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Search Results for " water solubility "

Targets Recommended: Others

26

抑制剂 & 化合物

5

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6538	Hydroxypropyl Cellulose	Others	Others
	Hydroxypropyl Cellulose 是纤维素的衍生物，兼具水溶性和有机溶解性，用作食品添加剂和 DNA 分离的筛分基质。
T50013	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid	Others	Others
	4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid 是一种合成化合物，具有强大的抗肿瘤活性，对肿瘤细胞有高效性和选择性，但其在水中的溶解性差且在高浓度下有潜在毒性。
T4545	Propacetamol Hydrochloride 盐酸丙帕他莫,Propacetamol HCL	Others	Others
	Propacetamol Hydrochloride (Propacetamol HCL) 是 paracetamol(acetaminophen) 的前药，具有改善的水溶性。当口服非甾体抗炎药不合适或矛盾时，丙帕西莫是一种静脉给药的镇痛药。
T14050	5-FAM 5-羧基荧光素,5-Carboxyfluorescein	Others	Others
	5-FAM (5-Carboxyfluorescein) 是一种绿色荧光探针(Ex/Em 为 490 nm/520 nm)，可用于肽，蛋白质和核苷酸的标记。
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T33606	NBI-30545	Others	Others
	NBI-30545 is a potent corticotropin-releasing factor-1 antagonist with sufficient lipophilicity and water solubility for the treatment of stress disorders.
T19167	8pyDTZ	Others	Others
	8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission and improved water solubility. It can be used for in vivo luminescence imaging.
T80936	Trisulfo-Cy3-acid disodium
	Trisulfo-Cy3-acid disodium, 作为一种Cy3（Cyanine3）染料衍生物，具备三个磺酸根离子（sulfonate），从而提供了优化的水溶性特征。
T69608	TG11-77 HCl	Others	Others
	TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T69609	TG11-77 free base	Others	Others
	TG11-77 free base is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 free base has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 free base are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T30538	BMS-695735 CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888	Others	Others
	BMS-695735, a benzimidazole inhibitor of insulin-like growth factor-1 receptor, has broad-spectrum antitumor activity in vivo. It was found that BMS-695735 had strong inhibition of CYP3A4, induction of CYP3A4 mediated by PXR transactivation, poor water so
T81067	Sulfo-Cy3(Me)COOH sodium
	Sulfo-Cy3(Me)COOH sodium 为含磺酸根离子的 Cy3（Cyanine3）染料衍生物，而 Trisulfo-Cy3-acid disodium 含 sulfonate （磺酸根离子），水溶性更佳。
T82852	BMI-Glu
	BMI-Glu，一种选择性γ-谷氨酰转肽酶(GGT)荧光探针，具有Km值为69.63 µM的高敏感性，以及优异的水溶性和生物相容性。
T18940	Cy2 CY2 Non-Sulfonated,Cyanine2	Others	Others
	Cy2 (CY2 Non-Sulfonated)是一种花青染料，波长长，吸收和发射可调，消光系数高，水溶性好。 Cy2 可用于标记寡核苷酸、肽和蛋白质中的氨基。
T82866	Biotin-PEG-Biotin (MW 20000)
	Biotin-PEG-azide (MW 2000) 为含有生物素标记的聚乙二醇 (PEG) 衍生物。该生物素（Biotin）作为酶辅因子，在蛋白质标记应用中具有重要作用，而PEG是低毒性且具亲水性的水溶性聚合物。
T63319	Antitubercular agent-32	Others	Others
	Antitubercular agent-32 是Benzothiazinone 衍生物，对结核分枝杆菌 M. tuberculosis 具有抑制作用，并表现出良好的代谢稳定性及水溶性。 Antitubercular agent-32 可以作用于 decaprenylphosphoryl-β-D-ribose 2'-氧化酶 (DprE1,IC50: 3.9 μM)，表现出抗结核效果。
T67948	OY-101	Others	Others
	OY-101为口服生效的特异性P-glycoprotein(P-gp)抑制剂。该化合物可增强耐药性肿瘤的敏感性，并有效逆转多药耐药现象。相较于Tetrandrine，OY-101在水溶性、细胞毒性以及逆转活性方面均表现出改进。
T71577	KOS-1584	Others	Others
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration,...
T68860	Iso-Fludelone	Others	Others
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T82868	Biotin-PEG-azide (MW 2000)
	Biotin-PEG-azide (MW 2000) 为生物素修饰的PEG衍生物，其中生物素用作蛋白质标记的酶辅因子，PEG为低毒性亲水聚合物。叠氮部分则作为离去基，可通过铜催化与炔烃发生反应，从而增强生物素对靶点的结合效率。
T84794	DBCO-PEG2-DBCO	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	DBCO-PEG2-DBCO为一种点化学试剂，含有两端DBCO基团的PEG连接子(linker)。DBCO基团以其应变促进的高能量特征，常被用于无铜点击化学反应。该化合物中的聚乙二醇链提高了水溶性。级别为T试剂级，仅限研究使用。
T31657	Epothilone F	Others	Others
	Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing
T74120	Cy5 maleimide
	Cy5 maleimide 是一种 CY 染料。CY 为花菁 (Cyanine) 的缩写，是由奇数个甲基单位连接的两个氮原子组成的化合物。菁类化合物具有波长长、吸收和发射可调、消光系数高、水溶性好、合成相对简单等特点。CY 系类染料常被用于蛋白，抗体以及小分子化合物的标记，对于蛋白抗体的标记，可以通过简单的混合反应来完成结合，以下我们介绍了蛋白抗体标记的标记方法，具有一定的参考意义。储存方式：避光。
T75337	Cy5.5-SE (DIPEA)	Others	Others
	Cy5.5-SE (Cyanine5.5 NHS ester) DIPEA 是一种以奇数个甲基单位连接两个氮原子的花菁(Cyanine)染料。该染料特点包括长波长、可调吸收发射、高消光系数、良好水溶性及合成相对简单。常用于蛋白、抗体和小分子化合物的标记，特别是蛋白抗体的标记，通过简单混合反应即可完成结合。储存应避光。
T84793	DBCO-PEG2-NHS ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	DBCO-PEG2-NHS 酯是一种配备NHS酯的聚乙二醇(PEG)点击化学试剂，具备叠氮基团，可于中性或微碱性环境下与伯胺（例如赖氨酸残基侧链或氨基硅烷包被表面）实现特异性高效的共价键合成。其聚乙二醇间隔臂的亲水性显著增强了水溶性，并提供灵活长链结构以极大降低空间位阻，优化了连接效率。主要应用于无铜点击化学反应中。产品为试剂级，仅限研究使用。
T36400	para-amino-Blebbistatin	Others	Others
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Hydroxypropyl Cellulose

Cat.No: T6538

Target: Others

4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoic acid

Cat.No: T50013

Target: Others

Propacetamol Hydrochloride

Cat.No: T4545

Synonym: 盐酸丙帕他莫,Propacetamol HCL

Target: Others

Cat.No: T14050

Synonym: 5-羧基荧光素,5-Carboxyfluorescein

Target: Others

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

Cat.No: T33606

Target: Others

Cat.No: T19167

Target: Others

Trisulfo-Cy3-acid disodium

Cat.No: T80936

Cat.No: T69608

Target: Others

TG11-77 free base

Cat.No: T69609

Target: Others

Cat.No: T30538

Synonym: CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888

Target: Others

Sulfo-Cy3(Me)COOH sodium

Cat.No: T81067

Cat.No: T82852

Cat.No: T18940

Synonym: CY2 Non-Sulfonated,Cyanine2

Target: Others

Biotin-PEG-Biotin (MW 20000)

Cat.No: T82866

Antitubercular agent-32

Cat.No: T63319

Target: Others

Cat.No: T67948

Target: Others

Cat.No: T71577

Target: Others

Cat.No: T68860

Target: Others

Biotin-PEG-azide (MW 2000)

Cat.No: T82868

Cat.No: T84794

Target: Others, ADC Linker

Cat.No: T31657

Target: Others

Cat.No: T74120

Cy5.5-SE (DIPEA)

Cat.No: T75337

Target: Others

DBCO-PEG2-NHS ester

Cat.No: T84793

Target: Others, ADC Linker

para-amino-Blebbistatin

Cat.No: T36400

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T20597	Alginic acid Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine	Apoptosis; Autophagy; Histamine Receptor	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Alginic acid (Snow acid algin G) 是一种从褐海藻中提取的天然多糖，具有抗过敏和抗炎活性。 Alginic acid 抑制组胺释放，可用于食品工业。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
T81026	Tectorigenin sodium sulfonate	Others	Others
	Tectorigenin sodium sulfonate，一种经鸢尾黄素磺化并与饱和盐水混合得到的化合物，拥有高水溶性及优良抗氧化特性。
T82148	Hydrogenated soya phosphatidylcholines	Others	Others
	Hydrogenated soya phosphatidylcholines 是一种用于提升水溶性药物口服给药效果的天然产物，它能够增加药物负荷和溶解度，从而延长药物释放时间。
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln	Others	Others
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。

天然产物

Cat.No: T20597

Synonym: Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine

Target: Apoptosis, Autophagy, Histamine Receptor

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated, ADC Cytotoxin

Tectorigenin sodium sulfonate

Cat.No: T81026

Target: Others

Hydrogenated soya phosphatidylcholines

Cat.No: T82148

Target: Others

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01616	SULT2B1 Protein, Human, Recombinant (His) SULT2B1,sulfotransferase family 2B member 1,HSST2	Human	E. coli
	Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 ca...
TMPY-01617	SULT1B1 Protein, Human, Recombinant (His) sulfotransferase family, cytosolic, 1B, member 1,SULT1B2,ST1...	Human	E. coli
	Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver, perip...

重组蛋白

SULT2B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01616

Species: Human

Expression System: E. coli

SULT1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01617

Species: Human

Expression System: E. coli

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