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Search Results for " neurotoxin "

Targets Recommended: Others

45

抑制剂 & 化合物

10

天然产物

12

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13664	DSP-4 hydrochloride Neurotoxin DSP 4 (hydrochloride)	Others	Others
	DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) 是一种高选择性的神经毒素，主要是来自蓝斑 (LC) 的神经元，容易通过血脑屏障。它对成年和发育中大鼠去甲肾上腺素能神经元具有神经毒性作用，可用于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。
T12214	Neurotoxin Inhibitor	Others	Others
	Neurotoxin Inhibitor is an inhibitor of neurotoxin.
T4081	MPTP hydrochloride MPTP-hydrochloride	Apoptosis; Dopamine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	MPTP hydrochloride 是 MPP+ 的前体，是一种多巴胺神经毒素，具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒，可以导致帕金森症，被广泛应用于帕金森动物模型的构建。
T27794	λ-Cyhalothrin lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon	Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂，含有 α-氰基，用于防治多种害虫。它是一种钠通道神经毒素，靶向中枢神经系统中神经元膜。
T9354	2,4-Difluorobenzaldehyde 2,4-Difluoro-benzaldehyde,2,4-二氟苯甲醛	Others	Others
	2,4-Difluorobenzaldehyde 靶点-A 型肉毒杆菌神经毒素（肉毒杆菌）。
T28655	Sabeluzole R 58735,R58735,R-58735	Microtubule Associated	Cytoskeletal Signaling
	Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用，抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用，可用于研究阿尔茨海默症。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种神经毒素 MPTP 的有毒代谢物，也是一种 5-羟色胺转运体 (SERT) 的高亲和力底物。MPP+ iodide 对多巴胺能神经元有毒，可以在动物模型中导致帕金森症。
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T14763	BoNT-IN-1	Others	Others
	BoNT-IN-1 is a potent Botulinum neurotoxin A light chain (BoNTA LC) inhibitor(IC50 : 0.9 uM).
T26937	C562-1101	Others	Others
	C562-1101 is a novel potent botulinum neurotoxin serotype E (BoNT/E) inhibitor.
T34794	Tecoram	Others	Others
	Tecoram is a dithiocarbamate and a possible neurotoxin.
T33346	Methylaminoalanine-nickel(II) L-Bmma-nickel(II),L-Medap-nickel(II)	Others	Others
	Methylaminoalanine-nickel(II) can be regarded as a naturally occurring neurotoxin.
T13819	Pi-Methylimidazoleacetic acid hydrochloride	Others	Others
	Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.
T33644	Nephilatoxin 7 NPTX 7,NPTX7,NPTX-7	Others	Others
	Nephilatoxin 7 is a neurotoxin of the Joro spider (Nephila clavata).
T25890	NSC-84096 CID 256758,CID-256758,CID256758	Others	Others
	NSC-84096 is an endopeptidase activity inhibitor of botulinum neurotoxin type A light chain (rBoNT/A-LC).
T32850	Lolitrem A	Others	Others
	Lolitrem A is a neurotoxin from staggers-producing ryegrass pastures.
T69377	BoNT-IN-33	Others	Others
	BoNT-IN-33 is a potent inhibitor of Botulinum neurotoxin/A light chain (BoNT/A LC).
TP2064	ω-Conotoxin MVIIC
	Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
T26961	CBIP	Others	Others
	CBIP is a small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC). CBIP possesses low micromolar activity against BoNT/A.
T21464	Methiocarb Mercaptodimethur,Mesurol	Others	Others
	Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a potent neurotoxin.
T84691	1R-cis-Permethrin 1R-cis-NRDC-143,顺式苄氯菊二丙酯	Others	Others
	1R-cis-Permethrin为一种杀虫剂以及神经毒素，主要通过延长钠通道激活来影响神经元膜。
TP2062	ω-Conotoxin GVIA
	Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
T31582	DSP 4 DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4	Others	Others
	DSP 4 is a selective neurotoxin selective for noradrenergic neurons in the locus coeruleus noradrenergic system and capable of crossing the blood–brain barrier and cyclizes to a reactive aziridinium derivative that is accumulated into the noradrenergic ne
TP1223	Apamin Apamine
	Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin is a bee venom compone
T83223	AaHI
	AaHI，源自北非蝎子Androctonus australis hector的毒液，这种化合物是一种神经毒素，常用作开发能够中和毒素的活性物质的工具。
T80160	ω-Hexatoxin-Hv1a ω-ACTX-Hv1,ω-Atracotoxin-HV1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Hexatoxin-Hv1a，一种从毒液蜘蛛 (Hadronyche versuta) 分离得到的神经毒素，能够阻断电压门控钙通道 (calcium channels)。
T80064	Dendrotoxin-I DTX-I	Potassium Channel	Membrane transporter/Ion channel
	Dendrotoxin-I是一种高效的K+通道阻滞剂，特异性针对KV1.1和KV1.2电压门控钾通道亚基。该化合物为从Dendroaspis蛇毒中提取的神经毒素。
T80078	Calciseptin	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calciseptine 是从黑曼巴Dendroaspis p. polylepis分离得到的天然神经毒素。含有60个氨基酸和四个二硫键，特异性阻断L型钙通道（calcium channel）[1]。
TP2077	α-Bungarotoxin
	Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM
TP1576	SNAP-25 187-203
	This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT/E)-treated cells, albeit at higher concentrations
T80454	BmK-M1	Sodium Channel	Membrane transporter/Ion channel
	BmK-M1，一种含64个氨基酸通过四个二硫桥交联形成的蝎子毒素，作用于抑制Na+通道，属于心脏毒素和神经毒素类。
T20396	Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa	Others	Others
	Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot
TP2016	Huwentoxin-IV Huwentoxin IV
	Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin recepto
T75746	Apamin TFA
	Apamin TFA (Apamine TFA) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+激活的 K+(SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
T80704	α-Pompilidotoxin α-PMTX
	α-Pompilidotoxin (α-PMTX) 是从 Anoplius samariensis 的毒液中分离的一种神经毒素。它能剂量依赖性地增强兴奋性突触后电流（EPSCs），并且这种增强作用是可逆的。α-Pompilidotoxin 在神经科学研究中被作为实验工具广泛应用。
T80427	Jingzhaotoxin-II	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-II是由32个氨基酸组成的神经毒素，包括两个酸性残基和两个碱性残基。该毒素能够抑制电压门控钠通道(VGSC)，并在心肌细胞上明显减缓TTX抗性(TTX-R) VGSC的快速失活，其IC50值为0.26μM。
T80530	Spinoxin SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13	Potassium Channel	Membrane transporter/Ion channel
	Spinoxin是一种从Heterometrus spinifer蝎子毒液中提取的神经毒素，由34个氨基酸残基组成，通过4个二硫桥交联。它能有效抑制Kv1.3钾通道（IC50= 63 nM），是研发诊断及治疗自身免疫性疾病和癌症策略时的潜在分子靶点。
T69578	D-Ibotenic Acid	Others	Others
	D-Ibotenic Acid is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere. It is a conformationally-restricted analogue of the neurotransmitter glutamate, and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist. Because of this, ibotenic acid can be a powerful neurotoxin, and is employed as a brain-...
T83136	alpha-Cobratoxin
	alpha-Cobratoxin 是从泰国眼镜蛇的毒液中提取的神经毒素，具有调节神经系统、抗病毒和镇痛的活性。此外，alpha-Cobratoxin 对急性及慢性多发性硬化症表现出免疫抑制作用，目前正在被进一步研究其在肾上腺脊髓神经病方面的潜在应用。
T80426	Jingzhaotoxin-IX	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-IX是由35个氨基酸残基组成的C端酰胺化神经毒素。该化合物既抑制电压门控钠通道（包括河豚毒素抗性和河豚毒素敏感亚型）又抑制Kv2.1通道，但对延迟整流钾通道Kv1.1、1.2和1.3无效。
T81519	Pentapeptide-3
	Pentapeptide-3为源自韦氏腹蛇毒素waglerin-1的五肽神经毒素，作为尼古丁乙酰胆碱受体(nAChRs)的竞争性拮抗剂，能够在突触后膜发挥阻滞神经的效果。该化合物具有抗衰老功能，可与其他化妆品肽配合使用。
T75856	Huwentoxin-IV TFA
	Huwentoxin-IV TFA是一种具有高效性和选择性的钠通道阻滞剂，能够抑制Nav1.7、Nav1.2、Nav1.3和Nav1.4神经元，其IC50分别为26、150、338和400nM。通过优先结合于神经毒素受体位点4，Huwentoxin-IV TFA特异性地阻断周围神经的Nav1.7亚型。该化合物适用于炎症性及神经性疼痛动物模型的研究。
T80166	α-Conotoxin BuIA
	α-Conotoxin BuIA 是一种麻痹性肽类神经毒素，同时也是竞争性nAChR拮抗剂。它对nAChR亚型表现出不同的IC50值：0.258 nM（α6/α3β2）、1.54 nM（α6/α3β4）、5.72 nM（α3β2）。该化合物可用于鉴别包含β2与β4亚单位的nAChR亚型。此外，α-Conotoxin BuIA 对αxβ2nAChR的区分能力按照α6>α3>α2>α4的顺序减弱。
T80165	α-Conotoxin GID
	α-Conotoxin GID为一种麻痹性肽类神经毒素，能选择性地拮抗nAChR，具有不同亚型的IC50值：5 nM（α7）、3 nM（α3β2）和150 nM（α4β2）。该化合物是含有丰富二硫键的小分子肽，拥有缓解慢性疼痛的潜在效用。α-Conotoxin GID含C端羧酸酯结构，替换为羧酰胺会使其对α4β2nAChR的作用降低。该化合物可从锥螺科海洋生物中提取。
T83894	4A7C-301-Nurr1 Agonist 4A7C-301-Nuclear Receptor-Related 1
	4A7C-301-Nurr1激动剂是一种核受体相关1（Nurr1）的激动剂。它通过与Nurr1配体结合域（LBD；IC50 = 48.22 nM）结合，增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性（EC50s = 6.53 和 50-70 µM，分别）。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡，并减少运动和嗅觉缺陷，而不诱发类似运动障碍的行为。

化合物

DSP-4 hydrochloride

Cat.No: T13664

Synonym: Neurotoxin DSP 4 (hydrochloride)

Target: Others

Neurotoxin Inhibitor

Cat.No: T12214

Target: Others

MPTP hydrochloride

Cat.No: T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Cat.No: T27794

Synonym: lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon

Target: Sodium Channel, Parasite

2,4-Difluorobenzaldehyde

Cat.No: T9354

Synonym: 2,4-Difluoro-benzaldehyde,2,4-二氟苯甲醛

Target: Others

Cat.No: T28655

Synonym: R 58735,R58735,R-58735

Target: Microtubule Associated

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

Cat.No: T14763

Target: Others

Cat.No: T26937

Target: Others

Cat.No: T34794

Target: Others

Methylaminoalanine-nickel(II)

Cat.No: T33346

Synonym: L-Bmma-nickel(II),L-Medap-nickel(II)

Target: Others

Pi-Methylimidazoleacetic acid hydrochloride

Cat.No: T13819

Target: Others

Cat.No: T33644

Synonym: NPTX 7,NPTX7,NPTX-7

Target: Others

Cat.No: T25890

Synonym: CID 256758,CID-256758,CID256758

Target: Others

Cat.No: T32850

Target: Others

Cat.No: T69377

Target: Others

ω-Conotoxin MVIIC

Cat.No: TP2064

Cat.No: T26961

Target: Others

Cat.No: T21464

Synonym: Mercaptodimethur,Mesurol

Target: Others

1R-cis-Permethrin

Cat.No: T84691

Synonym: 1R-cis-NRDC-143,顺式苄氯菊二丙酯

Target: Others

ω-Conotoxin GVIA

Cat.No: TP2062

Cat.No: T31582

Synonym: DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4

Target: Others

Cat.No: TP1223

Synonym: Apamine

Cat.No: T83223

ω-Hexatoxin-Hv1a

Cat.No: T80160

Synonym: ω-ACTX-Hv1,ω-Atracotoxin-HV1

Target: Calcium Channel

Cat.No: T80064

Synonym: DTX-I

Target: Potassium Channel

Cat.No: T80078

Target: Calcium Channel

α-Bungarotoxin

Cat.No: TP2077

SNAP-25 187-203

Cat.No: TP1576

Cat.No: T80454

Target: Sodium Channel

Levadopa Related Compound A

Cat.No: T20396

Synonym: 6-Hydroxydopa, L-,L-Hydroxydopa

Target: Others

Cat.No: TP2016

Synonym: Huwentoxin IV

Cat.No: T75746

α-Pompilidotoxin

Cat.No: T80704

Synonym: α-PMTX

Jingzhaotoxin-II

Cat.No: T80427

Target: Sodium Channel

Cat.No: T80530

Synonym: SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13

Target: Potassium Channel

D-Ibotenic Acid

Cat.No: T69578

Target: Others

alpha-Cobratoxin

Cat.No: T83136

Jingzhaotoxin-IX

Cat.No: T80426

Target: Sodium Channel

Cat.No: T81519

Huwentoxin-IV TFA

Cat.No: T75856

α-Conotoxin BuIA

Cat.No: T80166

α-Conotoxin GID

Cat.No: T80165

4A7C-301-Nurr1 Agonist

Cat.No: T83894

Synonym: 4A7C-301-Nuclear Receptor-Related 1

Cat. No.	Product Name	Target	Signaling Pathways
T22911	β-N-methylamino-L-alanine hydrochloride L-BMAA hydrochloride	Others	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) 是由蓝细菌产生的一种神经毒素，既有导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病可能性。
T5071	4-Methyl-2-oxopentanoic acid 4-甲基-2-氧代戊酸,4-Methyl-2-oxovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	4-Methyl-2-oxopentanoic acid 是一种非正常代谢物，是一种神经毒素和代谢毒素。
T8264	3-Methyl-2-oxovaleric acid	Endogenous Metabolite	Metabolism
	3-Methyl-2-oxovaleric acid 是神经毒素，代谢毒素和酸性原，它是支链氨基酸不完整分解产生的异常代谢物。
T5232	3-Methyl-2-oxobutanoic acid 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) 是大肠杆菌中泛酸的前体。它是由支链氨基酸的不完全分解产生的一种异常代谢物。
T8227	5'-Methylthioadenosine Methylthioadenosine,5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine	Endogenous Metabolite	Metabolism
	5'-Methylthioadenosine 是由 S-腺苷蛋氨酸在多胺合成过程中生成的核苷，通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡来抑制肿瘤，同时控制肿瘤组织的炎症微环境。
T19130	Porphobilinogen	Others	Others
	Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.
T34885	Tinyatoxin TNX,TTN,TTX
	Tinyatoxin is a neurotoxin that works through vanillin receptors on sensory nerves.
T13820	Pi-Methylimidazoleacetic acid	Others	Others
	Pi-Methylimidazoleacetic acid is a potential neurotoxin.
T75539	Nereistoxin	Others	Others
	Nereistoxin (Nereistoxine) 是一种神经毒素，从海洋环节动物 Lumbriconereis heteropoda 中分离出来，可以通过阻断烟碱乙酰胆碱受体发挥作用。
T36068	Brevetoxin B	Others	Others
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

β-N-methylamino-L-alanine hydrochloride

Cat.No: T22911

Synonym: L-BMAA hydrochloride

Target: Others

4-Methyl-2-oxopentanoic acid

Cat.No: T5071

Synonym: 4-甲基-2-氧代戊酸,4-Methyl-2-oxovaleric acid

Target: Others, Endogenous Metabolite

3-Methyl-2-oxovaleric acid

Cat.No: T8264

Target: Endogenous Metabolite

3-Methyl-2-oxobutanoic acid

Cat.No: T5232

Synonym: 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid

Target: Others, Endogenous Metabolite

5'-Methylthioadenosine

Cat.No: T8227

Synonym: Methylthioadenosine,5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine

Target: Endogenous Metabolite

Porphobilinogen

Cat.No: T19130

Target: Others

Cat.No: T34885

Synonym: TNX,TTN,TTX

Pi-Methylimidazoleacetic acid

Cat.No: T13820

Target: Others

Cat.No: T75539

Target: Others

Cat.No: T36068

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00411	BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO) Botulinum neurotoxin type C,Botulinum neurotoxi...	Clostridium botulinum C phage	E. coli
	BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00054	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) Toxin II,Neurotoxin II,AaHII,Alpha-mammal toxin AaH...	Androctonus australis	E. coli
	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484.
TMPH-00409	BoNT/A Protein, Clostridium botulinum, Recombinant (His & SUMO) Bontoxilysin-A,bonT,botA,Botulinum neurotoxin type ...	Clostridium botulinum	E. coli
	BoNT/A Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00055	Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) AmmVIII,Neurotoxin 8,Alpha-anatoxin Amm VIII,Amm VI...	Androctonus mauritanicus	Baculovirus Insect Cells
	Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 11.3 kDa and the accession number is Q7YXD3.
TMPH-00415	BoNT/E Protein, Clostridium butyricum, Recombinant (His & SUMO) Bontoxilysin-E,BoNT/E,Botulinum neurotoxin type E	Clostridium butyricum	E. coli
	BoNT/E Protein, Clostridium butyricum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.7 kDa and the accession number is P30995.
TMPH-03741	BoNT/F Protein, Clostridium botulinum, Recombinant (His) Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin typ...	Clostridium botulinum	E. coli
	Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ...
TMPH-00412	BoNT/D Protein, Clostridium botulinum, Recombinant (B2M & His) Bontoxilysin-D,Botulinum neurotoxin type D,BoNT/D,b...	Clostridium botulinum	E. coli
	BoNT/D Protein, Clostridium botulinum, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 64.5 kDa and the accession number is P19321.
TMPH-00410	BoNT/B Protein, Clostridium botulinum, Recombinant (His) Botulinum neurotoxin type B,BoNT/B,Bontoxilysin-B,b...	Clostridium botulinum	P. pastoris (Yeast)
	BoNT/B Protein, Clostridium botulinum, Recombinant (His) is expressed in Yeast.
TMPH-01779	RNASE2 Protein, Human, Recombinant (His) Ribonuclease US,Eosinophil-derived neurotoxin,Non-s...	Human	E. coli
	This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. RNASE2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.5 kDa and the accession number is P10153.
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) ATX II,Delta-AITX-Avd1c,Toxin II,Delta-actitoxin-Avd1c,N...	Anemonia sulcata	P. pastoris (Yeast)
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin ...	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)...
TMPH-03483	Saxiphilin Protein, Aquarana catesbeiana, Recombinant (His) Saxiphilin	Lithobates catesbeiana	HEK293 Cells
	Binds specifically to the neurotoxin saxitoxin. Its physiological role may be to transport or sequester an endogenous organic molecule other than Fe(3+). It may participate in a detoxification mechanism for neutralizing a microbial toxin. Saxiphilin Protein, Aquarana catesbeiana, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 43.7 kDa and the accession number is P31226.

重组蛋白

BoNT/C Protein, Clostridium botulinum, Recombinant (His & SUMO)

Cat.No: TMPH-00411

Species: Clostridium botulinum C phage

Expression System: E. coli

AaH II Protein, Androctonus australis, Recombinant (His & SUMO)

Cat.No: TMPH-00054

Species: Androctonus australis

Expression System: E. coli

BoNT/A Protein, Clostridium botulinum, Recombinant (His & SUMO)

Cat.No: TMPH-00409

Species: Clostridium botulinum

Expression System: E. coli

Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc)

Cat.No: TMPH-00055

Species: Androctonus mauritanicus

Expression System: Baculovirus Insect Cells

BoNT/E Protein, Clostridium butyricum, Recombinant (His & SUMO)

Cat.No: TMPH-00415

Species: Clostridium butyricum

Expression System: E. coli

BoNT/F Protein, Clostridium botulinum, Recombinant (His)

Cat.No: TMPH-03741

Species: Clostridium botulinum

Expression System: E. coli

BoNT/D Protein, Clostridium botulinum, Recombinant (B2M & His)

Cat.No: TMPH-00412

Species: Clostridium botulinum

Expression System: E. coli

BoNT/B Protein, Clostridium botulinum, Recombinant (His)

Cat.No: TMPH-00410

Species: Clostridium botulinum

Expression System: P. pastoris (Yeast)

RNASE2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01779

Species: Human

Expression System: E. coli

Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Cat.No: TMPH-00056

Species: Anemonia sulcata

Expression System: P. pastoris (Yeast)

Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)

Cat.No: TMPH-03037

Species: Naja kaouthia

Expression System: E. coli

Saxiphilin Protein, Aquarana catesbeiana, Recombinant (His)

Cat.No: TMPH-03483

Species: Lithobates catesbeiana

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0391	Acrylamide-2,3,3-d3
	Acrylamide-2,3,3-d3 是 Acrylamide 的氘代化合物。Acrylamide 的 CAS 号为 79-06-1。Acrylamide monomer 是丙烯酰胺类的成员。它具有致癌剂、神经毒素、诱变剂、烷化剂和美拉德反应产物的作用。

同位素标记化合物

Acrylamide-2,3,3-d3

Cat.No: TMIJ-0391

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