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Search Results for " urea cycle "

Targets Recommended: Others

3

抑制剂 & 化合物

5

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T30127	Argininosuccinic acid	Others	Others
	Argininosuccinic acid can be obtained during the urea cycle from citrulline, aspartate, and ATP by argininosuccinic acid synthetase.
T76208	Arginase
	Arginase 是尿素循环的一种酶。Arginase 催化 L-精氨酸水解为 L-鸟氨酸和尿素。
T78059	Glucagon (Human) Hyperglycemic-glycogenolytic factor,Glukagon	Others	Others
	Glucagon 对蛋白质和氨基酸的代谢产生显著的调节作用。它抑制了氨基酸与肝脏、肌肉以及胰腺蛋白的结合，增加氮的排出，并促进肝脏内尿素的合成。同时，Glucagon 增加了肝脏中转氨酶和尿素循环酶的浓度，提高了肝脏对氨基酸的摄取，并加强了氨基酸与肝糖原之间的结合，从而降低了血液中的氨基酸浓度。

化合物

Argininosuccinic acid

Cat.No: T30127

Target: Others

Cat.No: T76208

Glucagon (Human)

Cat.No: T78059

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2O2701	L-Ornithine hydrochloride L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐	Others; Endogenous Metabolite	Metabolism; Others
	L-Ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) 通过提高能量消耗效率和促进氨的排泄而具有抗疲劳作用。它是尿素循环中的关键反应物之一。
T5267	N-Acetyl-L-glutamic acid Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸，是动物细胞培养基的组成成分，是一种酿酒酵母和人类的代谢物。
T2931	2-Amino-5-ureidopentanoic acid DL-Citrulline,Citrulline,瓜氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-5-ureidopentanoic acid (Citrulline) 存在于肝脏中，不是蛋白质的构成成分，为人体脲循环的一个重要中间物，可与鸟氨酸、精氨酸合用治疗高氨血症。
T5257	L-Homocitrulline 高瓜氨酸,Homo-L-citrulline,Homocitrulline	Others; Endogenous Metabolite	Metabolism; Others
	L-Homocitrulline (Homocitrulline) 是一种代谢物，可在尿素循环障碍患者的尿液中大量检测到。在某些情况下，由于尿素循环的鸟氨酸供应耗尽而导致的氨甲酰磷酸酯的积累可能是 L-Homocitrulline 和高精氨酸合成增强的原因。
T4728	4-Acetamidobutanoic acid N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID,4-乙酰氨基丁酸	GABA Receptor; Endogenous Metabolite; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) 可在血液、粪便和尿液以及人体前列腺组织中找到，也存在于从酵母到人类的所有真核生物中。它是GABA 衍生物，具有抗氧化和抗菌活性。

天然产物

L-Ornithine hydrochloride

Cat.No: T2O2701

Synonym: L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐

Target: Others, Endogenous Metabolite

N-Acetyl-L-glutamic acid

Cat.No: T5267

Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

2-Amino-5-ureidopentanoic acid

Cat.No: T2931

Synonym: DL-Citrulline,Citrulline,瓜氨酸

Target: Others, Endogenous Metabolite

L-Homocitrulline

Cat.No: T5257

Synonym: 高瓜氨酸,Homo-L-citrulline,Homocitrulline

Target: Others, Endogenous Metabolite

4-Acetamidobutanoic acid

Cat.No: T4728

Synonym: N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID,4-乙酰氨基丁酸

Target: GABA Receptor, Endogenous Metabolite, Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02817	OTCase Protein, Mouse, Recombinant (His & SUMO) Ornithine carbamoyltransferase, mitochondrial,Otc,Ornithine ...	Mouse	E. coli
	Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
TMPH-01817	OTCase Protein, Human, Recombinant (His & SUMO) Ornithine carbamoyltransferase, mitochondrial,OTC,Ornithine ...	Human	E. coli
	Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. OTCase Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.1 kDa and the accession number is P00480.
TMPH-02560	CPS1 Protein, Mouse, Recombinant (His) Carbamoyl-phosphate synthetase I,CPS1,CPSase I,Carbamoyl-pho...	Mouse	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TMPH-01037	CPS1 Protein, Human, Recombinant (His) CPS1,CPSase I,Carbamoyl-phosphate synthetase I,Carbamoyl-pho...	Human	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P31327.
TMPJ-00732	ASS1 Protein, Human, Recombinant (His) Citrulline--Aspartate Ligase,Argininosuccinate Synthase,ASS1...	Human	E. coli
	Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullin...
TMPH-03257	CPS1 Protein, Rat, Recombinant (His & Myc) Carbamoyl-phosphate synthase [ammonia], mitochondrial,CPSase...	Rat	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.7 kDa and the accession number is P07756.
TMPJ-01058	ARG2 Protein, Human, Recombinant (His) ARG2,Kidney-type arginase,Type II arginase,Arginase-2, mitoc...	Human	E. coli
	Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not founded in the liver, heart and pancreas. ARG2 has been implicated in the regulation of the arginine/ornithine concentrations in the cell. ARG2 may take part in the regulation of extra-urea cycle arginine metabolism and in down-regulation of nitric oxide synthesis. The extrahepatic ar...
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His) Arginase-1,Type I arginase,Liver-type arginase,Arg1	Mouse	P. pastoris (Yeast)
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i...
TMPH-02527	ASS1 Protein, Mouse, Recombinant (His & Myc) Ass,Citrulline--aspartate ligase,Ass1,Argininosuccinate synt...	Mouse	E. coli
	One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. ASS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 5...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin...	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....

重组蛋白

OTCase Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02817

Species: Mouse

Expression System: E. coli

OTCase Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01817

Species: Human

Expression System: E. coli

CPS1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02560

Species: Mouse

Expression System: E. coli

CPS1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01037

Species: Human

Expression System: E. coli

ASS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00732

Species: Human

Expression System: E. coli

CPS1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03257

Species: Rat

Expression System: E. coli

ARG2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01058

Species: Human

Expression System: E. coli

Arginase-1/ARG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02524

Species: Mouse

Expression System: P. pastoris (Yeast)

ASS1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02527

Species: Mouse

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02526

Species: Mouse

Expression System: E. coli

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