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Search Results for " non-classical "

Targets Recommended: PD-1/PD-L1

8

抑制剂 & 化合物

1

天然产物

2

化合物库

8

重组蛋白

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Cat. No.	Product Name
L8720	细胞焦亡化合物库		1066 compounds
	1066 种细胞焦亡相关的化合物，可以用于细胞焦亡相关研究。
L6710	中药抗炎分子库		1246 compounds
	1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合，是药物开发、药理研究的有效工具；

化合物库

细胞焦亡化合物库

Cat.No: L8720

Compounds: 1066

中药抗炎分子库

Cat.No: L6710

Compounds: 1246

Cat. No.	Product Name	Target	Signaling Pathways
T35394	Sintilimab (anti-PD-1) IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体，具有显著的抗肿瘤活性，通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T15694	L-Homopropargylglycine	Others	Others
	L-Homopropargylglycine 是一种蛋氨酸类似物，常用于生物正交非经典氨基酸标记中来检测细菌活性和检测蛋白合成。
TP1565L1	Foxy-5 Ammonium Salt Foxy-5 Ammonium Salt（881188-51-8 Free base)	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Foxy-5 Ammonium Salt是 WNT5A 激动剂，是 WNT5A 的一个模拟肽，是 Wnt 家族的非经典成员。Foxy-5 Ammonium Salt可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导，并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 Ammonium Salt在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。
T68070	Fezolamine	Norepinephrine	Neuroscience
	Fezolamine 是一种新型可口服的非三环类化合物，具有抗抑郁活性。它在体外阻断[3H]去甲肾上腺素的突触体摄取方面的选择性是摄取[4H]3-羟色胺或[3H]多巴胺的3至2倍。在使用单胺耗尽动物的经典行为测试中，它阻止了利血平和四苯的抑制作用。
T26611	AM7499 AM 7499,AM-7499	Others	Others
	AM7499 is a non-selective cannabinoid receptor agonist with remarkably high in vitro and in vivo potency. It is readily hydrolysed by plasma esterases and to be less prone to deposition in bodily fat than existing classical cannabinoid agonists.
T76709	Zimberelimab
	Zimberelimab 是一种全人源IgG4抗PD-1单克隆抗体，具有很高的亲和力和选择性。 Zimberelimab 具有抗肿瘤活性，可用于各种癌症研究，包括宫颈癌、非小细胞肺癌和霍奇金淋巴瘤。
T84543	Arachidoyl Ethanolamide N-Arachidoylethanolamine	Others	Others
	Arachidoyl ethanolamide, a saturated fatty acyl ethanolamide lacking classical (CB1/CB2) activity, plays a role in a complex system comprising central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology. This system has paved the way for extensive research in diverse fields such as memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation. Unlike other compounds, Arachidoyl ethanolamide does not bind to the murine ...
T81423	Polzastobart JTX 8064
	Polzastobart (JTX-8064) 为一种人源化IgG4单克隆抗体，特异性与LILRB2结合，阻断其与配体及MHC I分子（经典与非经典）的相互作用。此抗体通过抑制LILRB2与HLA-A/B和/或HLA-G（癌细胞免疫耐受的标志）的结合，可增强巨噬细胞产生促炎细胞因子。Polzastobart 作为巨噬细胞免疫检查点抑制剂发挥作用。

化合物

Sintilimab (anti-PD-1)

Cat.No: T35394

Synonym: IBI308,Sintilimab (anti-PD-1)

Target: PD-1/PD-L1

L-Homopropargylglycine

Cat.No: T15694

Target: Others

Foxy-5 Ammonium Salt

Cat.No: TP1565L1

Synonym: Foxy-5 Ammonium Salt（881188-51-8 Free base)

Target: Wnt/beta-catenin

Cat.No: T68070

Target: Norepinephrine

Cat.No: T26611

Synonym: AM 7499,AM-7499

Target: Others

Cat.No: T76709

Arachidoyl Ethanolamide

Cat.No: T84543

Synonym: N-Arachidoylethanolamine

Target: Others

Cat.No: T81423

Synonym: JTX 8064

Cat. No.	Product Name	Target	Signaling Pathways
T37709	2,2,2-Trichloroethanol	Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。

天然产物

2,2,2-Trichloroethanol

Cat.No: T37709

Target: Potassium Channel, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01103	LILRA3/CD85e Protein, Human, Recombinant (His & Avi) HM43,LIR-4HM43e3,HM31,ILT-6,LIR4,CD85e,LILRA3,ILT6	Human	HEK293 Cells
	Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds b...
TMPJ-00538	LILRA3/CD85e Protein, Human, Recombinant (His & Avi), Biotinylated Leukocyte immunoglobulin-like receptor subfamily A member 3,...	Human	HEK293 Cells
	Leukocyte immunoglobulin-like receptor subfamily A member 3 is also known as CD85 antigen-like family member E, Immunoglobulin-like transcript 6, ILT-6, Leukocyte immunoglobulin-like receptor 4, LIR-4 and Monocyte inhibitory receptor HM43/HM31. In humans, it is encoded by the LILRA3 gene. It acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2.It is detected in B-cells, natural kil...
TMPJ-00022	LGALS7 Protein, Human, Recombinant Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p53-Induced Gene 1 ...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ...
TMPJ-00063	CD160 Protein, Human, Recombinant (hFc) CD160 Antigen,CD160,BY55,Natural Killer Cell Receptor BY55	Human	HEK293 Cells
	CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain. It is weakly homologous to KIR2DL4. CD160 is expressed in the spleen, peripheral blood, and small intestine. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD16...
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His) C3 and PZP-like alpha-2-macroglobulin domain-containing prot...	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
TMPJ-00654	LGALS8 Protein, Human, Recombinant Prostate Carcinoma Tumor Antigen 1,Po66-CBP,Galectin-8,PCTA-...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be...
TMPJ-00563	LGALS3 Protein, Human, Recombinant (His) Galactose-Specific Lectin 3,LGALS3,35 kDa Lectin,Gal-3,MAC2,...	Human	HEK293 Cells
	Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papillary carcinoma, and lowly during tumor progression. LGALS3 is probably forms homo- or heterodimers and secreted by a non-classical secretory pathway and associates with the cell surface. LGALS3 plays an important role during the acquisition of vasculogenic mimicry and angiogenic...
TMPH-01524	KPNA1 Protein, Human, Recombinant (His) Nucleoprotein interactor 1,SRP1-beta,Karyopherin subunit alp...	Human	E. coli
	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta ...

重组蛋白

LILRA3/CD85e Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01103

Species: Human

Expression System: HEK293 Cells

LILRA3/CD85e Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00538

Species: Human

Expression System: HEK293 Cells

LGALS7 Protein, Human, Recombinant

Cat.No: TMPJ-00022

Species: Human

Expression System: E. coli

CD160 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00063

Species: Human

Expression System: HEK293 Cells

Complement C4-B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02605

Species: Mouse

Expression System: E. coli

LGALS8 Protein, Human, Recombinant

Cat.No: TMPJ-00654

Species: Human

Expression System: E. coli

LGALS3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00563

Species: Human

Expression System: HEK293 Cells

KPNA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01524

Species: Human

Expression System: E. coli

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