol

Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Antifection; HSV Microbiology/Virology
1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇,局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
T4716 Pyrrole-2-carboxylic acid

吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline

Endogenous Metabolite Metabolism
Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类,从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。

天然产物

2-Methylsuccinic acid
Cat.No: T5231
Synonym: Pyrotartaric Acid,Methylbutanedioic acid,甲基丁二酸
Target: Others, Endogenous Metabolite
1-Docosanol
Cat.No: T0884
Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol
Target: Antifection, HSV
Pyrrole-2-carboxylic acid
Cat.No: T4716
Synonym: 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline
Target: Endogenous Metabolite
Cat. No. Product Name Species Expression System
TMPY-04779 BTN3A2 Protein, Human, Recombinant (His)

BTF3,BT3.2,BTF4,BTN3.2,CD277,butyrophilin subfamily 3 member...

Human HEK293 Cells
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted...
TMPY-04483 IRAK4 Protein, Human, Recombinant (His)

IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...

Human Baculovirus Insect Cells
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPY-01061 FGF-10 Protein, Human, Recombinant

fibroblast growth factor 10,KGF2

Human E. coli
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla...
TMPY-04311 RAB11B Protein, Human, Recombinant (His)

H-YPT3,RAB11B, member RAS oncogene family

Human HEK293 Cells
The two recurrent dominant mutations in RAB11B leading to a neurodevelopmental syndrome, likely caused by altered GDP/GTP binding that inactivate the protein and induce GEF binding and protein mislocalization.
TMPY-00025 Mammaglobin B/SCGB2A1 Protein, Human, Recombinant (hFc)

UGB3,MGB2,LPNC,LPHC,LIPHC,secretoglobin family 2A member 1

Human HEK293 Cells
SCGB2A1 represented a novel, prognostic factor for CRC, and that expression of SCGB2A1 correlated with chemoresistance, radioresistance and cancer cell stemness. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers and may represent a novel and attractive target for the immunotherapy of patients harbouring recurrent disease resistant to chemotherapy.
TMPY-06802 HSV 2 (strain 333) Glycoprotein D/gD Protein (His)

HSV2 HEK293 Cells
Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immun...
TMPJ-00588 CEACAM7 Protein, Human, Recombinant (His)

CGM2,Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

Human HEK293 Cells
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7) is a member of the immunoglobulin superfamily A and CEA family. CEACAM7 localizes to the cell membrane and contains one Ig-like C2-type domain and one Ig-like V-type domain. The expression of CEACAM7 is significantly decreased in rectal cancer. Differences in CEACAM7 expression levels between long-term survivors and those with recurrent disease introduce a potential tumor marker to define a subset of patients who benefit most fr...
TMPJ-00517 WIF-1 Protein, Human, Recombinant (His)

Wnt Inhibitory Factor 1,WIF-1,WIF1

Human HEK293 Cells
Wnt Inhibitory Factor 1 (WIF1) is a secreted protein, which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis.WIF1 may be involved in mesoderm segmentation. WIF1 is a tumor suppress...
TMPY-04476 MVK Protein, Human, Recombinant (His & GST)

POROK3,LRBP,MVLK,MK,mevalonate kinase

Human Baculovirus Insect Cells
Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia,...
TMPY-02849 WIF1 Protein, Mouse, Recombinant (His)

AW107799,WIF-1,WNT inhibitory factor 1

Mouse HEK293 Cells
WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein that binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downre...
TMPJ-00361 Endoglin Protein, Human, Recombinant (Trx & His)

CD105,END,Endoglin,ENG

Human E. coli
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an...
TMPY-05028 NOTCH2NL Protein, Human, Recombinant (mFc)

notch 2 N-terminal like,N2N

Human HEK293 Cells
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH family. NOTCH2NL promote the clonal expansion of human cortical progenitors, ultimately leading to higher neuronal output. At the molecular level, NOTCH2NL function by activating the Notch pathway through inhibition of cis Delta/Notch interactions. NOTCH2NL ectopic expression delay...
TMPY-01854 DPP10 Protein, Human, Recombinant (His)

DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non-function...

Human HEK293 Cells
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p...
TMPJ-00329 CD19 Protein, Rhesus macaque, Recombinant (hFc)

B-Lymphocyte Antigen CD19,CD19,Differentiation Antigen CD19,...

Rhesus HEK293 Cells
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr...
TMPY-01605 STIM1 Protein, Human, Recombinant (His)

stromal interaction molecule 1,TAM1,GOK,STRMK,IMD10,D11S4896...

Human HEK293 Cells
Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human primary cells and tumor cell lines. It contains one EF-hand domain and one SAM (sterile alpha motif) domain. STIM1 / GOK plays a role in mediating Ca2+influx following depletion of intracellular Ca2+stores. It acts as Ca2+sensor in the endoplasmic reticulum via its EF-hand domain...

重组蛋白

BTN3A2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04779
Species: Human
Expression System: HEK293 Cells
IRAK4 Protein, Human, Recombinant (His)
Cat.No: TMPY-04483
Species: Human
Expression System: Baculovirus Insect Cells
FGF-10 Protein, Human, Recombinant
Cat.No: TMPY-01061
Species: Human
Expression System: E. coli
RAB11B Protein, Human, Recombinant (His)
Cat.No: TMPY-04311
Species: Human
Expression System: HEK293 Cells
Mammaglobin B/SCGB2A1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00025
Species: Human
Expression System: HEK293 Cells
HSV 2 (strain 333) Glycoprotein D/gD Protein (His)
Cat.No: TMPY-06802
Species: HSV2
Expression System: HEK293 Cells
CEACAM7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00588
Species: Human
Expression System: HEK293 Cells
WIF-1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00517
Species: Human
Expression System: HEK293 Cells
MVK Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04476
Species: Human
Expression System: Baculovirus Insect Cells
WIF1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02849
Species: Mouse
Expression System: HEK293 Cells
Endoglin Protein, Human, Recombinant (Trx & His)
Cat.No: TMPJ-00361
Species: Human
Expression System: E. coli
NOTCH2NL Protein, Human, Recombinant (mFc)
Cat.No: TMPY-05028
Species: Human
Expression System: HEK293 Cells
DPP10 Protein, Human, Recombinant (His)
Cat.No: TMPY-01854
Species: Human
Expression System: HEK293 Cells
CD19 Protein, Rhesus macaque, Recombinant (hFc)
Cat.No: TMPJ-00329
Species: Rhesus
Expression System: HEK293 Cells
STIM1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01605
Species: Human
Expression System: HEK293 Cells
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