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Search Results for " inflammatory factors "

Targets Recommended: HIF/HIF Prolyl-Hydroxylase

12

抑制剂 & 化合物

8

天然产物

2

化合物库

15

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L9000	细胞凋亡化合物库		1760 compounds
	1760 种与凋亡相关的生物活性小分子化合物的特有集合，多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

细胞凋亡化合物库

Cat.No: L9000

Compounds: 1760

Cat. No.	Product Name	Target	Signaling Pathways
T64336	Izilendustat	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate 是一种脯氨酰羟化酶抑制剂。
T0446	Naphazoline hydrochloride 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物，是一种眼血管收缩剂。
T61233	Penehyclidine hydrochloride Penequinine hydrochloride	NF-κB; AChR	Neuroscience; NF-κB
	Penehyclidine hydrochloride (Penequinine hydrochloride) 是M1和M3拮抗剂，并激活肺组织中的NF-κB。 Penehyclidine hydrochloride 抑制炎症因子的释放，并显示出抗胆碱能特性。
T1482	Ciclopirox 环吡酮,HOE296b,环吡酮胺	ATPase; Ferroptosis; Antibacterial; Autophagy; Antifungal	Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Ciclopirox (HOE296b) 是一种合成的抗真菌剂，可研究浅表真菌病。
T12848	SB-657510	Others; Neurotensin Receptor	GPCR/G Protein; Others
	SB-657510 是 urotensin II (UII) receptor (UT) 拮抗剂。对于人，猴，猫，大鼠和小鼠的UT 的 Ki 值分别为 61、17、30、65 和 56 nM。SB-657510 通过抑制 UII 诱导的人类血管内皮细胞中炎性介质，如粘附分子，使细胞因子和组织因子上调从而发挥抗炎作用。SB 657510对糖尿病小鼠模型中糖尿病相关动脉粥样硬化疾病具有治疗作用。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T63006	DHU-Se1	Others	Others
	DHU-Se1 是一种有效的抗炎剂。DHU-Se1 能够刺激巨噬细胞释放活性硒化合物，降低细胞炎症因子的表达，如 iNOS 和 TNF-α。DHU-Se1 能够阻断巨噬细胞从 M0 到 M1 的极化，从而缓解炎症过程。
T62342	CSF1R-IN-4	Others	Others
	CSF1R-IN-4 是一种 CSF-1R 的有效抑制剂。其中 CSF-1R 表达于巨噬细胞中，巨噬细胞的存活和分化依赖于 CSF-1/CSF-1R 信号通路。CSF1R-IN-4 能够影响 TAM 和胶质瘤细胞之间炎症因子的交换。CSF1R-IN-4 具有潜力进行癌症疾病的研究。
T72102	Glucocorticoid receptor modulator 1	Others	Others
	Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂，IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。
T62364	CSF1R-IN-5	Others	Others
	CSF1R-IN-5 是一种 CSF1R 的有效抑制剂。其中 CSF-1R 表达于巨噬细胞中，巨噬细胞的存活和分化依赖于 CSF-1/CSF-1R 信号通路。CSF1R-IN-5 可以影响 TAM 和胶质瘤细胞之间炎症因子的交换。CSF1R-IN-5 具有潜力进行癌症疾病的研究。
T78732	BO-1	Others	Others
	BO-1是一种苯甲酸酯类抗菌活性化合物。它能够抑制多重耐药金黄色葡萄球菌，同时与环丙沙星等抗生素显示协同效应。此外，BO-1可逆转该菌株的耐药性，并在小鼠体内降低IL-6及C反应蛋白的水平。
T74799	NF-κB-IN-8	NF-κB	NF-κB
	NF-κB-IN-8 是一种化合物，其作用机制为竞争性抑制 LPS 与 MD-2 之间的相互作用。该化合物通过与 MD-2 结合，有效降低炎症因子的产生，并能够抑制 ALP 的酶活性。因此，NF-κB-IN-8 在急性肺损伤（ALI）等炎症性疾病的研究中具有潜在应用价值。

化合物

Cat.No: T64336

Target: HIF/HIF Prolyl-Hydroxylase

Naphazoline hydrochloride

Cat.No: T0446

Synonym: 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl

Target: Adrenergic Receptor

Penehyclidine hydrochloride

Cat.No: T61233

Synonym: Penequinine hydrochloride

Target: NF-κB, AChR

Cat.No: T1482

Synonym: 环吡酮,HOE296b,环吡酮胺

Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal

Cat.No: T12848

Target: Others, Neurotensin Receptor

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

Cat.No: T63006

Target: Others

Cat.No: T62342

Target: Others

Glucocorticoid receptor modulator 1

Cat.No: T72102

Target: Others

Cat.No: T62364

Target: Others

Cat.No: T78732

Target: Others

Cat.No: T74799

Target: NF-κB

Cat. No.	Product Name	Target	Signaling Pathways
T3887	Rosarin	Others	Others
	Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS，IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
TN4234	Hydrangenol	NOS; NF-κB; Nrf2; NO Synthase; Antifection; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Hydrangenol 是一种天然产物，可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 是口服有效的抗光老化化合物，可以预防皱纹的形成。Hydrangenol 可以降低 MMP 和炎症细胞因子的表达，增加保湿因子和抗氧化基因的水平。
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
T3123	Allicin	ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome
	Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat
TN3070	4beta-Hydroxywithanolide E	PARP; HSP; NF-κB; COX	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo

天然产物

Cat.No: T3887

Target: Others

Cat.No: T6S1049

Target: ATPase

Cat.No: TN4234

Target: NOS, NF-κB, Nrf2, NO Synthase, Antifection, Autophagy

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Cat.No: T3123

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

4beta-Hydroxywithanolide E

Cat.No: TN3070

Target: PARP, HSP, NF-κB, COX

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00327	M-CSF/CSF1 Protein, Human, Recombinant (His) Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St...	Human	HEK293 Cells
	Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His) CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in...
TMPJ-00623	BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc) Tumor necrosis factor ligand 7A,TNF superfamily member 13b,T...	Rhesus	HEK293 Cells
	TNFSF13B is also known as B-cell activating factor (BAFF), BLyS and TNLG7A, is a member of TNF ligand superfamily. TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. Identification of TNFSF13B as candidate causative genes supports conjectures on involvement of the immune system in BVVL and amyotrophic lateral s...
TMPK-01165	MCEMP1 Protein, Mouse, Recombinant (hFc) MGC132456,C19orf59,MCEMP1	Mouse	HEK293 Cells
	A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or downregulated by exogenous transfection in an attempt to investigate their effects on the release of inflammatory factors, the expression of immunoglobulins, the activity of T cell subsets and natural killer (NK) cells, as well as T lymphocyte apoptosis.
TMPK-01137	FAM3D Protein, Human, Recombinant (hFc) OIT1,EF7,FAM3D	Human	HEK293 Cells
	The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t...
TMPJ-00397	IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated CD217,IL17RA,interleukin 17 receptor A,IL17Rinterleukin-17 r...	Human	HEK293 Cells
	CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines...
TMPY-06836	NR3C1 Protein, Human, Recombinant (His) GCCR,GRL,GR,nuclear receptor subfamily 3, group C, member 1 ...	Human	E. coli
	NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. NR3C1 is a transcriptional regulator of many drug-metabolizing enzymes and anti-inflammatory molecules. NR3C1 polymorphisms associate with obesi...
TMPY-01466	S100A12 Protein, Human, Recombinant MRP6,MRP-6,S100A12,S100 calcium binding protein A12,CAGC,p6,...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of i...
TMPY-01879	S100A14 Protein, Human, Recombinant (His) S100 calcium binding protein A14,BCMP84,S100A15	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of in...
TMPY-01000	BVES Protein, Human, Recombinant (GST) CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,...	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi...
TMPY-04260	p38 Protein, Human, Recombinant (His) mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...	Human	Baculovirus Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His) TNFAIP5,pentraxin 3,PTX3,TSG-14	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...
TMPY-04550	JNK2 Protein, Human, Recombinant (His) JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...
TMPY-01926	S100A10 Protein, Human, Recombinant (His) ANX2L,S100 calcium binding protein A10,p10,CLP11,MGC111133,G...	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of int...

重组蛋白

M-CSF/CSF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00327

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

Cat.No: TMPY-02028

Species: Human

Expression System: HEK293 Cells

BAFF/TNFSF13B Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00623

Species: Rhesus

Expression System: HEK293 Cells

MCEMP1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01165

Species: Mouse

Expression System: HEK293 Cells

FAM3D Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01137

Species: Human

Expression System: HEK293 Cells

IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00397

Species: Human

Expression System: HEK293 Cells

NR3C1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06836

Species: Human

Expression System: E. coli

S100A12 Protein, Human, Recombinant

Cat.No: TMPY-01466

Species: Human

Expression System: E. coli

S100A14 Protein, Human, Recombinant (His)

Cat.No: TMPY-01879

Species: Human

Expression System: E. coli

BVES Protein, Human, Recombinant (GST)

Cat.No: TMPY-01000

Species: Human

Expression System: E. coli

p38 Protein, Human, Recombinant (His)

Cat.No: TMPY-04260

Species: Human

Expression System: Baculovirus Insect Cells

Pentraxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01816

Species: Human

Expression System: HEK293 Cells

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

JNK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04550

Species: Human

Expression System: Baculovirus Insect Cells

S100A10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01926

Species: Human

Expression System: E. coli

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