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抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T35995	Ferrichrome (iron-free)
	Ferrichrome (iron-free) 是一种异羟肟酸盐铁载体，可由各种真菌产生（包括 U. sphaerogena），促进这些生物体对铁的螯合和吸收，还被细菌用作异源铁载体，包括铜绿假单胞菌和副溶血性弧菌。 Ferrichrome (iron-free) (0.8 μM) 可以抑制由刀豆球蛋白 A 诱导的小鼠脾脏单核细胞增殖，并减少刀豆球蛋白 A 刺激的 CD4+ T 细胞的数量。它还以浓度依赖性方式抑制过氧化氢对 LDL 的血红素催化氧化。
T1637	Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺	Mitophagy; Beta Amyloid; Others; Ferroptosis; HIF/HIF Prolyl-Hydroxylase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Metabolism; Neuroscience; Others
	Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物，减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平，诱导细胞凋亡。
T35994	Erastin2 35MEW28	Ferroptosis	Apoptosis
	Erastin2 是一种铁死亡诱导剂，通过与亲脂性自由基捕获抗氧化剂ferrostatin-1或铁螯合剂去铁胺（DFO）来诱导细胞死亡。
T30852L	CGP-75254A Free Acid CGP-75254A	Others	Others
	CGP-75254A Free Acid is a novel oral iron chelator.
T31784	Ferric citrate JTT 751	Others	Others
	Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.

化合物

Ferrichrome (iron-free)

Cat.No: T35995

Synonym:

Target:

Deferoxamine Mesylate

Cat.No: T1637

Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺

Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy

Erastin2

Cat.No: T35994

Synonym: 35MEW28

Target: Ferroptosis

CGP-75254A Free Acid

Cat.No: T30852L

Synonym: CGP-75254A

Cat. No.	Product Name	Target	Signaling Pathways
TN1873	Lirinidine	Others; Antioxidant	Others; oxidation-reduction
	Lirinidine 是一种分离自L. tulipifera叶片生物碱，具有抗氧化 (antioxidant) 和抗癌作用。它在体外表现出中等的铁还原能力和较小的自由基清除能力，可用于研究化妆品。
T8948	Ferroheme protoheme,Hematin,heme	Others	Others
	Ferroheme (protoheme) 是一种亚铁离子和卟啉的复合物，也是脂肪酸结合大鼠肝脏脂肪酸结合蛋白的同位异构抑制剂。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
T72594	Broussochalcone A	Others	Others
	Broussochalcone A 是一种具有抗氧化和抑制黄嘌呤氧化酶（IC50=2.21 μM）功能的化合物，能清除自由基，抑制铁诱导的脂质过氧化和脂多糖（LPS）激活的巨噬细胞中一氧化氮（NO）的合成。此外，Broussochalcone A 通过增加ROS水平和激活FOXO3信号通路，诱导人肾癌细胞的凋亡（Apoptosis）。

天然产物

Lirinidine

Cat.No: TN1873

Synonym:

Target: Others, Antioxidant

Ferroheme

Cat.No: T8948

Synonym: protoheme,Hematin,heme

Target: Others

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00513	LTF Protein, Human, Recombinant (His) Lactoferroxin-A,Talalactoferrin,LTF,Lactotransferrin,Lactofe...	Human	HEK293 Cells
	Lactotransferrin is a member of the transferrin family that transfer iron to the cells and control the level of free iron in the blood and external secretions. Lactotransferrin is a secreted protein and contains two transferrin-like domains. Lactotransferrin can be cleaved into the following four chains: Kaliocin-1, Lactoferroxin-A, Lactoferroxin-B, and Lactoferroxin-C. Lactoferroxin A, Lactoferroxin B, and Lactoferroxin C have opioid antagonist activity. Lactoferroxin A shows preference for mu-...
TMPJ-01142	CDO1 Protein, Human, Recombinant (His) CDO-I,CDO,Cysteine Dioxygenase Type I,CDO1,Cysteine Dioxygen...	Human	E. coli
	Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic c...