bombesin

Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide.

[D-Phe12]-Bombesin acetate 抑制铃蟾素刺激的分泌。

Bombesin acetate(31362-50-2 free base) 是一种 14 个氨基酸的肽，是从欧洲火腹蟾蜍 (Bombina bombina) 的皮肤中分离出来的。它在哺乳动物中有两个已知的同源物，称为神经调节蛋白 B 和胃泌素释放肽。

[D-Phe12,Leu14]-Bombesin acetate 抑制铃蟾素刺激的分泌。

[Lys3]-Bombesin 是具有生物活性的肽类化合物，用于 PET（正电子发射断层扫描）成像检测 GRPR（胃泌素释放肽受体）阳性的前列腺癌。此外，[Lys3]-Bombesin 及其单克隆抗体的免疫缀合物能特异性诱导 CD64 依赖的单核细胞和中性粒细胞介导的小细胞肺癌细胞裂解。

Bombesin receptor antagonist

'(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin(6-14)是一种蛙皮素(bombesin)拮抗剂，主要应用于癌症研究领域。'

Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

Ranatensin acetate 是一种从 Rana pipiens 皮肤中分离出来的十一肽，是一种天然存在的铃蟾肽样肽。

Alytesin acetate 是一种两栖类铃蟾肽样肽。

BA 1 acetate(183241-31-8 free base) 是一种有效的铃蟾肽受体激动剂（BB1、BB2 和 BB3 的 IC50 值分别为 0.26、1.55 和 2.52 nM）。它增强肥胖和糖尿病原发性肌细胞中的葡萄糖转运，还可在体外刺激 NCI-H1299 肺癌细胞增殖。

Litorin acetate 是一种两栖类铃蟾肽衍生物，是一种铃蟾肽受体激动剂。它刺激平滑肌收缩，刺激胃泌素、胃酸和胰腺分泌，抑制体内营养。

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) 是广谱神经肽反向激动剂和拮抗剂。 ghrelin 受体的强效完全反向激动剂(EC50 = 5.2 nM)；减少组成型生长素释放肽受体信号传导。它也是速激肽、缓激肽、CCK 和铃蟾肽受体的拮抗剂。在体外诱导细胞凋亡并抑制癌细胞生长。

'(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate)' 是一种对 Substance P 及 Bombesin 担任拮抗作用的化合物，能针对眼部三叉神经反向刺激引起的炎症反应产生效果。

GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用，但 GMP 对此无影响。

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. In

BA 1 TFA是一种bombesin (BB)受体家族的激动剂，与Bombesin受体亚型3 (BRS3)、胃泌素释放肽受体 (GRPR)以及神经调节素B受体 (NMBR)具有高度亲和力，其IC50值分别为6、0.4、2.5 nM。

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro.

Neuromedin C (porcine) 是一种铃蟾肽样神经肽，可从猪脊髓中获得。Neuromedin C (porcine) 对大鼠子宫具有收缩活性。Neuromedin C (porcine) 有研究神经系统相关疾病的潜力。

RC-3095 TFA (RC-3095(TFA)) 是蛙皮素 胃泌素释放肽受体选择性拮抗剂。它能降低关节炎小鼠的胃氧化损伤，从而发挥保护作用。

Ranatensin, a undecapeptide isolated from skin of Rana pipiens, is a naturally occurring bombesin-like peptide.

Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength peptide.

BIM-26226 是一种胃泌素释放肽，是一种强效选择性的bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50值在纳摩尔范围内。BIM-26226 可用于癌症研究。

Neuromedin B 是由10个氨基酸组成的神经肽，属于蛙肽家族，为铃蟾肽相关肽。

Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice

RC-3095 acetate is an antagonist of bombesin/gastrin-releasing peptide receptor (GRPR). It exerts protective effects by reducing gastric oxidative injury in the arthritic mice.

Amphibian bombesin-like peptide