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Search Results for " insertion "

Targets Recommended: EGFR HER BTK RIP kinase

15

抑制剂 & 化合物

17

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9072	Tuxobertinib BDTX-189	EGFR; HER; BTK; RIP kinase	Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。
T64124	Sunvozertinib DZD9008,DZD 9008,DZD-9008	EGFR; BTK	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sunvozertinib (DZD9008) 是一种有效的 ErbBs 和 BTK 抑制剂，对EGFR、Her2和突变型表皮生长因子有抑制作用。 Sunvozertinib 显示 EGFR 外显子 20 NPH 插入、EGFR 外显子 20 ASV 插入、EGFR L858R 和 T790M 突变以及 Her2 外显子 20 YVMA 和 EGFR WT A431 有抑制作用， IC50 分别为 20.4、20.4、1.1、7.5 和 80.4 nM 。
T31932	GJ071 oxalate GJ 071,GJ-071,GJ071	Others	Others
	GJ071 oxalate 是一种无义抑制剂。无义抑制剂（NonSups）诱导“读出”，即在提前终止密码子处选择近同源tRNA，并将相应的氨基酸插入新生多肽中。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
TP1573L	CLIP 86-100 acetate(648881-58-7 free base)	Others	Others
	CLIP 86-100 acetate(648881-58-7 free base) 这是称为 CLIP 的 II 类相关不变链肽的氨基酸 86 至 100 片段。主要组织相容性复合物 II 类分子显示外源蛋白的肽片段，以触发免疫系统的防御反应。在将外源肽插入结合槽之前，去除一个占位肽 CLIP。这是通过分子 DM 实现的，它被证明可以增加 CLIP 肽与 II 类的解离速率。
T31933	GJ072 GJ-072,GJ 072	Others	Others
	GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.
TP1573	CLIP (86-100) CLIP 86-100
	CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide called CLIP. The major histocompatibility complex class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the binding groove, a place-holding peptide CLIP is removed. CLIP (86-100) is accomplished by the molecule DM, which is shown to increase the dissociation rate of a CLIP peptide from class...
T63792	LDC0496	Others	Others
	LDC0496 是 EGFR 的有效抑制剂。LDC0496 能够显著抑制 EGFR 和 Her2 外显子 20 插入突变，并对野生型 EGFR 和激酶组内的选择性。
T9304	(S)-Sunvozertinib N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(S)-Sunvozertinib (DZD9008) 是 Sunvozertinib 的 S-对映体，能够抑制EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变及 Her2 外显子 20 YVMA 插入，也能够抑制BTK。
T71991	PUN-96956	Others	Others
	PUN-96956 is a novel BAM complex inhibitor, interfering with BamA-related processes and affect folding and insertion of OMPs. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
T37862	9(R)-HODE	Others	Others
	9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to produce 9(R)-HODE when incubated with linoleic acid. The physiological function of 9(R)-HODE and the enzyme that catalyzes its form...
T60997	GL0388	Others	Others
	GL0388 是一种Bax 激活剂，可导致 Bax 插入线粒体膜，从而诱导 Bax 介导的细胞凋亡。GL0388 在体内抑制乳腺癌异种移植的肿瘤生长，并且对多种癌细胞表现出抗增殖活性，IC50值为 0.299-1.57 μM。
T69498	DBPR112 HCl	Others	Others
	DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib alon...
T63573	WF-47-JS03	Others	Others
	WF-47-JS03 是选择性的、有效的、能够透过血脑屏障的 RET 激酶抑制剂，比对激酶插入域受体 (KDR) 的选择性高 500 多倍。WF-47-JS03 作用于转染 KIF5B-RET 的 Ba/F3 细胞 (IC50: 1.7 nM) 和转染 CCDC6-RET 的 LC-2/ad 肺癌细胞 (IC50: 5.3 nM)。

化合物

Cat.No: T9072

Synonym: BDTX-189

Target: EGFR, HER, BTK, RIP kinase

Cat.No: T64124

Synonym: DZD9008,DZD 9008,DZD-9008

Target: EGFR, BTK

Cat.No: T31932

Synonym: GJ 071,GJ-071,GJ071

Target: Others

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

CLIP 86-100 acetate(648881-58-7 free base)

Cat.No: TP1573L

Target: Others

Cat.No: T31933

Synonym: GJ-072,GJ 072

Target: Others

Cat.No: TP1573

Synonym: CLIP 86-100

Cat.No: T63792

Target: Others

(S)-Sunvozertinib

Cat.No: T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

Cat.No: T71991

Target: Others

Cat.No: T37862

Target: Others

Cat.No: T60997

Target: Others

Cat.No: T69498

Target: Others

Cat.No: T63573

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01299	EMC4 Protein, Human, Recombinant (His) TMEM85,EMC4,ER membrane protein complex subunit 4,Transmembr...	Human	E. coli
	Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spann...
TMPH-01332	Ferrochelatase Protein, Human, Recombinant (His & Myc) Ferrochelatase, mitochondrial,Heme synthase,Protoheme ferro-...	Human	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX. Ferrochelatase Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P22830.
TMPH-00265	Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO) Ferrochelatase, mitochondrial,Protoheme ferro-lyase,FECH,Hem...	Bovine	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX. Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Mycd tag. The predicted molecular weight is 58.1 kDa and the accession number is P22600.
TMPH-03593	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His) Thiol-activated cytolysin,Pneumolysin,ply	Streptococcus pneumoniae	E. coli
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum...
TMPH-03592	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His) Thiol-activated cytolysin,ply,Pneumolysin	Streptococcus pneumoniae	P. pastoris (Yeast)
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum...
TMPH-03634	GRA3 Protein, Toxoplasma gondii, Recombinant (His) P30,GRA3,Dense granule protein 3	Toxoplasma gondii	E. coli
	Direct host-parasite interaction occurs at the cytoplasmic faces of the parasitophorous vacuole membrane (PVM) and the host endoplasmic reticulum (ER) membrane via GRA3 and host CAMLG association. Direct insertion of GRA3 ER retrieval motif into the host ER membrane contributes to the host ER recruitment to the PVM. GRA3 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 10.8 kDa and the accession number is ...
TMPH-00675	BamA Protein, E. coli O157:H7, Recombinant (His) Outer membrane protein assembly factor BamA,yaeT,bamA	E. coli	E. coli
	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. BamA Protein, E. coli O157:H7, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 47.6 kDa and the accession number is P0A942.
TMPH-00188	BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) Adenosylmethionine-8-amino-7-oxononanoate aminotransferase B...	Bacteroides fragilis	E. coli
	Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p...
TMPJ-00666	CLIC2 Protein, Human, Recombinant (His) CLIC2,XAP121,Chloride Intracellular Channel Protein 2	Human	E. coli
	Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be d...
TMPJ-01311	EPT1 Protein, Human, Recombinant (GST) hEPT1,Selenoprotein I,SELI,EPT1,Ethanolaminephosphotransfera...	Human	E. coli
	Ethanolaminephosphotransferase 1 (EPT1) is an enzyme that belongs to the CDP-Alcohol Phosphatidyltransferase Class-I Family. EPT1 is a Selenoprotein, which contains a Selenocysteine (Sec) residue at its active site. The Selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of Selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop sig...
TMPJ-00704	SCO1 Protein, Human, Recombinant (GST) Protein SCO1 Homolog Mitochondrial,SCOD1,SCO1	Human	E. coli
	Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4...
TMPY-04075	CLIC1 Protein, Human, Recombinant (His) NCC27,G6,chloride intracellular channel 1	Human	E. coli
	Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. CLIC1 acts as a put...
TMPY-02768	Selenoprotein M Protein, Human, Recombinant (His) SEPM	Human	E. coli
	Selenoprotein M is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine M is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures....
TMPY-01948	COQ7 Protein, Human, Recombinant (His) CLK1,coenzyme Q7 homolog, ubiquinone (yeast),CAT5,CLK-1	Human	HEK293 Cells
	Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which belongs to theCOQ7 family. It is expressed dominantly in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. Th...
TMPH-02638	HSPA5 Protein, Mouse, Recombinant (E. coli, His) Hspa5,Heat shock protein 70 family protein 5,Endoplasmic ret...	Mouse	E. coli
	Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ER...
TMPY-04423	CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST) VWS1,RP1-272L16.2,calcium/calmodulin-dependent protein kinas...	Human	Baculovirus Insect Cells
	Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a membera...
TMPY-01187	Rac1 Protein, Human, Recombinant (GST) Rac-1,p21-Rac1,MIG5,ras-related C3 botulinum toxin substrate...	Human	Baculovirus Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, bind...

重组蛋白

EMC4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01299

Species: Human

Expression System: E. coli

Ferrochelatase Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01332

Species: Human

Expression System: E. coli

Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00265

Species: Bovine

Expression System: E. coli

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)

Cat.No: TMPH-03593

Species: Streptococcus pneumoniae

Expression System: E. coli

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)

Cat.No: TMPH-03592

Species: Streptococcus pneumoniae

Expression System: P. pastoris (Yeast)

GRA3 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03634

Species: Toxoplasma gondii

Expression System: E. coli

BamA Protein, E. coli O157:H7, Recombinant (His)

Cat.No: TMPH-00675

Species: E. coli

Expression System: E. coli

BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc)

Cat.No: TMPH-00188

Species: Bacteroides fragilis

Expression System: E. coli

CLIC2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00666

Species: Human

Expression System: E. coli

EPT1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01311

Species: Human

Expression System: E. coli

SCO1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00704

Species: Human

Expression System: E. coli

CLIC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04075

Species: Human

Expression System: E. coli

Selenoprotein M Protein, Human, Recombinant (His)

Cat.No: TMPY-02768

Species: Human

Expression System: E. coli

COQ7 Protein, Human, Recombinant (His)

Cat.No: TMPY-01948

Species: Human

Expression System: HEK293 Cells

HSPA5 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02638

Species: Mouse

Expression System: E. coli

CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04423

Species: Human

Expression System: Baculovirus Insect Cells

Rac1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01187

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T38356	1,2-Dipalmitoyl-13C-sn-glycero-3-PC
	1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation...

同位素标记化合物

1,2-Dipalmitoyl-13C-sn-glycero-3-PC

Cat.No: T38356

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