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Targets Recommended: Glucocorticoid Receptor Antibacterial Antibiotic

41

抑制剂 & 化合物

19

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0181	Loteprednol etabonate Lotemax,Alrex,氯替泼诺	Glucocorticoid Receptor; Antibacterial; Antibiotic	Endocrinology/Hormones; Microbiology/Virology
	Loteprednol etabonate (Lotemax) 是具有抗炎活性的皮质类固醇，用于眼科。
T3461	Losartan Carboxylic Acid EXP-3174,E-3174	RAAS	Endocrinology/Hormones
	Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。
TP1144L	Corticotropin-releasing factor (human) acetate Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)	CRFR	GPCR/G Protein
	Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。
T28926	TASP0390325 TASP 0390325,TASP-0390325	Vasopressin Receptor	GPCR/G Protein
	TASP0390325 是一种具有口服活性和高亲和力的精氨酸加压素受体 1B（V1B 受体）拮抗剂，在动物实验钟显示出抗抑郁和抗焦虑活性，可在体内阻断垂体前叶V1B受体。
TP1022	Protirelin Acetate TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Protirelin Acetate (TRH Acetate) 是高度保守的神经肽，具有促甲状腺激素水平的激素控制作用，及神经调节的能力。
TP1648L	[Gln8]-C517 (LH-RH), chicken acetate [Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base)	Others	Others
	[Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base) 是一种鸟类下丘脑肽，可刺激垂体前叶释放促性腺激素，从而调节生殖功能。
T62893	SM-2470	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SM-2470 是一种α1-adrenoceptor拮抗剂，具有降压活性，可减低前神经节肾上腺神经活性和主动脉降压神经活性。SM-2470 具有降胆固醇活性，可抑制胆固醇吸收。
TP1155L	Human growth hormone-releasing factor acetate	GHSR	GPCR/G Protein
	Human growth hormone-releasing factor acetate 是一种下丘脑多肽，通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。
T3316	Fluorometholone 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。
TP1238L	ACTH 1-14 acetate(25696-21-3 free base) Adrenocorticotropic Hormone Fragment 1-14 acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T37111	Corticotropin-releasing factor (human) (acetate)
	Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
TP1648	[Gln8]-C517 (LH-RH), chicken
	[Gln8] Luteinizing hormone releasing hormone ([Gln8] LH-RH), Avian hypothalamic peptide that stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
T71590	AHR-5645B fumarate	Others	Others
	AHR-5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes.
T69174	AHR-5645B free base	Others	Others
	AHR-5645B free base is a substituted benzamide which has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes.
T85273	Gonadorelin acetate	Others	Others
	Gonadorelin, a gonadotropin-releasing hormone receptor (GNRHR; Ki= 13 nM in CHO cells expressing the human receptor) agonist and tropic hormone, effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from rat anterior pituitary cultures at 0.1 μg doses. Additionally, it triggers LH release from bovine anterior pituitary cultures at a 1 μM concentration. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (ED50= 610.3 ng/kg). ...
T73663	Adrenocorticotropic hormone	Others	Others
	Adrenocorticotropic hormone (ACTH) 是一种由垂体前叶分泌的促肾上腺皮质激素(tropic hormone)，能够调节皮质醇和雄激素的产生。
T64270	Lutropin	Others	Others
	Lutropin 是一种异二聚体糖蛋白，是一种由垂体前叶促性腺细胞产生的激素，对卵泡的发育具有刺激作用。Lutropin 能够用于研究不孕症。
T80985	Thyrotropin Pretiron,TSH
	Thyrotropin (TSH)为促甲状腺激素，由垂体前叶的促甲状腺细胞分泌，主要功能是调节甲状腺的内分泌活动。
T78515	Follicle-stimulating hormone	Others	Others
	卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白，其参与调控动物的生殖能力与繁殖效率。
TP1144	Corticotropin-releasing factor (human) Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human
	Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b
T73664	Adrenocorticotropic hormone TFA
	Adrenocorticotropic hormone (ACTH) TFA，是由垂体前叶分泌，用于调节皮质醇和雄激素产生的促肾上腺皮质激素。
TP1011	ACTH (1-17) α1-17-ACTH
	ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.
T76595	(Des-His6)-ACTH (1-24) (human, bovine, rat)
	(Des-His6)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。
T82880	Biotin-H10
	Biotin-H10，作为一种特异性抑制剂，针对前梯度蛋白2 (AGR2)，其KD值为6.4 nM。此化合物能有效抑制癌细胞活力。
T76303	(p-Iodo-Phe7)-ACTH (4-10)
	'(p-Iodo-Phe7)-ACTH (4-10)'为垂体前腺产生和分泌的肾上腺皮质激素(ACTH)衍生物，担任黑素皮质素(MC)受体拮抗剂角色，能够抑制α-黑素细胞刺激激素(α-MSH)引发的大鼠过度梳理行为。
TP1247	ACTH (1-13) Adrenocorticotropic Hormone (1-13),ACTH 1-13
	ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an impor
TP1155	Human growth hormone-releasing factor Growth Hormone Releasing Factor human
	Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormo
T76510	[Asu1,6-Arg8]Vasopressin
	[Asu1,6-Arg8]Vasopressin 是一种加压素 (vasopressin) 激动剂，可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环AMP 积累和ACTH 释放。
T75713	Human growth hormone-releasing factor TFA
	Growth Hormone Releasing Factor human TFA 是下丘脑多肽，通过与GHRHR结合，刺激生长激素生成和释放。
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica...
T76591	(Des-Glu5)-ACTH (1-24) (human, bovine, rat)
	(Des-Glu5)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。
TP1302	Somatostatin
	Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and
T36070	(±)5(6)-EET	Others	Others
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...
T68525	Nafarelin acetate hydrate	Others	Others
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T70309	Dicetrorelix pamoate	Others	Others
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T38218	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC	Others	Others
	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂，在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症（ALS）模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET	Others	Others
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T83665	α-Helical CRF (9-41) TFA α-Helical Corticotropin-Releasing Factor (9-41)
	α-Helical CRF (9-41) 是一种合成的皮质酮释放因子（CRF）拮抗剂。它在0.5至5 µM浓度范围内，能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素（ACTH）。在体内研究中，α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放，并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外，α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间，并减少小鼠的类似暴饮暴食的乙醇消费。
T83769	TC 14012 hydrochloride H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2
	TC 14012是一种化学肽模拟的拮抗剂，针对趋化因子(C-X-C motif)受体4（CXCR4；IC50 = 2.9 nM）和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募（EC50 = 350 nM）。TC 14012可减少HIV在MT-4细胞中的细胞病理效应（EC50 = 0.4 nM），并以CXCR4依赖的方式抑制HIV在体外进入（IC50 = 19.3 nM）。它还能抑制由趋化因子(C-X-C motif)配体12（CXCL12）在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞（HUVECs）中诱导的迁移，当使用浓度范围从10到1,000 nM时。在通过左前降（LAD）冠状动脉结扎诱导的急性心肌梗死小鼠模型中，TC 14012（10 mg/kg）能减少梗死面积。
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....

化合物

Loteprednol etabonate

Cat.No: T0181

Synonym: Lotemax,Alrex,氯替泼诺

Target: Glucocorticoid Receptor, Antibacterial, Antibiotic

Losartan Carboxylic Acid

Cat.No: T3461

Synonym: EXP-3174,E-3174

Target: RAAS

Corticotropin-releasing factor (human) acetate

Cat.No: TP1144L

Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)

Target: CRFR

Cat.No: T28926

Synonym: TASP 0390325,TASP-0390325

Target: Vasopressin Receptor

Protirelin Acetate

Cat.No: TP1022

Synonym: TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

[Gln8]-C517 (LH-RH), chicken acetate

Cat.No: TP1648L

Synonym: [Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base)

Target: Others

Cat.No: T62893

Target: Adrenergic Receptor

Human growth hormone-releasing factor acetate

Cat.No: TP1155L

Target: GHSR

Fluorometholone

Cat.No: T3316

Synonym: 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson

Target: Glucocorticoid Receptor

ACTH 1-14 acetate(25696-21-3 free base)

Cat.No: TP1238L

Synonym: Adrenocorticotropic Hormone Fragment 1-14 acetate

Target: Adrenergic Receptor

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Corticotropin-releasing factor (human) (acetate)

Cat.No: T37111

[Gln8]-C517 (LH-RH), chicken

Cat.No: TP1648

AHR-5645B fumarate

Cat.No: T71590

Target: Others

AHR-5645B free base

Cat.No: T69174

Target: Others

Gonadorelin acetate

Cat.No: T85273

Target: Others

Adrenocorticotropic hormone

Cat.No: T73663

Target: Others

Cat.No: T64270

Target: Others

Cat.No: T80985

Synonym: Pretiron,TSH

Follicle-stimulating hormone

Cat.No: T78515

Target: Others

Corticotropin-releasing factor (human)

Cat.No: TP1144

Synonym: Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human

Adrenocorticotropic hormone TFA

Cat.No: T73664

Cat.No: TP1011

Synonym: α1-17-ACTH

(Des-His6)-ACTH (1-24) (human, bovine, rat)

Cat.No: T76595

Cat.No: T82880

(p-Iodo-Phe7)-ACTH (4-10)

Cat.No: T76303

Cat.No: TP1247

Synonym: Adrenocorticotropic Hormone (1-13),ACTH 1-13

Human growth hormone-releasing factor

Cat.No: TP1155

Synonym: Growth Hormone Releasing Factor human

[Asu1,6-Arg8]Vasopressin

Cat.No: T76510

Human growth hormone-releasing factor TFA

Cat.No: T75713

PACAP-related Peptide (rat) (trifluoroacetate salt)

Cat.No: T37435

Target: PACAP

(Des-Glu5)-ACTH (1-24) (human, bovine, rat)

Cat.No: T76591

Cat.No: TP1302

Cat.No: T36070

Target: Others

Nafarelin acetate hydrate

Cat.No: T68525

Target: Others

Dicetrorelix pamoate

Cat.No: T70309

Target: Others

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

Cat.No: T38218

Target: Others

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target: Others

α-Helical CRF (9-41) TFA

Cat.No: T83665

Synonym: α-Helical Corticotropin-Releasing Factor (9-41)

TC 14012 hydrochloride

Cat.No: T83769

Synonym: H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01233	AGR3 Protein, Mouse, Recombinant (His) AGR3,Anterior gradient protein 3,BCMP11,AG3	Mouse	HEK293 Cells
	Anterior gradient protein 3 (AGR3) is an 18 kDa member of the AGR family of proteins. It is expressed in the ciliated cells of the airway epithelium, not detected in the mucous cells. Mature human AGR3 shares 92% amino acid sequence identity with mouse AGR3. It is required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. AGR3 might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
TMPY-04205	AGR3 Protein, Human, Recombinant (mFc) hAG-3,AG3,HAG3,anterior gradient 3,PDIA18,BCMP11,AG...	Human	HEK293 Cells
	Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been...
TMPK-00698	AGR2 Protein, Mouse, Recombinant (His) AG2,HPC8,hAG-2,Anterior gradient protein 2 homolog,...	Mouse	E. coli
	Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in a diverse range of biological systems, including vertebrate tissue development, inflammatory tissue injury responses, and cancer progression.
TMPJ-00050	AG-3 Protein, Human, Recombinant (His) BCMP11,hAG-3,AG-3,AG3,Anterior Gradient Protein 3 H...	Human	HEK293 Cells
	Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.
TMPJ-00056	AG-2 Protein, Human, Recombinant (His) HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Hom...	Human	HEK293 Cells
	Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E...
TMPH-00488	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) Follicle-stimulating hormone alpha chain,Glycoprotein hormon...	Canine	P. pastoris (Yeast)
	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) is expressed in Yeast.
TMPH-00489	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc) Follitropin alpha chain,CGA,Luteinizing hormone alpha chain,...	Canine	E. coli
	Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-00713	GDF-11 Protein, Human, Recombinant Growth/differentiation factor 11,Bone morphogenetic protein ...	Human	HEK293 Cells
	Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The si...
TMPJ-00716	Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His) DAN Domain Family Member 4,Cerberus,Cerberus-Related Protein...	Human	HEK293 Cells
	Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in respon...
TMPY-02488	HOXA1 Protein, Human, Recombinant (His) BSAS,homeobox A1,HOX1F,HOX1	Human	E. coli
	Homeobox protein Hox-A1 is a transcription factor encoded by the HOXA1 gene. This gene is one of the four types of homeobox genes each of which contains a homeobox DNA sequence that codes for the homeodomain, a region of 60 amino acids responsible for the DNA binding exhibited by these homeobox proteins. These Homeobox genes are essential metazoan genes as they determine the identity of embryonic regions along the anterior-posterior axis. The homeobox protein Hox-A1 may be involved in the placem...
TMPK-01020	FSHB Protein, Mouse, Recombinant (hFc) FSH-beta,FSH-B,FSHB,FSH-β,Follitropin	Mouse	HEK293 Cells
	Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Mouse, Recombinant (hFc) is expressed in HE...
TMPH-01413	GDF11 Protein, Human, Recombinant (His & SUMO) Bone morphogenetic protein 11,GDF11,Growth/differentiation f...	Human	E. coli
	Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. GDF11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression...
TMPK-01285	FSHB Protein, Cynomolgus, Recombinant (His) Follitropin,FSH-B,FSH-beta,FSH-β,FSHB	Cynomolgus	HEK293 Cells
	Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. FSHB Protein, Cynomolgus, Recombinant (His) is expressed ...
TMPH-02579	CHRDL1 Protein, Mouse, Recombinant (His & Myc) Nrln1,Neuralin-1,Ng1,Neurogenesin-1,Chrdl1,Ventroptin,Chordi...	Mouse	Baculovirus Insect Cells
	Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the ind...
TMPJ-00356	GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc) GHBP,GHR,Somatotropin receptor,growth hormone receptor,growt...	Mouse	HEK293 Cells
	Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its receptor in its extracellular domain. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway lead...
TMPY-02769	RNASET2 Protein, Human, Recombinant (His) bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2	Human	Baculovirus Insect Cells
	RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy....
TMPY-01875	SCGN Protein, Human, Recombinant (His) SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calcium b...	Human	E. coli
	Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ...
TMPY-02248	Myocilin Protein, Human, Recombinant (His) myocilin, trabecular meshwork inducible glucocorticoid respo...	Human	HEK293 Cells
	Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the ...
TMPY-02840	Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) UBE1,ubiquitin-like modifier activating enzyme 1,UBA1A,SMAX2...	Human	Baculovirus Insect Cells
	UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w...

重组蛋白

AGR3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01233

Species: Mouse

Expression System: HEK293 Cells

AGR3 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04205

Species: Human

Expression System: HEK293 Cells

AGR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00698

Species: Mouse

Expression System: E. coli

AG-3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00050

Species: Human

Expression System: HEK293 Cells

AG-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00056

Species: Human

Expression System: HEK293 Cells

Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His)

Cat.No: TMPH-00488

Species: Canine

Expression System: P. pastoris (Yeast)

Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His & Myc)

Cat.No: TMPH-00489

Species: Canine

Expression System: E. coli

GDF-11 Protein, Human, Recombinant

Cat.No: TMPJ-00713

Species: Human

Expression System: HEK293 Cells

Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-00716

Species: Human

Expression System: HEK293 Cells

HOXA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02488

Species: Human

Expression System: E. coli

FSHB Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01020

Species: Mouse

Expression System: HEK293 Cells

GDF11 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01413

Species: Human

Expression System: E. coli

FSHB Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01285

Species: Cynomolgus

Expression System: HEK293 Cells

CHRDL1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02579

Species: Mouse

Expression System: Baculovirus Insect Cells

GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00356

Species: Mouse

Expression System: HEK293 Cells

RNASET2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02769

Species: Human

Expression System: Baculovirus Insect Cells

SCGN Protein, Human, Recombinant (His)

Cat.No: TMPY-01875

Species: Human

Expression System: E. coli

Myocilin Protein, Human, Recombinant (His)

Cat.No: TMPY-02248

Species: Human

Expression System: HEK293 Cells

Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02840

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0268	Relugolix-d6
	Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T36383	L-Thyroxine-13C9,15N L-Thyroxine-13C9,15N
	L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode...

同位素标记化合物

Cat.No: TMIJ-0268

L-Thyroxine-13C9,15N

Cat.No: T36383

Synonym: L-Thyroxine-13C9,15N

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