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Targets Recommended: PDE

22

抑制剂 & 化合物

7

天然产物

1

化合物库

7

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name
L1900	抗糖尿病库		683 compounds
	683 种生物活性小分子化合物；

化合物库

抗糖尿病库

Cat.No: L1900

Compounds: 683

Cat. No.	Product Name	Target	Signaling Pathways
T33589	Nanterinone UK-61260,UK61260,UK 61260	PDE	Metabolism
	Nanterinone (UK 61260) 是一种口服的部分磷酸二酯酶抑制剂，是一种新型的正性肌力和平衡血管扩张化合物。Nanterinone 口服后，可使急性血流动力学得到明显改善，这可能取决于先前存在的左心室充盈压。
T24270	KS370G KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide	Others	Others
	KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂，可减少梗阻肾脏中胶原蛋白的沉积，并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达，改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。
T19722	Benazeprilat CGS14831,CGS-14831,CGS 14831	RAAS; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性，可与其他其他类别的化合物（包括噻嗪类利尿剂和钙通道阻滞剂）联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。
T15487	HMR 1556	Others	Others
	HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).
T25010	AK-2-38 AK -2-38,AK2-38	Others	Others
	AK-2-38 is a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium.
T32426	KT 1 KT-1,KT1	Others	Others
	KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood flow, coronary blood flow, peak posit
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T24690	Pyrromecaine HCl Bumecaine hydrochloride,Pyrromecaine	Others	Others
	Pyrromecaine is a local anesthetic used for surface anesthesia. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favorable effect on the contractility of the left ventricle, and on the myocardial blood flow following the ligation of the
T28321	PD 122860 PD-122860,PD122860	Others	Others
	PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wa
T3689L	Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate	Others	Others
	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/
T83221	a-Bag Cell Peptide (1-7)
	α-Bag Cell Peptide (1-7)是α-bag cell peptide的NH2末端片段，具有抑制左上象限(LUQ)神经元及阻止袋细胞去极化的功能。
T84723	(1S)-CCR2 antagonist 1	Others	Others
	(1S)-CCR2 antagonist 1为CCR2 antagonist1的左旋异构体，后者是一种针对C-C趋化因子受体2型(CCR2)的高亲和性且长效的拮抗剂，具有2.4 nM的Ki值。
TP2096	ELA-21 (human)
	High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP produc
T83220	a-Bag Cell Peptide (1-8)
	α-Bag Cell Peptide (1-8)为α-bag cell peptide的NH2末端片段，能够抑制左上象限(LUQ)神经元活动，并防止袋细胞去极化。
T69990	Ruboxistaurin mesylate monohydrate	Others	Others
	Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T36004	1-O-Hexadecyl-sn-glycerol 1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol	Others	Others
	1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-Hexadecyl-sn-glycerol (50 μM) increases coronary flow and left ventricular developed pressure and reduces malondialdehyde (MDA) formation ex vivo in a rat heart model of ischemia/reperfusion injury. [2].Maulik, N., Tosaki, A., Engelman, R.M., et al. Myocardial salvage by chimyl al...
T60825	FC9402	Others	Others
	FC9402 是硫化物醌氧化还原酶 (SQOR) 的高效选择性抑制剂。FC9402 可调节心血管，减轻 TAC 诱导的心肌细胞肥大和左心室 (LV) 纤维化。
T36555	Tyr-α-CGRP (human) (trifluoroacetate salt)
	Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated rig...
T72213	Efonidipine hydrochloride NZ-105 hydrochloride	Others	Others
	Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。
T35598	Neuromedin U-25 (human) (trifluoroacetate salt)
	Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ...
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET	Others	Others
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T83769	TC 14012 hydrochloride H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2
	TC 14012是一种化学肽模拟的拮抗剂，针对趋化因子(C-X-C motif)受体4（CXCR4；IC50 = 2.9 nM）和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募（EC50 = 350 nM）。TC 14012可减少HIV在MT-4细胞中的细胞病理效应（EC50 = 0.4 nM），并以CXCR4依赖的方式抑制HIV在体外进入（IC50 = 19.3 nM）。它还能抑制由趋化因子(C-X-C motif)配体12（CXCL12）在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞（HUVECs）中诱导的迁移，当使用浓度范围从10到1,000 nM时。在通过左前降（LAD）冠状动脉结扎诱导的急性心肌梗死小鼠模型中，TC 14012（10 mg/kg）能减少梗死面积。

化合物

Cat.No: T33589

Synonym: UK-61260,UK61260,UK 61260

Target: PDE

Cat.No: T24270

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

Target: Others

Cat.No: T19722

Synonym: CGS14831,CGS-14831,CGS 14831

Target: RAAS, Endogenous Metabolite

Cat.No: T15487

Target: Others

Cat.No: T25010

Synonym: AK -2-38,AK2-38

Target: Others

Cat.No: T32426

Synonym: KT-1,KT1

Target: Others

Cat.No: T22685

Synonym: CP 471474

Target: Others

Pyrromecaine HCl

Cat.No: T24690

Synonym: Bumecaine hydrochloride,Pyrromecaine

Target: Others

Cat.No: T28321

Synonym: PD-122860,PD122860

Target: Others

Ruboxistaurin mesylate

Cat.No: T3689L

Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Target: Others

a-Bag Cell Peptide (1-7)

Cat.No: T83221

(1S)-CCR2 antagonist 1

Cat.No: T84723

Target: Others

Cat.No: TP2096

a-Bag Cell Peptide (1-8)

Cat.No: T83220

Ruboxistaurin mesylate monohydrate

Cat.No: T69990

Target: Others

1-O-Hexadecyl-sn-glycerol

Cat.No: T36004

Synonym: 1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol

Target: Others

Cat.No: T60825

Target: Others

Tyr-α-CGRP (human) (trifluoroacetate salt)

Cat.No: T36555

Efonidipine hydrochloride

Cat.No: T72213

Synonym: NZ-105 hydrochloride

Target: Others

Neuromedin U-25 (human) (trifluoroacetate salt)

Cat.No: T35598

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target: Others

TC 14012 hydrochloride

Cat.No: T83769

Synonym: H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2

Cat. No.	Product Name	Target	Signaling Pathways
T5573	Coenzyme Q9 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降，改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。
T5968	DL-Homocysteine thiolactone hydrochloride DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐	Endogenous Metabolite	Metabolism
	DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。
T3S0509	Gaultherin	COX	Immunology/Inflammation; Neuroscience
	Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。
T4S1422	Praeruptorin E 白花前胡素 E,白花前胡素E	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
T4715	2'-Deoxyguanosine monohydrate 2'-脱氧鸟苷一水合物,Guanine-2'-deoxyriboside	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyguanosine monohydrate (Guanine-2'-deoxyriboside) 是内源性代谢产物的一种。
TN1367	Alismol 泽泻醇	Potassium Channel; Calcium Channel; PI3K	Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate

天然产物

Cat.No: T5573

Synonym: 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9

Target: Apoptosis, Endogenous Metabolite

DL-Homocysteine thiolactone hydrochloride

Cat.No: T5968

Synonym: DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐

Target: Endogenous Metabolite

Cat.No: T3S0509

Target: COX

Cat.No: T4S1422

Synonym: 白花前胡素 E,白花前胡素E

Target: Others, Calcium Channel

2'-Deoxyguanosine monohydrate

Cat.No: T4715

Synonym: 2'-脱氧鸟苷一水合物,Guanine-2'-deoxyriboside

Target: Others, Endogenous Metabolite

Cat.No: TN1367

Synonym: 泽泻醇

Target: Potassium Channel, Calcium Channel, PI3K

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02752	Lefty2 Protein, Mouse, Recombinant (His & Myc) Left-right determination factor B,Protein left<...	Mouse	E. coli
	Lefty2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli.
TMPY-00990	Lefty-A Protein, Human, Recombinant (hFc) LEFTYA,left-right determination factor 2,<...	Human	HEK293 Cells
	left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamily), and transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations i...
TMPJ-00238	Lefty-A Protein, Human, Recombinant (His) Endometrial bleeding-associated factor,TGFB4,TGF-β-4,EBAF,	Human	HEK293 Cells
	Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins a...
TMPH-01674	Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc) Nucleoprotein,N,Nucleocapsid protein	HMPV	E. coli
	Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.
TMPJ-00822	Cryptic Protein, Human, Recombinant (His) CFC1,Cryptic protein,Cryptic family protein 1	Human	HEK293 Cells
	Cryptic (CFC1) is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. It contains an EGF-like domain, and is glycosylated on its N-terminal during post-translational modification. Cryptic is identified as a NODAL coreceptor involved in the correct establishment of the left-right axis. It may play a role in mesoderm and/or neural patterning during gastrulation. The unnormal expression of this gene may causes a series of diseases such as HTX2, Transposition of t...
TMPK-00073	TDGF1/Cripto Protein, Human, Recombinant (His) TDGF1,Cripto,CR,CRGF	Human	HEK293 Cells
	TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involve...
TMPJ-00716	Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His) DAN Domain Family Member 4,Cerberus,Cerberus-Related Protein...	Human	HEK293 Cells
	Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in respon...

重组蛋白

Lefty2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02752

Species: Mouse

Expression System: E. coli

Lefty-A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00990

Species: Human

Expression System: HEK293 Cells

Lefty-A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00238

Species: Human

Expression System: HEK293 Cells

Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc)

Cat.No: TMPH-01674

Species: HMPV

Expression System: E. coli

Cryptic Protein, Human, Recombinant (His)

Cat.No: TMPJ-00822

Species: Human

Expression System: HEK293 Cells

TDGF1/Cripto Protein, Human, Recombinant (His)

Cat.No: TMPK-00073

Species: Human

Expression System: HEK293 Cells

Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-00716

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71205	Fosinopril-d7 sodium salt
	Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
TMIJ-0252	Benazeprilat-d5 Benazepril EP Impurity C-d5
	Benazeprilat-d5 是 Benazeprilat 的氘代化合物。Benazeprilat 的 CAS 号为 86541-78-8。Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性，可与其他其他类别的化合物（包括噻嗪类利尿剂和钙通道阻滞剂）联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...

同位素标记化合物

Fosinopril-d7 sodium salt

Cat.No: T71205

Cat.No: T71065

Cat.No: T69600

Benazeprilat-d5

Cat.No: TMIJ-0252

Synonym: Benazepril EP Impurity C-d5

Cat.No: T71402

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