首页工具

登录

搜索结果

Search Results for " overload "

Targets Recommended: Others Ferroptosis Antibacterial

12

抑制剂 & 化合物

6

天然产物

1

化合物库

2

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L9700	内质网应激化合物库		193 compounds
	193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

内质网应激化合物库

Cat.No: L9700

Compounds: 193

Cat. No.	Product Name	Target	Signaling Pathways
T1457	Deferasirox ICL 670,CGP-72670,地拉罗司	Others; Ferroptosis; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Deferasirox (CGP-72670) 是一种口服铁螯合剂，用于治疗慢性铁过载。
T19692	Deferitrin GT 56252,GT 56 252,地夫立群,GT-56252,GT-56-252	Others	Others
	Deferitrin (GT-56-252) 是一种具有口服活性的三叉戟铁螯合剂，是去铁硫素 (DFT) 类似物。它有用于严重的 β 地中海贫血的潜力。它用于输血引起的慢性铁超负荷。
T8891	Homo-VK-II-36 Homo-V-II-36	Others	Others
	Homo-VK-II-36 (Homo-V-II-36) 是一种卡维地洛类似物，其作用是通过 RyR2 通道抑制储存超载诱导的钙释放。
T32046	HBED CHELII,CHEL II,CHEL-II	Others	Others
	HBED (CHELII) 是一种铁螯合剂，可用于治疗慢性铁过载和急性铁中毒的研究。
T10874	CP-060	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CP-060 是一种 Ca2+ 拮抗剂，能够抑制 Ca2+ 过载，具有抗氧化、保护心脏的作用。
T13639	Deferasirox (Fe3+ chelate)	Apoptosis	Apoptosis
	Deferasirox (Fe3+ chelate) 是一种可口服的铁螯合剂，具有潜在的抗癌活性，抑制 MCL-1 的抗凋亡活性，可用于研究铁超负荷。
T85022	CN128 R-CN128	Others	Others
	CN128, an orally bioavailable iron chelator, features a side chain hydroxy group serving as an alternate sacrificial glucuronidation site to mitigate metabolic inactivation at the 3-hydroxy group. When administered at doses of 150 and 450 µmol/kg, CN128 enhances iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload.
T31363	Deferitazole magnesium FBS0701,FBS-0701,SSP-004184,SHP-602,SHP602,Deferitazole free base	Others	Others
	Deferitazole magnesium is a potential chelator for iron overload treatment.
T68284	NP-04634	Others	Others
	NP-04634 is a calcium antagonist and protective agent against calcium overload and mitochondrial disruption.
T40694	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid	Others	Others
	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid exhibits hypoglycemic activity and operates through a mechanism dependent on the response to oral glucose overload.
T64249	CYP11B1-IN-2	Others	Others
	CYP11B1-IN-2 (compound 7aa) 是一种选择性的、口服具有活力的 CYP11B1 抑制剂，能够作用于 human CYP11B1 (IC50: 9 nM) 和 rat CYP11B1 (IC50: 25 nM)。CYP11B1-IN-2 能够用于研究皮质醇过量所致疾病。
T84718	Folic acid disodium Vitamin B9 disodium,Vitamin M disodium	Others	Others
	Folic acid disodium，Folic acid的口服活性钠盐形式，具有固有溶出速率（IDR）为4.96·105g/s。它作为单碳转移反应中的辅助因子，有助于防治神经管缺陷、缺血和癌症。Folic acid disodium的过量可能会损害胚胎大脑发展并促进癌前细胞变化的增长；而其缺乏则可能导致巨幼细胞性贫血。

化合物

Cat.No: T1457

Synonym: ICL 670,CGP-72670,地拉罗司

Target: Others, Ferroptosis, Antibacterial

Cat.No: T19692

Synonym: GT 56252,GT 56 252,地夫立群,GT-56252,GT-56-252

Target: Others

Cat.No: T8891

Synonym: Homo-V-II-36

Target: Others

Cat.No: T32046

Synonym: CHELII,CHEL II,CHEL-II

Target: Others

Cat.No: T10874

Target: Calcium Channel

Deferasirox (Fe3+ chelate)

Cat.No: T13639

Target: Apoptosis

Cat.No: T85022

Synonym: R-CN128

Target: Others

Deferitazole magnesium

Cat.No: T31363

Synonym: FBS0701,FBS-0701,SSP-004184,SHP-602,SHP602,Deferitazole free base

Target: Others

Cat.No: T68284

Target: Others

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

Cat.No: T40694

Target: Others

Cat.No: T64249

Target: Others

Folic acid disodium

Cat.No: T84718

Synonym: Vitamin B9 disodium,Vitamin M disodium

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TWP2911	Thymidine beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Thymidine (DThyd) 是一种细胞同步剂，是脱氧核糖核酸的特殊前体。它可在 DNA 复制前在 G1/S 边界阻滞细胞，是DNA 合成抑制因子。
T20819	Ammonium iron(III) citrate 柠檬酸铁铵,柠檬酸铁 (III) 铵,Ferric ammonium citrate	Others; Ferroptosis	Apoptosis; Others
	Ammonium iron(III) citrate (Ferric ammonium citrate) 是一种非运铁蛋白结合的铁的生理形式，会引起的细胞内铁超负荷从而导致细胞铁死亡，能增强蛋白质产生。
TN2082	Pinostrobin	Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Pinostrobin 是一种 PCSK9抑制剂，可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物，并具有抗氧化，抗炎，抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
TN5073	Strophanthidin 毒毛旋花子甙元,Strophanthidine,葡萄球菌素	ATPase; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇，可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性，1到100 μ mol/L 抑制Na+/K+-ATPase 活性，10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。
T3415	Secoisolariciresinol diglucoside 亚麻木酚素,LGM2605	ROS	Immunology/Inflammation
	Secoisolariciresinol diglucoside (LGM2605) 在铁过载诱导的氧化还原炎症损伤的体外模型中具有细胞保护作用。 Secoisolariciresinol Diglucoside(25 mg/kg b.w.) 通过抑制 ROS 水平介导的酶和非酶抗氧化剂水平升高来防止肝脏受到过氧化损伤，从而发挥抗高血糖作用。
TN1086	Dehydrotrametenolic acid Dehydroeburicoic acid,去氢齿孔酸,松苓新酸	Apoptosis; TNF; NOS; Caspase; NO Synthase	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Dehydrotrametenolic acid (Dehydroeburicoic acid) 是从茯苓的菌核中分离的一种甾醇，具有抗肿瘤活性、抗炎和抗糖尿病作用。它通过 caspase-3途径诱导细胞凋亡。

天然产物

Cat.No: TWP2911

Synonym: beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Ammonium iron(III) citrate

Cat.No: T20819

Synonym: 柠檬酸铁铵,柠檬酸铁 (III) 铵,Ferric ammonium citrate

Target: Others, Ferroptosis

Cat.No: TN2082

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Cat.No: TN5073

Synonym: 毒毛旋花子甙元,Strophanthidine,葡萄球菌素

Target: ATPase, Calcium Channel

Secoisolariciresinol diglucoside

Cat.No: T3415

Synonym: 亚麻木酚素,LGM2605

Target: ROS

Dehydrotrametenolic acid

Cat.No: TN1086

Synonym: Dehydroeburicoic acid,去氢齿孔酸,松苓新酸

Target: Apoptosis, TNF, NOS, Caspase, NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His) RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST) Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.

重组蛋白

AKT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

Cat.No: TMPK-01170

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0342	Aniline-d5
	Aniline-d5 是 Aniline 的氘代化合物。Aniline 的 CAS 号为 62-53-3。Aniline 通过铁过载和通过血红素加氧酶 1 上调诱导氧化应激对脾脏产生毒性。它会导致 p-IKKα 和 p-IKKβ 显着增加，进而增加 NF-κB 和 AP-1 结合活性。

同位素标记化合物

Cat.No: TMIJ-0342

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼