32
12
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39
Cat. No. | Product Name | ||
---|---|---|---|
L6610 | 抗感染天然产物库 | 1060 compounds | |
1060 个抗感染相关的天然产物集合,是药物开发、药理研究的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11539 |
HCV-IN-29
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HCV-IN-29 是一种丙型肝炎病毒抑制剂。 | |||
T8139 |
Sulfamethoxazole sodium
新诺明钠,Ro 4-2130 sodium,磺胺甲恶唑钠 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfamethoxazole sodium (Ro 4-2130 sodium) 是一种磺胺类抗菌素。它常用于各种尿道病原体的研究,与 Trimethoprim 联用,可用于尿路感染的研究。 | |||
T1283 |
Clinafloxacin
克林沙星,PD 127391,CI-960,AM-1091 |
Antibacterial; Antibiotic | Microbiology/Virology |
Clinafloxacin (CI-960) 是一种高效广谱氟喹诺酮类抗生素,抑制革兰氏阳性、革兰氏阴性和厌氧病原体。它对金黄色葡萄球菌的 DNA 促旋酶和拓扑异构酶 IV 有抑制作用,IC50值分别为 0.92 µg/ml 和 1.62 µg/ml。 | |||
T20058 |
Prothioconazole
HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893 |
Antifungal | Microbiology/Virology |
Prothioconazole (Proline 480 SC Fungicide) 是一种手性三唑类杀菌剂,用于植物病原控制。 | |||
T37746 |
N-phenylacetyl-L-Homoserine lactone
|
Others | Others |
N-phenylacetyl-L-Homoserine lactone 可衰减病原体鲍曼不动杆菌的群体感应,可用于研究细菌感染。 | |||
T13667L1 |
Dusquetide aceate
Dusquetide aceate (931395-42-5 Free base) |
Antibacterial | Microbiology/Virology |
Dusquetide aceate 是一种针对损伤相关分子模式和病原体相关分子模式的先天免疫防御调节剂。 Dusquetide aceate 具有抗炎和抗菌活性。 | |||
T9000 |
Pyrimorph
|
Antifungal | Microbiology/Virology |
Pyrimorph 是一种杀真菌剂,对 oomycetes 具有良好抑菌活性。 | |||
T23133 |
Pentamidine
|
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology |
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。 | |||
T8886 |
NITD-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂,可抑制 DENV RdRp 介导的 RNA 延伸。 | |||
T8591 |
RNase L-IN-2
5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one |
Others | Others |
RNase L-IN-2 是 RNase L 的激活剂,EC50 为 22 uM;对多种类型的 RNA 病毒(包括人类病原体人类副流感病毒 3 型)具有广谱抗病毒活性,在有效浓度下没有细胞毒性。 | |||
T10222 |
ABMA
|
Parasite | Microbiology/Virology |
ABMA是一种广谱抑制剂,面向细胞内毒素和病原体。通过选择性作用于宿主细胞的晚期内体,而非直接针对毒素或病原体本身,ABMA有效地保护细胞免遭病毒、细胞内细菌及寄生虫等多种病原体的侵害,展现出广谱的抗感染活性。 | |||
T34092 |
Pneumocysterol
|
Others | Others |
Pneumocysterol is a sterol detected in the opportunistic pathogen Pneumocystis carinii hominis. | |||
T25174 |
Brassilexin
Brassilexine |
Others | Others |
Brassilexin is a cyclobrassinin hydrolase inhibitor, a unique enzyme from the fungal pathogen Alternaria brassicicola. | |||
T12991 |
SPR206
|
Others | Others |
SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen. | |||
T32537 |
LAI-1
LAI 1,Legionella autoinducer-1,Legionella autoinducer 1 |
Others | Others |
LAI-1 is a regulator of bacterial signaling, modulating gene regulation and cellular responses of eukaryotic cells (amoebae or macrophages) and a variety of processes including pathogen-host cell interactions. | |||
T61234 |
Stemphyperylenol
|
Others | Others |
Stemphyperylenol exhibits potent antifungal activity against Alternaria solani, a plant pathogen, with a minimum inhibitory concentration (MIC) value of 1.57 μM. | |||
T25256 |
Pitstop1
Clathrin inhibitor 1,Clathrin-inhibitor-1,Clathrin IN 1 |
Others | Others |
Clathrin-IN-1 is a selective clathrin inhibitor that acts by addressing clathrin function in cell physiology with potential applications as an inhibitor of virus and pathogen entry and as a modulator of cell signaling. | |||
T85033 |
Byssochlamic Acid
(+)-Byssochlamic acid |
Others | Others |
Byssochlamic acid, a mycotoxin identified in the agricultural fungal pathogen B. fulva, exhibits lethality in mice with an LD50 of 94 mg/kg. | |||
T61437 |
HPK1-IN-26
|
Others | Others |
HPK1-IN-26, a novel compound, is a potent inhibitor of both HPK1 and GLK. This small molecule exhibits promise in aiding the study of animal pathogen infection [1]. | |||
T28161 |
NEU-1045
NEU 1045,NEU1045 |
Others | Others |
NEU-1045 is a T. brucei proliferation inhibitor, and is a promising lead with cross-pathogen activity. NEU-1045 inhibited T. brucei, T. cruzi, and L. major proliferation with good potency (T. brucei EC50 = 0.37 μM; T. cruzi EC50 = 2.8 μM; L. major EC50 = | |||
T36401 |
DCVC
|
Others | Others |
DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p... | |||
T35774 |
HC Toxin
|
Others | Others |
HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. | |||
T37337 |
N-3-oxo-hexadecanoyl-L-Homoserine lactone
|
Others | Others |
N-3-oxo-hexadecanoyl-L-Homoserine lactone is an unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria, including strains of Agrobacterium vitis and Pseudomonas. Like other AHLs, this C16-containing form is thought to be involved in quorum sensing. Substituted, long-chain AHLs, including N-3-oxo-tetradecanoyl-L-homoserine lactone , prime for systemic acquired resistance to pathogen attack in plants. | |||
T61067 |
MurB-IN-1
|
Others | Others |
MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of bacterial cell wall. With a binding affinity of K d 3.57 μM, MurB-IN-1 effectively hinders the activity of MurB, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1]. | |||
T39548 |
Amustaline dihydrochloride
S-303 dihydrochloride |
Others | Others |
Amustaline (S-303) dihydrochloride is a nucleic acid-targeted alkylator recognized for its efficacy as a pathogen inactivation agent in blood components containing red blood cells. This compound comprises three key elements: an acridine anchor (a non-covalently bonding intercalator targeting nucleic acids), an effector (a bis-alkylator group that interacts with nucleophiles), and a linker (a flexible carbon chain with a labile ester bond, hydrolyzing at neutral pH to non-reactive products). | |||
T71325 |
ANA-773
|
Others | Others |
ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which... | |||
T76040 |
Dusquetide TFA
|
Others | Others |
Dusquetide (SGX942) TFA 是一类天然防御调节因子(IDR)。Dusquetide TFA 通过与 p62 结合调节 PAMPs 和 DAMPs 的天然免疫应答。Dusquetide TFA 在减轻炎症和增加细菌感染清除方面都显示出活性。 | |||
T37283 |
1-Palmitoyl Lysophosphatidic Acid (sodium salt)
|
Others | Others |
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, pipe... | |||
T80090 |
Lugdunin
|
Antibiotic | Microbiology/Virology |
Lugdunin是一种具有抗菌活性的肽类抗生素。该化合物能够通过破坏细菌细胞膜的电位来抑制革兰氏阳性菌的生长,特别是对金黄色葡萄球菌(Staphylococcus aureus)表现出高效能,有效降低其在皮肤和鼻腔的定植能力。此外,Lugdunin还能在人类角质形成细胞和小鼠皮肤中促进LL-37和CXCL8/MIP-2的表达。 | |||
T60286 |
DHFR-IN-2
|
Others | Others |
DHFR-IN-2 (化合物 4e) 是一种有效且非竞争性的MtDHFR 抑制剂,其IC50值为 7 μM。来自结核分枝杆菌 (MtDHFR) 的二氢叶酸还原酶具有很高的未开发潜力,可以成为抗结核病 (TB) 新药的靶标,因为它对病原体存活很重要。DHFR-IN-2可用于结核病(TB)研究。 | |||
T41240 |
Verrucarin A
|
Others | Others |
Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂,来源于Myrothecium verrucaria,可抑制白血病细胞系生长,并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。 | |||
T37394 |
13(S)-HpOTrE
|
Others | Others |
13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.1 In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.[2],[3],[4] Treatment of to... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9599 |
3,4,5-Trimethoxybenzaldehyde
|
Anti-infection; Antibacterial | Microbiology/Virology |
3,4,5-Trimethoxybenzaldehyde 是合成各种药物,特别是治疗细菌感染的甲氧苄啶的中间体,它有抗念珠菌功效并抑制粘附和生物膜。 | |||
T19458 |
N-Hydroxypipecolic acid
1-Hydroxy-2-piperidinecarboxylic acid,NHP |
Others | Others |
N-Hydroxypipecolic acid (NHP) 是植物代谢产物和系统性获得性抗性调节剂,可与免疫信号水杨酸协调建立系统性获得性抗性,诱导系统获得性耐药对细菌和卵菌感染。它在植物叶片中系统地积累,以应对病原菌的侵袭。 | |||
TN2943 |
3-Hydroxy-6-methoxyflavone
|
Others | Others |
3-Hydroxy-6-methoxyflavone 可与抗生素联合用药来治疗 ESKAPE 病原体感染。 | |||
T6S0270 |
Ononin
Formononetin 7-O-β-D-glucopyranoside,Formononetin glucoside,Ononoside,芒柄花苷,Formononetin 7-O-glucoside |
Antibacterial | Microbiology/Virology |
Ononin (Formononetin 7-O-glucoside) 是一种能够抑制土壤中杂 Pluchea lanceolata 生长的异黄酮。 | |||
T21771 |
Pyoluteorin
|
Antibiotic | Microbiology/Virology |
Pyoluteorin 是一种抗生素 (antibiotic),可抑制 Oomycete fungi,包括植物病原体 Oomycete fungi,并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。 | |||
T13605 |
Cercosporin
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelength. Cercosporin contains the perylene quinone structural features necessary for PKC activity (I | |||
TN4579 |
Monomethylsulochrin
|
Antifection | Microbiology/Virology |
Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM. | |||
TN3450 |
Artanin
|
Antifection | Microbiology/Virology |
Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml. | |||
T75454 |
Penicitide A
|
Others | Others |
Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae 和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。 | |||
TN4748 |
Penduletin
|
VEGFR; COX; Prostaglandin Receptor; Antifection | Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Tyrosine Kinase/Adaptors |
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity. | |||
T83904 |
Polymyxin E2 sulfate
Colistin B sulfate |
Others | Others |
Polymyxin E2 是一种肽类抗生素,也是最初从B. polymyxa分离出的阳离子脂肽抗生素colistin的主要成分。该化合物对植物致病菌X. oryzae具有活性(EC50 = 0.21 µg/ml),并且在温室研究中,当以200 µg/ml的浓度应用时,能够预防和逆转水稻细菌性叶枯病。 | |||
T79757 |
Meliadubin B
|
NO Synthase | Immunology/Inflammation |
Meliadubin B是一种具有显著生物活性的天然三萜类化合物。它能有效抑制人中性粒细胞中超氧阴离子的产生,具有炎症抑制作用(EC50为5.54 μM)。同时,Meliadubin B也能抑制诱导型一氧化氮合酶的活性。此外,该化合物还能对抗水稻病原真菌Magnaporthe oryzae,显示出显着的抑制效果,其IC50为182.50 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03640 |
34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc)
34 kDa membrane antigen,Pathogen-specific membrane ... |
Treponema pallidum | E. coli |
This antigen is a pathogen-specific membrane immunogen. 34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.1 kDa and the accession number is P19478. | |||
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPK-01246 |
GDF-15 Protein, Mouse, Recombinant (His)
MIC1,Placental TGF-beta,Placental TGF-β,PTGF-beta,PTGFBPTGF-... |
Mouse | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... | |||
TMPH-03094 |
Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO)
Pollen allergen Phl p 5b,Allergen Phl p Vb |
Phleum pratense | E. coli |
Has ribonuclease activity. May be involved in host-pathogen interactions. Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.1 kDa and the accession number is Q40963. | |||
TMPH-02577 |
CHID1 Protein, Mouse, Recombinant (His & Myc)
Stabilin-1-interacting chitinase-like protein,CHID1,GL008,Ch... |
Mouse | HEK293 Cells |
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). | |||
TMPH-02363 |
TROSPA Protein, Ixodes scapularis, Recombinant (His)
Tick receptor for ospA,TROSPA |
Ixodes scapularis | Baculovirus Insect Cells |
Serves as a receptor for ospA protein of B.burgdorferi, the Lyme disease agent. Required for spirochetal colonization. Essential for pathogen adherence to the vector. TROSPA Protein, Ixodes scapularis, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 21.7 kDa and the accession number is Q5SDL7. | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
Serine-rich adhesin for platelets,Serine-rich repeat protein... |
Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
TMPH-01083 |
CHID1 Protein, Human, Recombinant (His)
GL008,SI-CLP,SB139,Chitinase domain-containing protein 1,Sta... |
Human | E. coli |
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). CHID1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9BWS9. | |||
TMPK-00255 |
CD209/DC-SIGN Protein, Human, Recombinant (His)
CD209,DC-SIGN,CLEC4L,CD209 molecule,DC-SIGN1,MGC129965,CDSIG... |
Human | HEK293 Cells |
C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens, including viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. Pathogens exploit CD209 family proteins to promote infection and evade the immune recognition system. | |||
TMPK-00632 |
MD2/LY96 Protein, Cynomolgus, Recombinant (His)
ESOP-1,LY96,Lymphocyte antigen 96,ESOP1,MD-2 |
Cynomolgus | E. coli |
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0. | |||
TMPY-05009 |
Asp f 1 Protein, Neosartorya fumigata, Recombinant (His)
|
Neosartorya fumigata | HEK293 Cells |
Asp f 1 (Aspergillus fumigatus allergen 1) is a major allergen produced by the mycelia of Aspergillus fumigatus. It is not present in spores and can be used as a specific marker for the detection of germination of this fungus. Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically complex allergic disorder caused by the fungal pathogen Aspergillus fumigatus. | |||
TMPH-01553 |
GBP2 Protein, Human, Recombinant (E. coli, His)
Interferon-induced guanylate-binding protein 2,GBP2,Guanylat... |
Human | E. coli |
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. GBP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.4 kDa and the accession number is P32456. | |||
TMPK-01242 |
MD2/LY96 Protein, Human, Recombinant (His)
MD-2,Ly-96,ESOP-1,Lymphocyte antigen 96,LY96,ESOP1 |
Human | E. coli |
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1. | |||
TMPH-01525 |
CMAHP Protein, Human, Recombinant (His & Myc)
CMAHP,Inactive cytidine monophosphate-N-acetylneuraminic aci... |
Human | E. coli |
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates. However, it may play a role in Wnt signaling. | |||
TMPY-06179 |
IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST)
|
Streptococcus pyogenes | E. coli |
IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST) is expressed in E. coli expression system with... | |||
TMPH-03158 |
PAD Protein, Porphyromonas gingivalis, Recombinant (His)
Peptidylarginine deiminase |
Porphyromonas gingivalis | E. coli |
Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth. PAD Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weig... | |||
TMPK-01244 |
GDF-15 Protein, Mouse, Recombinant (hFc)
PTGFBPTGF-beta,PTGFB,PLAB,NAG-1,Placental TGF-β,RG-1,GDF15,G... |
Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... | |||
TMPY-06023 |
IdeS Protein, Streptococcus pyogenes, Recombinant (His)
|
Streptococcus pyogenes | E. coli |
IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. IdeS Protein, Streptococcus pyogenes, Recombinant (His) is expressed in E. coli expression system with His t... | |||
TMPK-00665 |
GDF-15 Protein, Cynomolgus, Recombinant (His)
PTGFBPTGF-beta,PTGFBPTGF-β,MIC-1,NAG-1,MIC1,PTGF-beta,PTGF-β... |
Cynomolgus | E. coli |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... | |||
TMPK-00663 |
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
PTGF-β,GDF-15,NAG-1,PTGF-beta,PDF,PTGFBPTGF-beta,GDF15,Place... |
Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... | |||
TMPK-00026 |
IL-9 Protein, Mouse, Recombinant (hFc)
P40,IL-9,Interleukin-9,Cytokine P40,T-cell growth factor P40... |
Mouse | HEK293 Cells |
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Mouse, Re... | |||
TMPK-00025 |
IL-9 Protein, Human, Recombinant (hFc)
HP40,Cytokine P40,白细胞介素,Interleukin-9,白介素,P40,T-cell growth ... |
Human | HEK293 Cells |
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Human, Re... | |||
TMPK-01245 |
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
RG-1,GDF15,Placental TGF-beta,GDF-15,PTGFBPTGF-beta,NAG-1,PT... |
Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... | |||
TMPK-00197 |
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
Placental TGF-β,GDF15,RG-1,MIC-1,PTGFB,PTGF-beta,PDF,PTGF-β,... |
Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... | |||
TMPK-00568 |
IL-9 Protein, Cynomolgus, Recombinant (His)
P40,HP40,IL-9,T-cell growth factor P40,Interleukin-9,Cytokin... |
Cynomolgus | HEK293 Cells |
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Cynomolgu... | |||
TMPK-00664 |
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
Placental TGF-beta,PTGFBPTGF-β,PLAB,MIC-1,GDF15,NAG-1,RG-1,P... |
Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... | |||
TMPK-00198 |
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
MIC-1,PTGFBPTGF-β,GDF15,PTGF-β,GDF-15,PTGF-beta,Placental TG... |
Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... | |||
TMPJ-00216 |
IL-12B Protein, Human, Recombinant
Interleukin-12 subunit beta,IL-12B,CLMF p40,NKSF2,Interleuki... |
Human | HEK293 Cells |
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells develop... | |||
TMPJ-01283 |
UGRP1 Protein, Human, Recombinant
Uteroglobin-Related Protein 1,Secretoglobin Family 3A Member... |
Human | E. coli |
Uteroglobin-Related Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amino acid sequence similarity with uteroglobin. UGRP1 is expressed predominantly in the lung and low levels of expression are detected in the thyroid. Expression of UGRP1 in lung epithelial cells is enhanced by IL-10 and decreased through the activities of IL-9 and IL-5. UGRP1 inter... | |||
TMPJ-01330 |
CD299 Protein, Human, Recombinant (His & Flag)
DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami... |
Human | HEK293 Cells |
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso... | |||
TMPJ-00809 |
CFH Protein, Human, Recombinant (His)
CFH,Complement factor H |
Human | HEK293 Cells |
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessi... | |||
TMPJ-00136 |
MBL2 Protein, Human, Recombinant (His)
Collectin-1,Mannose-Binding Lectin,COLEC1,Mannan-Binding Pro... |
Human | HEK293 Cells |
Mannose-Binding Protein C (MBP-C) belongs to the Collectin family of innate immune defense proteins. MBL binds to an array of carbohydrate patterns on pathogen surfaces. Collectin family members share common structural features: a cysteine rich amino-terminal domain, a collagen-like region, an α-helical coiled-coil neck domain and a carboxy terminal C-type Lectin or carbohydrate recognition domain (CRD). MBL homotrimerizes to form a structural unit joined by N-terminal disulfide bridges. These h... | |||
TMPY-01406 |
REG3G Protein, Human, Recombinant (His)
UNQ429,PAP-1B,LPPM429,REG-III,regenerating islet-derived 3 γ... |
Human | HEK293 Cells |
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on the primary structures of the encoded proteins of the genes, which are associated with tissue repair and have been directly implicated ... | |||
TMPY-01816 |
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3,TSG-14 |
Human | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... | |||
TMPH-02671 |
Gasdermin-D Protein, Mouse, Recombinant (His & Myc)
Gasdermin-D,Gasdermin domain-containing protein 1,Gsdmd |
Mouse | E. coli |
Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis.; Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4/CASP11 in response to canon... | |||
TMPY-03465 |
Flagellin Protein, Listeria monocytogenes, Recombinant (His)
flaA |
Listeria monocytogenes | E. coli |
The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility for cells to get to the surface. In nature this bacterium is a saprophyte and contaminated produce is an avenue for infection. Previous studies have documented the ability of this organism to attach to and colonize plant tissue. Motility mutants were generated in three wild ... | |||
TMPH-02633 |
TRIM21 Protein, Mouse, Recombinant (His)
Tripartite motif-containing protein 21,E3 ubiquitin-protein ... |
Mouse | Baculovirus Insect Cells |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... | |||
TMPH-02632 |
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti... |
Mouse | E. coli |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... | |||
TMPH-02690 |
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi... |
Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |