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Search Results for " catabolic "

Targets Recommended: Others Endogenous Metabolite

15

抑制剂 & 化合物

6

天然产物

7

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T5593	L-Alanyl-L-glutamine L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln	Others; Endogenous Metabolite	Metabolism; Others
	L-Alanyl-L-glutamine (Ala-Gln) 是一种由丙氨酸和谷氨酰胺组成的二肽，对抗氧化系统有益，能够减轻炎症，并能够在分解代谢情况下调节热休克蛋白 (HSP) 的反应。
T13089	TAS-114 TAS114,TAS 114	Others	Others
	TAS-114 是一种具有口服活性的 dUTPase 和二氢嘧啶脱氢酶 (DPD) 的双重抑制剂。 TAS-114 靶向5-FU的细胞间代谢以增强抗肿瘤活性，调节分解代谢途径以改善5-FU的全身可用性。
T0309	Ipriflavone Osteofix,依普黄酮	advanced glycation end products	Others
	Ipriflavone (Osteofix) 是一种合成异黄酮衍生物，可用于抑制骨吸收。
T60738	JNJ-1289	Smo	Stem Cells
	JNJ-1289 是一种具有选择性、有效性和竞争性人精胺氧化酶 (hSMOX) 抑制剂，IC50 值为 50 nM。JNJ-1289 具有潜在的抗癌和抗炎活性，可用于研究多胺分解代谢类疾病。
T33613	NCGC00135472 NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472	Others	Others
	NCGC00135472 (DRV1 (GPR32) agonist C2A)是具有促分解功能的人Resolvin D1受体激动剂,可在β阻滞素和 cAMP 测定中激活人溶解蛋白 D1 受体 DRV1/GPR32 受体，EC50 分别为 0.37 uM 和 0.05 uM。NCGC00135472在过表达重组DRV1的细胞中引起快速阻抗变化，刺激血清处理的酶聚糖的吞噬作用。
T5952	Diniconazole 烯唑醇,Rac-diniconazole	Antibacterial	Microbiology/Virology
	Diniconazole (Rac-diniconazole) 是新型杀菌剂, 抑制由酵母细胞色素P-450催化的羊毛甾醇14α-脱甲基化。
T21482	Uniconazole	P450; ROS Kinase	Metabolism; Tyrosine Kinase/Adaptors
	Uniconazole 是植物生长调节剂，能够抑制细胞色素 P450 707As (Ki=68 nM)。他是分解脱落酸的酶家族成员，能够抑制赤霉素和甾醇的生物合成。
T70345	JAS239	Others	Others
	JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing C...
T70805	Diethylnorspermine HBr	Others	Others
	Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..
T74510	TFMU-ADPr
	TFMU-ADPr作为监测聚ATP-核糖糖水解酶(PARG)活性的底物，以其释放的荧光团直接反映PAR水解酶总活性而常用。该化合物因具备优良的反应性、通用性、稳定性及易用性，成为体外评估小分子抑制剂及研究ATP-核糖基分解代谢酶调控的首选工具。
T76134	α-Galactosidase	Others	Others
	α-Galactosidase(EC 3.2.1.22)，即 α-半乳糖苷酶，是一种糖苷水解酶，广泛存在于动植物和微生物中，常用于生化研究。α-Galactosidase 可以催化 α-1,6 连接的末端半乳糖残基的水解，包括低聚半乳糖、半乳甘露聚糖和半乳糖脂。催化许多分解代谢过程，包括糖蛋白、糖脂和多糖的裂解。
T74511	TFMU-ADPr triethylamine	Others	Others
	TFMU-ADPr triethylamine 作为监测聚 ATP-核糖糖水解酶 (PARG) 活性的标准底物，能够通过释放荧光团直接报告 PAR 水解酶的总活性。其特点包括高反应性、广泛的通用性、稳定性以及便于使用，使其成为体外评估小分子抑制剂以及研究 ATP-核糖基分解代谢酶调控的优选工具。
T76124	Acyl coenzyme A synthetase	Others	Others
	Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。
T37531	Glycerophosphorylethanolamine (sodium salt)	Others	Others
	Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-β (1-40) (Aβ40)in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease. 1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997) 2.Blusztajn, J.K...
T35683	2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6	Others	Others
	2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste...

化合物

L-Alanyl-L-glutamine

Cat.No: T5593

Synonym: L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln

Target: Others, Endogenous Metabolite

Cat.No: T13089

Synonym: TAS114,TAS 114

Target: Others

Cat.No: T0309

Synonym: Osteofix,依普黄酮

Target: advanced glycation end products

Cat.No: T60738

Target: Smo

Cat.No: T33613

Synonym: NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472

Target: Others

Cat.No: T5952

Synonym: 烯唑醇,Rac-diniconazole

Target: Antibacterial

Cat.No: T21482

Target: P450, ROS Kinase

Cat.No: T70345

Target: Others

Diethylnorspermine HBr

Cat.No: T70805

Target: Others

Cat.No: T74510

α-Galactosidase

Cat.No: T76134

Target: Others

TFMU-ADPr triethylamine

Cat.No: T74511

Target: Others

Acyl coenzyme A synthetase

Cat.No: T76124

Target: Others

Glycerophosphorylethanolamine (sodium salt)

Cat.No: T37531

Target: Others

2-deoxy-D-Glucose-13C6

Cat.No: T35683

Synonym: 2-deoxy-D-Glucose-13C6

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0254	Probucol DH-581,普罗布考	Virus Protease; ABC; Lipid	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Probucol (DH-581) 是一种抗高脂血症药物，可通过增加 LDL 分解代谢率来降低血液中的胆固醇水平。
T5283	NADH disodium salt Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠	Others; Endogenous Metabolite	Metabolism; Others
	NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用，包括糖酵解，柠檬酸循环和β-氧化。
T7989	Trimethyl phosphate	Others	Others
	Trimethyl phosphate 是一种有机磷化合物，是催化磷酸化化合物水解的酶的抑制剂，已被用作合成肽和其他蛋白质的反应物，用作合成有机和无机化合物的催化剂，以及用作合成药物的试剂。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
T5251	Phenylpyruvic acid 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸	Others; Endogenous Metabolite	Metabolism; Others
	Phenylpyruvic acid (3-Phenylpyruvic acid) 可以通过乳酸脱氢酶合成3-苯基乳酸 (PLA)。
T64533	Ceramide (Egg, Chicken)	Apoptosis	Apoptosis
	Ceramide (Egg, Chicken)在鞘脂的合成代谢和分解代谢途径中起主要作用。Ceramide (Egg, Chicken)刺激许多细胞分化，生长抑制，细胞衰老和凋亡。

天然产物

Cat.No: T0254

Synonym: DH-581,普罗布考

Target: Virus Protease, ABC, Lipid

NADH disodium salt

Cat.No: T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠

Target: Others, Endogenous Metabolite

Trimethyl phosphate

Cat.No: T7989

Target: Others

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

Phenylpyruvic acid

Cat.No: T5251

Synonym: 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸

Target: Others, Endogenous Metabolite

Ceramide (Egg, Chicken)

Cat.No: T64533

Target: Apoptosis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03055	LYG1 Protein, Human, Recombinant (His) SALW1939,lysozyme G-like 1	Human	Baculovirus Insect Cells
	LYG1 (Lysozyme G1) is a Protein Coding gene. It belongs to the glycosyl hydrolase 23 family. Glycoside hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. LYG1 exhibits hydrolase activity, acting on glycosyl bonds (inferred); lysozyme activity (inferred). It is found in the extracellular region and may function in the cell wall macromolecule catabolic process, metabolic process...
TMPY-00611	UBE2B Protein, Mouse, Recombinant mHR6B,ubiquitin-conjugating enzyme E2B,Rad6b,HR6B,E2-14k,261...	Mouse	E. coli
	The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role in muscle protein homeostasis during catabolic conditions.
TMPH-01597	KYAT1 Protein, Human, Recombinant (His & SUMO) Kynurenine aminotransferase 1,KYAT1,Glutamine--phenylpyruvat...	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl...
TMPH-02615	CBS Protein, Mouse, Recombinant (His) Cystathionine beta-synthase,Serine sulfhydrase,Beta-thionase...	Mouse	E. coli
	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
TMPJ-00496	PGM2 Protein, Human, Recombinant (His) Phosphopentomutase,Phosphodeoxyribomutase,Glucose phosphomut...	Human	E. coli
	Phosphoglucomutase-2 (PGM2) is a member of PGM family, which catalyzes the inter-conversion of sugar phosphates and participates in anabolic and catabolic reactions. When cells are grown in glucose, PGM catalyzes the conversion of glucose-6-phosphate to glucose-1-phosphate an important precursor required for the synthesis of UDP glucose and trehalose. PGM2 catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphope...
TMPY-01579	GBA3 Protein, Human, Recombinant (His) glucosidase, beta, acid 3 (gene/pseudogene),GBA3,MGC126878,K...	Human	Baculovirus Insect Cells
	Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r...
TMPH-02536	BNIP3 Protein, Mouse, Recombinant (Cell-Free, His) Bnip3,BCL2/adenovirus E1B 19 kDa protein-interacting protein...	Mouse	E. coli
	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP...

重组蛋白

LYG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03055

Species: Human

Expression System: Baculovirus Insect Cells

UBE2B Protein, Mouse, Recombinant

Cat.No: TMPY-00611

Species: Mouse

Expression System: E. coli

KYAT1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01597

Species: Human

Expression System: E. coli

CBS Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02615

Species: Mouse

Expression System: E. coli

PGM2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00496

Species: Human

Expression System: E. coli

GBA3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01579

Species: Human

Expression System: Baculovirus Insect Cells

BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)

Cat.No: TMPH-02536

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T36055	Nitisinone-13C6 Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F...

同位素标记化合物

Nitisinone-13C6

Cat.No: T36055

Synonym: Nitisinone-13C6

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