38
29
27
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13324 |
VUF11207 fumarate
|
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T6739 |
Zoledronic Acid
CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa |
Apoptosis; Rho; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint |
Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐,能抑制破骨细胞的分化和凋亡,具有高效的抗骨质再吸收活性,也有抗癌作用。 | |||
T21299 |
Zoledronic acid monohydrate
唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate |
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐,具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡,有抗癌作用。 | |||
T16159 |
Muramyl dipeptide
MDP |
NOD | Immunology/Inflammation; NF-κB |
Muramyl dipeptide (MDP) 是合成的免疫反应肽,由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达,直接促进成骨细胞分化,通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子,也是NLRP1激动剂。 | |||
T1925 |
PLX647
|
c-Fms; c-Kit | Tyrosine Kinase/Adaptors |
PLX647 是具有口服活性的、高效的、特异性的FMS 和KIT 双激酶抑制剂,IC50分别为 28 和 16 nM。它 (1 μM) 在 400 个激酶组中显示出对 FMS 和 KIT 有选择性,但 FLT3 和 KDR 除外 (IC50=91 和 130 nM)。 | |||
T61531 |
NFATc1-IN-1
|
RANKL/RANK | NF-κB |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1]. | |||
T9823 |
WAY-325398
|
Others | Others |
WAY-325398是一种呋喃衍生物。WAY-325398抑制破骨细胞形成,10μM 时抑制率为14.11%。 | |||
T13159 |
Tiludronate disodium
Tiludronic Acid disodium,Tiludronic acid disodium |
ATPase | Membrane transporter/Ion channel |
Tiludronate disodium (Tiludronic acid disodium) 是一种破骨细胞液泡 H(+)-ATPase 抑制剂,具有抗骨吸收和抗炎特性。 Tiludronate disodium 可用于有关代谢性骨病的研究。 | |||
T0379 |
Risedronic Acid
Risedronate,利塞膦酸 |
Others; Transferase | Metabolism; Others |
Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。 | |||
T9917 |
Denosumab
|
RANKL/RANK | NF-κB |
Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性,可降髋部、低椎骨以及非椎骨骨折的风险。 | |||
T77567 |
BCPA
|
Others | Others |
BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化,减弱 Pin1 蛋白的减少,从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。 | |||
T27371 |
FR-167356
FR167356,FR 167356 |
ATPase | Membrane transporter/Ion channel |
FR-167356 是 a3 异构体液泡型 H+-ATPase 的特异性抑制剂,对破骨细胞质膜、肾刷状缘膜和巨噬细胞微粒体的 IC50 分别为 170 nM、370 nM 和 220 nM。 FR-167356 减少 B16-F10 细胞的骨转移。 | |||
T2188 |
Thonzonium Bromide
嘧苯十六铵,通佐溴胺 |
Proton pump; Antibacterial; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Thonzonium bromide 是一种单阳离子表面活性剂,在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收,并在体内阻止 LPS 诱导的骨丢失。 | |||
T69656 |
E197
|
Others | Others |
E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone. | |||
T29109 |
VPC12249
VPC-12249,VPC 12249 |
Others | Others |
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity. | |||
T30089 |
AP-22161
AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161 |
Others | Others |
AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast absorption. | |||
T26514 |
ABD56
ABD-56,ABD 56 |
Others | Others |
ABD56 inhibits osteoclast formation and activity in vitro and in vivo. | |||
T26512 |
ABD-295
|
Others | Others |
ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo. | |||
T83032 |
Anti-osteoporosis agent-7
|
Others | Others |
Anti-osteoporosis agent-7 (Compound 133) 作为一种潜在的抗骨质疏松剂,对破骨细胞的形成展示了高度的抑制效果。 | |||
T40328 |
Betulinic acid derivative-1
|
Others | Others |
Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM. | |||
T61764 |
Zoledronic acid disodium tetrahydrate
|
Others | Others |
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while also demonstrating anti-cancer properties [1]. | |||
T82359 |
G-{d-Arg}-GDSP
|
||
G-{d-Arg}-GDSP为RGD多肽类似物,具有与整合素粘附受体结合的能力,能够抑制细胞对纤维连接蛋白的附着及破骨细胞的重吸收。 | |||
T39037 |
Tiludronate disodium hemihydrate
Tiludronic acid disodium hemihydrate,替鲁膦酸二钠半水合物 |
Others | Others |
Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4]. | |||
T72008 |
E09241
|
Others | Others |
E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling. | |||
T79472 |
CSF1R-IN-17
|
c-Fms | Tyrosine Kinase/Adaptors |
CSF1R-IN-17(compound 9)是一种选择性高的CSF1R拮抗剂,表现出0.2 nM的低IC50值,并能有效抑制破骨细胞的分化。 | |||
T73056 |
Tiludronate
Tiludronic acid |
Others | Others |
Tiludronate (Tiludronic Acid) 是一种口服活性双膦酸盐,可以起到骨调节作用。Tiludronate 用于代谢性骨疾病的研究。Tiludronate 是破骨细胞空泡 H(+)-ATP 酶的有效抑制剂。 | |||
T84510 |
17β-Hydroxywortmannin
Wortmannin-17β-ol |
Others | Others |
17β-Hydroxywortmannin是一种口服活性的PI-3-kinase激酶抑制剂,其IC50值为0.5 nM,能够以IC50为10 nM抑制破骨细胞吸收,同时具备抗肿瘤活性。 | |||
T38128 |
Leukotriene D4
LTD4 |
Endogenous Metabolite; Drug Metabolite | Metabolism |
Leukotriene D4 (LTD4) 是一种由花生四烯酸形成的强效促炎介质,是一种支气管收缩剂,可诱导成骨细胞衰老。Leukotriene D4 诱导潜在致癌基因的转录活性,可用于研究哮喘。 | |||
T78208 |
Leramistat
HMC-C-01-A,MBS2320 |
Mitochondrial Metabolism | Metabolism |
Leramistat (HMC-C-01-A; MBS2320)为线粒体复合物1抑制剂,关与调控细胞代谢及免疫代谢。该化合物被用于抑制诸如特应性皮炎的皮肤病、自身免疫性与炎症性疾病和癌症,以及破骨细胞介导的疾病。 | |||
T78037 |
Hepcidin-1 (mouse) TFA
|
||
Hepcidin-1 (mouse) TFA是调控铁代谢平衡的肽类激素。该化合物通过提高TRAP、组织蛋白酶K及MMP-9的mRNA水平并促进TRAP-5b蛋白的分泌,同时降低FPN1蛋白表达,导致细胞内铁含量上升。此外,Hepcidin-1 (mouse) TFA还有助于破骨细胞的分化。 | |||
T81171 |
SH491
|
Others | Others |
SH491(Compound 33)是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞(BMM)分化为破骨细胞(IC50: 11.8 nM)。同时,SH491降低了破骨细胞形成的相关标记基因(TRAP、CTSK、MMP-9和ATPase v0d2)以及相应蛋白(TRAP、CTSK、MMP-9)的表达。 | |||
T76786 | Cabiralizumab | ||
Cabiralizumab (FPA 008) 是一种抗 CSF1R 单克隆抗体 (MAb)。Cabiralizumab 可增强 T 细胞浸润和抗肿瘤 T 细胞免疫反应。Cabiralizumab 抑制破骨细胞的活化并阻止骨质破坏,可用于类风湿性关节炎 (RA) 的研究。Cabiralizumab 可与 Nivolumab 结合用于肺癌研究。 | |||
T37409 |
DPC-AJ1951 (trifluoroacetate salt)
DPC-AJ1951 (trifluoroacetate salt) |
Others | Others |
DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants... | |||
T78816 |
Anti-osteoporosis agent-4
|
NF-κB | NF-κB |
Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化,减弱RANKL诱导的破骨细胞生成,并展示出强抑制作用,具有 IC50 值为358.29 nM。此外,该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活,表明其在防治骨质疏松症中的潜在应用价值。 | |||
T80108 |
Hepcidin-1 (mouse)
|
||
Hepcidin-1 (mouse) 是调控铁平衡的内源性多肽激素,通过上调TRAP、组织蛋白酶K和MMP-9的mRNA水平及增强TRAP-5b蛋白的分泌作用。此外,Hepcidin-1 (mouse) 降低FPN1蛋白水平并提升细胞内铁含量,且促进破骨细胞的分化。 | |||
T73885 |
Methyl gerfelin
|
Others | Others |
Methyl gerfelin通过与三种关键细胞蛋白乙二醛酶 1 (GLO1)、固醇结合蛋白 2 (SCP2) 和富含谷氨酰胺的四肽重复蛋白 A (SGTA) 结合,抑制破骨细胞的分化。研究表明,Methyl gerfelin是一种与类黄酮相关的强效GLO1抑制剂。 | |||
T40463 |
Relacatib
SB-462795 |
Others | Others |
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ... | |||
T83848 |
VnP-16 TFA
|
||
VnP-16是一种合成肽段,对应vitronectin的氨基酸270-281,vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时,能促进人类成骨细胞的附着和扩散,此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内,VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3816 |
Velutin
|
NF-κB; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; NF-κB |
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
TN5888 |
Toddaculin
|
Others | Others |
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。 | |||
TN2347 |
Methylsticin
麻醉椒苦素,Methysticin |
Others | Others |
Methylsticin (Methysticin) 是一种卡瓦内酯,从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。 | |||
TN1149 |
6''-O-acetylsaikosaponin A
|
Others | Others |
6''-O-Acetylsaikosaponin A 是一种分离自柴胡根中的乙酰柴胡皂苷,表现出一定的破骨细胞抑制活性。 | |||
T2731 |
Usnic Acid
Usniacin,松萝酸,地衣酸 |
Antibacterial; Autophagy | Autophagy; Microbiology/Virology |
Usnic Acid (Usniacin) 是地衣次生代谢产物,具有独特的二苯并呋喃骨架。它是一种抗菌剂、抗肿瘤剂和酶抑制剂。 | |||
T3384 |
Wedelolactone
蟛蜞菊内酯,IKK Inhibitor II |
Apoptosis; NF-κB; Lipoxygenase; Caspase | Apoptosis; Metabolism; NF-κB; Proteases/Proteasome |
Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物,通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录,具有抗癌,抗炎和抗氧化活性。 | |||
T3488 |
Tectorigenin
4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素 |
Apoptosis | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
TN1606 |
(-)-Epiafzelechin
|
Antioxidant; COX | Immunology/Inflammation; Neuroscience; oxidation-reduction |
(-)-Epiafzelechin 是一种 COX 抑制剂,具有抗氧和抗炎活性,在成熟卵巢切除小鼠模型中的骨保护作用,刺激成骨细胞活性和抑制破骨细胞活性的能力,可用于研究类风湿性关节炎。 | |||
TN2143 |
3,7,4'-Trihydroxyflavone
Resokaempferol,5-Deoxykampferol |
DNA | DNA Damage/DNA Repair |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物,可抑制 NF-κB 配体 (RANKL) 受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。 | |||
T6S2099 |
Geraniin
|
Antioxidant; TNF | Apoptosis; oxidation-reduction |
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。 | |||
T6677 |
Sophocarpine
|
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
TN4785 |
Picrasidine I
|
NF-κB; ROS; MAPK | Immunology/Inflammation; MAPK; NF-κB |
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors. | |||
T16846 |
Sauristolactam
Saurolactam |
Others | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi | |||
T83033 |
Anti-osteoporosis agent-2
|
||
Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂,能抑制RANKL诱导的破骨细胞分化。 | |||
TMA1743 |
Ergosterol peroxide
|
ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to | |||
T71479 |
Kahweol oleate
|
Others | Others |
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T27711 |
Kahweol Eicosanate
J002075,J 002075,J-002075 |
Others | Others |
Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast | |||
T71478 |
Kahweol stearate
|
Others | Others |
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T68641 |
Kahweol Acetate
|
Others | Others |
Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
TN3802 |
Dehydrodiconiferyl alcohol
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Dehydrodiconiferyl alcohol (DHCA) 是一种从葫芦中分离出来的木脂素,通过作为雌激素受体激动剂抑制破骨细胞分化和卵巢切除术诱导的骨质流失。 | |||
T68642 |
Kahweol palmitate
|
Others | Others |
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
T79932 |
Eudebeiolide B
Plebeiolide D |
NF-κB | NF-κB |
Eudebeiolide B,一种自荔枝草分离得的化合物,能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成,适用于研究与破骨细胞相关的疾病。 | |||
T71480 |
Kahweol linoleate
|
Others | Others |
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
TN2533 |
1-Hydroxy-2,3,4,7-tetramethoxyxanthone
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel | |||
TN1663 |
Ganoderic acid DM
灵芝酸DM,灵芝酸 DM |
PARP; Androgen Receptor; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr | |||
TN4094 |
Gallocatechin gallate
|
IL Receptor; NF-κB; ROS; MAPK; PPAR; Fatty Acid Synthase | DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabetic effects by increasing sensitivity | |||
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone
|
IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear factor kappa-B ligand,Receptor... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPJ-00607 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Receptor activator of nuclear factor κ-B ligand,Osteoprotege... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1. | |||
TMPJ-01252 |
CLEC2D Protein, Mouse, Recombinant (His)
Clec2d,Clr-b,Clrb,Ocil,Osteoclast inhibitory lectin... |
Mouse | HEK293 Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tu... | |||
TMPH-02264 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)
Tumor necrosis factor ligand superfamily member 11,Osteoprot... |
Human | HEK293 Cells |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPJ-00674 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Receptor activator of NF-KB,TNFRSF11A,Osteoclast di... |
Mouse | HEK293 Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br... | |||
TMPH-02960 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His & SUMO)
Tnfsf11,Receptor activator of nuclear factor kappa-B ligand,... |
Mouse | E. coli |
TNFSF11 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.9 kDa and the accession number is O35235. | |||
TMPJ-01472 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
Osteoclast differentiation factor,Receptor activato... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1. | |||
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPJ-01218 |
M-CSF/CSF1 Protein, Rat, Recombinant
CSF1,集落刺激因子,CSF-1,Macrophage colony-stimulating factor 1,M-C... |
Rat | HEK293 Cells |
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. MCSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It is involved in the regu... | |||
TMPY-02575 |
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr... |
Human | Baculovirus Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli... | |||
TMPJ-00327 |
M-CSF/CSF1 Protein, Human, Recombinant (His)
Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St... |
Human | HEK293 Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio... | |||
TMPJ-00349 |
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O... |
Human | HEK293 Cells |
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive... | |||
TMPH-02629 |
ADAM12 Protein, Mouse, Recombinant (His & Myc)
Disintegrin and metalloproteinase domain-containing protein ... |
Mouse | Baculovirus Insect Cells |
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. ADAM12 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.4 kDa and the accession number is Q61824. | |||
TMPH-03259 |
Carbonic Anhydrase 2 Protein, Rat, Recombinant (His)
CA-II,Carbonate dehydratase II,Carbonic anhydrase II,Cyanami... |
Rat | E. coli |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.7 kDa and the accession number is P27139. | |||
TMPK-00657 |
SPARC Protein, Cynomolgus, Recombinant (His)
BM-40,EGM_15571,SPARC,ON |
Cynomolgus | HEK293 Cells |
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues.The capacity of SPARC to influence pathways involved in extracellular matrix assembly such as procollagen processing and collagen fibril formation as well as the capacity to influence osteoblast differentiation and osteoclast activity will be addressed. | |||
TMPK-00323 |
M-CSF/CSF1 Protein, Human, Recombinant (His & Avi)
CSF-1,Lanimostim,M-CSF,MCSF,MGC31930,CSF1,集落刺激因子 |
Human | HEK293 Cells |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. M-CSF/CSF1 Protein, Human, Recombinant (... | |||
TMPK-01117 |
OSCAR Protein, Mouse, Recombinant (hFc)
PIgR-3,Poly-Ig receptor 3,OSCAR,MGC33613,mOSCAR,PIGR3 |
Mouse | HEK293 Cells |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... | |||
TMPK-00324 |
M-CSF/CSF1 Protein, Human, Recombinant (His & Avi), Biotinylated
CSF-1,M-CSF,MGC31930,MCSF,CSF1,Lanimostim,集落刺激因子 |
Human | HEK293 Cells |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. M-CSF/CSF1 Protein, Human, Recombinant (... | |||
TMPJ-00799 |
ANXA2 Protein, Human, Recombinant
ANXA2,Calpactin I Heavy Chain,ANX2,p36,LPC2D,PAP-IV,ANX2L4,C... |
Human | E. coli |
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell... | |||
TMPK-01092 |
OSCAR Protein, Human, Recombinant (hFc)
Poly-Ig receptor 3,PIGR3,OSCAR,PIgR-3,MGC33613,mOSCAR |
Human | HEK293 Cells |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... | |||
TMPY-00176 |
FNDC4 Protein, Human, Recombinant (mFc)
fibronectin type III domain containing 4,FRCP1 |
Human | HEK293 Cells |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, trea... | |||
TMPH-02659 |
FPR2 Protein, Mouse, Recombinant (GST & His & Myc)
Fpr2,Formyl peptide receptor 2,Formylpeptide receptor-relate... |
Mouse | E. coli |
High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors. Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. FPR2 Protein, Mouse,... | |||
TMPH-03267 |
CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f... |
Rat | E. coli |
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ... | |||
TMPJ-00225 |
Siglec-15 Protein, Mouse, Recombinant (His)
Siglec-15,Sialic acid-binding Ig-like lectin 15,CD33L3,CD33 ... |
Mouse | HEK293 Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPJ-01419 |
CSF1R Protein, Cynomolgus, Recombinant (His)
CSF-1-R,CSF-1 receptor,Proto-oncogene c-Fms,M-CSF-R,Macropha... |
Cynomolgus | HEK293 Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ... | |||
TMPJ-01418 |
CSF1R Protein, Cynomolgus, Recombinant (hFc)
M-CSF-R,CSF1R,CSF-1-R,CSF-1 receptor,CSF-1R,Macrophage colon... |
Cynomolgus | HEK293 Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ... | |||
TMPY-00975 |
FSTL3 Protein, Mouse, Recombinant (His)
E030038F23Rik,Flrg,follistatin-like 3 (secreted glycoprotein... |
Mouse | HEK293 Cells |
Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall structure and activity profile similar to that of FST, including binding and neutralization of activin. FLRG/Fstl3 is expressed in a wide range of adult tissues, not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation. Isoform 1 or t... |