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Search Results for " hepatotoxic "

Targets Recommended: ATPase Platelet aggregation

8

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0712	Suloctidil	ATPase; Platelet aggregation	Membrane transporter/Ion channel; Others
	Suloctidil 是一种外周血管扩张剂，作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性，可治疗痴呆和血栓形成病症。
T32579	Lasiocarpine HCl Lasiocarpine hydrochloride	Others	Others
	Lasiocarpine HCl is a hepatotoxic and carcinogenic food contaminant.
T32982	Luteoskyrin Flavomycelin	Others	Others
	Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.
T40688	Fulvine	Others	Others
	Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo.
T61515	5-HT7 receptor ligand 1	Others	Others
	5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions with substrates of CYP3A4 or CYP2D6 enzymes [1].
T69106	Avarol	Others	Others
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.
T63337	CYP2C19-IN-1	Others	Others
	CYP2C19-IN-1 是强效的，无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM)，能够用于研究寨卡病毒 (ZIKV) 感染。
T35777	Nodularin	Others	Others
	The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff...

化合物

Cat.No: T0712

Target: ATPase, Platelet aggregation

Lasiocarpine HCl

Cat.No: T32579

Synonym: Lasiocarpine hydrochloride

Target: Others

Cat.No: T32982

Synonym: Flavomycelin

Target: Others

Cat.No: T40688

Target: Others

5-HT7 receptor ligand 1

Cat.No: T61515

Target: Others

Cat.No: T69106

Target: Others

Cat.No: T63337

Target: Others

Cat.No: T35777

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2147	Retrorsine	P450; OCT	Membrane transporter/Ion channel; Metabolism
	Retrorsine 特异性地抑制肝细胞增殖，并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。
T2S1158	4,5-Dicaffeoylquinic acid 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C	Others; HBV; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物，有抗病毒、抗肝毒性活性。
T3409	Plantamajoside Y0160,C10485,大车前苷,车前子甙	Others	Others
	Plantamajoside (Y0160) 是一种苯丙烷类糖苷，从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。
T4S1718	Punicalin	HBV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。
T3879	Silychristin 水飞蓟亭,水飞蓟汀,Silicristin	Lipoxygenase	Metabolism
	Silychristin (Silicristin) 是甲状腺激素转运体MCT8的有效抑制剂，能强烈抑制 T3 的摄取(IC50:110 nM)。它是一种水飞蓟果实中富含的黄酮类化合物，具有抗氧化作用。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
T6S1784	Brazilin Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素	Apoptosis; Others; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体，有软骨保护和抗炎活性。它抑制细胞增殖，促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。
T6S0735	Flavokawain B 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis; Others	Apoptosis; Others
	Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。
TN3835	Desacetyldoronine	Others	Others
	Desacetyldoronine is a hepatotoxic pyrrolizidine alkaloid.
TL0011	Adonifoline	Others	Others
	Adonifoline is a hepatotoxic pyrrolizidine alkaloid.
TN3180	6-O-(3'',4''-Dimethoxycinnamoyl)catalpol	Others	Others
	6-O-(3'',4''-Dimethoxycinnamoyl)catalpol has anti-hepatotoxic activity.
T40627	Trichodesmine	Others	Others
	Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo.
T40856	7-Acetylintermedine	Others	Others
	7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.
T25724	Ligularine	Others	Others
	Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.
T81795	Microcystin-WR
	Microcystin-WR为蓝藻代谢产物中的一种微囊藻毒素，对小鼠表现出肝脏毒性。
TN7344	Erucifoline N-oxide	Others	Others
	Erucifoline N-oxide是一种从Senecio persoonia中天然提取的化合物，具备肝脏保护功能。
TN3913	Echimidine	Antifection	Microbiology/Virology
	Echimidine, a major hepatotoxic dehydropyrrolizidine alkaloid produced by E. plantagineum, in the honey (780 ng/g) and in the subsequent mead samples (236-540 ng/mL). Echimidine-N-Oxide has antifungal activity.
TN4346	Jaconine	Others	Others
	Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.

天然产物

Cat.No: TN2147

Target: P450, OCT

4,5-Dicaffeoylquinic acid

Cat.No: T2S1158

Synonym: 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C

Target: Others, HBV, Endogenous Metabolite

Cat.No: T3409

Synonym: Y0160,C10485,大车前苷,车前子甙

Target: Others

Cat.No: T4S1718

Target: HBV, HIV Protease

Cat.No: T3879

Synonym: 水飞蓟亭,水飞蓟汀,Silicristin

Target: Lipoxygenase

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

Cat.No: T6S1784

Synonym: Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素

Target: Apoptosis, Others, AMPK, Autophagy

Cat.No: T6S0735

Synonym: 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Desacetyldoronine

Cat.No: TN3835

Target: Others

Cat.No: TL0011

Target: Others

6-O-(3'',4''-Dimethoxycinnamoyl)catalpol

Cat.No: TN3180

Target: Others

Cat.No: T40627

Target: Others

7-Acetylintermedine

Cat.No: T40856

Target: Others

Cat.No: T25724

Target: Others

Cat.No: T81795

Erucifoline N-oxide

Cat.No: TN7344

Target: Others

Cat.No: TN3913

Target: Antifection

Cat.No: TN4346

Target: Others

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