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Search Results for " quorum-sensing "

Targets Recommended: Antibacterial

60

抑制剂 & 化合物

11

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T78823	Quorum Sensing-IN-3 QS-IN-1	Antibacterial	Microbiology/Virology
	Quorum Sensing-IN-3 (QS-IN-1)是一种对细菌群体感应有抑制作用的化合物，可抑制细菌之间的信息交流，抑制生物膜的形成。
T41287	N-3-Oxo-octanoyl-L-homoserine lactone	Others	Others
	N-3-Oxo-octanoyl-L-homoserine lactone 是一种群体感应信号分子，是农杆菌自诱导剂。
T16226	N-(Ketocaproyl)-DL-homoserine lactone N-(Ketocaproyl)-D,L-homoserine lactone,N-(3-氧代己酰)-DL-高丝氨酸内酯	Antibacterial	Microbiology/Virology
	N-(Ketocaproyl)-DL-homoserine lactone 是群体感应自动诱导剂。它是 LuxR 的天然配体。
T78935	Quorum Sensing-IN-2	Others	Others
	Quorum Sensing-IN-2（compound 23e）是一款不影响细菌生长的群体感应抑制剂，具有减少细菌致病性的功能。该化合物在抑制细菌感染方面表现出效力，同时具有极低的溶血活性。在铜绿假单胞菌PAO1引起的菌血症模型中，Quorum Sensing-IN-2与环丙沙星共同作用，显示了协同效应。
T60595	Quorum Sensing-IN-1	Others	Others
	Quorum Sensing-IN-1 是一种小分子的群体感应抑制剂。
T22374	N-(beta-Ketocaproyl)-L-hoMoserine lactone N-3-氧-己酰高丝氨酸内酯,N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone	Others	Others
	N-(beta-Ketocaproyl)-L-hoMoserine lactone (N-(Ketocaproyl)-L-homoserine lactone) 是群体调节感应的成分之一。
T22375	N-hexanoyl-L-Homoserine lactone 己酰-L-高丝氨酸内酯,C6-HSL	Others; Antibacterial	Microbiology/Virology; Others
	N-hexanoyl-L-Homoserine lactone (C6-HSL) 是一种可扩散信号分子，参与控制基因表达、影响细胞代谢和群体感应。
T13789	N-dodecanoyl-L-Homoserine lactone C12-HSL,十二烷酰-L-高丝氨酸内酯	Others	Others
	N-dodecanoyl-L-Homoserine lactone (C12-HSL) 是群体感应 (QS) 信号分子的一种。它适配体可用于阻止群体感应，并能够阻碍铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成。
T5816	Qstatin	Antibacterial	Microbiology/Virology
	QStatin 是一种弧菌物种群体感应的选择性SmcR 抑制剂，EC50值为 208.9 nM。与 SmcR 紧密结合并改变了蛋白质的柔韧性，从而改变了其转录调控活性。并减弱其在水生宿主中的毒力。它可用于水产养殖的可持续性抗弧菌病药物。
T70878	P516-0475	Others	Others
	P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
T25822	ML366 ML 366,ML-366	Others	Others
	ML366 is a Vibrio cholerae Quorum Sensing inhibitor Acting via the LuxO response regulator.
T30687	CAI-1 Cholerae autoinducer 1,Cholerae autoinducer-1	Others	Others
	CAI-1 is a vibrio cholerae quorum-sensing autoinducer.
T24929	V-06-018 V 06 018	Others	Others
	V-06-018 is a quorum-sensing modulator. It also acts as a LasR antagonist.
T71516	RhlR Agonist S4	Others	Others
	RhlR agonist S4 is a quorum sensing modulator as an RhlR agonist.
T31572	DPO	Others	Others
	DPO is a quorum sensing (QS) self-inducer that binds and activates the transcription factor VQMA.
T71515	RhlR Antagonist E22	Others	Others
	RhlR antagonist E22 is a quorum sensing modulator as an RhlR antagonist.
T71730	QS inhibitor 1	Others	Others
	QS inhibitor 1 is a novel potent inhibitor of quorum sensing (QS) pathways.
T71940	QS inhibitor 2	Others	Others
	QS inhibitor 2 is a novel potent inhibitor of quorum sensing (QS) pathways.
T37912	Furanone C-30	Others	Others
	Synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing in vivo and promotes bacterial clearance in a mouse pulmonary infection model. Hentzer et al (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22 3803 PMID:12881415
T38154	N-3-hydroxydecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Different quorum sensing molecules are produced at different times in bacterial population growth and have distinct cellular effects mediated through changes in gene expression. N-3-hydroxydecanoyl-L-Homoserine lactone is a small diffusible signaling molecule secreted by various bacteria. This lactone is produced via lactonolysis from 3-oxodecanoyl-homoserine lactone, al...
T36988	N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone	Others	Others
	N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone is a long-chain N-acyl-homoserine lactone (AHL) produced by some Gram-negative bacteria and is involved in quorum sensing. Quorum sensing enables bacteria to change gene expression based on cues from nearby bacteria and from eukaryotic hosts about nutrients, environmental conditions, or threats. Due to the benefit of quorum sensing for bacterial survival, quorum sensing molecules are potential targets for controlling bacterial infections. In...
T68982	Hordenine sulfate	Others	Others
	Hordenine sulfate inhibits the activity of PDK3, inhibits quorum sensing, and acts as an antibiofilm agent against bacteria.
T71860	Ambuic acid	Others	Others
	Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when adminis...
T38313	L-Homoserine lactone (hydrochloride)	Others	Others
	L-Homoserine lactone is a synthetic intermediate.1,2It has been used in the synthesis of organoselenium chemistry intermediates and analogs of bacterial quorum-sensing signaling molecules. 1.Koch, T., and Buchardt, O.Synthesis of L-(+)-selenomethionineSynthesis1065-1067(1993) 2.Chhabra, S.R., Harty, C., Hooi, D.S.W., et al.Synthetic analogues of the bacterial signal (quorum seensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulatorsJ. Med. Chem.46(1)97-104(2003)
T37339	N-3-oxo-tetradecanoyl-L-Homoserine lactone 3-oxo-C14-HSL,N-3-oxo-myristoyl-L-Homoserine lactone,N-3-oxo-tetradecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is ...
T37342	N-butyryl-L-Homocysteine thiolactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-...
T61353	PqsR-IN-2	Others	Others
	PqsR-IN-2 (Compound 19) is a highly potent inhibitor of PqsR, the transcriptional regulator responsible for quorum sensing in Pseudomonas aeruginosa. It effectively suppresses pyocyanin production without causing significant cytotoxicity, making it a promising compound for therapeutic applications [1].
T38559	Competence-Stimulating Peptide-2 (CSP-2)
	Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide synthesized by Streptococcus pneumoniae. ComD2, a compatible receptor of CSP-2, exhibits an EC 50 value of 50.7 nM.
T61169	PqsR-IN-1	Others	Others
	PqsR-IN-1 (Compound 18) is a potent inhibitor of PqsR, which is a transcriptional regulator involved in the quorum sensing mechanism of Pseudomonas aeruginosa. This compound effectively reduces the production of pyocyanin and exhibits minimal cytotoxicity [1].
T84471	N-3-hydroxyoctanoyl-L-Homoserine lactone OH-C8-HSL	Others	Others
	N-3-hydroxyoctanoyl-L-Homoserine lactone, a small diffusible signaling molecule secreted by various bacteria, plays a critical role in quorum sensing—a regulatory system used by bacteria to control gene expression according to cell density changes. This compound is generated via lactonolysis from 3-oxooctanoyl-homoserine lactone and can either activate or suppress gene expression and biofilm formation. Its production and function vary within the bacterial population growth phases, consequently m...
T37747	N-tetradecanoyl-L-Homoserine lactone C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-tetradecanoyl-L-Homoserine lactone (C14-HSL) is a small diffu...
T69957	Quoromycin	Others	Others
	Quoromycin is a novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo.
T37738	N-cis-tetradec-9Z-enoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene...
TP1631L	Competence-Stimulating Peptide-12261 acetate Competence-Stimulating Peptide-12261 acetate (1235882-91-3 free base)	Others	Others
	Competence-Stimulating Peptide-12261 acetate (1235882-91-3 free base) 是感觉刺激肽的片段，是一种抑制胚管 (GT) 形成的群体感应分子。
T37879	N-undecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37736	N-cis-hexadec-9Z-enoyl-L-Homoserine lactone N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic...
T61108	YXL-13	Others	Others
	YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13 significantly diminishes both the pathogenicity and drug resistance of PAO1 by inhibiting the quorum sensing (QS) system. Thus, YXL-13 holds great potential for studying antibacterial properties [1].
T37680	3-hydroxy Palmitic Acid methyl ester	Others	Others
	3-hydroxy Palmitic acid methyl ester (3-hydroxy PAME) is an esterized long-chain fatty acid involved in quorum sensing in R. solanacearum, a bacteria that causes lethal wilting in plants. 3-hydroxy-PAME (175 nM) increases levels of PhcA-regulated virulence factors, greater than 20-, 30-, and 25-fold for EPS I, EGL, and PME, respectively, in the AW1-83 strain of R. solanacearum.
T39175	CSP1
	CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.
T36989	N-3-hydroxydecanoyl-DL-Homoserine lactone	Others	Others
	N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule.1It activates SdiA (EC50= 0.6 μM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028/pJNS25 strain ofS. enterica.2 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387...
T37737	N-cis-octadec-9Z-enoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene...
T37337	N-3-oxo-hexadecanoyl-L-Homoserine lactone	Others	Others
	N-3-oxo-hexadecanoyl-L-Homoserine lactone is an unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria, including strains of Agrobacterium vitis and Pseudomonas. Like other AHLs, this C16-containing form is thought to be involved in quorum sensing. Substituted, long-chain AHLs, including N-3-oxo-tetradecanoyl-L-homoserine lactone , prime for systemic acquired resistance to pathogen attack in plants.
T37745	N-pentadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T83096	Antibiofilm agent-2	Others	Others
	Antibiofilm agent-2（化合物 4T）是一种具有3.6 μM IC50的高效生物膜抑制剂。作为针对铜绿假单胞菌的抗菌增效剂，它能够抑制群体感应系统和铁稳态。
T37743	N-octadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T74029	cis-11-Methyl-2-dodecenoic acid	Others	Others
	cis-11-Methyl-2-dodecenoic acid 是群体感应 (QS) 信号分子，在微生物及真菌的细胞外通讯系统中扮演扩散信号因子(DSF)的角色。它参与调控多种细菌病原体的毒性及生物膜的生成。
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...
T37711	δ2-cis-Hexadecenoic Acid	Others	Others
	One of the first organisms in which quorum sensing was observed were Myxobacteria, a group of gram-negative bacteria, found mainly in soil and also common to marine and freshwater systems. The cellular membranes of autotrophic bacteria contain mono-unsaturated fatty acids. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). δ2-cis-Hexadecenoic acid is an unusual fatty a...
T36523	Extracellular Death Factor
	Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing pop...
T37338	N-3-oxo-pentanoyl-L-Homoserine lactone	Others	Others
	N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone toE. colicontaining the transcription factor LuxR when used at a concentration of 230 nM.2It acts as an autoinducer to activate theV. fischeriluminescence system inE. coliwhen used at concentrations ranging from 20 to 200 nM. 1.Chhabra, S.R., Stead, P., Bainton, ...

化合物

Quorum Sensing-IN-3

Cat.No: T78823

Synonym: QS-IN-1

Target: Antibacterial

N-3-Oxo-octanoyl-L-homoserine lactone

Cat.No: T41287

Target: Others

N-(Ketocaproyl)-DL-homoserine lactone

Cat.No: T16226

Synonym: N-(Ketocaproyl)-D,L-homoserine lactone,N-(3-氧代己酰)-DL-高丝氨酸内酯

Target: Antibacterial

Quorum Sensing-IN-2

Cat.No: T78935

Target: Others

Quorum Sensing-IN-1

Cat.No: T60595

Target: Others

N-(beta-Ketocaproyl)-L-hoMoserine lactone

Cat.No: T22374

Synonym: N-3-氧-己酰高丝氨酸内酯,N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone

Target: Others

N-hexanoyl-L-Homoserine lactone

Cat.No: T22375

Synonym: 己酰-L-高丝氨酸内酯,C6-HSL

Target: Others, Antibacterial

N-dodecanoyl-L-Homoserine lactone

Cat.No: T13789

Synonym: C12-HSL,十二烷酰-L-高丝氨酸内酯

Target: Others

Cat.No: T5816

Target: Antibacterial

Cat.No: T70878

Target: Others

Cat.No: T25822

Synonym: ML 366,ML-366

Target: Others

Cat.No: T30687

Synonym: Cholerae autoinducer 1,Cholerae autoinducer-1

Target: Others

Cat.No: T24929

Synonym: V 06 018

Target: Others

RhlR Agonist S4

Cat.No: T71516

Target: Others

Cat.No: T31572

Target: Others

RhlR Antagonist E22

Cat.No: T71515

Target: Others

Cat.No: T71730

Target: Others

Cat.No: T71940

Target: Others

Cat.No: T37912

Target: Others

N-3-hydroxydecanoyl-L-Homoserine lactone

Cat.No: T38154

Target: Others

N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone

Cat.No: T36988

Target: Others

Hordenine sulfate

Cat.No: T68982

Target: Others

Cat.No: T71860

Target: Others

L-Homoserine lactone (hydrochloride)

Cat.No: T38313

Target: Others

N-3-oxo-tetradecanoyl-L-Homoserine lactone

Cat.No: T37339

Synonym: 3-oxo-C14-HSL,N-3-oxo-myristoyl-L-Homoserine lactone,N-3-oxo-tetradecanoyl-L-Homoserine lactone

Target: Others

N-butyryl-L-Homocysteine thiolactone

Cat.No: T37342

Target: Others

Cat.No: T61353

Target: Others

Competence-Stimulating Peptide-2 (CSP-2)

Cat.No: T38559

Cat.No: T61169

Target: Others

N-3-hydroxyoctanoyl-L-Homoserine lactone

Cat.No: T84471

Synonym: OH-C8-HSL

Target: Others

N-tetradecanoyl-L-Homoserine lactone

Cat.No: T37747

Synonym: C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone

Target: Others

Cat.No: T69957

Target: Others

N-cis-tetradec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37738

Target: Others

Competence-Stimulating Peptide-12261 acetate

Cat.No: TP1631L

Synonym: Competence-Stimulating Peptide-12261 acetate (1235882-91-3 free base)

Target: Others

N-undecanoyl-L-Homoserine lactone

Cat.No: T37879

Target: Others

N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37736

Synonym: N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Target: Others

Cat.No: T61108

Target: Others

3-hydroxy Palmitic Acid methyl ester

Cat.No: T37680

Target: Others

Cat.No: T39175

N-3-hydroxydecanoyl-DL-Homoserine lactone

Cat.No: T36989

Target: Others

N-cis-octadec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37737

Target: Others

N-3-oxo-hexadecanoyl-L-Homoserine lactone

Cat.No: T37337

Target: Others

N-pentadecanoyl-L-Homoserine lactone

Cat.No: T37745

Target: Others

Antibiofilm agent-2

Cat.No: T83096

Target: Others

N-octadecanoyl-L-Homoserine lactone

Cat.No: T37743

Target: Others

cis-11-Methyl-2-dodecenoic acid

Cat.No: T74029

Target: Others

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

Target: Others

δ2-cis-Hexadecenoic Acid

Cat.No: T37711

Target: Others

Extracellular Death Factor

Cat.No: T36523

N-3-oxo-pentanoyl-L-Homoserine lactone

Cat.No: T37338

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1722	Hamamelitannin	Antifection	Microbiology/Virology
	Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚，是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。
T37341	N-Acetyltyramine	Antibacterial	Microbiology/Virology
	N-Acetyltyramine 是一种群体感应抑制剂，由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。
TN1925	Methyl anthranilate	Others; Antibacterial	Microbiology/Virology; Others
	Methyl anthranilate 是一种植物香料提取物，在食品加工业中广泛用于制备食用香精和食品添加剂。它是一种群体感应抑制剂和抗温和气单胞菌的生物膜剂。
T38373	2-heptyl-3-hydroxy-4(1H)-Quinolone 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal	Others	Others
	2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。它增加了铜绿假单胞菌中lasB 基因的表达，增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌，以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时，它还会降低铜绿假单胞菌生长介质中的铁含量，并在硫酸铁溶液中充当一种铁螯合剂。
T71788	Hordenine hydrochloride	Others	Others
	Hordenine hydrochloride is a biochemical that inhibits the activity of PDK3, inhibits quorum sensing, and acts as an antibiofilm agent against bacteria.
TN3896	Drimenol	Antifection	Microbiology/Virology
	Drimenol shows antifungal activity, it is able to affect Botrytis cinerea growth with the EC50 value of 80 ppm. Drimendiol also shows quorum sensing inhibition activity.
T81722	N-(3-Oxodecanoyl)-L-homoserine lactone 3-Oxo-C10-HSL
	N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) 作为一种信号分子，在细菌群体感应中充当自诱导分子的角色。
T80018	cis-2-Dodecenoic acid	Others	Others
	cis-2-Dodecenoic acid，最初在Burkholderia cenocepacia中被发现，能够干扰细菌的群体感应系统，从而抑制细菌生物膜的形成和毒力因子的产生。
T11219	Equisetin	Others	Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...
T75448	Aculene D	Others	Others
	Aculene D, 一种真菌代谢物，针对Chromobacterium violaceum CV026表现出群体感应(QS)抑制活性。该化合物能在亚抑制浓度下，显著削减由N-己酰基-l-高丝氨酸内酯(C6-HSL)触发的C. violaceum CV026培养物中紫罗兰素的产生。
T35751	Violacein	Others	Others
	Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 &#181M, respectively). It is also active aga...

天然产物

Cat.No: TN1722

Target: Antifection

N-Acetyltyramine

Cat.No: T37341

Target: Antibacterial

Methyl anthranilate

Cat.No: TN1925

Target: Others, Antibacterial

2-heptyl-3-hydroxy-4(1H)-Quinolone

Cat.No: T38373

Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Target: Others

Hordenine hydrochloride

Cat.No: T71788

Target: Others

Cat.No: TN3896

Target: Antifection

N-(3-Oxodecanoyl)-L-homoserine lactone

Cat.No: T81722

Synonym: 3-Oxo-C10-HSL

cis-2-Dodecenoic acid

Cat.No: T80018

Target: Others

Cat.No: T11219

Target: Others

Cat.No: T75448

Target: Others

Cat.No: T35751

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03177	RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) Elastase modulator,rhlR,Regulatory protein RhlR,HTH-type	Pseudomonas aeruginosa	E. coli
	Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.6 kDa and the accession n...
TMPH-00735	LuxS Protein, E. coli, Recombinant (His & Myc) luxS,S-ribosylhomocysteine lyase,Autoinducer-2 production pr...	E. coli	E. coli
	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
TMPH-00734	LuxS Protein, E. coli, Recombinant (His) AI-2 synthesis protein,Autoinducer-2 production protein LuxS...	E. coli	E. coli
	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). LuxS Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th...

重组蛋白

RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03177

Species: Pseudomonas aeruginosa

Expression System: E. coli

LuxS Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00735

Species: E. coli

Expression System: E. coli

LuxS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00734

Species: E. coli

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71293	Nifuroxazide-d4
	Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S...

同位素标记化合物

Nifuroxazide-d4

Cat.No: T71293

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