首页工具

登录

搜索结果

Search Results for " lymphocyte-mediated "

Targets Recommended: S1P Receptor LPL Receptor

7

抑制剂 & 化合物

2

天然产物

11

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T3258	Ponesimod ACT-128800	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ponesimod (ACT-128800) 是一种选择性 S1P1可口服激动剂，在放射性配体结合试验中的 IC50值为 6 nM。它可高效激活 S1P1介导的信号转导，EC50为5.7 nM。它可预防淋巴细胞介导的组织炎症，具有潜在的免疫调节活性。
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra	Others	Others
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T28708	Sch 24937	Others	Others
	Sch 24937 is a potent immunosuppressant on B lymphocyte mediated immune responses.
T37675	3-Deaza-2'-deoxyadenosine	Others	Others
	3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.
T77188	Tifcemalimab
	Tifcemalimab (JS004) 是一种人源化抗 BTLA(B 和 T 淋巴细胞衰减因子) 单克隆抗体。Tifcemalimab 通过与 BTLA 结合，阻断 HVEM-BTLA 的相互作用，从而阻断BTLA 介导的抑制信号通路。Tifcemalimab 可用于癌症的研究。
T76241	Trichomide A
	Trichomide A 是一种有效的 SHP2激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A 具有研究免疫相关皮肤病的潜力。

化合物

Cat.No: T3258

Synonym: ACT-128800

Target: S1P Receptor, LPL Receptor

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Target: Others

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: BTK

Cat.No: T28708

Target: Others

3-Deaza-2'-deoxyadenosine

Cat.No: T37675

Target: Others

Cat.No: T77188

Cat.No: T76241

Cat. No.	Product Name	Target	Signaling Pathways
T7981	2-Fluoroadenosine	Others	Others
	2-Fluoroadenosine 是淋巴细胞介导的细胞溶解的有效抑制剂。
T0311	Salicyl alcohol α,2-Toluenediol,o-Methylolphenol,2-Hydroxybenzyl alcohol,水杨醇,邻羟基苄醇,Saligenin,Saligenol,Diathesin	Others	Others
	Salicyl alcohol 是一种来自杨梅的淋巴细胞介导的细胞溶解的抑制剂。

天然产物

2-Fluoroadenosine

Cat.No: T7981

Target: Others

Salicyl alcohol

Cat.No: T0311

Synonym: α,2-Toluenediol,o-Methylolphenol,2-Hydroxybenzyl alcohol,水杨醇,邻羟基苄醇,Saligenin,Saligenol,Diathesin

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPY-00517	LSP1 Protein, Human, Recombinant (His) lymphocyte-specific protein 1,WP34,pp52	Human	HEK293 Cells
	LSP1 (Lymphocyte Specific Protein 1) is a Protein Coding gene. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. LSP1 is a lymphocyte-specific intracellular Ca2(+)-binding protein. LSP1 localizes to nascent phagocytic cups during Fcgamma receptor-mediated phagocytosis, where it displays the same ...
TMPJ-00110	GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His) Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis factor receptor su...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and...
TMPK-00184	CD20 Protein, Human, Recombinant (His & Avi), Biotinylated MS4A-1,CD20,B-lymphocyte surface antigen B1,Membran...	Human	E. coli
	B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. CD20...
TMPK-00183	CD20 Protein, Human, Recombinant (His & Avi) MS4A2,Ly-44,LEU-16,MS4A1,Bp35,CD20 receptor,CVID5,MS4A-1,B1,...	Human	E. coli
	B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. CD20...
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His) TIM3,Hepatitis A virus cellular receptor 2,KIM-3,T-cell memb...	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ...
TMPJ-00845	CTSE Protein, Human, Recombinant (His) CTSE,Cathepsin E	Human	HEK293 Cells
	Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. It is expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. CTSE is an intrac...
TMPJ-00380	AOC3 Protein, Human, Recombinant (His) Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens...	Human	HEK293 Cells
	Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf...
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) mitogen-activated protein kinase kinase kinase kinase 2,GCK,...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express...
TMPH-03279	DPP4/CD26 Protein, Rat, Recombinant (His & SUMO) Dpp4,Dipeptidyl peptidase IV,DPP IV,CD26,Dipeptidyl peptidas...	Rat	E. coli
	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular ...
TMPJ-00226	SLAMF1 Protein, Mouse, Recombinant (His) signaling lymphocytic activation molecule,SLAM family member...	Mouse	HEK293 Cells
	Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been...

重组蛋白

IL-15RA Protein, Human, Recombinant (hFc, Human Cells)

Cat.No: TMPJ-01099

Species: Human

Expression System: HEK293 Cells

LSP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00517

Species: Human

Expression System: HEK293 Cells

GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00110

Species: Mouse

Expression System: HEK293 Cells

CD20 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00184

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00183

Species: Human

Expression System: E. coli

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00599

Species: Human

Expression System: HEK293 Cells

CTSE Protein, Human, Recombinant (His)

Cat.No: TMPJ-00845

Species: Human

Expression System: HEK293 Cells

AOC3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00380

Species: Human

Expression System: HEK293 Cells

Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04412

Species: Human

Expression System: Baculovirus Insect Cells

DPP4/CD26 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03279

Species: Rat

Expression System: E. coli

SLAMF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00226

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

同位素标记化合物

Acalabrutinib-d4

Cat.No: TMIH-0065

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼