pifithrin-α, p-nitro, cyclic

Pifithrin-α, p-Nitro, Cyclic (PFN-α) 是 p53 的细胞渗透性和活性形式抑制剂。它对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级，ED50为30 nM。它也作为 p53 转录后的活性抑制剂。

m-Cresol, alpha,alpha,alpha-trifluoro-6-nitro-, p-nitrobenzoate is a bioactive chemical.

Phthalimide, N-(5-(p-aminophenoxy)pentyl)-3-nitro- is a bioactive chemical.

p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH 是一种水溶性多肽，可用作组织蛋白酶 D、胃蛋白酶及其前体的底物，并在生化分析中具有潜在应用价值。