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Cat. No. | Product Name | ||
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L3200 | 自噬库 | 1248 compounds | |
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16777 |
ROC-325
|
Apoptosis; Autophagy | Apoptosis; Autophagy |
ROC-325 是一种有效的口服活性自噬抑制剂,具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。 | |||
T1885 |
Siramesine hydrochloride
Lu 28-179 hydrochloride,西拉美新盐酸盐 |
Ferroptosis; Sigma receptor; lysosomal autophagy | Apoptosis; Autophagy; GPCR/G Protein |
Siramesine hydrochloride (Lu 28-179 hydrochloride) 是一种选择性 sigma-2 受体激动剂,可引发 Y 细胞的细胞死亡并在体内表现出有效的抗癌活性。Siramesine 对 sigma-2 受体具有亚纳摩尔亲和力,并且对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍。 | |||
T4620 |
Siramesine
西拉美新,Lu 28-179 |
Sigma receptor | GPCR/G Protein |
Siramesine (Lu 28-179) 是sigma-2受体激动剂,通过线粒体的不稳定溶酶体触发细胞死亡,有强大的抗癌活性。它对 sigma-2 受体具有亚纳摩尔亲和力,IC50为 0.12 nM。它对 sigma-2 受体的选择性是 sigma-1 受体的 140倍,IC50为 17 nM。 | |||
T60036 |
ML-SA5
|
Autophagy | Autophagy |
ML-SA5 是一种 MCOLN1 激动剂,通过扰乱自噬体和溶酶体之间的融合来阻止自噬通量。 | |||
T11142 |
EACC
|
Autophagy | Autophagy |
EACC 是自噬的可逆抑制剂,可阻断自噬通量。它对自噬体特异性的 SNARE Stx17 易位具有选择性抑制作用,从而阻止自噬体与溶酶体的融合。 | |||
T77945 |
TriGalNAc CBz
|
LYTACs | PROTAC |
TriGalNAc CBz 为 GalNAc 衍生物。作为一种 ASGPR 配体,TriGalNAc CBz 在 mRNA 药物递送及LYTAC研究中靶向溶酶体。 | |||
T77553 |
MHI-148
IR-808 |
||
MHI-148 是一种具有肿瘤靶向性的近红外七甲氨酸菁染料,可用于检测、诊断和研究癌症。MHI-148 可被肿瘤细胞的溶酶体和线粒体吸收并积累,但在正常细胞的溶酶体和线粒体不吸收。 | |||
T1908 |
MHY1485
|
mTOR; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
MHY1485 是一种 mTOR 激活剂。它通过抑制自噬体和溶酶体之间的融合来抑制自噬过程,导致 LC3II 蛋白的积累和自噬体增大。 | |||
T21992 |
Vacuolin-1
|
PI3K; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
Vacuolin-1 是一种细胞渗透性抑制剂,可抑制 Ca2+ 依赖性溶酶体与细胞膜的融合。它通过抑制溶酶体内容物的释放起作用。它是一种有效的选择性 PIKfyve 抑制剂,通过损害溶酶体成熟来抑制晚期自噬。 | |||
T37885 |
1-Dodecylimidazole
|
Antifungal | Microbiology/Virology |
1-Dodecylimidazole 是溶酶体活性洗涤剂。1-Dodecylimidazole 通过在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。它显示出降胆固醇和广谱抗真菌活性。 | |||
T73550 |
CUR5g
|
Others | Others |
CUR5g 是一种有效的自噬 (autophagy) 抑制剂。CUR5g 通过阻断自噬体-溶酶体融合选择性地抑制癌细胞中的自噬体降解。CUR5g 通过依赖 UVRAG 的机制阻止 STX17 募集到自噬体,导致自噬体无法与溶酶体融合。CUR5g 可提高顺铂 (Cisplatin) 在体外和体内对 A549 细胞的抗癌作用。 | |||
T33674 |
NIM-7
NIM7 |
Others | Others |
NIM-7 is a fluorescent probe, allowing lipid droplets and lysosomes to be labelled simultaneously and with high specificity, being visualized readily through yellow and red fluorescence, using different excitation and detection channels. | |||
T39855 |
LysoTracker Red
LysoTracker Red DND-99 |
||
LysoTracker Red (LysoTracker Red DND-99) is a paraformaldehyde fixable probe that concentrates into acidic compartments of cells and tissues. LysoTracker Red is an indicator of cell death in a manner similar to other standard assays (Annexin, terminal dUTP nick end labeling, Nile blue sulfate, neutral red, and acridine orange). LysoTracker Red is a marker for late endosomes and lysosomes. | |||
T84988 |
3β,5α,6β-Trihydroxycholanic Acid
|
Others | Others |
3β,5α,6β-Trihydroxycholanic acid, a metabolite derived from 5α,6β-dihydroxycholestanol, exhibits elevated levels in dried blood spots of patients diagnosed with Niemann-Pick disease type C, a neurodegenerative disorder characterized by the accumulation of cholesterol and sphingolipids in lysosomes. | |||
T35922 |
NAADP (sodium salt)
|
Others | Others |
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to... | |||
T61328 |
CO delivery molecule 1
|
||
CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and lysosomes. Such localization leads to the manifestation of CO-induced toxicity effects. Notably, the anti-inflammatory properties of CO delivery molecule 1, quantified through TNF-α suppression, are evident at nanomolar concentrations even without CO release. Furthermore, visible-light-induced CO release further enhances its anti-inflammatory effects [1]. | |||
T36370 |
4-Methylumbelliferyl-α-L-Iduronide (free acid)
|
Others | Others |
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an... | |||
T79556 |
NDBM
|
Autophagy | Autophagy |
NDBM为一种结合Pim-1 kinase的肿瘤特异性探针,具备释放强荧光及细胞毒性,用于筛选及杀伤肿瘤细胞。该化合物特异性地靶向溶酶体并对pH值具有高度敏感性,适用于监测自噬(autophagy)过程及细胞内环境在外部刺激下的pH变化。 | |||
T78371 |
Ac2-26 ammonium
|
||
Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。 | |||
T35930 |
Ganglioside GM2 Mixture (sodium salt)
|
Others | Others |
Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. Gan... | |||
T77876 |
Py-MAA-Val-Cit-PAB-MMAE
AAJ8D6-PY-Val-Cit-MMAE |
Others; Drug-Linker Conjugates for ADC | Antibody-drug Conjugate/ADC Related; Others |
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) 是一款ADC Linker,专用于合成抗体药物偶联物Zapadcine-3a (ADC)。Zapadcine-3a 对抗多种肿瘤表现出高效的活性,其作用机理为定位TRAILR2并通过肿瘤细胞内的溶酶体被摄取,进而针对性释放致死的小分子,从而特异性消灭TRAILR2阳性的肿瘤细胞,并能够有效地治愈肿瘤。 | |||
T77186 |
Zilovertamab vedotin
|
Others; Antibody-Drug Conjugates (ADCs) | Antibody-drug Conjugate/ADC Related; Others |
Zilovertamab vedotin (VLS-101) 是一种抗体-活性分子偶联物 (ADC), 主要由人源化单克隆抗体 zilovertamab 和单甲基 vedotin 组成的抗微管细胞毒素。该药物通过与肿瘤细胞表面的ROR1结合, 触发快速内化及向溶酶体的转运, 进而裂解释放单甲基 vedotin, 诱导细胞凋亡。适用于癌症的研究领域。 | |||
T77131 | Clervonafusp alfa | ||
Clervonafusp alfa (VAL-1221) 作为一种融合蛋白,针对胞浆及溶酶体糖原进行靶向。该化合物结合了穿透细胞的抗体Fab部分与重组人酸性葡萄糖苷酶 (rhGAA),通过核苷转运体ENT-2进入细胞质,再利用甘露糖-6-磷酸受体(M6PRs)导向溶酶体。主要应用于晚发型庞贝病的研究领域。 | |||
T36805 |
TPC2-A1-N
TPC2-A1-N |
Others | Others |
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1]. | |||
T36806 |
TPC2-A1-P
TPC2-A1-P |
Others | Others |
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N . TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3]. Two-pore channels (TPC1-3) are ancient members of the voltage-gated ion channel superfamily. TPCs are expressed throughout the en... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6564 |
Leupeptin Hemisulfate
亮肽素 |
Serine Protease; Cysteine Protease | Proteases/Proteasome |
Leupeptin hemisulfate 是一种蛋白酶抑制剂,具有细胞膜渗透性、可逆性、竞争性和口服活性。Leupeptin hemisulfate 可以抑制 Cathepsin B、Cathepsin H、Cathepsin L 的活性,阻断两性溶酶体的融合。Leupeptin hemisulfate 还具有抗炎活性。 | |||
T6740 |
Bafilomycin A1
巴佛洛霉素A1,巴佛洛霉素 A1 |
Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00672 |
Azurocidin/CAP37 Protein, Human, Recombinant (His)
AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,AZU1 |
Human | HEK293 Cells |
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n... | |||
TMPH-02334 |
RAB12 Protein, Human, Recombinant (His & Myc)
Ras-related protein Rab-12,RAB12 |
Human | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degrada... | |||
TMPJ-00497 |
CTSB Protein, Human, Recombinant (His)
APPS,CPSB,APP Secretase,Cathepsin B1,Cathepsin B,CTSB |
Human | HEK293 Cells |
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor... | |||
TMPJ-00264 |
LAMP1 Protein, Human, Recombinant (hFc)
LAMP-1,CD107a,Lysosome-Associated Membrane Glycoprotein 1,LA... |
Human | HEK293 Cells |
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal sto... | |||
TMPY-00131 |
Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)
NPC,Niemann-Pick disease, type C1 |
Human | HEK293 Cells |
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty... | |||
TMPJ-00299 |
LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)
LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysosomal... |
Mouse | HEK293 Cells |
Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc... | |||
TMPY-02885 |
CD1B Protein, Human, Recombinant (hFc)
CD1,CD1A,CD1b molecule,R1,CD1B |
Human | HEK293 Cells |
CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD... | |||
TMPJ-00298 |
CD36 Protein, Human, Recombinant (aa 27-432, His)
LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb... |
Human | HEK293 Cells |
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio... | |||
TMPY-03986 |
PIST Protein, Human, Recombinant (His)
CAL,dJ94G16.2,golgi-associated PDZ and coiled-coil motif con... |
Human | E. coli |
GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells. The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin binds to the PDZ domain of PIST. The co-localization of PIST and Rhotekin at the Golgi apparatus can be detected in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized ce... | |||
TMPY-02252 |
LAMTOR2 Protein, Human, Recombinant (His)
Ragulator2,p14,MAPBPIP,MAPKSP1AP,RP11-336K24.9,HSPC003,late ... |
Human | E. coli |
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factor... | |||
TMPY-00732 |
Cathepsin C Protein, Human, Recombinant (His)
DPP-I,PLS,JP,cathepsin C,CPPI,DPPI,PDON1,PALS,DPP1,JPD,HMS |
Human | HEK293 Cells |
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active c... | |||
TMPJ-00837 |
LAMP1 Protein, Mouse, Recombinant (His)
Lysosomal membrane glycoprotein A,CD107a,LAMP-1,CD107 antige... |
Mouse | HEK293 Cells |
Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAM... | |||
TMPY-02090 |
Cystatin B Protein, Human, Recombinant (His)
PME,EPM1A,STFB,ULD,cystatin B (stefin B),EPM1,CST6 |
Human | E. coli |
Cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to thecystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the prot... | |||
TMPY-02063 |
Alpha-2-macroglobulin Protein, Human, Recombinant (His)
α-2-macroglobulin,FWP007,CPAMD5,A2MD,S863-7,alpha-2-macroglo... |
Human | Baculovirus Insect Cells |
alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it ha... |