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Search Results for " amide-type "

Targets Recommended: Sodium Channel

10

抑制剂 & 化合物

3

天然产物

1

化合物库

1

重组蛋白

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Cat. No.	Product Name
L7810	高溶解性多官能团片段化合物库		1159 compounds
	高溶解性多官能团片段库包含1159 种片段分子

化合物库

高溶解性多官能团片段化合物库

Cat.No: L7810

Compounds: 1159

Cat. No.	Product Name	Target	Signaling Pathways
T0946	Mepivacaine hydrochloride Mepivacaine HCl,盐酸甲哌卡因	Sodium Channel	Membrane transporter/Ion channel
	Mepivacaine hydrochloride (Mepivacaine HCl) 是具有局部麻醉特性的酰胺衍生物。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。
T0364	Dibucaine 地布卡因,Cinchocaine	CaMK; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Dibucaine (Cinchocaine) 是钠通道抑制剂和有效的SChE 抑制剂。
T6953	Prilocaine Citanest,丙胺卡因,Propitocaine,NSC 40027	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T0386	Ropivacaine hydrochloride 盐酸罗哌卡因,Ropivacaine monohydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine hydrochloride 可用于神经性疼痛的缓解。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T31773	Fenlean FLZ	Beta Amyloid; Src	Angiogenesis; Neuroscience; Tyrosine Kinase/Adaptors
	Fenlean (FLZ) 是酪氨酸激酶 Src 抑制剂，是来自Annona glabra的鳞甲酰胺的合成环状衍生物，具有细胞保护活性，在帕金森病慢性 MPTP/丙磺舒类小鼠模型中保护酪氨酸羟化酶功能。Fenlean 可以抑制线粒体中Aβ的产生，可用于研究年龄相关性黄斑变性和帕金森。
T67896	CB2R/FAAH modulator-1	Cannabinoid Receptor; FAAH	GPCR/G Protein; Metabolism; Neuroscience
	CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂，同时也是脂肪酸酰胺水解酶(FAAH)抑制剂（IC50=4 μM），可减少促炎和增加抗炎细胞因子的产生，常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
T36380	GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
	GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans...
T37934	15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F2α	Others	Others
	Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo...

化合物

Mepivacaine hydrochloride

Cat.No: T0946

Synonym: Mepivacaine HCl,盐酸甲哌卡因

Target: Sodium Channel

Cat.No: T0364

Synonym: 地布卡因,Cinchocaine

Target: CaMK, Sodium Channel, AChR

Cat.No: T6953

Synonym: Citanest,丙胺卡因,Propitocaine,NSC 40027

Target: ATPase, Sodium Channel

Ropivacaine hydrochloride

Cat.No: T0386

Synonym: 盐酸罗哌卡因,Ropivacaine monohydrochloride

Target: Potassium Channel, Sodium Channel

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

Cat.No: T31773

Synonym: FLZ

Target: Beta Amyloid, Src

CB2R/FAAH modulator-1

Cat.No: T67896

Target: Cannabinoid Receptor, FAAH

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)

Cat.No: T36380

15-keto-17-phenyl trinor Prostaglandin F2α

Cat.No: T37934

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7846	Aegeline	Others; Antifungal	Microbiology/Virology; Others
	Aegeline 是从 Aegle marmelos 的叶子中分离出来的一种生物碱酰胺，有抗高血糖和抗血脂异常的活性。
T0012	Cinchonine LA40221,(8R,9S)-Cinchonine,奎宁树,辛可宁	Apoptosis; P-gp; Parasite	Apoptosis; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Cinchonine (LA40221) 是金鸡纳树皮中的一种天然产物。它可激活内质网应激诱导的人肝癌细胞凋亡。它是一种酰胺类局部麻醉剂。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。

天然产物

Cat.No: T7846

Target: Others, Antifungal

Cat.No: T0012

Synonym: LA40221,(8R,9S)-Cinchonine,奎宁树,辛可宁

Target: Apoptosis, P-gp, Parasite

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01189	GFPT1 Protein, Human, Recombinant GFAT1,CMSTA1,GFAT,glutamine--fructose-6-phosphate transamina...	Human	E. coli
	Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a member of the N-terminal nucleophile aminotransferases and the first rate-limiting enzyme for the entry of glucose into the hexosamine biosynthesis pathway (HBP) in mammals. GFAT transfers the amino group from the L-glutamine amide to the D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. GFAT exists as a homotetramer in cytoplasm, and is proposed to be most likely involved in re...

重组蛋白

GFPT1 Protein, Human, Recombinant

Cat.No: TMPY-01189

Species: Human

Expression System: E. coli

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