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Search Results for " pancreatic carcinoma "

Targets Recommended: Raf

9

抑制剂 & 化合物

2

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9693	TBAP-001	Raf	MAPK
	TBAP-001是RAF 激酶的泛抑制剂，IC50为 62 nM。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
TQ0157	EIPA L593754,MH 12-43	Sodium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。
T28475	Pyrazoloacridine PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Pyrazoloacridine (PD 115934) 是一种核酸结合剂，在 K562 细胞中抑制 topo I 和 II 的活性，IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。
T36864	GRP (human) (trifluoroacetate salt)
	Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-depend...
T77117	Toripalimab
	Toripalimab 是一个国产抗肿瘤 PD-1抗体。Toripalimab 是一种靶向 PD-1的选择性人源化单克隆抗体。Toripalimab 能够与 PD-1结合并阻断与其配体相互作用。Toripalimab 具有强效抗肿瘤作用，可用于黑色素瘤、肺癌、消化道肿瘤、肝胆和胰腺肿瘤、神经内分泌肿瘤、鼻咽癌和尿路上皮癌等肿瘤的研究。
T36643	PKI-166 hydrochloride	Others	Others
	Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable. Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID:10850439 \|Ulu et al (2013) Epidermal ...
T36497	CAY10735 CAY10735	Others	Others
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...
T36460	CAY10736 CAY10736	Others	Others
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...

化合物

Cat.No: T9693

Target: Raf

Cat.No: T15017

Target: TLR

Cat.No: TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

Pyrazoloacridine

Cat.No: T28475

Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Target: Apoptosis, Topoisomerase

GRP (human) (trifluoroacetate salt)

Cat.No: T36864

Cat.No: T77117

PKI-166 hydrochloride

Cat.No: T36643

Target: Others

Cat.No: T36497

Synonym: CAY10735

Target: Others

Cat.No: T36460

Synonym: CAY10736

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类化合物，一种拓扑异构酶 II (Topo II) 抑制剂。Daunorubicin hydrochloride 可以抑制 DNA 和 RNA 的合成，具有抗肿瘤活性。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。

天然产物

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy, ADC Cytotoxin

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01108	SMAD4 Protein, Human, Recombinant (His) DPC4,SMAD 4,Deletion Target in Pancreatic Carci...	Human	E. coli
	SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumo...
TMPY-01897	PRSS3 Protein, Human, Recombinant (His) PRSS4,TRY4,TRY3,RP11-176F3.3,T9,MTG,protease, serine 3	Human	HEK293 Cells
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His) Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI...	Mouse	HEK293 Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser...
TMPJ-00796	Serpin E2 Protein, Human, Recombinant (His) PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser...	Human	HEK293 Cells
	Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha...

重组蛋白

SMAD4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01108

Species: Human

Expression System: E. coli

PRSS3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01897

Species: Human

Expression System: HEK293 Cells

Serpin E2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01083

Species: Mouse

Expression System: HEK293 Cells

Serpin E2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00796

Species: Human

Expression System: HEK293 Cells

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