cereblon ligand 4

Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。

Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。

cIAP1 ligand 4, a ligand for E3 ligase, is utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras).

Cereblon Ligand -Linker Conjugates 2 TFA 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。

cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1].

K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].

Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。

Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物，用于 PROTAC 技术中。

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。

Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。

Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物，结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。

Pomalidomide 4'-PEG2-azide 是由E3 连接酶配体和linker 组成的偶联物，包括基于 Pomalidomide 的 cereblon 配体和linker。

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker，是合成的 E3 连接酶配体-linker 偶联物，可应用于 PROTAC 技术。

Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Thalidomide-4-O-C12-NH2 hydrochloride为基于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物可利用linker与目标蛋白配体结合，构建PROTAC分子，如THAL-SNS-032。

Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体，能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合，进而形成PROTAC分子，如THAL-SNS-032。

Thalidomide4'-ether-PEG1-azide 是一种以Thalidomide为基础，能够募集CRBN蛋白的cereblon配体。通过linker与靶蛋白配体连接，Thalidomide4'-ether-PEG1-azide可用于形成PROTAC分子。

Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) 是一种基于Pomalidomide的 E3 泛素连接酶 cereblon(CRBN) 配体，用于募集合成 cereblon 蛋白。Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride consists of a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker, making it suitable for PROTACs design.

Pomalidomide 4'-PEG3-azide 是一个包含 Pomalidomide 的 cereblon 配体和 1 个 linker 的 E3 连接酶配体-linker 偶联物，可用于 iRucaparib-TP3 的合成。

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate.

Thalidomide-4-O-C7-NH2 hydrochloride是一种Thalidomide衍生的CRBN配体，能够招募cereblon蛋白。该化合物能通过linker与目标蛋白配体结合，用于构建PROTAC分子，如THAL-SNS-032。

Thalidomide-4-O-C14-NH2 hydrochloride是一款衍生于Thalidomide的cereblon配体，能够招募CRBN蛋白。该化合物通过linker可与目标蛋白的配体结合，进而构建PROTAC分子，例如THAL-SNS-032。

Pomalidomide 4'-PEG5-amine是一种功能化的cereblon配体，用于PROTAC研究与开发；它结合了一个E3连接酶配体和一个末端带有氨基的PEG5连接体，以便与目标蛋白配体进行共轭。它是专为PROTAC研发设计的一系列功能化工具分子之一。

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated.

Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].

Pomalidomide 4'-PEG5-azide是一种E3泛素连接酶cereblon(CRBN)的基于Pomalidomide的配体，用于募集cereblon蛋白。通过linker，Pomalidomide 4'-PEG5-azide能够连接到蛋白质配体上，形成PROTAC。

Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in - see protocol for more information.) 0

Pomalidomide-amido-C4-amido-C6-NH-Boc, a synthesized conjugate, is a ligand-linker incorporating the cereblon ligand based on Pomalidomide and a PROTAC technology linker.

Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in - see protocol for more information.) 0

Pomalidomide 4'-alkylC6-azide，一种Pomalidomide基础上的E3泛素连接酶cereblon(CRBN)配体，其作用为募集cereblon蛋白。通过linker连接至蛋白质配体，Pomalidomide 4'-alkylC6-azide能够形成PROTAC。

Phenyl-glutarimide 4'-piperazine是一种具有piperazine功能化的cereblon配体，可用于PROTACDegrader的开发。该化合物可用于开发PG-PROTACs，与使用IMiD（immunomodulatory imide drug）类似物合成的PROTACs相比，展示出改善的水解稳定性和效力。

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs.

Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC.

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker. It functions as an E3 ligase ligand-linker conjugate and finds applications in the synthesis of PROTACs[1].

Thalidomide-4-O-C10-NH2 hydrochloride 是一种Thalidomide衍生的cereblon配体，能募集CRBN蛋白。该化合物可利用linker与特定的靶蛋白配体结合，用以构建PROTAC分子，如THAL-SNS-032。

Lenalidomide 4'-PEG2-azide是一种Cereblon配体，基于Lenalidomide开发，用于招募CRBN蛋白。通过linker，Lenalidomide 4'-PEG2-azide能与蛋白质配体连接，进而形成PROTAC。

Lenalidomide 4'-alkyl-C3-azide（化合物4a）是经过点击化学修饰的Lenalidomide，用于PROTACs的合成。作为一种口服活性免疫调节剂，Lenalidomide是泛素E3连接酶cereblon（CRBN）的配体。该化合物含Azide基团，能够通过铜催化的叠氮-炔环加成反应（CuAAc）与含Alkyne基团的分子反应，同时也能与含DBCO或BCN基团的分子通过菌株促进的炔-叠氮环加成反应（SPAAC）进行反应。