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Search Results for " glial "

Targets Recommended: Aquaporin PROTAC Linker

28

抑制剂 & 化合物

5

天然产物

3

化合物库

32

重组蛋白

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Cat. No.	Product Name
L7200	钙通道分子库		140 compounds
	140 种钙通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

钙通道分子库

Cat.No: L7200

Compounds: 140

神经再生化合物库

Cat.No: L7700

Compounds: 524

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T5102	TGN-020 TGN020	Aquaporin; PROTAC Linker	Membrane transporter/Ion channel; PROTAC
	TGN-020 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。TGN020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂，IC50为 3.1 μM。TGN020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。
T10624	BT-13	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	BT-13 是一种胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂，独立于 GDNF 配体发挥作用，能够促进体外感觉神经元神经突生长，减少大鼠神经病变的发生。
T17174	Troriluzole BHV4157,BHV-4157,BHV-4157a,FC 4157,BHV 4157	transporter	Metabolism
	Troriluzole 是一种具有口服活性谷氨酸调节剂，具有抗癌活性。Troriluzole 可提高位于神经胶质细胞的兴奋性氨基酸转运体的表达，可用于研究脊髓小脑性共济失调、阿尔茨海默病和广泛性焦虑症 (GAD) 。
T3515	TRC051384 HCl	HSP	Cytoskeletal Signaling; Metabolism
	TRC051384 HCl 是热休克蛋白 Hsp70 的诱导剂，可激活热休克因子-1 并增强神经元和神经胶质细胞中 Hsp72 的表达。
T33535	MW01-2-151SRM MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM	Others	Others
	MW01-2-151SRM 是一种新型可穿过血脑屏障的小分子小胶质细胞活化抑制剂，具有抗神经炎作用，可减弱神经炎症模型中的神经胶质细胞因子上调，可用研究创伤性脑损伤、阿尔茨海默病和海藻氨酸毒性。
T77092	Nadecnemab REGN-5069	Others	Others
	Nadecnemab 是一种靶向胶质细胞源性神经营养因子家族受体 GFRA3 的 IgG4κ 抗体。Nadecnemab 可用于膝骨关节炎和神经系统疾病。
T73286	SRI-42127	HuR	Chromatin/Epigenetic
	SRI-42127 是一种新型 RNA 调节因子 HuR 的小分子抑制剂，抑制肿瘤生长，可减弱脂多糖诱导的神经炎症模型中的神经胶质活化，通过抑制神经炎症反应来减轻神经损伤后的神经性疼痛。
T67733	BT44	Others	Others
	BT44是一种新的、第二代神经胶质细胞系衍生的神经营养因子模拟物，具有改善的生物活性，是治疗神经退行性疾病的先导化合物。
T13587	BT18	Others	Others
	BT18 是一种功能类似于胶质细胞源神经营养因子的分子模拟物。它能够影响 GDNF 家族受体 GFRα1 和 RET 受体酪氨酸激酶 RetA 的功能。
T3527	TRC051384 TRC 051384	HSP	Cytoskeletal Signaling; Metabolism
	TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂，可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率，激活热休克因子-1 并导致分子伴侣和抗炎活性升高，增强神经元和神经胶质细胞中 Hsp72 的表达。
T23454	TFB-TBOA	Others	Others
	glial glutamate transporter EAAT1 and EAAT2 inhibitor
T29021	TT-301 MW 189,MW189,TT301,TT 301,MW 189 ;MW189,MW-189	Others	Others
	TT-301 is a cytokine inhibitor and glial cell inhibitor.
T22913	L-CCG-lll	Others	Others
	inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate.
T76238	Zilganersen	Others	Others
	Zilganersen (ION373) 为GFAP抑制剂，属于反义寡核苷酸类。适用于亚历山大病(AxD)的研究。
T37699	Org 24598	Others	Others
	Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 \|Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibi...
T38202	PAQ	Others	Others
	PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. PAQ (25 or 50 mg/kg, twice per day) prevents loss of dopaminergic neurons in the substantia nigra in a mouse model of Parkinson's disease induced by MPTP.
T60344	L-Cytidine	Others	Others
	L-Cytidine 是Cytidine 的 L-构型形式。L-Cytidine 是一种嘧啶核苷，是RNA 的组成部分。Cytidine 可控制神经胶质谷氨酸循环，影响脑磷脂代谢，儿茶酚胺的合成和线粒体功能。
T64036	5-HT6R/MAO-B modulator 1	Others	Others
	5-HT6R/MAO-B modulator 1 是一种 5-HT6R 在 Gs 信号传导处的拮抗剂和不可逆的MAO-B 抑制剂，表现出胶质保护活性。5-HT6R/MAO-B modulator 1 对东莨菪碱诱导的记忆缺陷表现出诱导作用。
T39343	MW-150 hydrochloride MW01-18-150SRM hydrochloride,MW-150 hydrochloride	Others	Others
	MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) effectively suppresses the phosphorylation of MK2, a substrate of endogenous p38α MAPK, in activated glial cells.
T37167	Reduced Haloperidol	Others	Others
	Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing ...
T71174	PBT434 HBr	Others	Others
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g...
T37898	UDP-α-D-Glucose (sodium salt hydrate)	Others	Others
	UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2 1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurin...
T84534	Arachidonoyl-N-methyl amide	Others	Others
	Anandamide (AEA), an endogenous cannabinoid, interacts with both central (CB1) and peripheral (CB2) cannabinoid receptors. Its effects are concluded through the cellular uptake and enzymatic breakdown of its amide bond by fatty acid amide hydrolase. Arachidonoyl-N-methyl amide, an analog of anandamide, specifically targets the human CB1 receptor, displaying a binding affinity with a Ki of 60 nM. It completely inhibits rat glial gap junction intercellular communication at a concentration of 50 µM...
T63293	Axl-IN-7	Others	Others
	Axl-IN-7 是 AXL 的有效抑制剂。Axl-IN-7 能够用于研究 Axl 相关疾病，如癌症(如急性髓系白血病、乳腺癌、黑色素瘤、胰腺癌和神经胶质肿瘤)、免疫系统紊乱、肾脏疾病和心血管疾病。
T71576	SIM010603	Others	Others
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T35553	Ganglioside GQ1b Mixture (sodium salt)	Others	Others
	Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. It stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells when used at a concentration of 5 nM. Ganglioside GQ1b promotes differentiation of murine embryonic stem cells (mESCs) to neuronal precursor and glial cells via activation of the ERK1/2 pathway. It also induces differentiation of murine keratinocytes throu...
T36188	Ceramide Phosphoethanolamines (bovine)
	Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi...
T76014	IGF-I (24-41) (TFA)
	IGF-I (24-41) TFA（Insulin-like Growth Factor I (24-41) TFA）是类胰岛素生长因子I的一个氨基酸片段，覆盖24至41位点。作为一种70个氨基酸组成的多肽激素，IGF-I TFA对神经元和神经胶质细胞具有营养作用，而且在调节全身生长激素（GH）活性中扮演关键角色。它还具备合成代谢、抗氧化、抗炎及细胞保护功能，对躯体生长及行为发育调节作用显著。

化合物

Cat.No: T5102

Synonym: TGN020

Target: Aquaporin, PROTAC Linker

Cat.No: T10624

Target: c-RET

Cat.No: T17174

Synonym: BHV4157,BHV-4157,BHV-4157a,FC 4157,BHV 4157

Target: transporter

Cat.No: T3515

Target: HSP

Cat.No: T33535

Synonym: MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM

Target: Others

Cat.No: T77092

Synonym: REGN-5069

Target: Others

Cat.No: T73286

Target: HuR

Cat.No: T67733

Target: Others

Cat.No: T13587

Target: Others

Cat.No: T3527

Synonym: TRC 051384

Target: HSP

Cat.No: T23454

Target: Others

Cat.No: T29021

Synonym: MW 189,MW189,TT301,TT 301,MW 189 ;MW189,MW-189

Target: Others

Cat.No: T22913

Target: Others

Cat.No: T76238

Target: Others

Cat.No: T37699

Target: Others

Cat.No: T38202

Target: Others

Cat.No: T60344

Target: Others

5-HT6R/MAO-B modulator 1

Cat.No: T64036

Target: Others

MW-150 hydrochloride

Cat.No: T39343

Synonym: MW01-18-150SRM hydrochloride,MW-150 hydrochloride

Target: Others

Reduced Haloperidol

Cat.No: T37167

Target: Others

Cat.No: T71174

Target: Others

UDP-α-D-Glucose (sodium salt hydrate)

Cat.No: T37898

Target: Others

Arachidonoyl-N-methyl amide

Cat.No: T84534

Target: Others

Cat.No: T63293

Target: Others

Cat.No: T71576

Target: Others

Ganglioside GQ1b Mixture (sodium salt)

Cat.No: T35553

Target: Others

Ceramide Phosphoethanolamines (bovine)

Cat.No: T36188

IGF-I (24-41) (TFA)

Cat.No: T76014

Cat. No.	Product Name	Target	Signaling Pathways
T8276	Methyl palmitoleate	Others	Others
	Methyl palmitoleate 是棕榈油酸的类似物，也是一种脂肪酸甲酯，具有细胞保护性和促进生长性。
T5057	DL-O-Phosphoserine DL-O-磷酸丝氨酸,DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP	Others; Endogenous Metabolite	Metabolism; Others
	O-PHOSPHO-L-SERINE 是丝氨酸和磷酸的酯，是人类生物流体中的正常代谢物。O-phospho-L-serine 是一种吞噬抑制剂，抑制光损伤后的神经胶质细胞增殖和锥体细胞再生。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
T35605	Apoptolidin	Others	Others
	Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.

天然产物

Methyl palmitoleate

Cat.No: T8276

Target: Others

DL-O-Phosphoserine

Cat.No: T5057

Synonym: DL-O-磷酸丝氨酸,DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP

Target: Others, Endogenous Metabolite

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

Cat.No: T35605

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293) HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot...	Human	HEK293 Cells
	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPJ-00846	GFAP Protein, Human, Recombinant (His) Glial Fibrillary Acidic Protein,GFAP	Human	E. coli
	Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament (IF) protein which belongs to the intermediate filament family. GFAP is expressed in numerous cell types of the central nervous system (CNS), ependymal cells and phosphorylated by PKN1. GFAP, a class-III intermediate filament, is a cell-specific marker during the development of the central nervous system and distinguishes astrocytes from other glial cells. It is closely related to its non-epithelial family members, vimentin, desm...
TMPH-02674	GFAP Protein, Mouse, Recombinant Gfap,Glial fibrillary acidic protein	Mouse	Baculovirus Insect Cells
	GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
TMPH-02673	GFAP Protein, Mouse, Recombinant (His & SUMO) Glial fibrillary acidic protein,Gfap	Mouse	E. coli
	GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
TMPY-03185	METRN Protein, Mouse, Recombinant (hFc) meteorin, glial cell differentiation regulator,Hyra...	Mouse	HEK293 Cells
	METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. The encoded protein belongs to the meteorin family. It is broadly expressed in the brain, kidney, and other tissues. Meteorin is a novel secreted protein that is expressed in undifferentiated neural progenitors and the astrocyte lineage, including radial glia. It plays important role in the differentiation of glial cells and also in axonal network formation during neurogenesis. Meteorin selectively promoted astrocyt...
TMPH-00465	GFAP Protein, Danio rerio, Recombinant (His & Myc & SUMO) gfap,Glial fibrillary acidic protein	Danio rerio (Zebrafish)	E. coli
	N/A. GFAP Protein, Danio rerio, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 71.2 kDa and the accession number is Q58EE9.
TMPY-04535	GDNF Protein, Canine, Recombinant (hFc) glial cell derived neurotrophic factor,胶质细胞生长因子	Canine	HEK293 Cells
	GDNF Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40 kDa and the accession number is XP_005619436.1.
TMPY-02911	GDNF Protein, Rat, Recombinant (His) glial cell derived neurotrophic factor,胶质细胞生长因子	Rat	Baculovirus Insect Cells
	GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is Q07731-1.
TMPY-00419	HEPACAM Protein, Human, Recombinant (His) HEPACAM,MLC2A,hepatic and glial cell adhesion molec...	Human	HEK293 Cells
	HEPACAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q14CZ8-1.
TMPH-01381	GDNF Protein, Human, Recombinant (His & SUMO) Astrocyte-derived trophic factor,GDNF,Glial cell li...	Human	E. coli
	Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 31.1 kDa and the accession number is P39905.
TMPY-06970	GDNF Protein, Human, Recombinant ATF1,ATF2,HSCR3,胶质细胞生长因子,HFB1-GDNF,glial cell deriv...	Human	E. coli
	GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
TMPH-02305	VCAN Protein, Human, Recombinant (B2M & His & Myc) VCAN,Glial hyaluronate-binding protein,Versican cor...	Human	E. coli
	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
TMPJ-00090	FGF-9 Protein, Human, Recombinant Fibroblast Growth Factor 9,Heparin-Binding Growth Factor 9,F...	Human	E. coli
	Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c...
TMPJ-01011	FGF-9 Protein, Mouse, Recombinant (His) heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...	Mouse	E. coli
	Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPY-01085	VLDLR Protein, Human, Recombinant (His) VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,...	Human	HEK293 Cells
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ...
TMPY-01442	DMBT1 Protein, Human, Recombinant (His) GP340,deleted in malignant brain tumors 1,muclin	Human	HEK293 Cells
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPH-01675	Meteorin Protein, Human, Recombinant (His) Meteorin,METRN	Human	E. coli
	Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
TMPK-00109	Artemin Protein, Human, Recombinant (hFc) ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN	Human	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons.
TMPH-02579	CHRDL1 Protein, Mouse, Recombinant (His & Myc) Nrln1,Neuralin-1,Ng1,Neurogenesin-1,Chrdl1,Ventroptin,Chordi...	Mouse	Baculovirus Insect Cells
	Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the ind...
TMPJ-00688	Persephin Protein, Human, Recombinant PSPN,Persephin,PSP	Human	E. coli
	Persephin is a secreted protein, belongs to the glial cell linederived neurotrophic factor (GDNF) family of the TGF-β superfamily. It shares 38-46% amino acid (aa) identity with family members GDNF, neurturin and artemin. It is expressed at very low levels in most tissues. Mature protein contains a signal sequence, a pro-domain and a 96 aa mature sequence with several cysteines that are conserved among family members. It circulates as an unglycosylated disulfide-linked homodimer. Like other GDNF...
TMPJ-00290	GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) TRNR2,GDNFR-beta,TGF-β-related neurotrophic factor receptor ...	Human	HEK293 Cells
	GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kina...
TMPJ-00306	SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs...	Human	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ...
TMPJ-00305	SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His) Inhibitory Feceptor SHPS-1,MyD-1 Antig,Brain Ig-Like Molecul...	Cynomolgus	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ...
TMPY-05062	NRG2 Protein, Human, Recombinant (His) DON1,HRG2,NTAK	Human	HEK293 Cells
	Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted ...
TMPJ-00845	CTSE Protein, Human, Recombinant (His) CTSE,Cathepsin E	Human	HEK293 Cells
	Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. It is expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. CTSE is an intrac...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc) artemin,neublastin	Mouse	HEK293 Cells
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a...
TMPJ-01182	SIRP alpha Protein, Mouse, Recombinant (MIgG2a) SIRP,CD172 Antigen-Like Family Member A,SIRPA,MFR,Signal-Reg...	Mouse	HEK293 Cells
	SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-l...
TMPJ-00671	FABP7 Protein, Human, Recombinant (His) Fatty Acid-Binding Protein 7,Mammary-Derived Growth Inhibito...	Human	E. coli
	Fatty Acid-Binding Protein 7 (FABP7) is a cytoplasm protein that belongs to the Fatty-acid Binding Protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP7 is predominately expressed in brain and neural tissues. FABP7 is involved in fatty acid uptake and intracellular transport and is important in brain development. FABP7 plays a critical role in the transport of a so far unknow...
TMPJ-00448	NRG1 beta 1 Protein, Human, Recombinant (aa 2-246) NRG1β,HGL,NDF,NRG1,HRGA,HRG1-beta 1,Pro-neuregulin-1,HRG1-β1...	Human	E. coli
	Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and ...
TMPY-01755	VWC2 Protein, Human, Recombinant (His) PSST739,von Willebrand factor C domain containing 2,UNQ739	Human	HEK293 Cells
	Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein that contains two VWFC domains. VWC2 / Brorin is a BMP antagonist that may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neura...
TMPJ-01290	Neurturin Protein, Human, Recombinant Neurturin,NRTN	Human	E. coli
	Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Similarly to other TGFβ family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Neurturin contains the characteristic seven conserved cysteine residues nec...
TMPY-01695	CASPR2 Protein, Mouse, Recombinant (His) 5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI...	Mouse	HEK293 Cells
	CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media...

重组蛋白

GDNF Protein, Human, Recombinant (HEK293)

Cat.No: TMPY-02792

Species: Human

Expression System: HEK293 Cells

GFAP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00846

Species: Human

Expression System: E. coli

GFAP Protein, Mouse, Recombinant

Cat.No: TMPH-02674

Species: Mouse

Expression System: Baculovirus Insect Cells

GFAP Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02673

Species: Mouse

Expression System: E. coli

METRN Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03185

Species: Mouse

Expression System: HEK293 Cells

GFAP Protein, Danio rerio, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00465

Species: Danio rerio (Zebrafish)

Expression System: E. coli

GDNF Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-04535

Species: Canine

Expression System: HEK293 Cells

GDNF Protein, Rat, Recombinant (His)

Cat.No: TMPY-02911

Species: Rat

Expression System: Baculovirus Insect Cells

HEPACAM Protein, Human, Recombinant (His)

Cat.No: TMPY-00419

Species: Human

Expression System: HEK293 Cells

GDNF Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01381

Species: Human

Expression System: E. coli

GDNF Protein, Human, Recombinant

Cat.No: TMPY-06970

Species: Human

Expression System: E. coli

VCAN Protein, Human, Recombinant (B2M & His & Myc)

Cat.No: TMPH-02305

Species: Human

Expression System: E. coli

FGF-9 Protein, Human, Recombinant

Cat.No: TMPJ-00090

Species: Human

Expression System: E. coli

FGF-9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01011

Species: Mouse

Expression System: E. coli

VLDLR Protein, Human, Recombinant (His)

Cat.No: TMPY-01085

Species: Human

Expression System: HEK293 Cells

DMBT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01442

Species: Human

Expression System: HEK293 Cells

Meteorin Protein, Human, Recombinant (His)

Cat.No: TMPH-01675

Species: Human

Expression System: E. coli

Artemin Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00109

Species: Human

Expression System: HEK293 Cells

CHRDL1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02579

Species: Mouse

Expression System: Baculovirus Insect Cells

Persephin Protein, Human, Recombinant

Cat.No: TMPJ-00688

Species: Human

Expression System: E. coli

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00290

Species: Human

Expression System: HEK293 Cells

SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00306

Species: Human

Expression System: HEK293 Cells

SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His)

Cat.No: TMPJ-00305

Species: Cynomolgus

Expression System: HEK293 Cells

NRG2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05062

Species: Human

Expression System: HEK293 Cells

CTSE Protein, Human, Recombinant (His)

Cat.No: TMPJ-00845

Species: Human

Expression System: HEK293 Cells

Artemin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01576

Species: Mouse

Expression System: HEK293 Cells

SIRP alpha Protein, Mouse, Recombinant (MIgG2a)

Cat.No: TMPJ-01182

Species: Mouse

Expression System: HEK293 Cells

FABP7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00671

Species: Human

Expression System: E. coli

NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

Cat.No: TMPJ-00448

Species: Human

Expression System: E. coli

VWC2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01755

Species: Human

Expression System: HEK293 Cells

Neurturin Protein, Human, Recombinant

Cat.No: TMPJ-01290

Species: Human

Expression System: E. coli

CASPR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01695

Species: Mouse

Expression System: HEK293 Cells

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