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Search Results for " pumps "

Targets Recommended: Calcium Channel P-gp Drug Metabolite

15

抑制剂 & 化合物

3

天然产物

1

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T20714	Levolansoprazole 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole	Proton pump	Membrane transporter/Ion channel
	Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50：82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。
TP1911L	CALP3 acetate(261969-05-5 free base)	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CALP3 acetate(261969-05-5 free base) 是一种有效的 Ca2+ 通道阻滞剂，可激活 Ca2+ 结合蛋白的 EF 手基序。它可以通过调节钙调蛋白 (CaM)、Ca2+ 通道和泵的活性在功能上模拟增加的 [Ca2+]i。
T26911	Bromotetrandrine 5-Bromotetrandrine,W-198,BrTet,W 198,W198	Others	Others
	Bromotetrandrine is an P-glycoprotein inhibitor, which were developed and coadministered with chemotherapeutic drugs to overcome the effect of efflux pumps thus enhancing the chemosensitivity of therapeutics.
T24005	DJ101 DJ-101,DJ 101	Others	Others
	DJ101is an effective and metabolically stable inhibitor of tubulin. It can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.
TP2170	CALP3 TFA（261969-05-5 free base) CALP3 TFA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin, Ca2+ channels, and pumps.
T80247	Caloxin 3A1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Caloxin 3A1是生物活性肽，属于caloxins系列，特指抑制外质膜(Plasma membrane, PM) Ca2+泵的化合物。具体作用通过抑制质膜钙泵(PMCA)并保持对肌浆网Ca2+泵无影响；同时，该肽不干预ATP合成酰基磷酸中间产物的形成。
T36810	uPSEM 792 hydrochloride	Others	Others
	Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetra...
T75372	BODIPY FL Thapsigargin
	BODIPY FL Thapsigargin 作为一种高效绿色荧光染料，主要抑制细胞内肌浆/内质网中的serca型Ca2+泵。其应用焦点在于探究Thapsigargin在活细胞中的结合位置。储存需避光处理。
T75789	CALP3 TFA
	CALP3 TFA 是一种模拟 Ca2+ 的有效肽类 Ca2+ 通道阻断剂，能够激活 EF 手的 Ca2+ 结合蛋白。它通过影响钙调蛋白 (CaM)、Ca2+ 通道及泵的功能来模拟 [Ca2+]i 的增加，从而具备在控制 HIV 或缺血性神经元损伤等情况下调控细胞凋亡的能力。
T75326	ATP ditromethamine	Others	Others
	ATP ditromethamine（Adenosine 5'-triphosphate ditromethamine）作为体内能量储存和代谢的核心物质，不仅为代谢过程提供必需能量，而且在细胞中担任辅酶角色。此外，它在免疫和炎症反应中，扮演着关键的内源性信号分子角色。
T35902	Milbemycin A4 oxime	Others	Others
	Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, ...
T68480	4SC-207	Others	Others
	4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome a...
T37743	N-octadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone	Others	Others
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...

化合物

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

Levolansoprazole

Cat.No: T20714

Synonym: 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

CALP3 acetate(261969-05-5 free base)

Cat.No: TP1911L

Target: Calcium Channel

Bromotetrandrine

Cat.No: T26911

Synonym: 5-Bromotetrandrine,W-198,BrTet,W 198,W198

Target: Others

Cat.No: T24005

Synonym: DJ-101,DJ 101

Target: Others

CALP3 TFA（261969-05-5 free base)

Cat.No: TP2170

Synonym: CALP3 TFA

Target: Calcium Channel

Cat.No: T80247

Target: Calcium Channel

uPSEM 792 hydrochloride

Cat.No: T36810

Target: Others

BODIPY FL Thapsigargin

Cat.No: T75372

Cat.No: T75789

ATP ditromethamine

Cat.No: T75326

Target: Others

Milbemycin A4 oxime

Cat.No: T35902

Target: Others

Cat.No: T68480

Target: Others

N-octadecanoyl-L-Homoserine lactone

Cat.No: T37743

Target: Others

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T14293	Annonacin	Others	Others
	Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu
T40526	ATP dipotassium 腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium	Others	Others
	ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation.
TN5530	Volkensiflavone Talbotaflavone	Others	Others
	Volkensiflavone (Talbotaflavone) 是一种天然产物，存在于黄芪和藤黄中。它具有植物代谢物的作用,是一种次生代谢产物。Volkensiflavone 是一种双类黄酮，属于羟黄酮和羟黄酮。Volkensiflavone 可以作为佐剂用于过表达外排泵的多药耐药金黄色葡萄球菌的抗生素治疗。

天然产物

Cat.No: T14293

Target: Others

ATP dipotassium

Cat.No: T40526

Synonym: 腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium

Target: Others

Volkensiflavone

Cat.No: TN5530

Synonym: Talbotaflavone

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03788	ATP1B1 Protein, Human, Recombinant (His) ATPase, Na+/K+ transporting, β 1 polypeptide,ATPase, Na+/K+ ...	Human	HEK293 Cells
	ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+/K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha/beta heterodim...

重组蛋白

ATP1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03788

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0301	Levolansoprazole-d4
	Levolansoprazole-d4 是 Levolansoprazole 的氘代化合物。Levolansoprazole 的 CAS 号为 138530-95-7。Levolansoprazole 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成（IC50：82 µM）。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。

同位素标记化合物

Levolansoprazole-d4

Cat.No: TMIH-0301

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