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Search Results for " allergy "

Targets Recommended: Histamine Receptor

15

抑制剂 & 化合物

6

天然产物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；

化合物库

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

Cat. No.	Product Name	Target	Signaling Pathways
T26253	Tecastemizole Norastemizole,R-43512,R43512,R 43512,T 1348	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Tecastemizole (R 43512) 是 H1 受体的选择性拮抗剂，是阿司咪唑的主要代谢产物，具有抗炎作用。
T21419	Diphenhydramine 苯海拉明,Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Diphenhydramine (Syntedril) 是第一代具有抗胆碱能作用的H1 受体拮抗剂，它能透过血脑屏障。
T15259	Evatanepag CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Evatanepag (CP-533536 free acid) 是一种 EP2 受体选择性前列腺素 E2 (PGE2) 激动剂，可诱导局部骨形成，EC50 为 0.3 nM。它在大鼠骨折愈合模型中以单剂量局部给药时表现出愈合骨折的能力。
T3520	Setipiprant KYTH-105,塞替匹仑,ACT-129968	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Setipiprant (ACT-129968) 是一种口服的选择性 CRTH2 拮抗剂，IC50为6.0 nM。
T21390	Fexofenadine Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine (Carboxyterfenadine) 是一种抗组胺药物，用于治疗过敏症状，如鼻塞、花粉热和荨麻疹。与第一代抗组胺药相比，它通过血脑屏障并引起镇静的能力较差。
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T24771	SCH-336 SCH336,SCH 336	Cannabinoid Receptor	GPCR/G Protein
	SCH-336是一种 CB2受体激动剂(Ki-1.8 nM, EC50-2 nM)，具有有效性，选择性和口服活性。SCH-336对 CB1受体也具有生物活性，对CB2受体的选择性是CB1的100倍。SCH-336能够减少鸟苷5'-3- o -(硫)三磷酸与含hCB 的膜的结合，抑制 BaF3/CB2 细胞迁移，抑制小鼠延迟型超敏反应模型中的白细胞迁移，抑制小鼠过敏模型中抗原诱导的肺嗜酸性粒细胞增多。
T28372	PF-06462894 PF 6462894,PF-6462894,PF6462894	Others	Others
	PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM) with favorable properties. PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model.
T29545	Acamelin	Others	Others
	Acamelin is a quinone isolated from the Australian black wood acacia melanoxylon. It is responsible for the allergy-inducing properties of the species.
T71053	AHR-5333 mandelate	Others	Others
	AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis.
T26447	A 78773 A78773,A-78773	Others	Others
	A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflamma
TQ0032L	Rosiptor acetate AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate	Others	Others
	Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast cells and inhibits human leukocyte
T81590	OVA peptide
	OVA peptide，主要源于鸡蛋清，作为I类MHC（主要组织相容性复合体）分子H-2Kb（小鼠MHC的I类基因）所呈递的特定卵白蛋白Kb限制性表位。在过敏性研究领域，OVA peptide具有广泛应用。
T78641	ER-27319	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	ER-27319为吖啶酮衍生物，高效选择性抑制SYK，阻断其酪氨酸磷酸化和活性。本化合物阻止抗原刺激下人及大鼠肥大细胞释放过敏介质，IC50约为10 μM，适用于过敏性疾病研究。
T37604	ITK inhibitor	Others	Others
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome...

化合物

Cat.No: T26253

Synonym: Norastemizole,R-43512,R43512,R 43512,T 1348

Target: Histamine Receptor

Diphenhydramine

Cat.No: T21419

Synonym: 苯海拉明,Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255

Target: Histamine Receptor

Cat.No: T15259

Synonym: CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸

Target: Prostaglandin Receptor

Cat.No: T3520

Synonym: KYTH-105,塞替匹仑,ACT-129968

Target: GPR, Prostaglandin Receptor

Cat.No: T21390

Synonym: Carboxyterfenadine,Telfast,非索非那定,MDL 16.455,Allegra

Target: Histamine Receptor

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T24771

Synonym: SCH336,SCH 336

Target: Cannabinoid Receptor

Cat.No: T28372

Synonym: PF 6462894,PF-6462894,PF6462894

Target: Others

Cat.No: T29545

Target: Others

AHR-5333 mandelate

Cat.No: T71053

Target: Others

Cat.No: T26447

Synonym: A78773,A-78773

Target: Others

Rosiptor acetate

Cat.No: TQ0032L

Synonym: AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate

Target: Others

Cat.No: T81590

Cat.No: T78641

Target: Syk

Cat.No: T37604

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2290	Uvaol	Endogenous Metabolite; JNK; PPAR	DNA Damage/DNA Repair; MAPK; Metabolism
	Uvaol 存在于橄榄和初榨橄榄油中，具有抗炎、抗增殖和血管舒张活性。
T3S1534	Secoxyloganin 断氧化马钱苷,幼枝含断氧化马钱子甙,金银花	Anti-infection	Microbiology/Virology
	Secoxyloganin 是从Lonicera japonicaThunb 提取得到，能够抑制血流量减少，具有抗过敏活性。
T8297	Gomisin N	Apoptosis	Apoptosis
	Gomisin N 是从五味子中分离得到的一种天然产物，有镇静和催眠生物活性。它具有用于治疗过敏和抑制癌症增殖和诱导细胞凋亡的潜力。
TN3000	4,2'-Dihydroxy-4'-methoxychalcone	Others	Others
	4,2'-Dihydroxy-4'-methoxychalcone shows allergy-preventive effects.
T80019	17-Hydroxyneomatrine	Others	Others
	17-Hydroxyneomatrine 是一种从苦参 (Sophora flavescens) 提取的化合物，有效抑制人宫颈癌Hela细胞生长，并展现抗菌、抗过敏、抗肿瘤、抗心律失常、消肿、利尿、免疫调节等多种生物活性。
TN2517	1,7-Dihydroxy-2,3-dimethoxyxanthone	Others	Others
	1,7-Dihydroxy-2,3-dimethoxyxanthone may have medicinal use in the management of inflammation, asthma and allergy, it antagonises in a non competitive but, reversible manner the contractions induced by chemical inflammatory mediators in the guinea pig trac

天然产物

Cat.No: TN2290

Target: Endogenous Metabolite, JNK, PPAR

Cat.No: T3S1534

Synonym: 断氧化马钱苷,幼枝含断氧化马钱子甙,金银花

Target: Anti-infection

Cat.No: T8297

Target: Apoptosis

4,2'-Dihydroxy-4'-methoxychalcone

Cat.No: TN3000

Target: Others

17-Hydroxyneomatrine

Cat.No: T80019

Target: Others

1,7-Dihydroxy-2,3-dimethoxyxanthone

Cat.No: TN2517

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02499	Allergin-1 Protein, Mouse, Recombinant (His & Myc) Mca32,Gm885,Allergy inhibitory receptor 1,Mast cell...	Mouse	E. coli
	Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Allergin-1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.1 kDa and the accession number is Q3TB92.
TMPH-02578	CHI3L4 Protein, Mouse, Recombinant (His) Chil4,Secreted protein Ym2,Ym2,Chitinase-3-like protein 4,Ch...	Mouse	P. pastoris (Yeast)
	Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity.
TMPY-05710	Der p 23 Protein, Dermatophagoides pteronyssinus, Recombinant (His) endochitinase-like,Derp 23	Dermatophagoides pteronyssinus	HEK293 Cells
	Der p 23 is a new major allergen of D. pteronyssinus. The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. Der p 23 may be an essential component for diagnosis and specific immunotherapy of HDM allergy.
TMPK-00617	IL-13 Protein, Human, Recombinant (His & Avi) NC30,ALRH,IL13,MGC116786,MGC116789,P600,MGC116788,BHR1,IL-13...	Human	HEK293 Cells
	Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macro...
TMPK-00035	IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated binetrakin,BCGF1,IL4,白介素,白细胞介素,BSF1,IL-4,MGC79402,interleuki...	Human	HEK293 Cells
	Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor.
TMPK-00034	IL-4 Protein, Human, Recombinant (His & Avi) IL4,B cell growth factor 1,interleukin 4,BCGF1,BSF1,binetrak...	Human	HEK293 Cells
	Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. . IL-4 Protein, Human, Recombinant (His...
TMPK-00919	IL-4 Protein, Cynomolgus, Recombinant (His) BCGF-1,BSF-1,MGC79402,binetrakin,BCGF1,BSF1,BCDF,IL-4,B cell...	Cynomolgus	HEK293 Cells
	Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. . IL-4 Protein, Cynomolgus, Recombinant...
TMPY-03495	MID1IP1 Protein, Human, Recombinant (His) MIG12,S14R,MID1 interacting protein 1,THRSPL,STRAIT11499,G12...	Human	E. coli
	MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. The encoded protein belongs to the SPOT14 family. It is a homodimer in the absence of THRSP. MID1IP1 interacts with ACACA and ACACB. Its interaction with THRSP interferes with ACACA binding. It up-regulates ACACA enzyme activity and plays a role in the regulation of lipogenesis in the liver. MID1IP1 is required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol, and phospholipid. MID1IP1 is involved in the st...
TMPY-05438	CAN F 4 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Dog dander is an important cause of respiratory allergy but its content of allergenic components is still incompletely known. The size and the amino acid composition of the ligand-binding pocket indicate that Can f 4 is capable of binding only relatively small hydrophobic molecules which are different from those that Can f 2 is able to bind. The crystal structure of Can f 4 contained both monomeric and dimeric forms of the allergen, suggesting that Can f 4 is able to form transient (weak) dimers...

重组蛋白

Allergin-1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02499

Species: Mouse

Expression System: E. coli

CHI3L4 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02578

Species: Mouse

Expression System: P. pastoris (Yeast)

Der p 23 Protein, Dermatophagoides pteronyssinus, Recombinant (His)

Cat.No: TMPY-05710

Species: Dermatophagoides pteronyssinus

Expression System: HEK293 Cells

IL-13 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00617

Species: Human

Expression System: HEK293 Cells

IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00035

Species: Human

Expression System: HEK293 Cells

IL-4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00034

Species: Human

Expression System: HEK293 Cells

IL-4 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00919

Species: Cynomolgus

Expression System: HEK293 Cells

MID1IP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03495

Species: Human

Expression System: E. coli

CAN F 4 Protein, Canine, Recombinant (His)

Cat.No: TMPY-05438

Species: Canine

Expression System: HEK293 Cells

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