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Search Results for " varicella-zoster "

Targets Recommended: DNA/RNA Synthesis

16

抑制剂 & 化合物

2

天然产物

1

化合物库

9

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L1720	核苷类化合物库		334 compounds
	334 种核苷类化合物，包括核苷酸、核苷酸类似物及衍生物等，适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发；

化合物库

核苷类化合物库

Cat.No: L1720

Compounds: 334

Cat. No.	Product Name	Target	Signaling Pathways
T16911	Sorivudine BV-araU,索立夫定	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sorivudine (BV-araU) 是口服有效的，嘧啶核苷抗代谢药物。它的抗病毒活性来自某些 DNA 病毒中存在的特定胸苷激酶选择性转化为核苷酸，从而反过来会干扰病毒 DNA 合成。
T26987	CF-1743 CF1743	HSV	Microbiology/Virology
	CF-1743 是一种抗水痘带状疱疹病毒核苷，可抑制 VZV 复制。 CF-1743可用于水痘和带状疱疹感染的研究。
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T4226	Amenamevir ASP2151,阿莫奈韦	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Amenamevir (ASP2151) 是一种新型解旋酶引发酶抑制剂，对水痘带状疱疹病毒和 1 型和 2 型单纯疱疹病毒具有活性，EC50值为 14 ng/mL。
T60540	Netivudine	Others	Others
	Netivudine 是一种有效的核苷类逆转录酶抑制剂(NRTIs)，是一种核苷类似物，具有抗水痘带状疱疹病毒活性，可用于治疗人类免疫缺陷病毒(HIV)感染。Netivudine 通过抑制逆转录酶起作用，通过抑制作用减少体内的病毒载量，减缓疾病的进展。
T22454	Vidarabine monohydrate 维达拉滨一水合物,Vira-A monohydrate,Spongoadenosine monohydrate,阿糖腺苷一水合物	Others	Others
	Vidarabine, a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA, is used to treat varicella zoster and herpes simplex viruses.
T10615	BRL44385	HSV	Microbiology/Virology
	BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).
T26438	A 73209 A73209,A-73209	Others	Others
	A 73209 is a nucleoside analog of the oxetanocin family. A-73209 appears to be a potent and selective agent against herpes simplex virus and varicella-zoster virus infections.
T83261	6-Methoxypurine arabinoside Ara-m	Others	Others
	6-Methoxypurine arabinoside (Ara-m) 是一种抗水痘-带状疱疹病毒（VZV）活性物质，具有对8株VZV 50%抑制浓度差异，在0.5 - 3 microM范围内。
T29093	Valomaciclovir stearate A-174606.0,RP-606,EPB-348,ABT-606,MIV-606	Others	Others
	Valomaciclovir stearate is a DNA polymerase inhibitor. Valomaciclovir stearate is an orally available drug with broad-spectrum antiviral activity against a variety of important herpesviruses, including Epstein-Barr virus, or EBV (the first virus to be dir
T74385	Biotin-PEG7-C2-S-Vidarabine	Others	Others
	Biotin-PEG7-C2-S-Vidarabine 为一种含有 Vidarabine 的 PEG 类连接子，其中 Vidarabine 为对单纯疱疹病毒和水痘带状疱疹病毒有抗病毒效果的腺苷类似物。
T74384	Biotin-PEG8-Vidarabine	Others	Others
	Biotin-PEG8-Vidarabine 是一款以 PEG 链为基础的连接物，其特征为包含抗病毒分子 Vidarabine。Vidarabine 对于单纯疱疹病毒及水痘带状疱疹病毒展现出明显的抑制作用。
T29092	Valnivudine FV 100,FV100,FV-100	Others	Others
	Valnivudine 是 CF-1743 的前体，是一种口服有效和高效的抗带状疱疹 (HZ) 核苷类似物, 是一种双环核苷类似物 (BCNA). Valnivudine 具有抗病毒活性，可对水痘带状疱疹病毒 (VZV) 进行高度抑制。Valnivudine 在体内可以迅速广泛地转化为 CF-1743。
T74386	Biotin-PEG7-C2-NH-Vidarabine-S-CH3	Others	Others
	Biotin-PEG7-C2-NH-Vidarabine-S-CH3 是一种含 Vidarabine 的 PEG 类连接子。Vidarabine 为腺苷类似物，具抗病毒分子活性，有效针对单纯疱疹病毒及水痘带状疱疹病毒。
T35802	ML-345	Others	Others
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de...
T80655	BVDU 5′-Triphosphate BVdUTP,(E)-5-(2-Bromovinyl)-dUTP	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒（VZV）和单纯疱疹病毒 1 型（HSV-1）具有高度选择性，这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。

化合物

Cat.No: T16911

Synonym: BV-araU,索立夫定

Target: DNA/RNA Synthesis

Cat.No: T26987

Synonym: CF1743

Target: HSV

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

Cat.No: T4226

Synonym: ASP2151,阿莫奈韦

Target: DNA/RNA Synthesis, HSV

Cat.No: T60540

Target: Others

Vidarabine monohydrate

Cat.No: T22454

Synonym: 维达拉滨一水合物,Vira-A monohydrate,Spongoadenosine monohydrate,阿糖腺苷一水合物

Target: Others

Cat.No: T10615

Target: HSV

Cat.No: T26438

Synonym: A73209,A-73209

Target: Others

6-Methoxypurine arabinoside

Cat.No: T83261

Synonym: Ara-m

Target: Others

Valomaciclovir stearate

Cat.No: T29093

Synonym: A-174606.0,RP-606,EPB-348,ABT-606,MIV-606

Target: Others

Biotin-PEG7-C2-S-Vidarabine

Cat.No: T74385

Target: Others

Biotin-PEG8-Vidarabine

Cat.No: T74384

Target: Others

Cat.No: T29092

Synonym: FV 100,FV100,FV-100

Target: Others

Biotin-PEG7-C2-NH-Vidarabine-S-CH3

Cat.No: T74386

Target: Others

Cat.No: T35802

Target: Others

BVDU 5′-Triphosphate

Cat.No: T80655

Synonym: BVdUTP,(E)-5-(2-Bromovinyl)-dUTP

Target: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Signaling Pathways
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。

天然产物

Cat.No: TN1788

Target: Amylase

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06855	Varicella-zoster virus (VZV) (strain Oka vaccine) Glycoprotein B/gB Protein	VZV	CHO Cells
	Varicella-zoster virus (VZV) is a highly fusogenic virus, but the degree of fusion is dependent on the cell substrate in which the virus is propagated. Varicella-zoster virus (VZV) is classified as an alphaherpesvirus based on its growth characteristics and its ability to become latent in the nervous system of the host. Like all known herpesviruses, VZV encodes a homolog of glycoprotein B (gB). Glycoprotein B (gB) is the most conserved entry glycoprotein among herpesviruses with an amino acid se...
TMPK-01192	Varicella-zoster virus (strain Oka vaccine) Envelope glycoprotein E Protein (His) Envelope glycoprotein E,ORF68,gE	Varicella-zoster virus (strain Oka vaccine)	HEK293 Cells
	VZV glycoprotein E (gE) is most abundantly expressed on the surface of infected cells, and is an essential component for virus replication and cell-to-cell transmission. It is also the main target of virus-specific antibodies and T cell responses that is often selected as vaccine candidate antigen.
TMPH-03682	Varicella-zoster virus (strain Dumas) glycoprotein H/gH Protein (His & Myc) Envelope glycoprotein H,gH	HHV-3	E. coli
	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Varicella-zoster virus (strain Dumas) glycoprotein H/gH Protein (His & Myc) is expressed in E...
TMPH-03681	Varicella-zoster virus (strain Dumas) glycoprotein E/gE Protein (His & SUMO) Envelope glycoprotein E,gE	HHV-3	E. coli
	Varicella-zoster virus (strain Dumas) glycoprotein E/gE Protein (His & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO tag. The predicted molecular weight is 85.4 kDa and the accession number is P09259.
TMPY-06867	Varicella-zoster virus (VZV) (strain Oka vaccine) gH & gL Heterodimer Protein	VZV	CHO Cells
	Varicella-zoster virus (VZV) (strain Oka vaccine) gH & gL Heterodimer Protein is expressed in CHO mammalian cells. The predicted molecular weight is 85.17 kDa.
TMPH-03683	Varicella-zoster virus (strain Oka vaccine) glycoprotein H/gH Protein (His) Envelope glycoprotein H,gH	HHV-3	E. coli
	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Varicella-zoster virus (strain Oka vaccine) glycoprotein H/gH Protein (His) is expressed in E...
TMPH-03684	Varicella-zoster virus (strain Dumas) glycoprotein L/gL Protein (His & Myc) gL,Envelope glycoprotein L	HHV-3	E. coli
	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Varicella-zoster virus (strain Dumas) glycoprotein L/gL Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predi...
TMPY-06357	Varicella-zoster virus (VZV)/HHV-3 Glycoprotein E/gE Protein (His)	VZV	HEK293 Cells
	Varicella-zoster virus (VZV)/HHV-3 Glycoprotein E/gE Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.02 kDa and the accession number is Q9J3M8.
TMPH-03685	Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc) Envelope glycoprotein L,gL	HHV-3	E. coli
	The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The...

重组蛋白

Varicella-zoster virus (VZV) (strain Oka vaccine) Glycoprotein B/gB Protein

Cat.No: TMPY-06855

Species: VZV

Expression System: CHO Cells

Varicella-zoster virus (strain Oka vaccine) Envelope glycoprotein E Protein (His)

Cat.No: TMPK-01192

Species: Varicella-zoster virus (strain Oka vaccine)

Expression System: HEK293 Cells

Varicella-zoster virus (strain Dumas) glycoprotein H/gH Protein (His & Myc)

Cat.No: TMPH-03682

Species: HHV-3

Expression System: E. coli

Varicella-zoster virus (strain Dumas) glycoprotein E/gE Protein (His & SUMO)

Cat.No: TMPH-03681

Species: HHV-3

Expression System: E. coli

Varicella-zoster virus (VZV) (strain Oka vaccine) gH & gL Heterodimer Protein

Cat.No: TMPY-06867

Species: VZV

Expression System: CHO Cells

Varicella-zoster virus (strain Oka vaccine) glycoprotein H/gH Protein (His)

Cat.No: TMPH-03683

Species: HHV-3

Expression System: E. coli

Varicella-zoster virus (strain Dumas) glycoprotein L/gL Protein (His & Myc)

Cat.No: TMPH-03684

Species: HHV-3

Expression System: E. coli

Varicella-zoster virus (VZV)/HHV-3 Glycoprotein E/gE Protein (His)

Cat.No: TMPY-06357

Species: VZV

Expression System: HEK293 Cells

Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc)

Cat.No: TMPH-03685

Species: HHV-3

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0013	Acyclovir-d4
	Acyclovir-d4 是 Acyclovir 的氘代化合物。Acyclovir 的 CAS 号为 59277-89-3。Acyclovir是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。

同位素标记化合物

Cat.No: TMIJ-0013

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